scholarly journals Comparison of low dose oral Methotrexate vs Systemic Corticosteroids for treatment of Oral Lichen Planus

2021 ◽  
Vol 15 (5) ◽  
pp. 898-901
Author(s):  
Tooba Saeed ◽  
Saadia Firdous ◽  
Shahzad Iqbal Malik ◽  
Muhammad Aamir ◽  
Yasir Ishaq ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Complete Resolution ◽  
Oral Lichen Planus ◽  
Low Dose ◽  
Systemic Corticosteroids ◽  
Dose Oral ◽  
Group A ◽  
Mucosal Lesions ◽  
Group B ◽  
Oral Lichen

Background: Oral Lichen Planus (OLP) is a relatively common chronic inflammatory mucocutaneous disorder. WHO considers OLP a premalignant lesion. This makes management of OLP important to avoid its malignant transformation. Corticosteroids are considered as the first-line of treatment. Different other treatment modalities are also in use for OLP. But there is no statistically significant data available for a particular therapy. The recent evidences suggest methotrexate may effectively be used in low dose in the treatment of OLP. Aim: To compare the frequency of complete resolution of mucosal lesions of oral lichen planus with low dose oral methotrexate versus systemic corticosteroids. Methods: It was a randomized control trial conducted at Oral & Maxillofacial Surgery Department, King Edward Medical University/Mayo Hospital Lahore in six months. A sample of 60 patients was divided into two sub groups namely Group -A (methotrexate) and Group - B (corticosteroid) using lottery method. More than 75% resolution of mucosal lesions clinically was considered as complete resolution at the end of 8th week. Results: The mean age of the patients was 44.55±12.38 years. On 8th week, frequency of complete resolution of mucosal lesions was 73.3% in Group A and 60% in Group B with an insignificant difference (p-value<0.05). Conclusion: Methotrexate group A showed more complete resolution of mucosal lesions than corticosteroid group B with insignificant statistical difference. Keywords: Oral Lichen Planus, Mucosal lesions, Malignant transformation, Methotrexate, Corticosteroids

scholarly journals Triamcinolone acetate vs. combination of triamcinolone acetate and isotretinoin in treatment of oral lichen planus: a comparative study

2018 ◽  
Vol 4 (3) ◽  
pp. 776 ◽  
Author(s):  
Smruti Swain ◽  
Sruthi T. Radhakrishnan ◽  
Saroj K. Panigrahi ◽  
Manas R. Biswal
Keyword(s):  
Combination Therapy ◽  
Lichen Planus ◽  
Complete Resolution ◽  
Oral Lichen Planus ◽  
Lesion Size ◽  
Treatment Modalities ◽  
Chi Square ◽  
Group A ◽  
Group B ◽  
Oral Lichen

<p class="abstract"><strong>Background:</strong> There are many treatment modalities being practiced for oral lichen planus and many are under trial. However, none has been able to provide a complete permanent cure. This study aims to see if combination therapy with topical triamcinolone acetate and isotretinoin is superior to topical triamcinolone acetate alone, in treating oral lichen planus.</p><p class="abstract"><strong>Methods:</strong> Patients were randomly divided into 2 groups to receive either triamcinolone (0.5%) only (group A) or 0.5% triamcinolone with 0.1% isotretinoin (group B). Patients applied medication thrice daily and were followed up at, 2 week, 1st month, 2nd month and 3rd months. Size of lesion and symptoms were assessed at each visit. The data was analysed by chi square test.  </p><p class="abstract"><strong>Results:</strong> Patients in group B (combination therapy) showed significantly better improvement in symptoms at the end of 2<sup>nd</sup> week and 1<sup>st</sup> month as compared to group A. Decrease in lesion size was also better in group B with p values of 0.012, 0.004 and 0.022 at 2 weeks, 1<sup>st</sup> month and 2<sup>nd</sup> month respectively. Complete resolution of lesion was obtained in 53.33% people in group B and 26.67% people in group A.</p><p class="abstract"><strong>Conclusions:</strong> Combination of 0.5% triamcinolone acetate and 0.1% isotretinoin is superior to 0.5% triamcinolone acetate alone in treatment of oral lichen planus. It causes quicker relief in symptoms and decreases lesion size faster. Complete resolution of the lesions is also more when combination therapy is used.</p>

