scholarly journals Co-Evaluation of Climate Services. An analysis of the CLARA experience 

2021 ◽  
Author(s):  
Elisa Delpiazzo ◽  
Francesco Bosello
Keyword(s):  
Critical Issue ◽  
Internal Dynamic ◽  
Preliminary Evaluation ◽  
Strong Impact ◽  
Climate Services ◽  
Horizon 2020 ◽  
Potential Value ◽  
Development Framework ◽  
Climate Service

<p>This presentation aims to discuss some issues regarding the role of the economic evaluation of climate services in the context of the Horizon 2020 CLARA project. CLARA provides 14 innovative services based on a co-development approach involving service producers and specific final users. In this context, the first issue is the role of the evaluation in the co-development framework. Our understanding suggests that it cannot be one of the last steps in the process, but a preliminary evaluation should be presented in the co-design of the service. For this reason, we advise the use of the “maximum potential value” as a signal for both developers and users. It derives from a comparison between the values of two alternative knowledge sources (i.e. one other than the climate service and the other as a 100% skill climate service). The “maximum potential value” provides a benchmark against which to compare the final product. It gives insights to the producer how to improve the service, while the final user has a direct and understandable measure of likely benefits from climate service adoption. This directly supports a higher engagement of the final user, whose participation is essential in developing the service as well as in gathering information for the evaluation.</p><p>Moreover, the final user’s participation has a strong impact in assessing how the services enter the decision- making process that is sometimes an obscure issue in the internal dynamic of the organizations. Recognizing a benefit stimulate the discussion on how the tool may be used internally. This sometimes leads to changes in the service design to meet better the users’ requirements. Another critical issue is the final user’s ability to translate into actions the signals of the climate services as well as to predict and quantify costs and benefits of actions based on climate services forecasts.</p><p>All these issues are discussed presenting examples from the CLARA project, especially from a set of services related to renewable energy production and water management.</p>

Valuing climate services: experiences from the CLARA project

2020 ◽  
Author(s):  
Elisa Delpiazzo ◽  
Francesco Bosello
Keyword(s):  
Critical Issue ◽  
Internal Dynamic ◽  
Preliminary Evaluation ◽  
Strong Impact ◽  
Climate Services ◽  
Horizon 2020 ◽  
Service Adoption ◽  
Development Framework ◽  
Climate Service

<p>This presentation aims to discuss some issues regarding the role of the economic evaluation of climate services in the context of the Horizon 2020 CLARA project.</p><p>CLARA provides 14 innovative services based on a co-development approach involving service producers and specific final users. In this context, the first issue is the role of the evaluation in the co-development framework. Our understanding suggests that it cannot be one of the last steps in the process, but a preliminary evaluation should be presented in the co-design of the service. For this reason, we advise the use of the “maximum likely value” as a signal for both developers and users. It derives from a comparison between the values of two alternative knowledge sources (i.e. one other than the climate service and the other as a 100% skill climate service). The “maximum likely value” provides a benchmark against which to compare the final product. It gives insights to the producer how to improve the service, while the final user has a direct and understandable measure of likely benefits from climate service adoption. This directly supports a higher engagement of the final user, whose participation is essential in developing the service as well as in gathering information for the evaluation.</p><p>Moreover, the final user’s participation has a strong impact in assessing how the services enter the decision- making process that is sometimes an obscure issue in the internal dynamic of the organizations. Recognizing a benefit stimulate the discussion on how the tool may be used internally. This sometimes leads to changes in the service design to meet better the users’ requirements. Another critical issue is the final user’s ability to translate into actions the signals of the climate services as well as to predict and quantify costs and benefits of actions based on climate services forecasts.</p><p>All these issues are discussed presenting examples from the CLARA project, especially from a set of services related to renewable energy production and water management.</p>

scholarly journals Which Meteorological and Climatological Information Is Requested for Better Surfing Experiences? A Survey-Based Analysis

