Effectiveness of Aloe Vera Mouthwash in Comparison with Triamcinolone Acetonide 0.1% in Patients with OLP at A TCH

2021 ◽  
Vol 15 (11) ◽  
pp. 3138-3140
Author(s):  
Tahir Hassan ◽  
Muhammad Khurram Shahzad ◽  
Nazia Hanif ◽  
Madiha Anwar ◽  
Ayesha Ambreen ◽  
...  
Keyword(s):  
Triamcinolone Acetonide ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Tertiary Care ◽  
Aloe Vera ◽  
Care Hospital ◽  
Group A ◽  
Group B ◽  
Mouth Wash ◽  
Oral Lichen

Objective: To compare the efficacy of Aloe Vera Mouthwash versus 0.1% Triamcinolone Acetonide in patients presenting with oral lichen planus at a tertiary care hospital. Introduction: Oral lichen planus is a chronic immune mediated dermatosis with periods of remissions and relapses. There are many treatment options to treat this condition; aloe vera mouth wash is one of the newer and safer options. Methodology: A total of 100 patients with oral lichen planus (OLP) were randomly divided into two groups (group A and B, each having 50 patients).The patients in group A were given aloe vera mouth wash and in group B were given triamcinolone acetonide paste (0.1%). Efficacy was observed after 2 months of treatment completion. Results: Overall Efficacy was noted in 58(58%) of all study cases. In group A 37 patients (74%) showed efficacy and in group B 21 patients (42%) showed efficacy.More efficacy was noted in female patients (87%) treated with Aloe Vera Mouth wash than those of treated with triamcinolone acetate paste (45%). Patients belonging to old age group (36-50 year) showed more efficacy (75%) to aloe vera mouth wash than that of triamcinolone acetonide paste (36%) Conclusion: In our population Aloe vera mouth wash is more efficacious than triamcinolone acetonide (0.1%) in the treatment of oral lichen planus Keywords: Oral lichen planus, Aloe vera, Triamcinolone acetonide

scholarly journals Comparison of low dose oral Methotrexate vs Systemic Corticosteroids for treatment of Oral Lichen Planus

2021 ◽  
Vol 15 (5) ◽  
pp. 898-901
Author(s):  
Tooba Saeed ◽  
Saadia Firdous ◽  
Shahzad Iqbal Malik ◽  
Muhammad Aamir ◽  
Yasir Ishaq ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Complete Resolution ◽  
Oral Lichen Planus ◽  
Low Dose ◽  
Systemic Corticosteroids ◽  
Dose Oral ◽  
Group A ◽  
Mucosal Lesions ◽  
Group B ◽  
Oral Lichen

Background: Oral Lichen Planus (OLP) is a relatively common chronic inflammatory mucocutaneous disorder. WHO considers OLP a premalignant lesion. This makes management of OLP important to avoid its malignant transformation. Corticosteroids are considered as the first-line of treatment. Different other treatment modalities are also in use for OLP. But there is no statistically significant data available for a particular therapy. The recent evidences suggest methotrexate may effectively be used in low dose in the treatment of OLP. Aim: To compare the frequency of complete resolution of mucosal lesions of oral lichen planus with low dose oral methotrexate versus systemic corticosteroids. Methods: It was a randomized control trial conducted at Oral & Maxillofacial Surgery Department, King Edward Medical University/Mayo Hospital Lahore in six months. A sample of 60 patients was divided into two sub groups namely Group -A (methotrexate) and Group - B (corticosteroid) using lottery method. More than 75% resolution of mucosal lesions clinically was considered as complete resolution at the end of 8th week. Results: The mean age of the patients was 44.55±12.38 years. On 8th week, frequency of complete resolution of mucosal lesions was 73.3% in Group A and 60% in Group B with an insignificant difference (p-value<0.05). Conclusion: Methotrexate group A showed more complete resolution of mucosal lesions than corticosteroid group B with insignificant statistical difference. Keywords: Oral Lichen Planus, Mucosal lesions, Malignant transformation, Methotrexate, Corticosteroids

scholarly journals Comparison of Aloe Vera Mouthwash With Triamcinolone Acetonide 0.1% on Oral Lichen Planus: A Randomized Double-Blinded Clinical Trial

2011 ◽  
Vol 342 (6) ◽  
pp. 447-451 ◽  
Author(s):  
Arash Mansourian ◽  
Mahnaz Saheb-Jamee ◽  
Jalil Momen-Beitollahi ◽  
Fatemeh Momen-Heravi ◽  
Mahsa Esfehani ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Triamcinolone Acetonide ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Aloe Vera ◽  
Double Blinded ◽  
Oral Lichen

scholarly journals Comparison between uses of topical tacrolimus and triamcinolone ointment for the treatment of oral lichen planus.

