scholarly journals Unusual Metastases Site of Thyroid Papillary Carcinoma: A Case Report and Review of the Literature

2020 ◽  
pp. 1-2
Author(s):  
Hicham Ngham
Keyword(s):  
Poor Prognosis ◽  
Radioactive Iodine ◽  
Subcutaneous Tissue ◽  
Review Of The Literature ◽  
Unusual Site ◽  
Thyroid Papillary ◽  
Scalp Metastasis ◽  
Unusual Metastases ◽  
Skull Lesion

Thyroid carcinoma with cranial scalp metastasis is an unusual site. Although these metastases have poor prognosis, early diagnosis and administration of accurate therapy using radioactive iodine seems likely to improve the survival rate and the quality of life. We report a case of a 50-years old woman presented to our ENT department with a slowly evolving lesion in the subcutaneous tissue of the skull occurred 10 years after right lobo-isthmectomy. The treatment was based on resection of the skull lesion as well as thyroid totalization and radioactive iodine

scholarly journals Palliative Electrochemotherapy Treatment of Cutaneous Metastases in a Patient with Advanced Thyroid Papillary Carcinoma

2020 ◽  
Vol 9 (4) ◽  
pp. 221-224
Author(s):  
Daniela Cavaco ◽  
Sara Carvalhal ◽  
Valeriano Leite
Keyword(s):  
Quality Of Life ◽  
Subcutaneous Tissue ◽  
Papillary Thyroid ◽  
Cytostatic Agents ◽  
Invasive Treatment ◽  
Cutaneous Metastases ◽  
Electric Pulses ◽  
Relieve Pain ◽  
Thyroid Papillary

Advanced papillary thyroid carcinoma (PTC) with cutaneous metastases may cause pain, ulceration, and bleeding. Electrochemotherapy (ECT) is a minimally invasive treatment of tumors located in the skin and subcutaneous tissue. The electric pulses potentiate the toxicity of cytostatic agents entering the tumor cell. It is highly effective especially to relieve pain and improve the quality of life. The adverse events are local and transient. A case of progressive metastatic PTC who developed bleeding cutaneous metastases treated with ECT is described.

scholarly journals Bipolar Affective Disorder. Clinical Aspects and Comorbidity

2020 ◽  
Vol 28 (1) ◽  
pp. 166-179
Author(s):  
T.V. Dovzhenko ◽  
D.M. Tsarenko ◽  
T.Yu. Yudeeva
Keyword(s):  
Quality Of Life ◽  
Affective Disorder ◽  
Cognitive Abilities ◽  
Poor Prognosis ◽  
Bipolar Affective Disorder ◽  
Premature Mortality ◽  
Clinical Aspects ◽  
Review Of The Literature ◽  
Negative Prognostic Factor

The review of the literature describes the clinical features of bipolar affective disorder (BAD). Difficulties in diagnosing BAD due to the complex clinical picture that cause untimely diagnosis and the formation of an unfavorable course of the disease are examined in detail. The data on mental disorders it is necessary to differentiate BAD from are presented. The characteristics of the course of BAD are described in detail, including unfavorable forms and mixed bipolar conditions, which are difficult to diagnose and treat, and present a negative prognostic factor. The data on the deterioration of the cognitive abilities of patients with an increase in the number of episodes of BAD, which can occur even during euthymy, are considered. Particular attention is paid to the consideration of forms of mental and somatic pathology, comorbid BAD associated with a decrease in the quality of life, poor prognosis, increased disability, and premature mortality.

Psychological and Cognitive Aspects of Borderline Intellectual Functioning

2017 ◽  
Vol 22 (3) ◽  
pp. 159-166 ◽  
Author(s):  
Bastianina Contena ◽  
Stefano Taddei
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Intellectual Functioning ◽  
Clinical Impact ◽  
Review Of The Literature ◽  
Borderline Intellectual Functioning ◽  
General Quality ◽  
Meta Analyses ◽  
Over Time

Abstract. Borderline Intellectual Functioning (BIF) refers to a global IQ ranging from 71 to 84, and it represents a condition of clinical attention for its association with other disorders and its influence on the outcomes of treatments and, in general, quality of life and adaptation. Furthermore, its definition has changed over time causing a relevant clinical impact. For this reason, a systematic review of the literature on this topic can promote an understanding of what has been studied, and can differentiate what is currently attributable to BIF from that which cannot be associated with this kind of intellectual functioning. Using Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) criteria, we have conducted a review of the literature about BIF. The results suggest that this condition is still associated with mental retardation, and only a few studies have focused specifically on this condition.

