The relationship between febrile seizure and iron deficiency anemia in babylon children, Babylon Province

2018 ◽  
Vol 9 (10) ◽  
pp. 914
Author(s):  
Mudher Hasan Noor
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Deficiency Anemia ◽  
The Relationship

scholarly journals A HOSPITAL BASED OBSERVATIONAL STUDY TO STUDY THE ASSOCIATION OF IRON DEFICIENCY ANEMIA WITH FEBRILE SEIZURES IN CHILDREN OF AGE GROUP 6 MONTHS TO 5 YEARS AT TERTIARY CARE CENTER, HYDERABAD

2020 ◽  
pp. 1-3
Author(s):  
Lakshmi M ◽  
Sumapriya M ◽  
Channamsetty Anusha
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Serum Iron ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Age Group ◽  
Febrile Convulsions ◽  
The Relationship

BACKGROUND: Febrile convulsion (FC) is the most common CNS disorder in childhood. 2-5% of children (or 4.8 out of every 1000) are affected every year. Studies conducted on the effect of iron deficiency on febrile convulsions found in children have yielded completely conflicting results. Iron deficiency has been a risk factor for febrile convulsions in some studies, while in others, it was proved to be protective against febrile seizure as iron deficiency increases the threshold of neuron excitation. Aims: To study the relationship between iron deficiency anemia and febrile convulsion in children to prevent the treatable cause of FC. Objectives: Is to determine the relationship between iron deficiency anemia and febrile seizures and to find out the incidence of anemia in the febrile seizure in males and females. Methods: A Hospital-based observational study carried out at Andhra Mahila Sabha Hospital, Hyderabad, during the period May 2014 to May 2016 involving children aged about 6months to 5 years of age group with typical febrile convulsions meeting inclusion and exclusion criteria. The temperature at admission and nutritional status was recorded, and investigations like hemoglobin, blood indices (MCV, MCH, MCHC), RDW (Red Cell Distribution Width), serum iron, and peripheral smear did for detection of iron deficiency anemia and their relationship with febrile seizure was observed. Results: Out of 350 children enrolled, 131 (37.4%) were female, and 219 (62.6%) were males. In our study males was slightly more prone to febrile seizure with the ratio of M: F is 1.6:1. There is a significant association of iron deficiency anemia with FC, and there is increased frequency with increased incidence of iron deficiency anemia,(i.e.) seizures tend to repeat itself in the presence of iron deficiency anemia ( with P-value of <0.001, at CI of 95%). Conclusion: low serum iron levels and the presence of anemia can serve as strengthening factors for febrile seizures in children. Accordingly, children with febrile seizures are suggested to be monitored for the diagnosis and treatment of IDA.

The association between iron deficiency anemia and febrile seizure

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Parviz Karimi ◽  
Koroush Sayehmiri ◽  
Milad Azami ◽  
Zeinab Tardeh
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Mean Corpuscular Hemoglobin ◽  
Protective Effects ◽  
Corpuscular Hemoglobin

Abstract Objective Different studies have reported contradictory results regarding the relationship between iron deficiency anemia (IDA) and febrile seizure (FS). The present study was conducted to determine the effect of IDA on FS in children. Patients and methods This case-control study was conducted among 52 children with FS (the case group) and 18 children with afebrile seizures and 51 children with fever without seizures in the age range of 6 months to 5 years admitted to the pediatric ward of Imam Khomeini Hospital in Ilam from March 2016 to January 2017. Patients were selected using the convenience sampling method. Red blood cell (RBC) count as well as measurement of hemoglobin (Hb), hematocrit (Hct), ferritin, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were performed in all patients. The collected data were analyzed using SPSS16 software. Results A total of 34.6% in the FS group, 66.7% in the afebrile seizure group and 41.2% in the fever without seizure group suffered from IDA, which was not statistically significant between the three groups. Hb, Hct and RBC levels were higher in the case group and MCV, MCH, MCHC levels in the case group were lower than those in the control group. The odds ratio (OR) for FS compared to the febrile group was 0.756 [95% confidence interval (CI) = 0.34–1.68; p = 0.493] and that for FS compared to seizure was 0.265 (95% CI = 0.085–0.823; p = 0.022). Conclusions This study showed that IDA may have protective effects on the onset of FS, and based on the results, IDA is more common in children with afebrile seizures. Further and more comprehensive studies are recommended.

The relationship between iron parameters and platelet parameters in women with iron deficiency anemia and thrombocytosis

Platelets ◽  
2012 ◽  
Vol 24 (5) ◽  
pp. 348-351 ◽  
Author(s):  
Mi-Jung Park ◽  
Pil-Whan Park ◽  
Yiel-Hea Seo ◽  
Kyung-Hee Kim ◽  
Soon-Ho Park ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Iron Parameters ◽  
The Relationship

scholarly journals Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6

Blood ◽  
2011 ◽  
Vol 117 (2) ◽  
pp. 647-650 ◽  
Author(s):  
Anne Lenoir ◽  
Jean-Christophe Deschemin ◽  
Léon Kautz ◽  
Andrew J. Ramsay ◽  
Marie-Paule Roth ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Serine Protease ◽  
Iron Deficiency Anemia ◽  
Iron Homeostasis ◽  
Deficiency Anemia ◽  
Hepatic Iron ◽  
Master Regulator ◽  
Liver Iron ◽  
The Relationship

