scholarly journals ROLE OF RESISTANCE EXERCISE IN CONTROLLING INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) AND IT’S ASSOCIATION WITH METABOLIC DISEASE PREVENTION

2021 ◽  
Vol 2 (1) ◽  
pp. 1
Author(s):  
Fitri Fadhilah ◽  
Abdul Hadi Hassan ◽  
Hanna Goenawan ◽  
Herry Herman ◽  
Aziiz Mardanarian Rosdianto ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Growth Factor ◽  
Resistance Training ◽  
Muscle Hypertrophy ◽  
Metabolic Diseases ◽  
Insulin Like Growth Factor ◽  
Muscle Adaptation ◽  
Proliferation And Differentiation ◽  
Myogenic Activity

Based on data Riset Kesehatan Dasar (Riskesdas) in 2007, the number of people who had no or low physical activity reached 48.2 %. This condition contributes to the increasing number of metabolic disease cases such as hypertension, heart disease, stroke, and diabetes mellitus. Optimizing training approaches especially the aerobic type helps to counter metabolic diseases. Unfortunately, the benefits of resistance training (RT) are less understood. RT improves muscle strength, induces muscle hypertrophy, improvement of local muscular performance, and also helps to strengthen body balance and coordination. There is an interplay between training and hormone in muscle adaptation during resistance training. The hormone plays an important role in the regeneration of muscle after resistance training. The changes in hormone level cause hypertrophy. Regeneration and muscle hypertrophy are mediated by activation, proliferation, and differentiation of satellite cells. It is regulated by mitotic and myogenic activity, namely insulin-like growth factor-1 (IGF-1), which serves as a paracrine or autocrine. A better understanding of homeostasis hormone during training in skeletal muscle and its ultimate purpose to counter metabolic disease will lead us to a better treatment approach for the patient.

ROLE OF RESISTANCE EXERCISE IN CONTROLLING INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) AND IT�S ASSOCIATION WITH METABOLIC DISEASE PREVENTION

2019 ◽  
Vol 1 (1) ◽  
pp. 37
Author(s):  
Fitri Fadhilah ◽  
Abdul Hadi Hassan ◽  
Hanna Goenawan ◽  
Herry Herman ◽  
Aziiz Mardanarian Rosdianto ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Growth Factor ◽  
Resistance Training ◽  
Muscle Hypertrophy ◽  
Metabolic Diseases ◽  
Insulin Like Growth Factor ◽  
Muscle Adaptation ◽  
The People ◽  
Training Approach ◽  
Proliferation And Differentiation

Based on data Riset Kesehatan Dasar (Riskesdas) in 2007, the people who had no or low physical activity reached 48.2 %. This condition contributes to increase number of metabolic disease cases such as: hypertension, heart disease, stroke and diabetes mellitus. Optimizing training approach especially aerobic type helps to counter metabolic diseases. Unfortunately, benefits of resistance training (RT) is less understood. RT improves muscle strength, induce muscle hypertrophy, improvement of local muscular performance, and also help to strenghtening body balance and coordination. There is interplay between training and hormone in muscle adaptation during resistance training. Hormone plays an important role in the regeneration of muscle after resistance training. The changes of hormone level cause hypertrophy. Regeneration and muscle hypertrophy are mediated by activation, proliferation and differentiation of satellite cells. It is regulated by mitotic and myogenic activity, namely insulin-like growth factor-1 (IGF-1), which serves as a paracrine or autocrine. Better understanding of homeostasis hormone during training in skeletal muscle and its ultimate purpose to counter metabolic disease will lead us to better treatment approach for the patient.

Skeletal muscle stem cells: a symposium

2006 ◽  
Vol 31 (6) ◽  
pp. 771-772 ◽  
Author(s):  
David A. Hood ◽  
Thomas J. Hawke
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Growth Factor ◽  
Muscle Regeneration ◽  
Muscle Hypertrophy ◽  
Insulin Like Growth Factor ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells

Muscle stem cells are a population of cells that are important for both adaptations to exercise and muscle regeneration. This symposium was designed to highlight the role of these cells during muscle hypertrophy and development, and in response to insulin-like growth factor-1 (IGF-1) induced stimulation.

Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistance-trained rats

2004 ◽  
Vol 96 (3) ◽  
pp. 1097-1104 ◽  
Author(s):  
Sukho Lee ◽  
Elisabeth R. Barton ◽  
H. Lee Sweeney ◽  
Roger P. Farrar
Keyword(s):  
Growth Factor ◽  
Resistance Training ◽  
Muscle Mass ◽  
Muscle Hypertrophy ◽  
Insulin Like Growth Factor ◽  
Effective Measure ◽  
Factor I ◽  
Viral Expression ◽  
Igf I ◽  
Growth Factor I

Muscle hypertrophy is the product of increased drive through protein synthetic pathways and the incorporation of newly divided satellite cells. Gains in muscle mass and strength can be achieved through exercise regimens that include resistance training. Increased insulin-like growth factor-I (IGF-I) can also promote hypertrophy through increased protein synthesis and satellite cell proliferation. However, it is not known whether the combined effect of IGF-I and resistance training results in an additive hypertrophic response. Therefore, rats in which viral administration of IGF-I was directed to one limb were subjected to ladder climbing to test the interaction of each intervention on muscle mass and strength. After 8 wk of resistance training, a 23.3% increase in muscle mass and a 14.4% increase in peak tetanic tension (Po) were observed in the flexor hallucis longus (FHL). Viral expression of IGF-I without resistance training produced a 14.8% increase in mass and a 16.6% increase in Po in the FHL. The combined interventions produced a 31.8% increase in muscle mass and a 28.3% increase in Po in the FHL. Therefore, the combination of resistance training and overexpression of IGF-I induced greater hypertrophy than either treatment alone. The effect of increased IGF-I expression on the loss of muscle mass associated with detraining was also addressed. FHL muscles treated with IGF-I lost only 4.8% after detraining, whereas the untreated FHL lost 8.3% muscle mass. These results suggest that a combination of resistance training and overexpression of IGF-I could be an effective measure for attenuating the loss of training-induced adaptations.

Are We Exploring the Potential Role of Specialized Techniques in Muscle Hypertrophy?

2021 ◽  
Author(s):  
Witalo Kassiano ◽  
Bruna Daniella de Vasconcelos Costa ◽  
João Pedro Nunes ◽  
Andreo Fernando Aguiar ◽  
Belmiro F. de Salles ◽  
...  
Keyword(s):  
Resistance Training ◽  
Muscle Hypertrophy ◽  
Potential Role ◽  
Ecological Validity ◽  
Trained Subjects ◽  
Training Techniques ◽  
Methodological Rigor ◽  
Traditional Resistance Training ◽  
Intervening Variables

AbstractSpecialized resistance training techniques (e.g., drop-set, rest-pause) are commonly used by well-trained subjects for maximizing muscle hypertrophy. Most of these techniques were designed to allow a greater training volume (i.e., total repetitions×load), due to the supposition that it elicits greater muscle mass gains. However, many studies that compared the traditional resistance training configuration with specialized techniques seek to equalize the volume between groups, making it difficult to determine the inherent hypertrophic potential of these advanced strategies, as well as, this equalization restricts part of the practical extrapolation on these findings. In this scenario, the objectives of this manuscript were 1) to present the nuance of the evidence that deals with the effectiveness of these specialized resistance training techniques and — primarily — to 2) propose possible ways to explore the hypertrophic potential of such strategies with greater ecological validity without losing the methodological rigor of controlling possible intervening variables; and thus, contributing to increasing the applicability of the findings and improving the effectiveness of hypertrophy-oriented resistance training programs.

scholarly journals Fructose and Mannose in Inborn Errors of Metabolism and Cancer

Metabolites ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 479
Author(s):  
Elizabeth L. Lieu ◽  
Neil Kelekar ◽  
Pratibha Bhalla ◽  
Jiyeon Kim
Keyword(s):  
Metabolic Disease ◽  
Inborn Errors Of Metabolism ◽  
Metabolic Diseases ◽  
Treatment Options ◽  
Biochemical Properties ◽  
Biological Molecules ◽  
Diagnostic Tools ◽  
Inborn Errors ◽  
Mannose Metabolism

History suggests that tasteful properties of sugar have been domesticated as far back as 8000 BCE. With origins in New Guinea, the cultivation of sugar quickly spread over centuries of conquest and trade. The product, which quickly integrated into common foods and onto kitchen tables, is sucrose, which is made up of glucose and fructose dimers. While sugar is commonly associated with flavor, there is a myriad of biochemical properties that explain how sugars as biological molecules function in physiological contexts. Substantial research and reviews have been done on the role of glucose in disease. This review aims to describe the role of its isomers, fructose and mannose, in the context of inborn errors of metabolism and other metabolic diseases, such as cancer. While structurally similar, fructose and mannose give rise to very differing biochemical properties and understanding these differences will guide the development of more effective therapies for metabolic disease. We will discuss pathophysiology linked to perturbations in fructose and mannose metabolism, diagnostic tools, and treatment options of the diseases.

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