Heinz Body Hemolytic Anemia With Eccentrocytosis From Ingestion of Chinese Chive (Allium tuberosum) and Garlic (Allium sativum) in a Dog

A 4-year-old, intact male miniature schnauzer was presented with anorexia. The dog had ingested some Chinese steamed dumplings 2 days before, which contained Chinese chive (Allium tuberosum) and garlic (Allium sativum). Hematological examinations revealed severe Heinz body hemolytic anemia with eccentrocytosis and an increased concentration of methemoglobin, which was thought to result from oxidative damage to erythrocytes by constituents in these Allium plants. In this case, eccentrocytosis was a hallmark finding and could be detected easily, suggesting that this hematological abnormality is useful in diagnosing Allium plant-induced hemolysis.

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In vitro Propagation of Plants from Root Apex-Derived Calli in Chinese Chive (Allium tuberosum ROTTLER) and Garlic (Allium sativum L.).

Ikushugaku zasshi ◽

10.1270/jsbbs1951.43.349 ◽

1993 ◽

Vol 43 (3) ◽

pp. 349-354 ◽

Cited By ~ 4

Author(s):

Hirotoshi SHUTO ◽

Toshinori ABE ◽

Takeo SASAHARA

Keyword(s):

In Vitro Propagation ◽

Allium Sativum ◽

Root Apex ◽

Allium Tuberosum ◽

Chinese Chive

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Letter: Heinz body hemolytic anemia

Archives of Internal Medicine ◽

10.1001/archinte.136.9.1067a ◽

1976 ◽

Vol 136 (9) ◽

pp. 1067a-1067

Author(s):

E. P. Gabor

Keyword(s):

Hemolytic Anemia ◽

Heinz Body

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Heinz-Body Anaemia in the Newborn

PEDIATRICS ◽

10.1542/peds.19.6.1001 ◽

1957 ◽

Vol 19 (6) ◽

pp. 1001-1001

Keyword(s):

Hemolytic Anemia ◽

Case Reports ◽

Newborn Infants ◽

Term Infant ◽

Heinz Bodies ◽

Heinz Body ◽

Large Numbers ◽

Complete Reversal ◽

Staining Techniques ◽

Supravital Staining

The association of Heinz-bodies within erythrocytes, extreme distortion of the size and shape of erythrocytes and hemolytic anemia in newborn infants, especially premature infants, has been sporadically reported in the medical literature since 1948. Heinz-bodies are thought to be either remnants of disintegrated membranes of erythocytes or abnormal products of hemoglobin metablism, and are demonstrable only by supravital staining techniques. The present study contributes two case reports and discusses the sequence of the clinical and hematologic manifestations. The first patient was a full-term infant who developed jaundice and symptoms attributable to anemia at 2 weeks of life. The second infant was prematurely born, did not develop jaundice but showed large numbers of Heinz-bodies (70%) as the anemia progressed. Both patients responded well to a single transfusion of packed blood cells, with complete reversal of the abnormal peripheral blood findings. None of the usual causes of hemolysis could be demonstrated by extensive laboratory tests. Agents such as phenylhydrazine, known to produce Heinz-bodies, could not be incriminated. The phenomenon of Heinz-body formation in infants may be more common than is apparent as the technique of demonstration is not commonly a part of the routine study of infants with evidence of hemolytic anemia. This technique is described and illustrations of erythrocytes containing Heinz-bodies are provided.

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Effect of Total Nitrogen Concentration of Nutrient Solution in DFT System on the Initial Growth and Nutrient Uptake of Chinese Chive (Allium tuberosum Rottler ex Spreng.)

Journal of the Japanese Society for Horticultural Science ◽

10.2503/jjshs1.77.173 ◽

2008 ◽

Vol 77 (2) ◽

pp. 173-179 ◽

Cited By ~ 1

Author(s):

Zhan Hui Wu ◽

Toru Maruo ◽

Yutaka Shinohara

Keyword(s):

Nutrient Uptake ◽

Total Nitrogen ◽

Nutrient Solution ◽

Nitrogen Concentration ◽

Initial Growth ◽

Allium Tuberosum ◽

Total Nitrogen Concentration ◽

Chinese Chive

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Spurious, marked leukocytosis in 2 cats with Heinz body hemolytic anemia