Abstract Hepcidin is the master regulator of iron homeostasis. In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6). To determine the relationship between Bmp6 and matriptase-2 pathways, Tmprss6−/− mice (characterized by increased hepcidin levels and anemia) and Bmp6−/− mice (exhibiting severe iron overload because of hepcidin deficiency) were intercrossed. We showed that loss of Bmp6 decreased hepcidin levels; increased hepatic iron; and, importantly, corrected hematologic abnormalities in Tmprss6−/− mice. This finding suggests that elevated hepcidin levels in patients with familial iron-refractory, iron-deficiency anemia are the result of excess signaling through the Bmp6/Hjv pathway.

scholarly journals Iron Deficiency Association as A Possible Cause of First Febrile Seizure

2021 ◽  
Vol 15 (5) ◽  
pp. 1728-1730
Author(s):  
Zarmast Khan ◽  
Zabit Khan Naibzai ◽  
M. Adnan Ahmed Sethi ◽  
Shahid Ghaffar ◽  
Sumera Makhdoom ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Febrile Episode ◽  
Deficiency Anemia ◽  
First Episode ◽  
Medicine Department ◽  
The Relationship ◽  
Controlled Clinical Study ◽  
Possible Cause

Aim: A controlled clinical study was conducted to investigate the relationship between iron deficiency and first episode of febrile seizure in children 6-60 months of age. Place and Duration:In the Pediatric Medicine department of ShifaInternationalHospital Islamabadforsix months duration from 15thMay 2020 to 30thNovember 2020. Methods:Hematological parameters for iron levels, including HB, MCV, MCHC and plasma ferritin, were determined in 75 patients who experienced a first febrile episode. 75 children without febrile seizures were taken as controls and the same markers were compared in both groups. Results: The most important factors influencing the first attack of febrile seizure were HB, MCV, and serum ferritin levels. Conclusion: Iron deficiency is significantly associated with the occurrence of the first febrile episode in children. Key words:Iron deficiency anemia, Iron deficiency, Febrile convulsions, Febrile attacks.

scholarly journals Association of Iron Deficiency Anemia with Febrile Seizure in Children in a Tertiary Care Hospital

2021 ◽  
Vol 19 (1) ◽  
pp. 66-70
Author(s):  
Brajesh Raj Chaudhary ◽  
Kalpana Karmacharya Malla ◽  
Binod Gaire
Keyword(s):  
Risk Factors ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Binding Capacity ◽  
Tertiary Care ◽  
Transferrin Saturation ◽  
Deficiency Anemia ◽  
Seizure Threshold ◽  
Care Hospital

Background: Febrile seizure is the most common cause of seizure in children. Iron deficiency, by lowering seizure threshold, is proposed to be one of the risk factors for febrile seizure. Many studies have been done to determine the association of iron deficiency anemia with febrile seizure but the results are controversial. Hence, the present study was conducted to evaluate the association of iron deficiency anemia with febrile seizure in Nepalese children. Methods: A prospective age and sex matched case control study was performed in 68 cases of febrile seizures and 68 controls of febrile illness without seizure after calculating the sample size. The study was conducted from October 21, 2019 to October 20, 2020 in Pediatric ward and intensive care unit of College of Medical Sciences, Bharatpur, Nepal after obtaining ethical clearance from institutional review committee. Data entry was done in statistical packages for the social science version 20.Results: Mean of haematological parameters (haemoglobin and mean corpuscular volume) as well as mean of serum iron, ferritin and transferrin saturation were significantly less and total iron binding capacity was significantly high in cases as compared to controls (P <0.05). Iron deficiency anemia was significantly associated with cases (59.7%), with odds ratio of 2.5 (95% confidence interval =1.24 – 5.01) as compared to control (40.3%) (P <0.05).Conclusions: Iron deficiency anemia may be considered one of the risk factors for febrile seizure in children. Hence, Children with febrile seizure should be investigated and treated for Iron deficiency anemia.Keywords: Children; febrile seizure; iron deficiency anemia

scholarly journals Iron deficiency anemia as a risk factor for simple febrile seizures in pediatric patients

2019 ◽  
Vol 6 (4) ◽  
pp. 1414 ◽  
Author(s):  
Bharath Kumar T. ◽  
Kanimozhi Thandapani ◽  
Vinod Babu S.
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Febrile Seizure ◽  
Hematological Parameters ◽  
Significant Risk ◽  
Febrile Illness ◽  
Deficiency Anemia ◽  
P Value

Background: Febrile seizure (FS) is the most common cause of seizure in children, occurring between 6-60 months. It coincides with peak age of incidence for Iron deficiency anemia (IDA). Iron is required for optimal growth and development and its deficiency is associated with numerous problems including persistent cognitive and motor delays. The objective was to study the role of IDA as a risk factor for simple febrile seizure and its recurrenceMethods: A case control study was conducted among 90 febrile children - 45 cases with simple febrile seizure and 45 cases with febrile illness, between the age group of six months to five years of age at Sri Manakula Vinayagar Medical College and Hospital, Pondicherry, between September 2013 and June 2015. The hematological parameters like Hemoglobin, Serum ferritin and RDW were compared between the two groups with respect to fever and different temperature intervals, recurrence of FS.Results: Hb and Serum Ferritin levels were found to be significantly associated with simple febrile seizure, with p value of <0.002 and 0.001 respectively. Similar association was found at different temperature intervals. However, there was no association of hematological parameters with FS recurrence.Conclusions: IDA is a significant risk factor for FS in children while same may not have any effect on the recurrence of FS.

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