scholarly journals Iron Deficiency Association as A Possible Cause of First Febrile Seizure

2021 ◽  
Vol 15 (5) ◽  
pp. 1728-1730
Author(s):  
Zarmast Khan ◽  
Zabit Khan Naibzai ◽  
M. Adnan Ahmed Sethi ◽  
Shahid Ghaffar ◽  
Sumera Makhdoom ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Febrile Episode ◽  
Deficiency Anemia ◽  
First Episode ◽  
Medicine Department ◽  
The Relationship ◽  
Controlled Clinical Study ◽  
Possible Cause

Aim: A controlled clinical study was conducted to investigate the relationship between iron deficiency and first episode of febrile seizure in children 6-60 months of age. Place and Duration:In the Pediatric Medicine department of ShifaInternationalHospital Islamabadforsix months duration from 15thMay 2020 to 30thNovember 2020. Methods:Hematological parameters for iron levels, including HB, MCV, MCHC and plasma ferritin, were determined in 75 patients who experienced a first febrile episode. 75 children without febrile seizures were taken as controls and the same markers were compared in both groups. Results: The most important factors influencing the first attack of febrile seizure were HB, MCV, and serum ferritin levels. Conclusion: Iron deficiency is significantly associated with the occurrence of the first febrile episode in children. Key words:Iron deficiency anemia, Iron deficiency, Febrile convulsions, Febrile attacks.

scholarly journals Study of iron deficiency as a risk factor for first episode of simple febrile siezure

2017 ◽  
Vol 4 (5) ◽  
pp. 1881
Author(s):  
Rakesh Kumawat ◽  
Pukhraj Garg ◽  
B. S. Karnawat ◽  
Ishwari P. Verma ◽  
Akansha Arora ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Febrile Seizure ◽  
Serum Iron ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
First Episode ◽  
Control Group ◽  
Age Group ◽  
Text Book

Background: Febrile seizure are seizure that occur between the age of 6 month to 60 months with a temperature of 100.4f or higher, that are not the result of central nervous system infection or any metabolic imbalance and that occur in the absence of a history of prior afebrile seizure. Febrile seizures are the commonest cause of seizures in children, occuring in 2-5% of children. The maximum age of febrile convulsion occurrence is 14-18 months, which overlap with the maximum prevalence of iron deficiency anaemia which is 1-2 year old. 7 So far, the dilemma of cause of febrile seizure could not be solved. Standard text book still mention iron deficiency is associated with an increased risk of febrile seizure, thus screening for that problem and treating it appears appropriate.Methods: This case control study was done from June 2015 to December 2016. 60 cases of first episode of simple febrile seizure in age group of 6 month to 5 years were included in the study. A control group was selected from age and sex matched children admitted with febrile illness but without seizure. In all cases detailed clinical history, anthropometry, clinical sign of iron deficiency, CNS examination, CBC, PBF, Red cell indices, serum iron, serum ferritin and serum TIBC level was done. These were analysed in three groups mild, moderate, severe deficiency of anemia. A clinical correlation is tried to establish between overt and subtle iron deficiency with seizure.Results: Majority of subjects with first episode of simple febrile seizure were males (63.3%). Majority of cases of febrile seizure occur in the 6-24 months age group (83.3%). Incidence of anemia among case group subjects was 90.0% whereas the same in control group was 30 %. Mean RDW and TIBC levels in cases were significantly higher as compared to that in controls. MCV, Mean Serum ferritin and Serum Iron levels in cases were significantly lower as compared to that in controls.Conclusions: The findings in present study established an association between iron deficiency anemia and first episode of simple febrile seizures. 

scholarly journals A HOSPITAL BASED OBSERVATIONAL STUDY TO STUDY THE ASSOCIATION OF IRON DEFICIENCY ANEMIA WITH FEBRILE SEIZURES IN CHILDREN OF AGE GROUP 6 MONTHS TO 5 YEARS AT TERTIARY CARE CENTER, HYDERABAD

2020 ◽  
pp. 1-3
Author(s):  
Lakshmi M ◽  
Sumapriya M ◽  
Channamsetty Anusha
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Serum Iron ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Age Group ◽  
Febrile Convulsions ◽  
The Relationship

