scholarly journals Preparation of Co-conjugate Microporous Polymer Magnetic Tubular Composites and Application in Removal of Phosphate Ions

Author(s):  
S. Li ◽  
Z. L. Hu ◽  
Z. Q. Zhu ◽  
H. X. Sun ◽  
A. Li
2019 ◽  
Author(s):  
Chem Int

The assessment of groundwater is essential for the estimation of suitability of water for safe use. An attempt has been made to study the groundwater of selected areas of Punjab (Sheikhupura & Sahiwal) and Sindh (Sindh, Jawar Dharki and Dharki), Pakistan. The results indicate that pH, color and odor were all within limits of WHO that is pH ranges 6.5–8.5, colorless and odorless, respectively. The high values of suspended solids were observed in the Sindh-1 and Dharki samples. Microbiologically only Sahiwal and Jawar Dharki were found fit for drinking purpose. Trace metals analysis of Sheikhupura-1 and Sindh-1 showed that values do not fall within limits of WHO for Iron. The ionic concentration analysis showed that high bicarbonate (HCO3-), ions are present in the samples of Sahiwal and Dharki; Sindh-1 and Jawar Dharki samples showed very high concentration for chloride ions, all samples were satisfactory level for sulphate (SO42-), sodium, magnesium and phosphate ions except samples of Sindh-1 and Jawar Dharki. High concentration of calcium and potassium ions was observed in samples of Sindh-1, while all other samples were found fit for drinking purposes in respect of nitrate, nitrite and ammonium ions. The high concentration of Fluoride was found only in Sheikhupura-2 samples.


RSC Advances ◽  
2021 ◽  
Vol 11 (44) ◽  
pp. 27432-27442
Author(s):  
Lina Wang ◽  
Richard Malpass-Evans ◽  
Mariolino Carta ◽  
Neil B. McKeown ◽  
Shaun B. Reeksting ◽  
...  

Microporous polymer materials based on molecularly “stiff” structures provide intrinsic microporosity, typical micropore sizes of 0.5 nm to 1.5 nm, and the ability to bind guest species.


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ke Gong ◽  
Juyang Jiao ◽  
Chaoqun Xu ◽  
Yang Dong ◽  
Dongxiao Li ◽  
...  

Abstract Background Overexpressed vascular endothelial growth factor A (VEGFA) and phosphorylated signal transducer and activator of transcription 3 (P-STAT3) cause unrestricted tumor growth and angiogenesis of breast cancer (BRCA), especially triple-negative breast cancer (TNBC). Hence, novel treatment strategy is urgently needed. Results We found sphingosine 1 phosphate receptor 1 (S1PR1) can regulate P-STAT3/VEGFA. Database showed S1PR1 is highly expressed in BRCA and causes the poor prognosis of patients. Interrupting the expression of S1PR1 could inhibit the growth of human breast cancer cells (MCF-7 and MDA-MB-231) and suppress the angiogenesis of human umbilical vein endothelial cells (HUVECs) via affecting S1PR1/P-STAT3/VEGFA axis. Siponimod (BAF312) is a selective antagonist of S1PR1, which inhibits tumor growth and angiogenesis in vitro by downregulating the S1PR1/P-STAT3/VEGFA axis. We prepared pH-sensitive and tumor-targeted shell-core structure nanoparticles, in which hydrophilic PEG2000 modified with the cyclic Arg-Gly-Asp (cRGD) formed the shell, hydrophobic DSPE formed the core, and CaP (calcium and phosphate ions) was adsorbed onto the shell; the nanoparticles were used to deliver BAF312 (BAF312@cRGD-CaP-NPs). The size and potential of the nanoparticles were 109.9 ± 1.002 nm and − 10.6 ± 0.056 mV. The incorporation efficacy for BAF312 was 81.4%. Results confirmed BAF312@cRGD-CaP-NP could dramatically inhibit tumor growth and angiogenesis in vitro and in MDA-MB-231 tumor-bearing mice via downregulating the S1PR1/P-STAT3/VEGFA axis. Conclusions Our data suggest a potent role for BAF312@cRGD-CaP-NPs in treating BRCA, especially TNBC by downregulating the S1PR1/P-STAT3/VEGFA axis. Graphic abstract


2021 ◽  
Vol 126 ◽  
pp. 112121
Author(s):  
Yunfeng Wu ◽  
Yu Zang ◽  
Liang Xu ◽  
Jianjun Wang ◽  
Hongge Jia ◽  
...  

2014 ◽  
Vol 12 (0) ◽  
pp. 404-409 ◽  
Author(s):  
Fumihiko Ogata ◽  
Daisuke Imai ◽  
Megumu Toda ◽  
Masashi Otani ◽  
Naohito Kawasaki

2018 ◽  
Vol 7 (3) ◽  
pp. 300-307 ◽  
Author(s):  
Haq Nawaz Bhatti ◽  
Javeria Hayat ◽  
Munawar Iqbal ◽  
Saima Noreen ◽  
Sadia Nawaz

Author(s):  
Miran An ◽  
Bo-Yeon Kim ◽  
Hansol Seo ◽  
Aasif Helal ◽  
Hong-Seok Kim

Sign in / Sign up

Export Citation Format

Share Document