scholarly journals Segregation von Pigmentzellanomalien bei Kreuzungen zwischen dem Münchener Miniaturschwein Troll und der Deutschen Landrasse

2000 ◽  
Vol 43 (3) ◽  
pp. 277-286
Author(s):  
S. Müller ◽  
R. Wanke ◽  
W. Hermanns ◽  
O. Distl
Keyword(s):  
Coat Colour ◽  
Miniature Swine ◽  
Melanocytic Lesions ◽  
University Of Munich ◽  
Kit Gene ◽  
High Incidence ◽  
F2 Generation ◽  
The University ◽  
White Colour ◽  
Migration And Development

Abstract. Title of the paper: Segregation of melanocytic lesions in crosses among the Munich Miniature Swine Troll and German Landrace Since 1986, a line of Munich Miniature Swine (MMS) Troll showing a high incidence of spontaneous benign and malignant cutaneous melanocytic lesions has been established at the University of Munich. In order to study me inheritance of cutaneous melanocytic lesions in the Munich Miniature Swine Troll, we established the F1-, F2-, BIDL-, and BITroll-generations, starting with one melanoma-bearing MMS Troll boar and four non-affected sows of the German Landrace (DL) as founder animals. A total of 176 animals were available, 27 in the F1-, 111 in the F2-, 19 in the B|DL-, and 14 in the BITroll-generation. Benign melanocytic lesions with two distinct forms of basal melanocytic hyperplasia or nests of hyperplastic melanocytes like in human junctional nevus were observed in 10 (41,7%) F1-, 20 (18%) F2-, 2 (10,5%) BIDL-, and 7 (50%) BITroll-animals. Malignant melanomas were found in four (3,6%) F2- and one (7,1%) BITroll-animals, but did not occur in the F1- and BIDL-generations. The observed segregation pattern suggests a different mode of inheritance for benign melanocytic lesions and melanomas, respectively. An influence of SLA haplotypes could not be observed. However, a significant influence of coat colour on the occurence of melanoma could be found in the F2-generation. While around 65% of F2-animals had the German Landrace dominant white colour, melanomas were only found in black and red animals. Benign lesions of the junctional nevus type, too, were only found in black animals. A possible explanation is the lack of melanocytes in the skin of dominant white pigs caused by a mutation of the KIT-gene, which leads to a failure of melanoblast migration and development

scholarly journals Divergent Evolutional Mode and Purifying Selection of the KIT Gene in European and Asian Domestic Pig Breeds

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Lili Niu ◽  
KeYu Shi ◽  
Jing-Jing Xie ◽  
Sen Liu ◽  
Tao Zhong
Keyword(s):  
Purifying Selection ◽  
Coat Colour ◽  
Blood Parameters ◽  
Domestic Pigs ◽  
Kit Gene ◽  
History Of ◽  
Geographic Expansion ◽  
Phenotype Formation ◽  
White Colour ◽  
Selection Of

The recent geographic expansion of wild boars and the even more recent development of numerous domestic pigs have spurred exploration on pig domestic origins. The porcine KIT gene has been showed to affect pleiotropic effects, blood parameters, and coat colour phenotypes, especially the white colour phenotype formation in European commercial breeds. Here, we described the use of SNPs to identify different selection patterns on the porcine KIT gene and the phylogenetic relationships of the inferred haplotypes. The phylogenetic tree revealed four clades in European and Asian wild and domestic pigs: two major clades with European and Asian origins and one minor clade with Iberian origins as well as the other minor clade in Asia, consistent with the major introgression of domestic Asian pigs in Europe around 18th -19th century. The domestication history of pigs, which occurred in the domestication centers (Europe and Asia), has also been demonstrated by mtDNA analysis. Furthermore, both Asian and European domestic pigs evolved under purifying selection. This study indicated that domestic pigs in Europe and Asia have different lineage origins but the porcine KIT gene was undergoing a purifying selection during their evolutional histories.

International and Multidisciplinary Experiences in Engineering Courses at UNAM

2012 ◽  
Author(s):  
Vicente Borja ◽  
Alejandro Ramírez-Reivich ◽  
Marcelo López-Parra ◽  
Arturo Treviño Arizmendi ◽  
Luis F. Equihua Zamora
Keyword(s):  
Information Sharing ◽  
Product Innovation ◽  
Lessons Learned ◽  
Faculty Members ◽  
University Of California ◽  
Focal Points ◽  
User Centered Design ◽  
University Of Munich ◽  
Design Students ◽  
The University

A team of faculty members from the Universidad Nacional Autónoma de México (UNAM) has coordinated multidisciplinary courses in collaboration with universities from other countries. The team, who is composed by faculty from the School of Engineering and the School of Architecture, coordinates with pairs of Stanford University, the University of California at Berkeley, and the Technical University of Munich; to teach three particular design courses. All three courses are related to product innovation but they have different emphasis depending on the collaborating partner. The focal points of each of the three courses are: (1) innovation, (2) user centered design and sustainability and (3) transport in megacities of the future. Engineering and industrial design students are involved in the courses. They are organized in teams that include participants from the two collaborating universities. During the courses teams carry out projects working mostly at a distance; they use different means of communication and information sharing and also pay reciprocal visits between the universities involved in the collaboration. This paper describes each of the three courses highlighting their particular characteristics. The outcomes and results of the courses and specific projects are commented. In the end of the paper lessons learned are discussed and final remarks are presented.

scholarly journals SARS-CoV-2 Genomic Surveillance Reveals Little Spread From a Large University Campus to the Surrounding Community