Quality of life in schizophrenia: A review of the literature from 1995 to 2000

2002 ◽  
Vol 11 (2) ◽  
pp. 103-111 ◽  
Author(s):  
Jaya Pinikahana ◽  
Brenda Happell ◽  
Judy Hope ◽  
Nicholas A. Keks
Keyword(s):  
Quality Of Life ◽  
Review Of The Literature

scholarly journals Women in surgery: a systematic review of 25 years

BMJ Leader ◽  
2020 ◽  
pp. leader-2019-000199
Author(s):  
Charleen Singh ◽  
Caitlin Loseth ◽  
Noordeen Shoqirat
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Work Life ◽  
Current Status ◽  
Leadership Roles ◽  
Review Of The Literature ◽  
Life Balance ◽  
Surgical Residency ◽  
Meta Analyses

The number of women entering medicine significantly increased over the last decades. Currently, over half of the medical students are women but less than half are applying to surgery and even less go on to surgical specialties. Even fewer women are seen in leadership roles throughout the profession of surgery and surgical residency. Our purpose of the literature review is to identify any themes, which would provide insight to the current phenomenon. We used the Preferred Reporting Items for Systemic Reviews and Meta-Analyses method for a systematic review of the literature over a 20-year period (1998–2018). Five broad themes were identified: education and recruitment, career development, impact of/on life around the globe and surgical subspecialties as areas of barriers for women entering or considering surgery. The systematic review suggests there are opportunities to improve and encourage women entering the profession of surgery as well as the quality of life for surgeons. Creating systems for mentorship across programmes, having policies to support work–life balance and recognising surgical training overlaps with childbearing years are key opportunities for improvement. Improving the current status in surgery will require direction from leadership.

scholarly journals Understanding the quality of diabetes care in Japan: a systematic review of the literature

2021 ◽  
Author(s):  
Joanna Mitri ◽  
Takehiro Sugiyama ◽  
Hirokazu Tanaka ◽  
Mitsuru Ohsugi ◽  
Robert A. Gabbay
Keyword(s):  
Systematic Review ◽  
Diabetes Care ◽  
Review Of The Literature ◽  
Quality Of Diabetes Care

scholarly journals Extrusion of both Superficial and Deep Cuffs of a Functional Double-Cuff Peritoneal Dialysis Catheter after Significant Weight Loss

2021 ◽  
pp. 190-194
Author(s):  
Aravindh S. Ganapathy ◽  
Myron S. Powell ◽  
James L. Pirkle
Keyword(s):  
Weight Loss ◽  
Peritoneal Dialysis ◽  
Subcutaneous Tissue ◽  
Peritoneal Dialysis Catheter ◽  
Dialysis Catheter ◽  
Review Of The Literature ◽  
Significant Weight Loss ◽  
Exit Site ◽  
Special Circumstances ◽  
Uncommon Complication

Extrusion of the superficial cuff of a peritoneal dialysis (PD) catheter is an uncommon complication that may be associated with infection or malfunction. However, extrusion of both the superficial and deep cuffs of a double-cuff catheter is rare and uniformly associated with failure and peritonitis. We report a case of a presternal-type PD double-cuff catheter with extrusion of both cuffs through an abdominal exit site after 6 years of use that has remained functional, which has not been previously reported. In this case, the patient had achieved a 60-kg weight loss resulting in retraction of the subcutaneous tissue around both cuffs, while the catheter was held in place by the titanium connector between the presternal extension tubing and the inner, coiled catheter. In such special circumstances, extrusion of both cuffs may not necessitate urgent catheter removal. A review of the literature revealed previous cases of superficial cuff extrusions with catheters remaining functional but not with deep cuff extrusion.

scholarly journals An assessment of the use of patient reported outcome measurements (PROMs) in cancers of the pelvic abdominal cavity: identifying oncologic benefit and an evidence-practice gap in routine clinical practice

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Miss Charlotte L. Moss ◽  
Ajay Aggarwal ◽  
Asad Qureshi ◽  
Benjamin Taylor ◽  
Teresa Guerrero-Urbano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Abdominal Cavity ◽  
Patient Reported Outcome ◽  
Oncologic Outcomes ◽  
Review Of The Literature ◽  
Outcome Measurements ◽  
Patient Reported ◽  
Cancer Setting