Atmosphere ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 293
Author(s):  
Anna Boqué Ciurana ◽  
Enric Aguilar
Keyword(s):  
Decision Making ◽  
Online Survey ◽  
Climate Services ◽  
Tourism Sector ◽  
Potential Market ◽  
Climate Service ◽  
Adaptive Actions ◽  
Behavioral Perspective ◽  
Impacts Of Climate Change

This paper extends the work of previous research by investigating surfing practices and surf-recreation companies from a behavioral perspective. The study’s main aim is to gain insights into the role of meteorological/climatological information in decision-making related to the surf-tourism activities market. This information was gathered employing an online survey that asked respondents about where they surf and how they check forecasts for surfing. Climate services (CS) are promoted to support the decision-making process to better prepare for and adapt to the risks and opportunities of climate variability and change. The current market for CS is still in its early stages. In this paper, we report the findings from our recent investigation into the actual and potential market for CS for the Iberian Peninsula surf-tourism sector. Based on surfers’ and surf companies’ demands, it was found that an improved surfing climate service (herein, SCS) will have clear implications in the management of these tourism areas and provide insights into whether surfing activities may be successful. At the same time, such services can help to manage adaptive actions in regard to the impacts of climate change in surfing areas.

scholarly journals Ernst von Leyden (1832–1910): a pioneer in making oncology a respected medical discipline

2021 ◽  
Author(s):  
Peter Voswinckel ◽  
Nils Hansson
Keyword(s):  
International Association ◽  
German Society ◽  
Scientific Discipline ◽  
Strong Impact ◽  
Medical Discipline ◽  
History Of ◽  
National Socialists ◽  
New Research ◽  
German Physician

Abstract Purpose This article presents new research on the role of the renowned German physician Ernst von Leyden (1832–1910) in the emergence of oncology as a scientific discipline. Methods The article draws on archival sources from the archive of the German Society of Haematology and primary and secondary literature. Results Leyden initiated two important events in the early history of oncology: the first international cancer conference, which took place in Heidelberg, Germany, in 1906, and the founding of the first international association for cancer research (forerunner of today's UICC) in Berlin in 1908. Unfortunately, these facts are not mentioned in the most recent accounts. Both had a strong impact on the professionalization of oncology as a discipline in its own right. Conclusion Although not of Jewish origin, von Leyden was considered by the National Socialists to be “Jewish tainted”, which had a lasting effect on his perception at home and abroad.

scholarly journals Translational Science for Climate Services: Mapping and Understanding Users’ Climate Service Needs in CSSP China

2021 ◽  
Vol 35 (1) ◽  
pp. 64-76
Author(s):  
Sarah Opitz-Stapleton ◽  
Roger Street ◽  
Qian Ye ◽  
Jiarui Han ◽  
Chris D. Hewitt
Keyword(s):  
Climate Science ◽  
Service Needs ◽  
User Engagement ◽  
Translational Science ◽  
Regular User ◽  
Climate Services ◽  
Weather Information ◽  
The United Kingdom ◽  
Climate Service ◽  
User Groups

AbstractThe Climate Science for Service Partnership China (CSSP China) is a joint program between China and the United Kingdom to build the basis for climate services to support the weather and climate resilient economic development and welfare in China. Work Package 5 (WP5) provides the translational science on identification of: different users and providers, and their mandates; factors contributing to communication gaps and capacities between various users and providers; and mechanisms to work through such issues to develop and/or evolve a range of climate services. Key findings to emerge include that users from different sectors have varying capacities, requirements, and needs for information in their decision contexts, with a current strong preference for weather information. Separating climate and weather services when engaging users is often not constructive. Furthermore, there is a need to move to a service delivery model that is more user-driven and science informed; having sound climate science is not enough to develop services that are credible, salient, reliable, or timely for diverse user groups. Greater investment in building the capacity of the research community supporting and providing climate services to conduct translational sciences and develop regular user engagement processes is much needed. Such a move would help support the China Meteorological Administration’s (CMA) ongoing efforts to improve climate services. It would also assist in potentially linking a broader group of “super” users who currently act as providers and purveyors of climate services because they find the existing offerings are not relevant to their needs or cannot access CMA’s services.

