scholarly journals Study of iron deficiency as a risk factor for first episode of simple febrile siezure

2017 ◽  
Vol 4 (5) ◽  
pp. 1881
Author(s):  
Rakesh Kumawat ◽  
Pukhraj Garg ◽  
B. S. Karnawat ◽  
Ishwari P. Verma ◽  
Akansha Arora ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Febrile Seizure ◽  
Serum Iron ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
First Episode ◽  
Control Group ◽  
Age Group ◽  
Text Book

Background: Febrile seizure are seizure that occur between the age of 6 month to 60 months with a temperature of 100.4f or higher, that are not the result of central nervous system infection or any metabolic imbalance and that occur in the absence of a history of prior afebrile seizure. Febrile seizures are the commonest cause of seizures in children, occuring in 2-5% of children. The maximum age of febrile convulsion occurrence is 14-18 months, which overlap with the maximum prevalence of iron deficiency anaemia which is 1-2 year old. 7 So far, the dilemma of cause of febrile seizure could not be solved. Standard text book still mention iron deficiency is associated with an increased risk of febrile seizure, thus screening for that problem and treating it appears appropriate.Methods: This case control study was done from June 2015 to December 2016. 60 cases of first episode of simple febrile seizure in age group of 6 month to 5 years were included in the study. A control group was selected from age and sex matched children admitted with febrile illness but without seizure. In all cases detailed clinical history, anthropometry, clinical sign of iron deficiency, CNS examination, CBC, PBF, Red cell indices, serum iron, serum ferritin and serum TIBC level was done. These were analysed in three groups mild, moderate, severe deficiency of anemia. A clinical correlation is tried to establish between overt and subtle iron deficiency with seizure.Results: Majority of subjects with first episode of simple febrile seizure were males (63.3%). Majority of cases of febrile seizure occur in the 6-24 months age group (83.3%). Incidence of anemia among case group subjects was 90.0% whereas the same in control group was 30 %. Mean RDW and TIBC levels in cases were significantly higher as compared to that in controls. MCV, Mean Serum ferritin and Serum Iron levels in cases were significantly lower as compared to that in controls.Conclusions: The findings in present study established an association between iron deficiency anemia and first episode of simple febrile seizures. 

scholarly journals A HOSPITAL BASED OBSERVATIONAL STUDY TO STUDY THE ASSOCIATION OF IRON DEFICIENCY ANEMIA WITH FEBRILE SEIZURES IN CHILDREN OF AGE GROUP 6 MONTHS TO 5 YEARS AT TERTIARY CARE CENTER, HYDERABAD

2020 ◽  
pp. 1-3
Author(s):  
Lakshmi M ◽  
Sumapriya M ◽  
Channamsetty Anusha
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Serum Iron ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Age Group ◽  
Febrile Convulsions ◽  
The Relationship

BACKGROUND: Febrile convulsion (FC) is the most common CNS disorder in childhood. 2-5% of children (or 4.8 out of every 1000) are affected every year. Studies conducted on the effect of iron deficiency on febrile convulsions found in children have yielded completely conflicting results. Iron deficiency has been a risk factor for febrile convulsions in some studies, while in others, it was proved to be protective against febrile seizure as iron deficiency increases the threshold of neuron excitation. Aims: To study the relationship between iron deficiency anemia and febrile convulsion in children to prevent the treatable cause of FC. Objectives: Is to determine the relationship between iron deficiency anemia and febrile seizures and to find out the incidence of anemia in the febrile seizure in males and females. Methods: A Hospital-based observational study carried out at Andhra Mahila Sabha Hospital, Hyderabad, during the period May 2014 to May 2016 involving children aged about 6months to 5 years of age group with typical febrile convulsions meeting inclusion and exclusion criteria. The temperature at admission and nutritional status was recorded, and investigations like hemoglobin, blood indices (MCV, MCH, MCHC), RDW (Red Cell Distribution Width), serum iron, and peripheral smear did for detection of iron deficiency anemia and their relationship with febrile seizure was observed. Results: Out of 350 children enrolled, 131 (37.4%) were female, and 219 (62.6%) were males. In our study males was slightly more prone to febrile seizure with the ratio of M: F is 1.6:1. There is a significant association of iron deficiency anemia with FC, and there is increased frequency with increased incidence of iron deficiency anemia,(i.e.) seizures tend to repeat itself in the presence of iron deficiency anemia ( with P-value of <0.001, at CI of 95%). Conclusion: low serum iron levels and the presence of anemia can serve as strengthening factors for febrile seizures in children. Accordingly, children with febrile seizures are suggested to be monitored for the diagnosis and treatment of IDA.