Effectiveness of Aloe Vera Mouthwash in Comparison with Triamcinolone Acetonide 0.1% in Patients with OLP at A TCH

2021 ◽  
Vol 15 (11) ◽  
pp. 3138-3140
Author(s):  
Tahir Hassan ◽  
Muhammad Khurram Shahzad ◽  
Nazia Hanif ◽  
Madiha Anwar ◽  
Ayesha Ambreen ◽  
...  
Keyword(s):  
Triamcinolone Acetonide ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Tertiary Care ◽  
Aloe Vera ◽  
Care Hospital ◽  
Group A ◽  
Group B ◽  
Mouth Wash ◽  
Oral Lichen

Objective: To compare the efficacy of Aloe Vera Mouthwash versus 0.1% Triamcinolone Acetonide in patients presenting with oral lichen planus at a tertiary care hospital. Introduction: Oral lichen planus is a chronic immune mediated dermatosis with periods of remissions and relapses. There are many treatment options to treat this condition; aloe vera mouth wash is one of the newer and safer options. Methodology: A total of 100 patients with oral lichen planus (OLP) were randomly divided into two groups (group A and B, each having 50 patients).The patients in group A were given aloe vera mouth wash and in group B were given triamcinolone acetonide paste (0.1%). Efficacy was observed after 2 months of treatment completion. Results: Overall Efficacy was noted in 58(58%) of all study cases. In group A 37 patients (74%) showed efficacy and in group B 21 patients (42%) showed efficacy.More efficacy was noted in female patients (87%) treated with Aloe Vera Mouth wash than those of treated with triamcinolone acetate paste (45%). Patients belonging to old age group (36-50 year) showed more efficacy (75%) to aloe vera mouth wash than that of triamcinolone acetonide paste (36%) Conclusion: In our population Aloe vera mouth wash is more efficacious than triamcinolone acetonide (0.1%) in the treatment of oral lichen planus Keywords: Oral lichen planus, Aloe vera, Triamcinolone acetonide

scholarly journals Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249862
Author(s):  
Ana Andabak Rogulj ◽  
Iva Z. Alajbeg ◽  
Vlaho Brailo ◽  
Ivana Škrinjar ◽  
Ivona Žužul ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Secondary Outcome ◽  
Double Blind ◽  
Link Type ◽  
Lesion Diameter ◽  
Group A ◽  
Oral Lichen

Aim To evaluate the effectiveness of non-aromatic very rich in steranes (NAVS) naphthalan in the treatment of oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS). Null hypothesis was that there would be no difference between NAVS and topical steroids in the treatment of OLP and RAS. Methods The study consisted of two sub-trials conducted as randomized, double-blind controlled studies: first included OLP patients and second patients with RAS. Patients received either NAVS or 0.05% betamethasone dipropionate. Primary outcomes were activity score (OLP patients), No of lesions and lesion diameter (RAS patients) and pain intensity (VAS) while secondary outcome included the impact of the disease on quality of life assessed by Oral health impact profile (OHIP 14). Results No significant differences in terms of OLP clinical signs (p = 0.84, η2 = 0.001) and responses on the OHIP-14 (p = 0.81, η2 = 0.002) or on VAS (p = 0.14, η2 = 0.079) between NAVS and betamethasone groups were observed. In RAS patients, no significant differences between the groups in terms of lesion number (at days 3 and 5, p = 0.33 and p = 0.98, respectively), lesion diameter (days 3 and 5, p = 0.24 and p = 0.84, respectively) were observed. However, in NAVS group a significant reduction of lesions diameter was observed on the 3rd day, while in betamethasone group a significant reduction in lesions diameter was evident only after the 5th day. No significant differences in VAS (p > 0.05) and the OHIP-14 (p > 0.05) between groups were found. Conclusion No evidence of differences between the two compared interventions was found. Registration Retrospective registration of this trial was conducted in ClinicalTrials.gov on September 30, 2016; trial registration number: NCT02920658. https://clinicaltrials.gov/ct2/show/NCT02920658?term=NAVS&draw=2&rank=4.

