The effects of Combine Training Program on Level Adipsin and Insulin Resistance in Female Multiple Sclerosis Patients (MS)

Ali Shafiezadeh; zahra Raisi; Farzane Kaveh; mohammad Faramarzi; zahra hemati farsani;  ;  ;

doi:10.52547/jmj.19.1.7

The effects of Combine Training Program on Level Adipsin and Insulin Resistance in Female Multiple Sclerosis Patients (MS)

Pars of Jahrom University of Medical Sciences ◽

10.52547/jmj.19.1.7 ◽

2021 ◽

Vol 19 (1) ◽

pp. 54-62

Author(s):

Ali Shafiezadeh ◽

zahra Raisi ◽

Farzane Kaveh ◽

mohammad Faramarzi ◽

zahra hemati farsani ◽

...

Keyword(s):

Multiple Sclerosis ◽

Insulin Resistance ◽

Training Program ◽

Combine Training ◽

Multiple Sclerosis Patients

Download Full-text

Effect of a Combined Program of Strength and Dual Cognitive-Motor Tasks in Multiple Sclerosis Subjects

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17176397 ◽

2020 ◽

Vol 17 (17) ◽

pp. 6397

Author(s):

Carmen Gutiérrez-Cruz ◽

F.Javier Rojas-Ruiz ◽

Juan Carlos De la Cruz-Márquez ◽

Marcos Gutiérrez-Dávila

Keyword(s):

Multiple Sclerosis ◽

Training Program ◽

Force Measurement ◽

Intervention Group ◽

Daily Activities ◽

Control Group ◽

Motor Tasks ◽

Dual Tasking ◽

Combined Training ◽

Multiple Sclerosis Patients

This study investigated the effects of a 24-week combined training program (CTP) based on strength exercises and cognitive–motor tasks performed concurrently in participants with multiple sclerosis. A randomized, controlled intervention study was carried out. In total, 31 subjects with a confirmed diagnosis of multiple sclerosis (14 men and 17 women) were stratified and randomized into an intervention group (17 subjects) and a control group (14 subjects). The intervention group completed three weekly training sessions for 24 weeks, while the control group pursued their normal daily activities. In this program, cognitive–motor tasks were completed at once (dual tasking). A 3D photogrammetry connected to a selective attention system designed for dual tasking while walking was used. Ground reaction forces were measured using two force plates, one for sit-to-stand testing, while the other was used for static force measurement. Postural equilibrium was examined using a stabilometric plate based for Romberg test assessment. The 24-week training program for multiple sclerosis patients improved their static peak force by 11% (p < 0 .05), their rate of force development by 36% (p < 0.05), and their balance (p < 0.05). Performance in daily activities such as walking or sitting-to-standing improved significantly in multiple sclerosis participants. CTP training was effective in reducing the dual-task costs of step length (48%) and walking velocity (54%), as compared to a matched control group.

Download Full-text

Insulin Resistance is Related with Cognition Impairment in Multiple Sclerosis Patients

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2019.11.050 ◽

2020 ◽

Vol 37 ◽

pp. 101575

Author(s):

Mohammad Khalili ◽

Shaghayegh Khamodchyan ◽

Hormoz Ayromlou ◽

Abdorreza Naser-Moghadasi

Keyword(s):

Multiple Sclerosis ◽

Insulin Resistance ◽

Multiple Sclerosis Patients ◽

Cognition Impairment

Download Full-text

LDL and HDL lipoprotein subfractions in multiple sclerosis patients with decreased insulin sensitivity

Endocrine Regulations ◽

10.2478/enr-2018-0017 ◽

2018 ◽

Vol 52 (3) ◽

pp. 139-145 ◽

Cited By ~ 1

Author(s):

Zofia Radikova ◽

Adela Penesova ◽

Miroslav Vlcek ◽

Andrea Havranova ◽

Monika Sivakova ◽

...

Keyword(s):

Multiple Sclerosis ◽

Insulin Resistance ◽

Insulin Sensitivity ◽

Sensitivity Index ◽

Model Assessment ◽

Inverse Association ◽

Healthy Controls ◽

Newly Diagnosed ◽

Lipoprotein Subclasses ◽

Multiple Sclerosis Patients

AbstractObjectives. Increased metabolic and cardiovascular morbidity has been reported in multiple sclerosis (MS) patients. Previously, we have found decreased insulin sensitivity and hyperinsulinemia in a group of newly diagnosed MS patients. We hypothesize that these features may be associated with an altered lipid profile and low, intermediate, or high density lipoprotein (LDL, IDL, HDL) subclasses accelerating atherosclerosis and thus contributing to the cardiovascular risk increase in these patients.Subjects and methods. In a group of 19 newly diagnosed untreated MS patients with previously found hyperinsulinemia and insulin resistance and a matched group of 19 healthy controls, the lipoprotein subclasses profile was determined. Polyacrylamide gel electrophoresis was used to separate and measure the LDL (large LDL and small dense LDL), HDL (large, intermediate and small), and IDL (A, B and C) subclasses with the Lipoprint© System (Quantimetrix Corporation, Redondo Beach, CA, USA).Results. No difference was found either in the conventional lipid or lipoprotein subclasses profile between the MS patients and healthy controls. We found an inverse association between the level of IDL-B with fasting insulin (r=–0.504, p=0.032), the insulin resistance estimated by homeo-static model assessment – insulin resistance (HOMA-IR) (r=–0.498, p=0.035), insulin response expressed as area under the curve (AUC; r=–0.519, p=0.027), and area above the baseline (AAB; r=–0.476, p=0.045) and positive association with insulin sensitivity estimated by insulin sensitivity index (ISI) Matsuda (r=0.470, 0.048) in MS patients, but not in healthy controls suggesting the first signs in lipoprotein subclasses profile change.Conclusions. Our data indicate that changes in lipoprotein profile and subclasses are preceded by insulin resistance and hyperinsulinemia in patients with newly diagnosed MS.

Download Full-text