scholarly journals IMMUNOMODULATORY AND CLINICAL EFFECTIVITY OF THE DRUG "LAZOLEX" IN TREATMENT OF RECURRENT APHTHOUS STOMATITIS (RAS)

2021 ◽  
Author(s):  
MARIAM GOGOTISHVILI ◽  
NINO ABASHIDZE ◽  
NINO KORSANTIA ◽  
NATO KORSANTIA
Keyword(s):  
Immune System ◽  
Clinical Laboratory ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Patient Treatment ◽  
Clinical Activity ◽  
Dental Practice ◽  
Immunological Parameters ◽  
Traditional Therapy

The purpose of this study was to study the immunomodulatory and clinical properties of the Georgian drug “LAZOLEX” in patients with Recurrent Aphthous Stomatitis (RAS). Clinical and Immunological parameters were studied in 50 patients, the results showed the correlation between the condition of immune system and the severity of the RAS, i.e., the most severe immunosuppression was recorded in patients with severe stomatitis. 5% Gel of “LAZOLEX” compared to traditional therapy, showed the same high clinical activity, but the presence of immunocorrective properties in LAZOLEX manifested itself in an improvement in the quality of patient treatment: decrease of time of epithelization and a significant increase in the duration of remission. Conducted clinical, laboratory and immunological studies allow us to recommend LAZOLEX for active use in dental practice for RAS.

Recurrent aphthous stomatitis (RAS): a preliminary within-subject study of quality of life, oral health impacts and personality profiles

2014 ◽  
Vol 44 (4) ◽  
pp. 278-283 ◽  
Author(s):  
Mahmoud K. AL-Omiri ◽  
Jumana Karasneh ◽  
Mohannad M. Alhijawi ◽  
Abdalwhab M. A. Zwiri ◽  
Crispian Scully ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Health Impacts ◽  
Personality Profiles

scholarly journals Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Zahra Hadian ◽  
Ali Akbar Moghadamnia ◽  
Sohrab Kazemi ◽  
Atena Shirzad
Keyword(s):  
Quality Of Life ◽  
Inflammatory Diseases ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Omega 3 ◽  
Mucosal Disease ◽  
Related Quality ◽  
Health Related ◽  
Disease Questionnaire

Objective. Recurrent aphthous stomatitis is one of the most common chronic inflammatory diseases in oral mucosa. Beneficial effects of omega-3 supplements on some inflammatory diseases have been proved. The aim of present study was to evaluate the effect of omega-3 supplements in recurrent aphthous stomatitis management and improve oral health-related quality of life. Methods. In this double-blind clinical trial, 40 patients with minor recurrent aphthous stomatitis were randomly divided into case and control groups. The case group received 1000 mg capsules of omega-3, while the control group received placebo capsules for 6 months. The questionnaires of the ulcer severity score and the chronic oral mucosal disease questionnaire were filled by the patients in three steps, at the baseline session, after 3 months, and after 6 months. The data were analyzed by SPSS 22 software through ANOVA, Mann–Whitney, and chi-square tests. P < 0.05 was considered as significant. Results. In the omega-3 group, the ulcer severity score showed significant reduction by three-month and six-month follow-ups ( P < 0.0001 , P < 0.0001 , respectively). The mean score of the chronic oral mucosal disease questionnaire significantly improved by three-month and six-month follow-ups in the omega-3-receiving group. Conclusion. Use of omega-3 oral supplements decreased the severity of aphthous ulcer and improved oral health-related quality of life.

scholarly journals Differentiated Approach to the Diagnosis and Treatment of Tuberculous Spondylitis in Adults

2021 ◽  
Author(s):  
Primkul Nazirov ◽  
Alfiya Fakhridinova ◽  
Zulfiya Makhmudova ◽  
Bakhtiyar Djuraev
Keyword(s):  
Immune System ◽  
Clinical Laboratory ◽  
Medical Center ◽  
Spinal Tuberculosis ◽  
Spinal Column ◽  
Response To Treatment ◽  
Immunological Study ◽  
Immunological Parameters ◽  
Spinal Disorders ◽  
Functional Changes

The purpose of this study is to generalize the results of a complex clinical-laboratory, radiological and immunological study of patients with spinal tuberculosis. A comprehensive examination analysis was carried out in 192 patients with tuberculous spondy litis who were in the department of surgery for osteoarticular tuberculosis of the Republican Specialized Scientific and Practical Medical Center of Tuberculosis and Pulmonology in Tashkent, Uzbekistan. Severe degrees of spinal disorders were found in 48.7% of patients. Magnetic resonance imaging (MRI) and multi-slice spiral computed tomography (MSCT) allow establishing the stage and activity of a specific process in the spine, as well as complications. Spinal column instability was detected in 143 (74.5%) patients, paravertebral abscesses in 116 (60.4%) patients, and epidural abscesses in 75 (39.0%) patients. Changes in immunological parameters in patients with spinal tuberculosis were associated both with impaired regulation of immunogenetic and with the direct influence of the immune system at various stages of the process. The detection of certain patterns of immune system disorders in patients with tuberculous lesions of the spine allowed us to make a differentiated approach to their treatment in order to increase the effectiveness of the treatment. It can be concluded that at present, tuberculosis of bones and joints, especially the spine, is detected in an advanced stage in 50-80% of cases and has a widespread and complicated character with profound anatomical and functional changes and the presence of severe spinal disorders in 48.7% patients in Uzbekistan. Regarding spondylitis, it is immensely important to make an accurate diagnosis based on the clinical presentations, laboratory, radiological and immunological findings and by periodic assessment of the response to treatment, which is essential in atypical cases.

scholarly journals Quality of life in patients with Behcet's disease and Recurrent aphthous stomatitis

TURKDERM ◽  
2015 ◽  
Vol 49 (4) ◽  
pp. 276-284 ◽  
Author(s):  
Burcu Tuğrul Ayanoğlu ◽  
Aysel Gürler ◽  
Fatma Gülru Erdoğan ◽  
Özge Gündüz ◽  
Aslıhan Alhan
Keyword(s):  
Quality Of Life ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Behcet's Disease

scholarly journals A Clinic Trial Evaluating the Effects of Aloe Vera Fermentation Gel on Recurrent Aphthous Stomatitis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Yan Shi ◽  
Kehong Wei ◽  
Jiachen Lu ◽  
Jing Wei ◽  
Xiaojing Hu ◽  
...  
Keyword(s):  
High Throughput Sequencing ◽  
Aloe Vera ◽  
Specific Treatment ◽  
Healing Time ◽  
Oral Bacteria ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
History Of ◽  
Potential Benefits

Recurrent aphthous stomatitis (RAS) is the most common disorder in the oral mucosa that affects the daily quality of life of patients, and there is currently no specific treatment. In the present study, we developed aloe vera fermentation gel under the action of probiotics on aloe vera. In total, 35 patients with the history of aphthous stomatitis were enrolled to explore the potential benefits of aloe vera fermentation gel to treat RAS, and the healing-promotion effects were recorded and compared; microbial compositions in different groups were tested by high-throughput sequencing. Our results indicated that the duration of healing time of the aloe group showed potentially better effects because of the higher proportion of 4–6 day healing time (35% vs. 20%) and lower proportion of 7–10 day healing time (65% vs. 80%) compared with that of the chitosan group. Also, the use of aloe vera fermentation gel could return oral bacteria to normal levels and reduce the abundance of harmful oral bacteria including Actinomyces, Granulicatella, and Peptostreptococcus. These results suggest that aloe vera fermentation gel has the ability to treat patients with RAS and has positive prospects in clinical applications.

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