scholarly journals Iron Deficiency Association as A Possible Cause of First Febrile Seizure

2021 ◽  
Vol 15 (5) ◽  
pp. 1728-1730
Author(s):  
Zarmast Khan ◽  
Zabit Khan Naibzai ◽  
M. Adnan Ahmed Sethi ◽  
Shahid Ghaffar ◽  
Sumera Makhdoom ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Febrile Episode ◽  
Deficiency Anemia ◽  
First Episode ◽  
Medicine Department ◽  
The Relationship ◽  
Controlled Clinical Study ◽  
Possible Cause

Aim: A controlled clinical study was conducted to investigate the relationship between iron deficiency and first episode of febrile seizure in children 6-60 months of age. Place and Duration:In the Pediatric Medicine department of ShifaInternationalHospital Islamabadforsix months duration from 15thMay 2020 to 30thNovember 2020. Methods:Hematological parameters for iron levels, including HB, MCV, MCHC and plasma ferritin, were determined in 75 patients who experienced a first febrile episode. 75 children without febrile seizures were taken as controls and the same markers were compared in both groups. Results: The most important factors influencing the first attack of febrile seizure were HB, MCV, and serum ferritin levels. Conclusion: Iron deficiency is significantly associated with the occurrence of the first febrile episode in children. Key words:Iron deficiency anemia, Iron deficiency, Febrile convulsions, Febrile attacks.

scholarly journals Iron Deficiency Anemia (IDA) in Pregnant Women of Different Ages in Swat District, Khyber Pakhtunkhwa Pakistan

2017 ◽  
Author(s):  
Atta Ullah ◽  
Ali Muhammad Yousafzai ◽  
Gul Nabi Khan ◽  
Nasir Iqbal ◽  
Bashir Ahmad
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Deficiency Anemia ◽  
Age Group ◽  
Second Trimester ◽  
Third Trimester ◽  
Hb Concentration

Abstract: The aim of this study was to find out the incidence of anemia in pregnant women of Swat District; to analyze the iron variations and its dietary effects.Data were collected during the periods of January &ndash; September 2016. The study of samples comprised of 250 pregnant women in the different trimester. Blood sample from each woman was collected and full blood count (FBC) was conducted through Mindray BC-3000 plus hem analyzer for all pregnant individuals. Confirmed anemic cases were then examined for IDA with serum ferritin, serum iron, total iron binding capacity (TIBC) through Randox kit and serum transferrin saturation was estimated by formula (serum ferritin saturation =serum iron &times;100/TIBC). The total number of participants in the first trimester were 50, among them 26 women were suffer from iron deficiency anemia (IDA) with 52% weightage of prevalence rate, (mean Hb concentration 9.602 &plusmn; 0.87 g/dl). The rates of IDA were 63.3%; ( mean Hb concentration 8.48 &plusmn; 1.24 g/dl) and 54%; ( mean Hb concentration 9.18 &plusmn; 1.28 g/dl), among 150 and 50 participants in the second and third trimester, respectively. A significant correlation was found between serum ferritin and Hb, serum ferritin against MCV and serum ferritin against MCH. The high prevalence of anemia was found 78.2% in the age group from 26-30 followed by 78.2% in the age group 36-40 years compared to those of other age groups in the second trimester. In this study the prevalence of IDA in third trimester is lower compared to first and second trimester.

scholarly journals Relations between Iron Deficiency Anemia and Anemia from Hookworms Parasites