scholarly journals Chest CT texture-based radiomics analysis in differentiating COVID-19 from other interstitial pneumonia

2021 ◽  
Author(s):  
Damiano Caruso ◽  
Francesco Pucciarelli ◽  
Marta Zerunian ◽  
Balaji Ganeshan ◽  
Domenico De Santis ◽  
...  
Keyword(s):  
Interstitial Pneumonia ◽  
Potential Role ◽  
Texture Features ◽  
Roc Curves ◽  
Chest Ct ◽  
Preliminary Evaluation ◽  
Rt Pcr ◽  
Mean Intensity ◽  
Polymerase Chain

Abstract Purpose To evaluate the potential role of texture-based radiomics analysis in differentiating Coronavirus Disease-19 (COVID-19) pneumonia from pneumonia of other etiology on Chest CT. Materials and methods One hundred and twenty consecutive patients admitted to Emergency Department, from March 8, 2020, to April 25, 2020, with suspicious of COVID-19 that underwent Chest CT, were retrospectively analyzed. All patients presented CT findings indicative for interstitial pneumonia. Sixty patients with positive COVID-19 real-time reverse transcription polymerase chain reaction (RT-PCR) and 60 patients with negative COVID-19 RT-PCR were enrolled. CT texture analysis (CTTA) was manually performed using dedicated software by two radiologists in consensus and textural features on filtered and unfiltered images were extracted as follows: mean intensity, standard deviation (SD), entropy, mean of positive pixels (MPP), skewness, and kurtosis. Nonparametric Mann–Whitney test assessed CTTA ability to differentiate positive from negative COVID-19 patients. Diagnostic criteria were obtained from receiver operating characteristic (ROC) curves. Results Unfiltered CTTA showed lower values of mean intensity, MPP, and kurtosis in COVID-19 positive patients compared to negative patients (p = 0.041, 0.004, and 0.002, respectively). On filtered images, fine and medium texture scales were significant differentiators; fine texture scale being most significant where COVID-19 positive patients had lower SD (p = 0.004) and MPP (p = 0.004) compared to COVID-19 negative patients. A combination of the significant texture features could identify the patients with positive COVID-19 from negative COVID-19 with a sensitivity of 60% and specificity of 80% (p = 0.001). Conclusions Preliminary evaluation suggests potential role of CTTA in distinguishing COVID-19 pneumonia from other interstitial pneumonia on Chest CT.

scholarly journals The Unusual Role of Pro in Cu(II) Binding by His2-Cyclopentapeptide

2021 ◽  
Vol 22 (12) ◽  
pp. 6628
Author(s):  
Aleksandra Pieniężna ◽  
Aleksandra Kotynia ◽  
Justyna Brasuń
Keyword(s):  
Amino Acid ◽  
Potentiometric Titration ◽  
Amino Acid Residue ◽  
Strong Impact ◽  
Mononuclear Complexes ◽  
Study Results ◽  
Metal Ratio ◽  
Ph Range ◽  
L1 And L2

In this paper, we present findings from studying the interaction of copper(II) ions with the His2-cyclopentapeptide and the role of proline used for the purpose of potentiometric titration and UV-Vis, CD and EPR spectroscopic measurements. Experiments of two homodetic peptides differing by one amino acid residue were conducted for a ligand to metal ratio of 1:1 in the pH range 2.5–11.0. The presented studies reveal that peptides form only mononuclear complexes, and the CuH2L complex appears in the system first (for both L1 and L2). Study results show that the presence of Pro influences the structure of formed complexes and their stabilities and has a strong impact on the efficiency of copper(II) coordination.

