A case report of ectopic salivary gland tissue in the larynx

Submucosal laryngeal masses are challenging for ENT specialists as the diagnosis usually remains uncertain until histopathological examination is carried out. We report a case of a 54-year old man complaining of dysphonia and globus sensation. Flexible laryngoscopic examination showed a submucosal swelling in the right anterior laryngeal ventricle. Microlaryngoscopic excision of the submucosal mass was performed. Histological examination revealed salivary gland tissue. We found only a few cases in the literature of ectopic salivary gland tissue situated in the larynx. In these cases, the salivary gland tissue was also located at the anterior portion of the true or false vocal fold. Thus, it is necessary to consider this condition in the differential diagnosis of a submucosal mass in the anterior true or false vocal fold or laryngeal ventricle.

Download Full-text

Pleomorphic Adenoma Originating from Heterotopic Salivary Tissue of the Upper Neck: A Diagnostic Pitfall

Case Reports in Otolaryngology ◽

10.1155/2017/5767396 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Riccardo La Macchia ◽

Salvatore Stefanelli ◽

Vincent Lenoir ◽

Nicolas Dulguerov ◽

Jean-Claude Pache ◽

...

Keyword(s):

Salivary Gland ◽

Thyroid Nodule ◽

Pleomorphic Adenoma ◽

Histopathological Examination ◽

Metastatic Lymph Node ◽

Needle Aspiration ◽

Diagnostic Pitfall ◽

Salivary Gland Tissue ◽

Gland Tissue ◽

Needle Aspiration Cytology

Pleomorphic adenoma directly arising in the neck is thought to originate from heterotopic salivary gland tissue. In this article, we present the case of a 55-year-old female patient with a histologically proven pleomorphic adenoma located at the left mandibular angle, anteriorly to the sternocleidomastoid muscle and posteroinferiorly to the submandibular gland. As the patient also had an ipsilateral thyroid nodule with coarse calcifications, clinical and radiological features suggested a possible level II metastatic lymph node. However, ultrasound-guided fine needle aspiration cytology and postsurgery histopathological examination revealed a pleomorphic adenoma arising from heterotopic salivary gland tissue unrelated to a benign thyroid nodule. In this article, we provide a review of the existing literature on heterotopic salivary gland tissue and related neoplasms and discuss their imaging presentation.

Download Full-text

HETEROTOPIC SALIVARY GLAND

The Professional Medical Journal ◽

10.29309/tpmj/2018.25.02.467 ◽

2018 ◽

Vol 25 (02) ◽

pp. 332-334

Author(s):

Afra Samad ◽

Madiha Syed ◽

Arbaz Samad

Keyword(s):

Differential Diagnosis ◽

Salivary Gland ◽

Intestinal Obstruction ◽

Salivary Glands ◽

Histopathological Examination ◽

Exploratory Laparotomy ◽

Clinical Impression ◽

Gland Tissue ◽

History Of ◽

Bleeding Per Rectum

Background: Salivary glands heterotopia is defined as presence of salivary glandtissue outside its normal location.1 Salivary gland heterotopia in ileum leading to obstruction& intussusception is extremely rare. Only two such cases have been reported previously.Case Report: We report a case of 2 years old male who presented with history of vomiting,constipation and bleeding per rectum for one week. Clinical impression was intestinal obstructionand intussusception. An emergency exploratory laparotomy was performed and intraluminalileal polyp was resected. Histopathological examination of the excised polyp demonstratedsalivary gland tissue. Conclusion: Though extremely rare heterotopic salivary gland should beconsidered in differential diagnosis of intestinal obstruction and intussusception.

Download Full-text

A Case of a Stafne Bone Defect Associated with Sublingual Glands in the Lingual Side of the Mandible

Case Reports in Dentistry ◽

10.1155/2020/8851174 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Kamichika Hayashi ◽

Takeshi Onda ◽

Takahiro Iwasaki ◽

Mitsuru Takata ◽

Kiyotaka Mori ◽

...

Keyword(s):

Salivary Gland ◽

Bone Defect ◽

Traffic Accident ◽

Lingual Side ◽

Salivary Gland Tissue ◽

Gland Tissue ◽

Magnetic Resonance Imaging Mri ◽

The Right ◽

Similar Signal Intensity ◽

Stafne Bone Defect

A Stafne bone defect from the mandibular anterior to the premolar region is an extremely rare case. A case of a Stafne bone defect extending from the mandibular anterior to the premolar region was presented. Computed tomography (CT) and magnetic resonance imaging (MRI) suggested that salivary gland tissue connected to the sublingual glands was involved in the formation of the cavity. The patient was a 68-year-old man who was examined at our hospital’s emergency outpatient department after a traffic accident. He was referred to our department for the treatment of contusions of the lips and oral cavity. A bone defect in the lingual side of the mandible from the right anterior to the right premolar region was incidentally detected on CT. CT showed a rounded cavity in the lingual side of the mandible that had a lingual opening, was monocystic, and had a cortical margin. The margin of the cavity was relatively dull and regular. MRI showed that the tissue filling the cavity in the lingual side of the mandible had similar signal intensity as the sublingual glands and was contiguous with the normal sublingual glands. Based on these findings, the bone defect was diagnosed as a Stafne bone defect filled with salivary gland tissue connected to the sublingual gland tissue.