2015 ◽  
Vol 39 (2) ◽  
pp. 66-71
Author(s):  
Jamal A. AL Jabbar Attawi
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Deficiency Anemia ◽  
Control Group ◽  
Blood Samples ◽  
Male And Female ◽  
Female Patients ◽  
Parasitic Worms

     This research aimed at identifying the relationship of iron-deficiency anemia caused by insufficient dietary intake and the iron-deficiency anemia caused by parasitic worms such as hookworms. Whole blood was drawn from 40 specimens; 20 males and 20 females, normal healthy controls with age ranges 8-50 year. Blood samples were collected from 80 patients with symptoms of anemia, with age range from 10-50 year. After fecal examination, they were divided into two groups: Group one, iron-deficiency anemia with non-parasitic; and group two, iron-deficiency anemia with parasitic. Blood samples were divided into two container, one for the hemoglobin, other for serum ferritin and elements of iron, zinc in tubes without anticoagulants. Results demonstrated a significant decrease in the levels of serum iron, serum ferritin, and hemoglobin in male and female patients (in group one without parasitic worms) as compared with control groups. Furthermore (in two groups with and without parasitic worms), a significant decrease in the level of serum zinc in male and female patients as compared with control group. A significant decrease in the levels of serum iron, ferritin and hemoglobin were observed in male and female patients with iron-deficiency anemia caused by parasitic hookworms compared with control group. The worm burden was classified as light, moderate and heavy as estimated by egg counts per gram of faeces, so results showed the median increase with developing of iron deficiency anemia from parasitic hookworms.

scholarly journals Iron deficiency anaemia and its association with febrile seizures

2018 ◽  
Vol 5 (3) ◽  
pp. 1120
Author(s):  
Ramesh M. Nigade ◽  
Dhairyashil V. Khambalkar
Keyword(s):  
Iron Deficiency ◽  
Observational Study ◽  
Iron Deficiency Anemia ◽  
Serum Iron ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Research Centre ◽  
Age Group ◽  
Iron Deficient ◽  
Low Serum

Background: As reported by World Health Organization of total world’s population about 500 million to 2 billion people are deficient in iron. Iron deficiency is the most common hematological disease found in age group 6 months to 5 years. This age group generally coincides with the age group of occurrences of febrile seizures. Aim of this study was to study the role of iron deficiency in febrile seizures.Methods: This cross sectional, observational study done in the Pediatrics department of D. Y. Patil Hospital and Research Centre. 170 children of age group between 6months to 5 years will be included in the study over a period of 24 months from May 2015 to May 2017, Presenting with simple and complex febrile seizures to the emergency department and Pediatrics ward of hospital.Results: In the study the mean age of onset of febrile seizures is 21 months. Severity of anemia doesn’t have any correlation with occurrence of febrile seizures. Iron deficient in terms of low HB, low MCH, low MCV, high RDW, low serum Iron, high TIBC and low serum iron and TIBC ratio.Conclusions: From the current hospital based observational study we have concluded that, iron deficiency anemia was more frequent among children with febrile seizures. The result suggests that iron deficiency anemia may be a risk factor for febrile seizures screening for IDA should be considered in children with febrile seizures. All the investigations (Sr Iron, TIBC) carried out to evaluate iron deficiency anemia were significantly lower. This suggests that iron deficient children are more prone for febrile seizures.

scholarly journals ASSOCIATION OF FEBRILE SEIZURES WITH IRON DEFICIENCY ANEMIA: A PROSPECTIVE STUDY.

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Ajeet Gopchade
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Pediatric Patients ◽  
Febrile Seizures ◽  
Deficiency Anemia ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group ◽  
History Of

