The Relationship between Iron deficiency anemia and Febrile Convulsions in infant and Children

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
fatima shaaib ◽  
Asmaa Esh ◽  
Seham Azab ◽  
sahbaa hafez
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Febrile Convulsions ◽  
The Relationship

scholarly journals A HOSPITAL BASED OBSERVATIONAL STUDY TO STUDY THE ASSOCIATION OF IRON DEFICIENCY ANEMIA WITH FEBRILE SEIZURES IN CHILDREN OF AGE GROUP 6 MONTHS TO 5 YEARS AT TERTIARY CARE CENTER, HYDERABAD

2020 ◽  
pp. 1-3
Author(s):  
Lakshmi M ◽  
Sumapriya M ◽  
Channamsetty Anusha
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Serum Iron ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Age Group ◽  
Febrile Convulsions ◽  
The Relationship

BACKGROUND: Febrile convulsion (FC) is the most common CNS disorder in childhood. 2-5% of children (or 4.8 out of every 1000) are affected every year. Studies conducted on the effect of iron deficiency on febrile convulsions found in children have yielded completely conflicting results. Iron deficiency has been a risk factor for febrile convulsions in some studies, while in others, it was proved to be protective against febrile seizure as iron deficiency increases the threshold of neuron excitation. Aims: To study the relationship between iron deficiency anemia and febrile convulsion in children to prevent the treatable cause of FC. Objectives: Is to determine the relationship between iron deficiency anemia and febrile seizures and to find out the incidence of anemia in the febrile seizure in males and females. Methods: A Hospital-based observational study carried out at Andhra Mahila Sabha Hospital, Hyderabad, during the period May 2014 to May 2016 involving children aged about 6months to 5 years of age group with typical febrile convulsions meeting inclusion and exclusion criteria. The temperature at admission and nutritional status was recorded, and investigations like hemoglobin, blood indices (MCV, MCH, MCHC), RDW (Red Cell Distribution Width), serum iron, and peripheral smear did for detection of iron deficiency anemia and their relationship with febrile seizure was observed. Results: Out of 350 children enrolled, 131 (37.4%) were female, and 219 (62.6%) were males. In our study males was slightly more prone to febrile seizure with the ratio of M: F is 1.6:1. There is a significant association of iron deficiency anemia with FC, and there is increased frequency with increased incidence of iron deficiency anemia,(i.e.) seizures tend to repeat itself in the presence of iron deficiency anemia ( with P-value of <0.001, at CI of 95%). Conclusion: low serum iron levels and the presence of anemia can serve as strengthening factors for febrile seizures in children. Accordingly, children with febrile seizures are suggested to be monitored for the diagnosis and treatment of IDA.

The relationship between iron parameters and platelet parameters in women with iron deficiency anemia and thrombocytosis

Platelets ◽  
2012 ◽  
Vol 24 (5) ◽  
pp. 348-351 ◽  
Author(s):  
Mi-Jung Park ◽  
Pil-Whan Park ◽  
Yiel-Hea Seo ◽  
Kyung-Hee Kim ◽  
Soon-Ho Park ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Iron Parameters ◽  
The Relationship

scholarly journals Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6

Blood ◽  
2011 ◽  
Vol 117 (2) ◽  
pp. 647-650 ◽  
Author(s):  
Anne Lenoir ◽  
Jean-Christophe Deschemin ◽  
Léon Kautz ◽  
Andrew J. Ramsay ◽  
Marie-Paule Roth ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Serine Protease ◽  
Iron Deficiency Anemia ◽  
Iron Homeostasis ◽  
Deficiency Anemia ◽  
Hepatic Iron ◽  
Master Regulator ◽  
Liver Iron ◽  
The Relationship

Abstract Hepcidin is the master regulator of iron homeostasis. In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6). To determine the relationship between Bmp6 and matriptase-2 pathways, Tmprss6−/− mice (characterized by increased hepcidin levels and anemia) and Bmp6−/− mice (exhibiting severe iron overload because of hepcidin deficiency) were intercrossed. We showed that loss of Bmp6 decreased hepcidin levels; increased hepatic iron; and, importantly, corrected hematologic abnormalities in Tmprss6−/− mice. This finding suggests that elevated hepcidin levels in patients with familial iron-refractory, iron-deficiency anemia are the result of excess signaling through the Bmp6/Hjv pathway.