Oral lichen planus: immunohistology of mucosal lesions

2002 ◽  
Vol 31 (7) ◽  
pp. 410-414 ◽  
Author(s):  
Mariana Villarroel Dorrego ◽  
María Correnti ◽  
Rafael Delgado ◽  
Felix J. Tapia
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Mucosal Lesions ◽  
Oral Lichen

scholarly journals Comparative Efficacy of Low-Dose Oral Corticosteroids and Oral Mini Pulse Dexamethasone in Patients of Vitiligo

2016 ◽  
Vol 11 (1) ◽  
pp. 54-58
Author(s):  
Md Shirajul Islam Khan
Keyword(s):  
Side Effects ◽  
Low Dose ◽  
Oral Prednisolone ◽  
Oral Dexamethasone ◽  
Oral Corticosteroids ◽  
Dose Oral ◽  
Group A ◽  
Pulse Dexamethasone ◽  
The Mean ◽  
Group B

Introduction: Vitiligo is a common, acquired, discoloration of the skin with unknown etiology. There are numerous treatment options available for vitiligo, but none is universally effective. Systemic corticosteroids suppress immunity and lead to repigmentation but produce unacceptable side effects. Oral corticosteroid low dose treatment may be associated with fewer side effects than usual dose-treatment. Several data also showed that oral dexamethasone pulse treatment was effective in arresting progression of vitiligo yet fails to induce satisfactory repigmentation in the great majority of their patients.Objectives: A clinical trial was carried out to compare the efficacy of low-dose oral corticosteroids and oral mini pulse dexamethasone in patients of vitiligo.Materials and Methods: The study was conducted in the Department of Dermatology and Venereology, Combined Military Hospital (CMH), Dhaka, Bangladesh during January 2013 to December 2013. Total sixty patients of vitiligo were enrolled and divided into group A and group B. Thirty of group A patients were treated with oral prednisolone daily and thirty of group B patients were treated with oral dexamethasone pulse therapy weekly.Results: Out of sixty patients of vitiligo, maximum patients of both groups had progressive type of vitiligo. In Group-A, the duration of illness was an average of 10 months and in group-B, it was an average of 8.20 months. Single lesion was 15 (50%) for Group-A and 14 (46.7%) for Group-B. Multiple lesions were 15 (50%) & 16 (53.6%) for Group-A and Group-B respectively. The study showed that improvement rate was highest for the lesions on the extremities, which was 18 (34.6%) and lowest for back 03 (5.8%). Out of all patients from Group-A, the mean size of the lesions were 8.17cm, 5.90 cm, 4.32 cm and 3.57 cm at 1st visit, 2nd visit, 3rd visit and 4th visit respectively. In Group-B, the mean sizes of the lesions were 7.50 cm, 4.92 cm, 3.00 cm, and 4.75 cm at 1st visit, 2nd visit, 3rd visit and 4th visit respectively. Among the patients 27 (90%) of group-A and 25 (83.3%) of group B were improved after 16th week of treatment, slight response 4(13.3%) and 6(20%), moderate response 22(63.2%) and 18(59.4%) and marked response was 1(3.3%) and 1(3.3%) in group A and group B respectively.Conclusion: The study concluded that both the drugs, oral prednisolone and dexamethasone when used individually, were found to be equally effective in the treatment of vitiligo.Journal of Armed Forces Medical College Bangladesh Vol.11(1) 2015: 54-58

scholarly journals Comparison between uses of topical tacrolimus and triamcinolone ointment for the treatment of oral lichen planus.