Abstract Background Patient reported outcome measurements (PROMs) are emerging as an important component of patient management in the cancer setting, providing broad perspectives on patients’ quality of life and experience. The use of PROMs is, however, generally limited to the context of randomised control trials, as healthcare services are challenged to sustain high quality of care whilst facing increasing demand and financial shortfalls. We performed a systematic review of the literature to identify any oncological benefit of using PROMs and investigate the wider impact on patient experience, in cancers of the pelvic abdominal cavity specifically. Methods A systematic review of the literature was conducted using MEDLINE (Pubmed) and Ovid Gateway (Embase and Ovid) until April 2020. Studies investigating the oncological outcomes of PROMs were deemed suitable for inclusion. Results A total of 21 studies were included from 2167 screened articles. Various domains of quality of life (QoL) were identified as potential prognosticators for oncologic outcomes in cancers of the pelvic abdominal cavity, independent of other clinicopathological features of disease: 3 studies identified global QoL as a prognostic factor, 6 studies identified physical and role functioning, and 2 studies highlighted fatigue. In addition to improved outcomes, a number of included studies also reported that the use of PROMs enhanced both patient-clinician communication and patient satisfaction with care in the clinical setting. Conclusions This review highlights the necessity of routine collection of PROMs within the pelvic abdominal cancer setting to improve patient quality of life and outcomes.

scholarly journals Pneumatosis intestinalis in a radioactive iodine-refractory metastasic thyroid papillary carcinoma with BRAFV600E mutation treated with dabrafenib–trametinib: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
M. C. Martín-Soberón ◽  
S. Ruiz ◽  
G. De Velasco ◽  
R. Yarza ◽  
A. Carretero ◽  
...  
Keyword(s):  
Case Report ◽  
Papillary Carcinoma ◽  
Radioactive Iodine ◽  
Specific Treatment ◽  
Pneumatosis Intestinalis ◽  
Thyroid Papillary Carcinoma ◽  
Intestinal Pneumatosis ◽  
Abdominal Symptoms ◽  
Positron Emission ◽  
Thyroid Papillary

Abstract Background Pneumatosis intestinalis (PI) is a rare entity which refers to the presence of gas within the wall of the small bowel or colon which is a radiographic sign. The etiology and clinical presentation are variable. Patients with PI may present either with chronic mild non-specific symptoms or with acute abdominal pain with peritonitis. Some cases of intestinal pneumatosis have been reported as adverse events of new oncological treatments such as targeted therapies that are widely used in multiple tumors. Case presentation A 59-year-old caucasian female with radioactive iodine-refractory metastatic thyroid papillary carcinoma with BRAFV600E mutation was treated with dabrafenib and trametinib as a compassionate use. After 4 months treatment, positron emission tomography–computed tomography (PET–CT) showed PI. At the time of diagnosis, the patient was asymptomatic without signs of peritonitis. The initial treatment was conservative and no specific treatment for PI was needed. Unfortunately, after dabrafenib–trametinib withdrawal, the patient developed tumor progression with significant clinical worsening. Conclusions This case report is, in our knowledge, the first description of PI in a patient treated with dabrafenib–trametinib. Conservative treatment is feasible if there are no abdominal symptoms.

scholarly journals Pancreatic Cancer Exposome Profile to Aid Early Detection and Inform Prevention Strategies

2021 ◽  
Vol 10 (8) ◽  
pp. 1665
Author(s):  
Maria J. Monroy-Iglesias ◽  
Saoirse Dolly ◽  
Debashis Sarker ◽  
Kiruthikah Thillai ◽  
Mieke Van Hemelrijck ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Immune Responses ◽  
Inflammatory Markers ◽  
Poor Prognosis ◽  
Associated Factors ◽  
Review Of The Literature ◽  
Prevention Strategies ◽  
Factors Influencing ◽  
Detection Strategies

Pancreatic cancer (PCa) is associated with a poor prognosis and high mortality rate. The causes of PCa are not fully elucidated yet, although certain exposome factors have been identified. The exposome is defined as the sum of all environmental factors influencing the occurrence of a disease during a life span. The development of an exposome approach for PCa has the potential to discover new disease-associated factors to better understand the carcinogenesis of PCa and help with early detection strategies. Our systematic review of the literature identified several exposome factors that have been associated with PCa alone and in combination with other exposures. A potential inflammatory signature has been observed among the interaction of several exposures (i.e., smoking, alcohol consumption, diabetes mellitus, obesity, and inflammatory markers) that further increases the incidence and progression of PCa. A large number of exposures have been identified such as genetic, hormonal, microorganism infections and immune responses that warrant further investigation. Future early detection strategies should utilize this information to assess individuals’ risk for PCa.

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