scholarly journals Relationship between vitamin D consumption during pregnancy and neonatal congenital heart disease

2020 ◽  
Vol 1 (3) ◽  
pp. 13-17
Author(s):  
Mohammad Hosein Arjmandnia ◽  
Mostafa Vahedian ◽  
Maryam Yyosefi ◽  
Mehrnam Amouei ◽  
Sajad Rezvan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart

Vitamin D Kinetics and Parathyroid Gland Function in Patients with Congenital Heart Disease

2016 ◽  
Vol 11 (6) ◽  
pp. 700-706 ◽  
Author(s):  
Gaku Izumi ◽  
Kei Inai ◽  
Eriko Shimada ◽  
Toshio Nakanishi
Keyword(s):  
Vitamin D ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Parathyroid Gland ◽  
Congenital Heart ◽  
Gland Function

Impact of Anesthesia and Surgery for Congenital Heart Disease on the Vitamin D Status of Infants and Children

2013 ◽  
Vol 119 (1) ◽  
pp. 71-80 ◽  
Author(s):  
J. Dayre McNally ◽  
Kusum Menon ◽  
Pranesh Chakraborty ◽  
Lawrence Fisher ◽  
Kathryn A. Williams ◽  
...  
Keyword(s):  
Vitamin D ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Clinical Course ◽  
Tertiary Care ◽  
Vitamin D Status ◽  
Organ Systems ◽  
Vitamin D Levels ◽  
The Impact

Abstract Background: Vitamin D is recognized as a pleiotropic hormone important for the functioning of organ systems, including those central to critical illness pathophysiology. Recent studies have reported associations between vitamin D status and outcome among critically ill adults and children. Preoperative vitamin D status, impact of operative techniques, and relationship between immediate postoperative vitamin D levels and clinical course have not been described in the pediatric congenital heart disease (CHD) population. The objective of this study was to describe the impact of CHD surgery on vitamin D status and relationship between postoperative levels and clinical course. Methods: A prospective cohort study was conducted from 2009 to 2011 at a single tertiary care pediatric hospital. A total of 58 children with CHD were enrolled and blood collected preoperatively, intraoperatively, and postoperatively. Serum 25-hydroxyvitamin D (25OHD) was measured using liquid chromatography–mass spectrometry. Results: The mean preoperative 25OHD was 58.0 nm (SD, 22.4), with 42% being deficient (<50 nm). Postoperatively, we identified a 40% decline in 25OHD to 34.2 nm (SD, 14.5) with 86% being deficient. Intraoperative measurements determined that initiation of cardiopulmonary bypass coincided with abrupt decline. CHD patients requiring catecholamines had lower postoperative 25OHD (38.2 vs. 26.5 nm, P = 0.007), findings confirmed through multivariate logistic regression. Lower postoperative 25OHD was associated with increased fluid requirements and intubation duration. Conclusions: Most CHD patients are vitamin-D deficient postoperatively due to low preoperative levels and a significant intraoperative decline. Interventional studies will be required to determine whether prevention of postoperative vitamin D deficiency improves outcome.

scholarly journals Vitamin D Status in Neonates with Congenital Heart Disease: Its Changes with Heart Surgery and Relation to the Outcome

2022 ◽  
Vol 30 (1) ◽  
pp. 1-7
Author(s):  
Ziba Mosayebi ◽  
◽  
Mohamadreza Mirzaaghayan ◽  
Aliakbar Zeinaloo ◽  
Behdad Gharib ◽  
...  
Keyword(s):  
Vitamin D ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Heart Surgery ◽  
Vitamin D Status

Impact of Anesthesia and Surgery for Congenital Heart Disease on the Vitamin D Status of Infants and Children

2014 ◽  
Vol 58 (2) ◽  
pp. 81-82
Author(s):  
J. Dayre McNally ◽  
Kusum Menon ◽  
Pranesh Chakraborty ◽  
Lawrence Fisher ◽  
Kathryn A. Williams ◽  
...  
Keyword(s):  
Vitamin D ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Infants And Children ◽  
Vitamin D Status

Vitamin D Status After Cardiopulmonary Bypass in Children With Congenital Heart Disease