2018 ◽  
Vol 8 (1) ◽  
pp. 17-21
Author(s):  
Shaikh Ahmed ◽  
Md Rubayet Alam Prodhan ◽  
Rifat Rezwana ◽  
Jahan Sadia Afroz ◽  
Mottakin Ahmad ◽  
...  
Keyword(s):  
Triamcinolone Acetonide ◽  
Lichen Planus ◽  
Maxillofacial Surgery ◽  
Burning Sensation ◽  
Oral And Maxillofacial Surgery ◽  
Complete Relief ◽  
Topical Tacrolimus ◽  
Group A ◽  
Group B ◽  
Oral Lichen

Background: Lichen planus is a chronic mucocutaneous disease with primary or secondary involve- ment of the oral mucosa. In particular in case of erosive lichen planus most of the patients experience no long term symptoms relief of conventional topical treatment such as corticosteroid ointment. Topical tacrolimus applications to mucosal lesions seem to be an alternative treatment approach.Objective: The aim of this study was to compare the efficacy of topical tacrolimus ointment with that of triamcinolone acetonide ointment on patients suffering from oral lichen planus.Study design: This was a clinical trial.  Study setting and period: This study was conducted in outpatient department of Oral and Maxillofacial Surgery, Dhaka Dental College in the period between June 2013 to May 2014.Subjects: A total of sixty patients were enrolled. Out of sixty patients thirty patients used topical tacroli- mus 0.03% (Group A) and another thirty patients used topical triamcinolone acetonide( Group B) for the treatment of oral lichen planus.Methods: A total of sixty patients were asked to answer a questionnaire regarding the degree of pain and burning sensation in every two weeks according to visual analogue scale (VAS). In every two weeks change of colour and size and also any side effects of these drugs were assessed. Data were analyzed using Statistical Package for Social Science (SPSS), version 15.0 for windows.Results: At the end of 12th week follow up periods complete relief of pain and burning sensation in group A patients were 100% and in group B it was 30%. There was no side effect in two study group patients.Update Dent. Coll. j: 2018; 8 (1): 17-21

scholarly journals Serum 8-isoprostane levels in patients with resistant oral lichen planus before and after treatment with lycopene: a randomized clinical trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Aliaa Abdelmoniem Bedeir Eita ◽  
Azza Mohamed Zaki ◽  
Sabah Abdelhady Mahmoud
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Topical Steroids ◽  
Baseline Serum ◽  
Systemic Corticosteroids ◽  
End Of Treatment ◽  
Study Results ◽  
Wide Range ◽  
Significant Difference ◽  
Oral Lichen

Abstract Background Oral lichen planus is an autoimmune disease in which topical steroids are the first line of treatment. The adverse effects of systemic corticosteroids prescribed for resistant oral lichen planus cases advocate alternative modalities. Lycopene is an antioxidant with a wide range of beneficial properties. This trial aimed to evaluate the effect of pure lycopene as compared to systemic corticosteroids (Prednisolone) on the symptoms, signs and oxidative stress in patients with erosive oral lichen planus recalcitrant to topical steroids. Methods Twenty patients were randomly divided into the test (lycopene) and control (corticosteroids) groups. Numeric rating scale and Escudier et al. (Br J Dermatol 4:765–770, 2007. 10.1111/j.1365-2133.2007.08106.x) lesion scores were assessed at baseline and weeks 4 and 8 from baseline. Serum levels of 8-isoprostane were measured in all patients at baseline and at the end of treatment (week 8). Results There was a significant reduction in signs and symptoms after the end of treatment in each group. However, no significant difference was found between the lycopene and the corticosteroids group. Moreover, a significant reduction in 8-isoprostane levels was observed in the lycopene group from baseline and as compared to the control group. Conclusions Based on the study results, lycopene is a safe and effective therapeutic modality for resistant oral lichen planus. 8-isoprostane is a biomarker of lipid peroxidation that can be reduced by lycopene. Trial registration ID: PACTR202003484099670. 'Retrospectively registered on 11/3/2020'.

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