Veterinary Clinical Pathology ◽

10.1111/vcp.12860 ◽

2020 ◽

Vol 49 (2) ◽

pp. 232-239

Author(s):

Courtney E. Johnson ◽

Davis M. Seelig ◽

Frances M. Moore ◽

Tammy J. Ruska ◽

Daniel A. Heinrich

Keyword(s):

Hemolytic Anemia ◽

Heinz Body

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Elevated glutathione accelerates oxidative damage to erythrocytes produced by aromatic disulfide

Blood ◽

10.1182/blood.v73.1.312.312 ◽

1989 ◽

Vol 73 (1) ◽

pp. 312-317 ◽

Cited By ~ 22

Author(s):

Y Maede ◽

M Kuwabara ◽

A Sasaki ◽

M Inaba ◽

W Hiraoka

Keyword(s):

Electron Spin Resonance ◽

Oxidative Damage ◽

Electron Spin ◽

Normal Level ◽

Reduced Glutathione ◽

Spin Trapping ◽

High Concentration ◽

Heinz Body ◽

Spin Resonance ◽

Body Count

Abstract It has been shown that certain dogs have erythrocytes characterized by an inherited high concentration of reduced glutathione (GSH), five to seven times the normal level (high-GSH RBCs). We examined whether increased GSH in dog erythrocytes leads to increased protection against oxidative damage induced by acetylphenylhydrazine (APH) and/or 4- aminophenyl disulfide (4-AD). When erythrocytes were incubated with 30 mmol/L APH, the Heinz body count was appreciably higher in normal RBCs than in high-GSH RBCs, while there was no difference in the increase of the methemoglobin (metHb) concentration in both RBCs. In contrast, both the Heinz body count and metHb production were much higher in high-GSH RBCs than in normal RBCs when erythrocytes were incubated with 4-AD. Furthermore, the generation of the superoxide in erythrocytes treated with 4-AD, which was measured by spin trapping combined with electron spin resonance (ESR), was obviously higher in high-GSH RBCs than in normal RBCs. These results clearly indicate that erythrocyte GSH is an important defense against oxidative damage induced by certain compounds such as APH, but that, in contrast, elevated GSH appears to accelerate oxidative damage to erythrocytes produced by aromatic disulfides, such as 4-AD, which generated a superoxide in erythrocytes via its redox reaction with GSH.

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Control of Panama disease of banana by intercropping with Chinese chive (Allium tuberosum Rottler): cultivar differences

BMC Plant Biology ◽

10.1186/s12870-020-02640-9 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Zhenfang Li ◽

Tong Wang ◽

Chenling He ◽

Kelin Cheng ◽

Rensen Zeng ◽

...

Keyword(s):

Antifungal Activity ◽

Field Experiments ◽

Disease Incidence ◽

Inhibitory Effect ◽

Cultivar Differences ◽

Antifungal Compounds ◽

Panama Disease ◽

Allium Tuberosum ◽

Leaf Volatiles ◽

Chinese Chive

Abstract Panama disease (Fusarium wilt disease) caused by Fusarium oxysporum f. sp. cubense race 4 (FOC) severely threatens banana (Musa spp.) production worldwide. Intercropping of banana with Allium plants has shown a potential to reduce Panama disease. In this study, six cultivars of Chinese chive (Allium tuberosum Rottler) were selected to compare their differences in antifungal activity and active compounds. Three cultivars Duokang Fujiu 11, Fujiuhuang 2, and Duokang Sijiqing with higher levels of antifungal compounds were further used for intercropping with banana in the pots and field to compare their effects on growth and disease incidence of banana. The six cultivars showed significant differences in antifungal activity against FOC mycelia growth in both leaf volatiles and aqueous leachates. The aqueous leachates displayed stronger antifungal activity than the volatiles. FJH cultivar showed the best inhibitory effect among all six cultivars. Contents of three main antifungal compounds dipropyl trisulfide (DPT), dimethyl trisulfide (DMT), and 2-methyl-2-pentenal (MP) in volatiles and aqueous leachates varied considerably among cultivars. Pot and field experiments showed that intercropping with three selected Chinese chive cultivars significantly improved banana vegetative growth, increased photosynthetic characteristics and yield but decreased disease incidence of Panama disease. Our results indicate that intercropping with Chinese chive shows potential to reduce banana Panama disease and selection of appropriate cultivars is vital for effective disease control.

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