scholarly journals A study of febrile seizures in children in relation to iron deficiency anemia

2017 ◽  
Vol 4 (5) ◽  
pp. 1599
Author(s):  
Gautam Shah ◽  
Ritesh Parmar
Keyword(s):  
Risk Factor ◽  
Iron Deficiency ◽  
Sample Size ◽  
Iron Deficiency Anemia ◽  
Odds Ratio ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Large Sample Size ◽  
Febrile Convulsions

Background: Febrile seizures are the most common cause of convulsions in children between 6 months to 5 years, occurring in 2-5% of children. Iron deficiency is postulated as a risk factor for febrile seizures in children and it is an easily correctable condition. The objective of the study was to study the clinical profile and risk factors of febrile convulsions and to establish an association between febrile seizure and iron deficiency anemia.Methods: The study was carried out in Department of Pediatrics, Dhiraj General Hospital, Piparia, a tertiary care teaching hospital. 34 cases and 34 controls were included in the study. Controls were children of same age group presenting with short febrile illness but without any seizures. Febrile seizures were defined according to the AAP (American Academy of Pediatrics) criteria. Iron deficiency was diagnosed by hematologic investigations of haemoglobin value < 11 g/dl, MCV <70 fL and RDW > 15.6%.Results: Iron deficiency anemia was present in 23.52% (8/34) of cases as compared to 17.64% (6/34) in the control group. Odds ratio was 1.436 (95% CI 0.439-4.669, p value 0.549), which suggest there is no significant association of iron deficiency anemia with febrile convulsions. Subgroup analysis for association of iron deficiency anemia with simple febrile convulsion cases showed Odds ratio of 1.11 (95% CI 0.298-4.138), which suggests there is poor association of iron deficiency anemia with simple febrile convulsions. Subgroup analysis for association of iron deficiency anemia with complex febrile convulsion cases showed Odds ratio of 2.809 (95% CI 0.521-15.041), which suggests there is poor association of iron deficiency anemia with complex febrile convulsions. Wide confidence interval indicates less sample size. Study with large sample size is required for reliable interpretation.Conclusions:The study reveals iron deficiency anemia is not a significant risk factor in children presenting with febrile seizures. Further study with large sample size is required. 

The Relationship between Iron Deficiency Anemia and Dental caries

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Salahuldeen Hamid AbdelFattah ◽  
Wafaa Ezzat Ibrahim ◽  
Rasha Adel Fathy ◽  
Reham Khaled Abou-El-Fadl
Keyword(s):  
Dental Caries ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Multiple Regression Model ◽  
Deficiency Anemia ◽  
Dmf Index ◽  
Gingival Health ◽  
Increased Risk ◽  
Iron Profile ◽  
The Relationship

Abstract Background Iron deficiency anemia and dental caries are among the most prevalent diseases in some developing countries. However, few studies have been conducted to assess the association between Iron deficiency anemia (IDA) and early childhood caries (ECC). Objectives The aim of the study was to assess the association between IDA and ECC. Methods 40 children with proved iron deficiency anemia (using iron profile panel done initially) and another 40 healthy age and sex-matched children were examined by one trained and calibrated dentist where the oral status of all enrolled children was assessed in terms of the Decayed, Missing, Filled (DMF) index and gingival health using Gingival index of Loe and Sillness. Results Children with anemia had a significantly higher DMF index (4.37±4.44) than children without anemia (0.50±0.90) (P &lt; 0.001). It was found that there was a negative significant correlation between DMF index and the presence of anemia (r= -0.60, P &lt; 0.001), hemoglobin level (r= -0.454, P &lt; 0.001) and MCH level (r= -0.380, P = 0.001). The multiple regression model statistically significantly predicted DMF index (P = 0.001), (R2=0.34) and only the presence of anemia was found to add significantly to the model (P = 0.027). Conclusion Children with iron deficiency anemia have increased risk for development of dental caries than children without anemia. Any children with significant dental caries should be investigated for IDA and anemia should be treated if present.

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