Introduction: Febrile seizures are common in pediatric age group. These seizures are benign and self limiting and usually do not recur after 5 years of age. In pediatric patients viral illnesses are commonly associated with incidence of febrile seizures. Family history of febrile seizures may be present in many cases. Many studies have concluded that febrile seizures are more common in children having iron deficiency some other studies have even reported that iron deficiency is less frequent in children with febrile seizures. We conducted this study of iron deficiency anemia in children presenting with febrile seizures. Materials and Methods: 50 pediatric patients presenting with febrile seizures were included in this study on the basis of a predefined inclusion and exclusion criteria. Demographic details such as age and gender was noted. Previous history of febrile seizure was asked for and noted. Family and past history was noted. Serum Ferritin levels were determined in all the cases. Hemoglobin levels less than 11 gm/dl was taken as cutoff for the diagnosis of anemia. For statistical analysis SSPS 21.0 software was used and p value less than 0.05 was taken as statistically significant. Results: Out of 50 studied cases 36 (72.00%) were males and 14 (28.00%) were females with a M: F ratio of 1:0.38. The mean age of patients was found to be 18.18 +/- 11.32 months. Majority of the cases (74%) were having first onset of febrile seizures. Second and third episode of febrile seizures was seen in 8 (16%) and 5 (10%) cases respectively. 42 (84%) patients were found to have simple febrile seizures whereas remaining 8 (16%) patients had complex febrile seizures. criteria 36 (72%) patients were found to have iron deficiency anemia defined as serum Ferritin level below 12 microgram/lit. Conclusion: Iron deficiency anemia is associated with an increased risk of febrile seizures in pediatric age group. Keywords: Febrile Seizures, Iron deficiency anemia, Serum Ferritin, Hemoglobin.

scholarly journals Changes of Serum Ferritin, Hemoglobin, and Serum Iron (SI) and Treatment Effect of Iron Proteinsuccinylate Oral Solution Combined with Vitamin A and D Drops on Children with Nutritional Iron Deficiency Anemia

2022 ◽  
Vol 2022 ◽  
pp. 1-6
Author(s):  
Yan Ma ◽  
Yanbo Ma ◽  
Xiuqing Zhang ◽  
Xuejing Wang ◽  
Zhigang Sun
Keyword(s):  
Iron Deficiency ◽  
Vitamin A ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Treatment Effect ◽  
Serum Iron ◽  
Oral Solution ◽  
Deficiency Anemia ◽  
Control Group ◽  
Observation Group

Objective. The purpose was to evaluate the treatment effect of iron proteinsuccinylate oral solution combined with vitamin A and D drops on children with nutritional iron deficiency anemia. Methods. 124 children treated in the outpatient department of our hospital from January 2017 to January 2020 were selected as the study subjects. They were randomly divided into control and observation two groups. The control group was treated with iron proteinsuccinylate oral solution (1.5 mL/kg) in the morning and evening, respectively. The observation group received adjuvant treatment with oral vitamin A and D drops based on the treatment of the control group. The treatment effect of proteinsuccinylate oral solution combined with vitamin A and D drops was evaluated by the serum iron (SI), serum ferritin (SF), and transferrin (TRF) levels, the values of CD3+, CD4+, and CD4+/CD8+, and other evaluation indicators. Results. After treatment, the SI and SF levels of children in both groups significantly increased ( P < 0.01 ) while the TRF level significantly decreased ( P < 0.01 ), and the SI and SF levels in the observation group increased more significantly, and the TRF level decreased more significantly compared with those in the control group ( P < 0.01 ). After treatment, the values of CD3+, CD4+, and CD4+/CD8+ of children in both groups significantly increased compared with those before treatment ( P < 0.01 ), and the values of CD3+, CD4+, and CD4+/CD8+ increased more significantly in the observation group compared with those in the control group ( P < 0.01 ). In addition, the evaluation results of treatment effect showed that the markedly effective rate in the observation group was significantly higher than that in the control group ( P < 0.01 ). Conclusion. Iron proteinsuccinylate oral solution combined with vitamin A and D drops can better improve the anemia symptoms in children, with high application value.