scholarly journals U.S. TREND INFLATION REINTERPRETED: THE ROLE OF FISCAL POLICIES AND TIME-VARYING NOMINAL RIGIDITIES

2014 ◽  
Vol 19 (6) ◽  
pp. 1294-1308 ◽  
Author(s):  
Nicola Acocella ◽  
Giovanni Di Bartolomeo ◽  
Patrizio Tirelli
Keyword(s):  
Strong Impact ◽  
Fiscal Policies ◽  
Time Varying ◽  
Nominal Rigidities ◽  
Distortionary Taxation ◽  
Trend Inflation ◽  
Wage Indexation ◽  
Joint Evolution

This paper offers a reinterpretation of the Fed's time-varying implicit inflation target, based on two considerations. The first is that the need to alleviate the burden of distortionary taxation may justify the choice of a positive inflation rate. The second is based on compelling evidence that the degree of price and wage indexation falls with trend inflation. In fact, we find that a proper characterization of the joint evolution of fiscal variables and nominal rigidities has a strong impact on the Ramsey optimal policies, implying optimal inflation dynamics that are consistent with the observed evolution of U.S. trend inflation. By contrast, tax policies have been too lax, especially at the time of the controversial Bush tax cuts.

scholarly journals Role of Sigma-1 Receptor in Calcium Modulation: Possible Involvement in Cancer

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 139
Author(s):  
Ilaria Pontisso ◽  
Laurent Combettes
Keyword(s):  
Cell Survival ◽  
Cancer Progression ◽  
Strong Impact ◽  
Protective Function ◽  
Sigma 1 Receptor ◽  
Contact Sites ◽  
Calcium Modulation ◽  
Sigma 1 ◽  
Cancer Cell Survival

Ca2+ signaling plays a pivotal role in the control of cellular homeostasis and aberrant regulation of Ca2+ fluxes have a strong impact on cellular functioning. As a consequence of this ubiquitous role, Ca2+ signaling dysregulation is involved in the pathophysiology of multiple diseases including cancer. Indeed, multiple studies have highlighted the role of Ca2+ fluxes in all the steps of cancer progression. In particular, the transfer of Ca2+ at the ER-mitochondrial contact sites, also known as mitochondrial associated membranes (MAMs), has been shown to be crucial for cancer cell survival. One of the proteins enriched at this site is the sigma-1 receptor (S1R), a protein that has been described as a Ca2+-sensitive chaperone that exerts a protective function in cells in various ways, including the modulation of Ca2+ signaling. Interestingly, S1R is overexpressed in many types of cancer even though the exact mechanisms by which it promotes cell survival are not fully elucidated. This review summarizes the findings describing the roles of S1R in the control of Ca2+ signaling and its involvement in cancer progression.

Balancing of Values and the Value of Balancing (Part One)

2021 ◽  
pp. 13-24
Author(s):  
Gadis A. Gadzhiev ◽  
◽  
Elena A. Voinikanis ◽  
Keyword(s):  
Human Rights ◽  
Critical Issue ◽  
Specific Mode ◽  
Constitutional Order ◽  
Basic Law ◽  
The Relationship

The article discusses the specific mode of existence of values – balancing or op­timization when it comes to deontological values. The authors using examples of values such as the principles of law and human rights, the rules of balancing are analyzed, which, according to G. Hart's classification, are secondary norms. The critical issue for the legal balancing procedure is the relationship between legal reality and values as such. Are the constitutional and legal values set by the Basic Law (Constitution), or do they objectively exist in society as a general (pre-constitutional) order of values? Should the Basic Law be confined to its own text and remain value-neutral in this sense? Are legal values purely deonto­logical, or can they be related to utilitarian goals and interests? The second part of the article explores the value of balancing as one of the methods for resolving the most complex legal conflicts. The well-known dispute between J. Habermas and R. Alexy about the admissibility of balancing of human rights demonstrates how complex and philosophically rich the legal balancing procedure is. Based on Luhmann’s concept of the cognitive openness of law, at the end of the article, the authors substantiate their own position on the role of values in modern justice.

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