2016 ◽  
Vol 32 (8) ◽  
pp. 508-513 ◽  
Author(s):  
Riad Abou Zahr ◽  
Edward Vincent S. Faustino ◽  
Thomas Carpenter ◽  
Paul Kirshbom ◽  
E. Kevin Hall ◽  
...  
Keyword(s):  
Vitamin D ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Cardiopulmonary Bypass ◽  
Congenital Heart ◽  
Free Fraction ◽  
Vitamin D Binding Protein ◽  
Time Points ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Deficiency in 25-hydroxyvitamin D (25OHD) is associated with increased morbidity and mortality in the critically ill. Children who underwent surgery for congenital heart disease under cardiopulmonary bypass (CPB) are typically deficient in 25OHD. It is unclear whether this deficiency is due to CPB. We hypothesized that CPB reduces the levels of 25OHD in children with congenital heart disease. We conducted a prospective observational study on children aged 2 months to 17 years who underwent CPB. Serum was collected at 3 time points: immediately before, immediately after surgery, and 24 hours after surgery. 25-Hydroxyvitamin D, 1,25-dihydroxyvitamin D, 1,25(OH)2D, vitamin D binding protein, and albumin levels were measured. Levels were compared using repeated measures analysis of variance. We enrolled 20 patients, 40% were deficient in 25OHD with levels <20 ng/mL prior to surgery. Mean (±standard deviation) of 25OHD at the 3 time points was 21.3 ± 8 ng/mL, 19 ± 5.8 ng/mL, and 19.5 ± 6.6 ng/mL, respectively ( P = .02). The decrease in 25OHD was observed primarily in children with sufficient levels of 25OHD, with mean levels at the 3 time points: 26.8 ± 4.2 ng/mL, 21.5 ± 5.7 ng/mL, and 23.0 ± 4.9 ng/mL, respectively ( P < .001). Calculated means of free fraction of 25OHD at the 3 time points were 6.2 ± 2.8 pg/mL, 5.8 ± 2.2 pg/mL, and 5.5 ± 2.4 pg/mL, respectively, ( P = .04). Mean levels of 1,25(OH)2D were 63.7 ± 34.9 ng/mL, 53.2 ± 30.6 ng/mL, and 67.7 ± 23.5 ng/mL ( P = .04). Vitamin D binding protein and albumin levels did not significantly change. Cardiopulmonary bypass decreases 25OHD by reducing the free fraction. Current investigations are geared to establish whether vitamin D deficiency is associated with outcomes and if treatment is appropriate.

scholarly journals Vitamin D Deficiency and Its Response to Supplementation as “Stoss Therapy” in Children with Cyanotic Congenital Heart Disease Undergoing Open Heart Surgery

2019 ◽  
Vol 03 (01) ◽  
pp. 17-23
Author(s):  
Manoj Kumar Sahu ◽  
Chalattil Bipin ◽  
Harsha Vardhan Niraghatam ◽  
Ameya Karanjkar ◽  
Sarvesh Pal Singh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mechanical Ventilation ◽  
Congenital Heart Disease ◽  
Cardiac Surgery ◽  
Heart Disease ◽  
Congenital Heart ◽  
Control Group ◽  
Study Group ◽  
Significant Difference ◽  
Postoperative Convalescence

Abstract Background Data from many studies suggest that patients with congenital heart disease are vitamin D (vitD) deficient. Following cardiac surgery as a result of intraoperative institution of cardiopulmonary bypass (CPB), serum vitD levels become even low. This may affect postoperative convalescence in terms of mechanical ventilation, inotropic support, infection, and so forth. Objective We intended to study the prevalence of vitD deficiency pre and post cardiac surgery and the effect of vitD supplementation (stoss therapy) on postoperative convalescence of the children with tetralogy of Fallot (TOF) undergoing intracardiac repair (ICR). Methodology In this randomized controlled trial (RCT), 60 children younger than 18 years with TOF and serum vitD levels < 20ng/dL were randomized into two groups. The study group received vitD supplementation as “stoss therapy” at 10,000 units/kg body weight. All these children underwent ICR with CPB. Demographic data, preoperative, intraoperative, and postoperative variables were compared between the study and the control groups. Results Prevalence of severe vitD deficiency was 93.1%. When compared with the control group, study group showed higher serum vitD levels in the immediate preoperative period (p = 0.001), postoperative period following CPB (p = 0.012), and on the first postoperative day (p = 0.003). No statistically significant difference was observed in postoperative mechanical ventilation (p = 0.35), intensive care unit (ICU) stay (p = 0.15), and inotropic duration (p = 0.19). Conclusion Children with TOF are highly deficient of vitD, its level falls further after CPB, and supplementing vitD preoperatively does not influence postoperative recovery pattern. Supplementation of vitD as “stoss therapy” was useful in raising the serum levels before and after cardiac surgery.

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