Serum Hepcidin: Its Correlation with Serum Ferritin, Serum Iron and Hemoglobin in Patients of Iron Deficiency Anemia

2015 ◽  
Vol 14 (2) ◽  
pp. 105-113
Author(s):  
Sajjad H. Naqvi ◽  
Syed Faizan-ul-Hassan Naqvi ◽  
Iftikhar H. Naqvi ◽  
Muhammad Farhan ◽  
Tanveer Abbas ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Deficiency Anemia ◽  
Serum Hepcidin

scholarly journals Low serum zinc and magnesium–a possible risk factor for first episode Simple febrile seizures in children between 6 months to 5 years of age

2021 ◽  
Author(s):  
Aishwarya Lakshmi L. G. ◽  
Mohanraj Kannan ◽  
Rajakumar P. G. ◽  
Selvaraj R.
Keyword(s):  
Febrile Seizure ◽  
Serum Magnesium ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Mean Value ◽  
First Episode ◽  
Control Group ◽  
Case Group ◽  
High Grade Fever ◽  
Low Serum

Background: Febrile seizure is the most common type of seizure in children. The incidence of febrile seizure is 5-10% in India. There are multiple aetiologies like high grade fever; genetic predisposition, viral infections and trace elements deficiency like iron, zinc, magnesium and calcium are postulated to be risk factors for developing febrile seizures. Recent studies had shown there is a significant association between low serum zinc, low serum magnesium levels and febrile seizures in children.Methods: This was a case control study with 40 children in each group. Children aged 6 months to 5 years with first episode of simple febrile seizures who attends the out-patient department/emergency room (OPD/ER) were included in case group consecutively and 40 children with acute febrile illness without febrile seizures were included in control group. Serum zinc and magnesium levels were estimated for all the children along with other investigations after proper consent from parents. Using statistical package for the social sciences (SPSS) software, independent sample t test was used to analysis the observations between the two groups. Normal lab reference value of serum zinc was 60-120 μg/dl and serum magnesium was 1.7-2.5 mg/dl.Results: The incidence of febrile seizure was high (37.5%) in children between 1-2 years and male (55%) children had increased incidence when compared to female children in case group. The children with febrile seizure had significantly low levels of serum zinc with mean value of 35.08 μg/dl (±8.56) when compared to control group with mean value of 70.23 μg/dl (±13.41) and serum magnesium level in case group was 1.35 mg/dl (±0.29) versus 1.68 mg/dl (±0.42) in control group, which was also statistically significant.Conclusions: The incidence of febrile seizure was high in children between 1-2 years of age with male preponderance. The serum levels of both zinc and magnesium is significantly low in children with febrile seizure pointing a need of further studies in role of supplemental zinc and magnesium in this age group to reduce the incidence of febrile seizures. 

The association between iron deficiency anemia and febrile seizure

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Parviz Karimi ◽  
Koroush Sayehmiri ◽  
Milad Azami ◽  
Zeinab Tardeh
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Mean Corpuscular Hemoglobin ◽  
Protective Effects ◽  
Corpuscular Hemoglobin

Abstract Objective Different studies have reported contradictory results regarding the relationship between iron deficiency anemia (IDA) and febrile seizure (FS). The present study was conducted to determine the effect of IDA on FS in children. Patients and methods This case-control study was conducted among 52 children with FS (the case group) and 18 children with afebrile seizures and 51 children with fever without seizures in the age range of 6 months to 5 years admitted to the pediatric ward of Imam Khomeini Hospital in Ilam from March 2016 to January 2017. Patients were selected using the convenience sampling method. Red blood cell (RBC) count as well as measurement of hemoglobin (Hb), hematocrit (Hct), ferritin, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were performed in all patients. The collected data were analyzed using SPSS16 software. Results A total of 34.6% in the FS group, 66.7% in the afebrile seizure group and 41.2% in the fever without seizure group suffered from IDA, which was not statistically significant between the three groups. Hb, Hct and RBC levels were higher in the case group and MCV, MCH, MCHC levels in the case group were lower than those in the control group. The odds ratio (OR) for FS compared to the febrile group was 0.756 [95% confidence interval (CI) = 0.34–1.68; p = 0.493] and that for FS compared to seizure was 0.265 (95% CI = 0.085–0.823; p = 0.022). Conclusions This study showed that IDA may have protective effects on the onset of FS, and based on the results, IDA is more common in children with afebrile seizures. Further and more comprehensive studies are recommended.

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