BACKGROUND: Febrile convulsion (FC) is the most common CNS disorder in childhood. 2-5% of children (or 4.8 out of every 1000) are affected every year. Studies conducted on the effect of iron deficiency on febrile convulsions found in children have yielded completely conflicting results. Iron deficiency has been a risk factor for febrile convulsions in some studies, while in others, it was proved to be protective against febrile seizure as iron deficiency increases the threshold of neuron excitation. Aims: To study the relationship between iron deficiency anemia and febrile convulsion in children to prevent the treatable cause of FC. Objectives: Is to determine the relationship between iron deficiency anemia and febrile seizures and to find out the incidence of anemia in the febrile seizure in males and females. Methods: A Hospital-based observational study carried out at Andhra Mahila Sabha Hospital, Hyderabad, during the period May 2014 to May 2016 involving children aged about 6months to 5 years of age group with typical febrile convulsions meeting inclusion and exclusion criteria. The temperature at admission and nutritional status was recorded, and investigations like hemoglobin, blood indices (MCV, MCH, MCHC), RDW (Red Cell Distribution Width), serum iron, and peripheral smear did for detection of iron deficiency anemia and their relationship with febrile seizure was observed. Results: Out of 350 children enrolled, 131 (37.4%) were female, and 219 (62.6%) were males. In our study males was slightly more prone to febrile seizure with the ratio of M: F is 1.6:1. There is a significant association of iron deficiency anemia with FC, and there is increased frequency with increased incidence of iron deficiency anemia,(i.e.) seizures tend to repeat itself in the presence of iron deficiency anemia ( with P-value of <0.001, at CI of 95%). Conclusion: low serum iron levels and the presence of anemia can serve as strengthening factors for febrile seizures in children. Accordingly, children with febrile seizures are suggested to be monitored for the diagnosis and treatment of IDA.

scholarly journals Iron Deficiency Anemia: A Probable Risk Factor for First Episode of Simple Febrile Seizure

2016 ◽  
Vol 15 (07) ◽  
pp. 12-14
Author(s):  
Dr. Syama Prasad Sit ◽  
Dr. Swarupananda Maiti ◽  
Dr. Mani Kant ◽  
Dr. Sekhar Mandal ◽  
Dr. Achinta Mandal
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Deficiency Anemia ◽  
First Episode

scholarly journals Iron Deficiency Anemia as a Risk Factor for First Febrile Seizures a Case Control Study

2020 ◽  
Vol 8 (4) ◽  
pp. 24-29
Author(s):  
V. Ramgopal Rao ◽  
P. Anil Kumar
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Deficiency Anaemia ◽  
Febrile Illness ◽  
Febrile Seizures ◽  
Trigger Factor ◽  
Deficiency Anemia ◽  
First Episode ◽  
Deficiency Anaemia

Background: Febrile seizures in children are a common problem. Iron deficiency anaemia is known, among other contributing factors, to be an aggravating factor in febrile seizures. Iron deficiency anaemia is a condition that can be avoided and managed. The study goal was to identify iron deficiency anaemia as a trigger factor for febrile seizures (FS). To determine the association between Iron Deficiency Anemia (IDA) and the first episode of febrile seizures (FFS). Subjects and Methods: Investigation like hemoglobin, blood indices (MCV, MCH), and serum iron and serum ferritin are done for detection of iron deficiency anaemia and their relationship with the first episode of febrile seizure was observed. Results: In our study comprising 50 cases and 50 controls, 58% (29) of cases were diagnosed as IDA with FS, 18% (9) of controls were diagnosed as IDA with Febrile Illness (FI). This suggests IDA as a risk factor for febrile seizures with a significant P value of <0.001. Among 50 cases 42% (21) cases have FS without IDA and among 50 controls 82% (41) controls have FI without IDA were present in the current study. Conclusion: IDA was more common in children with FS than in those with febrile illness (FI) disease alone. The result suggests that the IDA can be a contributing factor to the FFS. Screening of IDA of children with FFS should be regarded. Fever can worsen the negative effects of anaemia or iron deficiency on the brain, which can lead to seizures.

scholarly journals Low serum zinc and magnesium–a possible risk factor for first episode Simple febrile seizures in children between 6 months to 5 years of age

2021 ◽  
Author(s):  
Aishwarya Lakshmi L. G. ◽  
Mohanraj Kannan ◽  
Rajakumar P. G. ◽  
Selvaraj R.
Keyword(s):  
Febrile Seizure ◽  
Serum Magnesium ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Mean Value ◽  
First Episode ◽  
Control Group ◽  
Case Group ◽  
High Grade Fever ◽  
Low Serum