2021 ◽  
Vol 8 (11) ◽  
Author(s):  
Andrew L Valesano ◽  
William J Fitzsimmons ◽  
Christopher N Blair ◽  
Robert J Woods ◽  
Julie Gilbert ◽  
...  
Keyword(s):  
The United States ◽  
Incidence Rates ◽  
Transmission Dynamics ◽  
University Of Michigan ◽  
University Campus ◽  
High Incidence ◽  
Study Interval ◽  
Washtenaw County ◽  
The University ◽  
Subsequent Wave

Abstract Background Coronavirus disease 2019 (COVID-19) has had high incidence rates at institutions of higher education (IHE) in the United States, but the transmission dynamics in these settings are poorly understood. It remains unclear to what extent IHE-associated outbreaks have contributed to transmission in nearby communities. Methods We implemented high-density prospective genomic surveillance to investigate these dynamics at the University of Michigan and the surrounding community during the Fall 2020 semester (August 16–November 24). We sequenced complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from 1659 individuals, including 468 students, representing 20% of cases in students and 25% of total cases in Washtenaw County over the study interval. Results Phylogenetic analysis identified >200 introductions into the student population, most of which were not related to other student cases. There were 2 prolonged student transmission clusters, of 115 and 73 individuals, that spanned multiple on-campus residences. Remarkably, <5% of nonstudent genomes were descended from student clusters, and viral descendants of student cases were rare during a subsequent wave of infections in the community. Conclusions The largest outbreaks among students at the University of Michigan did not significantly contribute to the rise in community cases in Fall 2020. These results provide valuable insights into SARS-CoV-2 transmission dynamics at the regional level.

Sir Hans Adolf Krebs (1900–81), pioneer of modern medicine, architect of intermediary metabolism

2009 ◽  
Vol 17 (3) ◽  
pp. 149-154 ◽  
Author(s):  
F W Leigh
Keyword(s):  
Royal Society ◽  
Nobel Laureate ◽  
Modern Medicine ◽  
Intermediary Metabolism ◽  
Otto Warburg ◽  
University Of Munich ◽  
North Germany ◽  
The University ◽  
Royal Society Of London

Summary Krebs was born in Hildesheim (North Germany) and graduated (MD) from the University of Munich in 1923. He was assistant to Otto Warburg (1926–30) who taught tissue slicing and manometry which Krebs used to complete his three great works: The Detoxification of Ammonia (Freiburg im Breisgau 1933), The Degradation of Foods to provide Energy for Life (Sheffield 1937) and Gluconeogenesis (Oxford 1963). He was elected Fellow of the Royal Society of London (FRS) in 1947, Nobel Laureate in 1953 and KBE in 1958.

scholarly journals An Industry of R&D

2014 ◽  
Vol 136 (10) ◽  
pp. 44-47
Author(s):  
Harry Hutchinson
Keyword(s):  
Electronic Systems ◽  
Massachusetts Institute ◽  
Massachusetts Institute Of Technology ◽  
Research Areas ◽  
Federal Institute ◽  
University Of Munich ◽  
World Class ◽  
Institute Of Technology ◽  
The University ◽  
The Tropics

This article discusses how Singapore is amassing a brain trust to compensate for resources that nature didn’t provide to it. CREATE or “Campus for Research Excellence and Technological Enterprise” is one of the most ambitious projects of Singapore’s National Research Foundation. CREATE seeks to unite Singapore’s universities with world-class research institutions to study issues ranging from urban planning to medical treatment. The organization has partnerships with 10 foreign universities, including Massachusetts Institute of Technology, the Technical University of Munich, Cambridge University, and the Swiss Federal Institute of Technology. There are five research groups in CREATE’s partnership with Massachusetts Institute of Technology. The research areas are infectious diseases, environmental sensing and modeling, biosystems and micromechanics, urban mobility, and low-energy electronic systems. The University of California, Berkeley, has two research programs with CREATE. One aims to improve the efficiency of buildings in the tropics, and the other is working on raising the electrical output of photovoltaic devices.

scholarly journals Follicular adenoma of the thyroid gland in children: a clinical spectrum

2021 ◽  
Author(s):  
Sylwester Gerus ◽  
Marcin Rasiewicz ◽  
Maciej Baglaj
Keyword(s):  
Thyroid Gland ◽  
Thyroid Disease ◽  
Follicular Adenoma ◽  
Operative Management ◽  
Clinical Aspects ◽  
Cytologic Examination ◽  
Thyroid Pathology ◽  
Management Algorithm ◽  
High Incidence ◽  
The University

IntroductionThe aim of the study was to assess of clinical aspects of thyroid follicular adenoma in children and attempt to elaborate management algorithm useful in a clinical practice.Material and methodsClinical database of all children operated due to thyroid disease in years 1993-2018 at the university pediatric surgical centre was reviewed. The children in whom postoperative histology report showed follicular adenoma were selected and their medical files were analysed in detail. Clinical course of the disease, medical and family history, results of imaging studies, details of surgical management and final outcome were assessed in each case.ResultsAmong 183 children operated on for thyroid pathology in the study period there were 56 patients with follicular adenoma ( 30,6%). Their age ranged from 7 to 18 years. Seven patients were found hypothyroid and further seven showed hyperthyroid status initially. Ultrasound scan showed a solitary nodule in 37 children (66,1%). Multiple nodules in one lobe were detected in 5 patients, while further 14 children showed bilateral thyroid pathology. The result of preoperative cytologic examination was suspicious in 12 children (21,4%). All children were subjected to an operative management. Forty- two children (75%) underwent at least unilateral total lobectomy. No patient showed a recurrent thyroid disease.ConclusionsFollicular adenoma in children presents a wide clinical and morphological spectrum. High incidence of associated diseases of other systems and congenital anomalies of the thyroid gland may indicate on complex etiology of follicular adenoma with participation of yet unknown endogenic factors in children.

Sign in / Sign up

Export Citation Format

Share Document