scholarly journals Immunohistochemistry of KRAS Protein in Colorectal Cancer

2020 ◽  
Author(s):  
Dody Novrial ◽  
Kamal Agung Wijayana ◽  
Hanif Kun Cahyani
Keyword(s):  
Colorectal Cancer ◽  
Kras Protein

scholarly journals Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Gongmin Zhu ◽  
Lijiao Pei ◽  
Hongwei Xia ◽  
Qiulin Tang ◽  
Feng Bi
Keyword(s):  
Colorectal Cancer ◽  
Routine Clinical Practice ◽  
Diagnosis And Treatment ◽  
Constitutive Activation ◽  
Downstream Signaling ◽  
Dismal Prognosis ◽  
Allele Specific ◽  
Kras Protein ◽  
Specific Inhibitors

AbstractColorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in approximately 40% of all CRC cases; its mutations result in constitutive activation of the KRAS protein, which acts as a molecular switch to persistently stimulate downstream signaling pathways, including cell proliferation and survival, thereby leading to tumorigenesis. Patients whose CRC harbors KRAS mutations have a dismal prognosis. Currently, KRAS mutation testing is a routine clinical practice before treating metastatic cases, and the approaches developed to detect KRAS mutations have exhibited favorable sensitivity and accuracy. Due to the presence of KRAS mutations, this group of CRC patients requires more precise therapies. However, KRAS was historically thought to be an undruggable target until the development of KRASG12C allele-specific inhibitors. These promising inhibitors may provide novel strategies to treat KRAS-mutant CRC. Here, we provide an overview of the role of KRAS in the prognosis, diagnosis and treatment of CRC.

scholarly journals The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment.

2012 ◽  
Vol 59 (4) ◽  
Author(s):  
Paulina Tokarz ◽  
Janusz Blasiak
Keyword(s):  
Colorectal Cancer ◽  
Cancer Prognosis ◽  
Nucleotide Polymorphisms ◽  
Rna Molecules ◽  
Metastatic Colonization ◽  
Wide Range ◽  
Genes Encoding ◽  
Kras Protein ◽  
A Disintegrin And Metalloproteinase

microRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression by targeting specific mRNAs. microRNAs play a role in several physiological processes in the cell, including migration, proliferation, differentiation and apoptosis. Apart from their role in regular metabolism, abnormal profiles of miRNA expression accompany cancer transformation, including colorectal cancer (CRC) metastasis. microRNAs may play a role in each phase of CRC metastasis including angiogenesis, invasion, intravasation, circulation, extravasation and metastatic colonization. microRNA levels may serve as a predictive CRC marker, which was confirmed by the serum level of miR-29a targeting KLF4, a marker of cell stemness, and the plasma level of miR-221 down-regulating c-Kit, Stat5A and ETS1, which are signal transducers and transcription factor, respectively. In turn, the level of miR-143 in CRC cells decreasing the amount of MACC1 (metastasis-associated in colon cancer-1) and oncogenic KRAS protein, may be utilized as a prognostic marker. Also, single nucleotide polymorphisms of genes encoding miRNAs, including miR-423 and miR-608, which correlate with tumor recurrence, may be useful as diagnostic, prognostic and predictive indicators in CRC metastasis. Pre-miR-34a and pre-miR-199a decreased the level of Axl, a tyrosine-protein kinase receptor, so they can be considered as drugs in antimetastatic therapy. On the other hand, miR-222 targeting ADAM-17, a disintegrin and metalloproteinase, and miR-328 interacting with ABCG2, an ABC transporter, may overcome drug resistance of cancer cells. microRNAs may be considered in wide-range application to facilitate CRC metastasis diagnosis, prognosis, prediction and therapy, however, further clinical, epidemiological and in vitro studies should be conducted to verify their utility.

Deletion mapping on chromosome 6 in colorectal cancer associated with ulcerative colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A121-A122
Author(s):  
T EZAKI ◽  
M WATANABE ◽  
S FUNAKOSHI ◽  
M NAGANUMA ◽  
T AZUMA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Deletion Mapping ◽  
Chromosome 6

Predicting adherence to colorectal cancer surveillance after plypectomy

2001 ◽  
Vol 120 (5) ◽  
pp. A602-A602
Author(s):  
S RAWL ◽  
S BLACKBURN ◽  
L HACKWARD ◽  
N FINEBERG ◽  
T IMPERIALE ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Surveillance ◽  
Colorectal Cancer Surveillance

Urokinase type plasminogen activator and inhibitor type-1 plasma levels in colorectal cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A599-A600 ◽  
Author(s):  
L HERSZENYI ◽  
F FARINATI ◽  
G ISTVAN ◽  
M PAOLI ◽  
G ROVERONI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Plasminogen Activator ◽  
Plasma Levels ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Inhibitor Type

A panel of mono- and dinucleotide microsatellite markers is required for reliable determination of the MSI status in colorectal cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A599-A599
Author(s):  
C ARNOLD ◽  
A GOEL ◽  
J CARETHERS ◽  
L WASSERMAN ◽  
C COMPTON ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Markers ◽  
Reliable Determination

Use of plasma MMP-2 to measure response to surgery and chemoradiotherapy in colorectal cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A159-A159
Author(s):  
M TUTTON ◽  
M GEORGE ◽  
S ECCLES ◽  
I SWIFT ◽  
M ABULAFI
Keyword(s):  
Colorectal Cancer

Adjuvant intraportal chemotherapy for dukes B2 or C colorectal cancer also receiving systemic treatment

2001 ◽  
Vol 120 (5) ◽  
pp. A611-A611
Author(s):  
S ROLAND ◽  
J BURY ◽  
C FOCAN
Keyword(s):  
Colorectal Cancer ◽  
Systemic Treatment

Barriers to colorectal cancer (CRS) screening in minority communities: inadequate knowledge of guidelines by physicians in training

2001 ◽  
Vol 120 (5) ◽  
pp. A604-A604
Author(s):  
M GENNARELLI ◽  
L JANDORF ◽  
C CROMWELL ◽  
H VALDIMARSDOTTIR ◽  
W REDD ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Minority Communities ◽  
Inadequate Knowledge
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