Background: Febrile seizure is the most common type of seizure in children. The incidence of febrile seizure is 5-10% in India. There are multiple aetiologies like high grade fever; genetic predisposition, viral infections and trace elements deficiency like iron, zinc, magnesium and calcium are postulated to be risk factors for developing febrile seizures. Recent studies had shown there is a significant association between low serum zinc, low serum magnesium levels and febrile seizures in children.Methods: This was a case control study with 40 children in each group. Children aged 6 months to 5 years with first episode of simple febrile seizures who attends the out-patient department/emergency room (OPD/ER) were included in case group consecutively and 40 children with acute febrile illness without febrile seizures were included in control group. Serum zinc and magnesium levels were estimated for all the children along with other investigations after proper consent from parents. Using statistical package for the social sciences (SPSS) software, independent sample t test was used to analysis the observations between the two groups. Normal lab reference value of serum zinc was 60-120 μg/dl and serum magnesium was 1.7-2.5 mg/dl.Results: The incidence of febrile seizure was high (37.5%) in children between 1-2 years and male (55%) children had increased incidence when compared to female children in case group. The children with febrile seizure had significantly low levels of serum zinc with mean value of 35.08 μg/dl (±8.56) when compared to control group with mean value of 70.23 μg/dl (±13.41) and serum magnesium level in case group was 1.35 mg/dl (±0.29) versus 1.68 mg/dl (±0.42) in control group, which was also statistically significant.Conclusions: The incidence of febrile seizure was high in children between 1-2 years of age with male preponderance. The serum levels of both zinc and magnesium is significantly low in children with febrile seizure pointing a need of further studies in role of supplemental zinc and magnesium in this age group to reduce the incidence of febrile seizures. 

scholarly journals Blue Rubber Bleb Nevus Syndrome: A Possible Cause for Growth Retardation and Pubertal Delay

2018 ◽  
Vol 28 (3) ◽  
pp. 294-296
Author(s):  
Yi Pan ◽  
Lu Zhang ◽  
Minghui Duan ◽  
Hong Yang ◽  
Duoduo Zhao ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Iron Deficiency ◽  
Growth Retardation ◽  
Rare Case ◽  
Clinical Presentation ◽  
Intravenous Iron ◽  
Deficiency Anemia ◽  
Pubertal Delay ◽  
Intravenous Iron Therapy ◽  
Possible Cause

Objective: The aim of this paper was to describe a rare case of blue rubber bleb nevus (BRBNS) with growth retardation and pubertal delay. Clinical Presentation and Intervention: A 16-year-old boy with severe iron deficiency anemia was diagnosed with BRBNS, showing growth retardation and pubertal delay simultaneously. The patient was treated conservatively with intravenous iron therapy, and his puberty advanced gradually. Conclusion: Given that growth retardation and pubertal delay are rare in BRBNS patients, this case reminds us to include BRBNS in the differential diagnosis of growth retardation.

The association between iron deficiency anemia and febrile seizure

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Parviz Karimi ◽  
Koroush Sayehmiri ◽  
Milad Azami ◽  
Zeinab Tardeh
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Mean Corpuscular Hemoglobin ◽  
Protective Effects ◽  
Corpuscular Hemoglobin

Abstract Objective Different studies have reported contradictory results regarding the relationship between iron deficiency anemia (IDA) and febrile seizure (FS). The present study was conducted to determine the effect of IDA on FS in children. Patients and methods This case-control study was conducted among 52 children with FS (the case group) and 18 children with afebrile seizures and 51 children with fever without seizures in the age range of 6 months to 5 years admitted to the pediatric ward of Imam Khomeini Hospital in Ilam from March 2016 to January 2017. Patients were selected using the convenience sampling method. Red blood cell (RBC) count as well as measurement of hemoglobin (Hb), hematocrit (Hct), ferritin, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were performed in all patients. The collected data were analyzed using SPSS16 software. Results A total of 34.6% in the FS group, 66.7% in the afebrile seizure group and 41.2% in the fever without seizure group suffered from IDA, which was not statistically significant between the three groups. Hb, Hct and RBC levels were higher in the case group and MCV, MCH, MCHC levels in the case group were lower than those in the control group. The odds ratio (OR) for FS compared to the febrile group was 0.756 [95% confidence interval (CI) = 0.34–1.68; p = 0.493] and that for FS compared to seizure was 0.265 (95% CI = 0.085–0.823; p = 0.022). Conclusions This study showed that IDA may have protective effects on the onset of FS, and based on the results, IDA is more common in children with afebrile seizures. Further and more comprehensive studies are recommended.

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