Download Full-text

Heterotopic Salivary Gland Tissue in the Larynx

American Journal of Otolaryngology and Head and Neck Surgery ◽

10.25107/2640-6640-v4-id1129 ◽

2018 ◽

Vol 4 (3) ◽

pp. 1-3

Author(s):

Rohan Bidaye ◽

Ashraf Mahmood ◽

Sam Arman ◽

Huw Griffiths

Keyword(s):

Salivary Gland ◽

Vocal Cord ◽

Male Patient ◽

Clinical Presentation ◽

English Literature ◽

Vocal Cords ◽

Subglottic Region ◽

Salivary Gland Tissue ◽

Gland Tissue ◽

False Vocal

Heterotopic Salivary Gland Tissue (HSGT) of the larynx is an extremely rare pathology, with only 8 cases reported in English literature. We are reporting 2 cases of HSGT in the larynx which we encountered in our practice. The first one is a unique presentation of a 45 year old female with HSGT in bilateral false vocal cords. While the second case is 50-year-old male patient with HSGT in the left false vocal cord and subglottic region. With these 2 cases, we would be discussing about the clinical presentation of this rare anomaly and add to the literature.

Download Full-text

Salivary Gland Tissue

10.32388/co1cjy ◽

2020 ◽

Author(s):

Keyword(s):

Salivary Gland ◽

Salivary Gland Tissue ◽

Gland Tissue

Download Full-text

A case of unusual heteratopic salivary gland tissue mimicking tonsillar neoplasm and review of literature

Journal of Otolaryngology-ENT Research ◽

10.15406/joentr.2018.10.00336 ◽

2018 ◽

Vol 10 (3) ◽

Author(s):

Aysegul Sule Altindal ◽

Nermin Unal

Keyword(s):

Salivary Gland ◽

Review Of Literature ◽

Salivary Gland Tissue ◽

Gland Tissue

Download Full-text

Pseudomonas laryngeal perichondritis: unexpected diagnosis

BMJ Case Reports ◽

10.1136/bcr-2020-237129 ◽

2020 ◽

Vol 13 (12) ◽

pp. e237129

Author(s):

Siti Salwa Zainal Abidin ◽

Thean Yean Kew ◽

Mawaddah Azman ◽

Marina Mat Baki

Keyword(s):

Diabetes Mellitus ◽

Pseudomonas Aeruginosa ◽

Vocal Fold ◽

Histopathological Examination ◽

Thyroid Cartilage ◽

Tracheal Aspirate ◽

Good Recovery ◽

Antituberculous Drug ◽

False Vocal ◽

Oral Ciprofloxacin

A 57-year-old male chronic smoker with underlying diabetes mellitus presented with dysphonia associated with cough, dysphagia and reduced effort tolerance of 3 months’ duration. Videoendoscope finding revealed bilateral polypoidal and erythematous true and false vocal fold with small glottic airway. The patient was initially treated as having tuberculous laryngitis and started on antituberculous drug. However, no improvement was observed. CT of the neck showed erosion of thyroid cartilage, which points to laryngeal carcinoma as a differential diagnosis. However, the erosion was more diffuse and appeared systemic in origin. The diagnosis of laryngeal perichondritis was made when the histopathological examination revealed features of inflammation, and the tracheal aspirate isolated Pseudomonas aeruginosa. The patient made a good recovery following treatment with oral ciprofloxacin.

Download Full-text

Branchial Cleft Fistula with Heterotopic Salivary Gland Tissue in the Lower Neck

ORL ◽

10.1159/000276148 ◽

1990 ◽

Vol 52 (4) ◽

pp. 265-268 ◽

Cited By ~ 4

Author(s):

T. Takimoto ◽

H. Kato

Keyword(s):

Salivary Gland ◽

Salivary Gland Tissue ◽

Gland Tissue ◽

Branchial Cleft ◽

Lower Neck

Download Full-text

Hyperglycemia Induces Generation of Reactive Oxygen Species and Accelerates Apoptotic Cell Death in Salivary Gland Cells

Pathobiology ◽

10.1159/000512639 ◽

2021 ◽

pp. 1-8

Author(s):

Naoyuki Matsumoto ◽

Daisuke Omagari ◽

Ryoko Ushikoshi-Nakayama ◽

Tomoe Yamazaki ◽

Hiroko Inoue ◽

...

Keyword(s):

Oxidative Stress ◽

Reactive Oxygen Species ◽

Salivary Gland ◽

Tissue Injury ◽

Ros Production ◽

Oxygen Species ◽

Saliva Secretion ◽

Salivary Gland Tissue ◽

Gland Tissue

Introduction: Type-2 diabetes mellitus (T2DM) is associated with several systemic vascular symptoms and xerostomia. It is considered that hyperglycemia-induced polyuria and dehydration cause decreased body-water volume, leading to decreased saliva secretion and, ultimately, xerostomia. In T2DM, increased production of reactive oxygen species (ROS) causes tissue damage to vascular endothelial cells as well as epithelial tissue, including pancreas and cornea. Hence, a similar phenomenon may occur in other tissues and glands in a hyperglycemic environment. Methods: Salivary gland tissue injury was examined, using T2DM model mouse (db/db). Transferase‐mediated dUTP nick‐end labeling (TUNEL) was conducted to evaluate tissue injury. The levels of malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine, Bax/Bcl-2 ratio were measured as indicator of oxidative stress. Moreover, in vitro ROS production and cell injury was evaluated by mouse salivary gland-derived normal cells under high-glucose condition culture. Results: In vivo and in vitro analysis showed a higher percentage of TUNEL-positive cells and higher levels of MDA and 8-hydroxy-2′-deoxyguanosine in salivary gland tissue of db/db mice. This suggests damage of saliva secretion-associated lipids and DNA by hyperglycemic-induced oxidative stress. To analyze the mechanism by which hyperglycemia promotes ROS production, mouse salivary gland-derived cells were isolated. The cell culture with high-glucose medium enhanced ROS production and promotes apoptotic and necrotic cell death. Conclusion: These findings suggest a novel mechanism whereby hyperglycemic-induced ROS production promotes salivary gland injury, resulting in hyposalivation.

Download Full-text