GENETIC DIVERSITY OF THE CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUSES CIRCULATING IN THE WORLD (REVIEW)

Vestnik ◽  
2021 ◽  
pp. 323-329
Author(s):  
Г.Н. Абуова ◽  
Т.В. Полукчи ◽  
Ф.А. Бердалиева ◽  
Д.С. Алиев ◽  
Л.Л. Сарыпбекова ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Migratory Birds ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
The World ◽  
Key Factor ◽  
Host Blood ◽  
The Relationship

Вирус Конго-Крымской геморрагической лихорадки является возбудителем тяжелой клещевой, часто смертельной, Конго-Крымской геморрагической лихорадки, которая широко распространена во всем мире. Передача вируса Конго-Крымской геморрагической лихорадки к человеку происходит через укус клеща, раздавливание зараженных клещей или контакт с инфицированной кровью человека. Миграция вируса способна через клещей с животными и перелетных птиц, в связи с чем имеется возможность исследования географического распространения посредством генетического анализа. В этом обзоре мы стремимся обобщить самые последние данные о генетическом разнообразии вирусов Конго-Крымской геморрагической лихорадки, циркулирующих в мире. Временной и пространственный анализ многообразия штаммов вируса может послужить ключевым фактором для лучшего понимания связи серопозитивности и уровня летальности. The Crimean-Congo hemorrhagic fever virus is the causative agent of severe tick-borne, often fatal, zoonotic Crimean-Congo hemorrhagic fever, which is widespread throughout the world. Transmission of the Crimean-Congo hemorrhagic fever virus to humans occurs through a tick bite, crushing of infected ticks or contact with infected host blood. The migration of the virus is possible through ticks with animals and migratory birds, and therefore it is possible to study the geographical distribution through genetic analysis. In this review, we aim to summarize the latest data on the genetic diversity of the Crimean-Congo hemorrhagic fever viruses circulating in the world. The temporal and spatial analysis of the diversity of virus strains can serve as a key factor for a better understanding of the relationship between seropositivity and the mortality rate.

scholarly journals Genetic Diversity of the M RNA Segment among Crimean-Congo Hemorrhagic Fever Virus Isolates in China

Virology ◽  
2002 ◽  
Vol 296 (1) ◽  
pp. 159-164 ◽  
Author(s):  
Shigeru Morikawa ◽  
Tang Qing ◽  
Zhao Xinqin ◽  
Masayuki Saijo ◽  
Ichiro Kurane
Keyword(s):  
Genetic Diversity ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
Virus Isolates

scholarly journals Crimean-Congo Hemorrhagic Fever Virus in Ticks from Migratory Birds, Morocco1

2013 ◽  
Vol 19 (2) ◽  
pp. 260-263 ◽  
Author(s):  
Ana M. Palomar ◽  
Aránzazu Portillo ◽  
Paula Santibáñez ◽  
David Mazuelas ◽  
Juan Arizaga ◽  
...  
Keyword(s):  
Migratory Birds ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus

scholarly journals The world areal of Crimean-Congo hemorrhagic fever virus

2006 ◽  
Vol 5 ◽  
pp. 79-86 ◽  
Author(s):  
S. Ye. Smirnova
Keyword(s):  
Hemorrhagic Fever ◽  
Domestic Animals ◽  
Fever Virus ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
Immunological Status ◽  
The World ◽  
Cchf Virus

Distribution of Crimean-Congo hemorrhagic fever (CCHF) virus based on virus isolations and results of seroepidemiological surveys. The were investigated 147 cases of ill (4 countries of Europe and Asia), immunological status of population (13 countries of Europe, Asia and Africa) and domestic animals (16 countries of Europe, Asia and Africa) and infected ticks (7 countries of Eu- rope and Asia). CCHF was first recognized in Azerbaijan, Armenia, Afghanistan, Iran, India and confirmed in Russia, Ukraine, Bulgaria, Yugoslavia (Europe), Uzbekistan, Tadzhikistan, Turkmenistan, Kazakhstan (Asia) and Uganda, Senegal, Kenya (Africa).

scholarly journals Migratory Birds, Ticks, and Crimean-Congo Hemorrhagic Fever Virus

2012 ◽  
Vol 18 (12) ◽  
pp. 2095-2097 ◽  
Author(s):  
Mats Lindeborg ◽  
Christos Barboutis ◽  
Christian Ehrenborg ◽  
Thord Fransson ◽  
Thomas G.T. Jaenson ◽  
...  
Keyword(s):  
Migratory Birds ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus

scholarly journals Nucleoside-modified mRNA vaccines protect IFNAR -/- mice against Crimean Congo hemorrhagic fever virus infection

2021 ◽  
Author(s):  
Sofia Appelberg ◽  
Lijo John ◽  
Norbert Pardi ◽  
Ákos Végvári ◽  
Sándor Bereczky ◽  
...  
Keyword(s):  
Immune Response ◽  
Global Health ◽  
Immune Responses ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Fatality Rate ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
High Fatality Rate ◽  
The World

Crimean-Congo hemorrhagic fever (CCHF), caused by Crimean-Congo hemorrhagic fever virus (CCHFV), is on the World Health Organizations’ list of prioritized diseases and pathogens. With global distribution, high fatality rate and no approved vaccine or effective treatment, CCHF constitutes a threat against global health. In the current study, we demonstrate that vaccination with nucleoside-modified mRNA-lipid nanoparticles (mRNA-LNP), encoding for the CCHFV nucleoprotein (N) or glycoproteins (GcGn) protect IFNAR -/- mice against lethal CCHFV infection. In addition, we found that both mRNA-LNP induced strong humoral and cellular immune responses in IFNAR -/- and immunocompetent mice and that neutralizing antibodies are not necessary for protection. When evaluating immune responses induced by immunization including CCHFV Gc and Gn antigens, we found the Gc protein to be more immunogenic compared to the Gn protein. Hepatic injury is prevalent in CCHF and contributes to the severity and mortality of the disease in humans. Thus, to understand the immune response in the liver after infection and the potential effect of the vaccine, we performed a proteomic analysis on liver samples from vaccinated and control mice after CCHFV infection. Similar to observations in humans, vaccination affected the metabolic pathways. In conclusion, this study shows that a CCHFV mRNA-LNP vaccine, based on viral nucleo- or glycoproteins, mediate protection against CCHFV induced disease. Consequently, genetic immunization is an attractive approach to prevent disease caused by CCHFV and we believe we have necessary evidence to bring this vaccine platform to the next step in the development of a vaccine against CCHFV infection. Importance Crimean-Congo hemorrhagic fever virus (CCHFV) is a zoonotic pathogen causing Crimean-Congo hemorrhagic fever (CCHF), a severe fever disease. CCHFV have a wide distribution and are endemic in several areas around the world. Cases of CCHF are also being reported in new areas, indicating an expansion of the disease, which is of high concern. Dispersion of the disease, high fatality rate and no approved vaccine makes CCHF a threat to global health. The development of a vaccine is thus of great importance. Here we show 100% protection against lethal CCHFV infection in mice immunized with mRNA-LNP encoding for different CCHFV proteins. The vaccination showed both robust humoral and cellular immunity. mRNA-LNP vaccines combine the ability to induce an effective immune response, the safety of a transient carrier and the flexibility of genetic vaccines. This and our results from the current study support the development of a mRNA-LNP based vaccine against CCHFV.

Sign in / Sign up

Export Citation Format

Share Document