2018 ◽  
Vol 8 (1) ◽  
pp. 17-21
Author(s):  
Shaikh Ahmed ◽  
Md Rubayet Alam Prodhan ◽  
Rifat Rezwana ◽  
Jahan Sadia Afroz ◽  
Mottakin Ahmad ◽  
...  
Keyword(s):  
Triamcinolone Acetonide ◽  
Lichen Planus ◽  
Maxillofacial Surgery ◽  
Burning Sensation ◽  
Oral And Maxillofacial Surgery ◽  
Complete Relief ◽  
Topical Tacrolimus ◽  
Group A ◽  
Group B ◽  
Oral Lichen

Background: Lichen planus is a chronic mucocutaneous disease with primary or secondary involve- ment of the oral mucosa. In particular in case of erosive lichen planus most of the patients experience no long term symptoms relief of conventional topical treatment such as corticosteroid ointment. Topical tacrolimus applications to mucosal lesions seem to be an alternative treatment approach.Objective: The aim of this study was to compare the efficacy of topical tacrolimus ointment with that of triamcinolone acetonide ointment on patients suffering from oral lichen planus.Study design: This was a clinical trial.  Study setting and period: This study was conducted in outpatient department of Oral and Maxillofacial Surgery, Dhaka Dental College in the period between June 2013 to May 2014.Subjects: A total of sixty patients were enrolled. Out of sixty patients thirty patients used topical tacroli- mus 0.03% (Group A) and another thirty patients used topical triamcinolone acetonide( Group B) for the treatment of oral lichen planus.Methods: A total of sixty patients were asked to answer a questionnaire regarding the degree of pain and burning sensation in every two weeks according to visual analogue scale (VAS). In every two weeks change of colour and size and also any side effects of these drugs were assessed. Data were analyzed using Statistical Package for Social Science (SPSS), version 15.0 for windows.Results: At the end of 12th week follow up periods complete relief of pain and burning sensation in group A patients were 100% and in group B it was 30%. There was no side effect in two study group patients.Update Dent. Coll. j: 2018; 8 (1): 17-21

scholarly journals Triamcinolone acetate vs. combination of triamcinolone acetate and isotretinoin in treatment of oral lichen planus: a comparative study

2018 ◽  
Vol 4 (3) ◽  
pp. 776 ◽  
Author(s):  
Smruti Swain ◽  
Sruthi T. Radhakrishnan ◽  
Saroj K. Panigrahi ◽  
Manas R. Biswal
Keyword(s):  
Combination Therapy ◽  
Lichen Planus ◽  
Complete Resolution ◽  
Oral Lichen Planus ◽  
Lesion Size ◽  
Treatment Modalities ◽  
Chi Square ◽  
Group A ◽  
Group B ◽  
Oral Lichen

<p class="abstract"><strong>Background:</strong> There are many treatment modalities being practiced for oral lichen planus and many are under trial. However, none has been able to provide a complete permanent cure. This study aims to see if combination therapy with topical triamcinolone acetate and isotretinoin is superior to topical triamcinolone acetate alone, in treating oral lichen planus.</p><p class="abstract"><strong>Methods:</strong> Patients were randomly divided into 2 groups to receive either triamcinolone (0.5%) only (group A) or 0.5% triamcinolone with 0.1% isotretinoin (group B). Patients applied medication thrice daily and were followed up at, 2 week, 1st month, 2nd month and 3rd months. Size of lesion and symptoms were assessed at each visit. The data was analysed by chi square test.  </p><p class="abstract"><strong>Results:</strong> Patients in group B (combination therapy) showed significantly better improvement in symptoms at the end of 2<sup>nd</sup> week and 1<sup>st</sup> month as compared to group A. Decrease in lesion size was also better in group B with p values of 0.012, 0.004 and 0.022 at 2 weeks, 1<sup>st</sup> month and 2<sup>nd</sup> month respectively. Complete resolution of lesion was obtained in 53.33% people in group B and 26.67% people in group A.</p><p class="abstract"><strong>Conclusions:</strong> Combination of 0.5% triamcinolone acetate and 0.1% isotretinoin is superior to 0.5% triamcinolone acetate alone in treatment of oral lichen planus. It causes quicker relief in symptoms and decreases lesion size faster. Complete resolution of the lesions is also more when combination therapy is used.</p>

scholarly journals Post-Operative Outcomes of Intravenous Lidocaine Infusion on Major Abdominal Surgery in Pediatric Patients: A Randomized Control Trial in a Tertiary Care Hospital

2018 ◽  
Vol 10 (1) ◽  
pp. 23-27
Author(s):  
Nirupama Saha ◽  
Nadiuzzaman Khan ◽  
Mirza Kamrul Zahid ◽  
Shah Alam Talukder ◽  
ASM Meftahuzzaman
Keyword(s):  
Abdominal Surgery ◽  
Tertiary Care ◽  
Major Abdominal Surgery ◽  
P Value ◽  
Care Hospital ◽  
Intravenous Lidocaine ◽  
Operative Outcomes ◽  
Group A ◽  
Randomized Control ◽  
Group B

Background: Post-operative outcomes of a major abdominal surgery depend on careful & effective post-operative management. But it is a critical job especially in children. Obtaining adequate analgesia after major surgery is a problematic issue and postoperative pain still imposes a major burden of suffering in surgical patients.Objectives: The principle objectives of the study is to evaluate the effects of intravenous lidocaine infusion in pain management of pediatric population undergone in major abdominal surgery; to reduce post-operative morbidity & enhance better surgical outcome in children.Methodology: This is a randomized control trial carried out from January 2015-June2015,in a tertiary care hospital among 60 cases of 4 to 14 years children with major abdominal surgery without having any pulmonary, cardiac, hepatic or renal insufficiency. Grouping of patients that is lidocaine infusion group (Group A) and control group (Group B) was made among admitted cases for elective abdominal surgery by simple random technique by means of lottery. For assessment of postoperative pain FLACC Scale was used in both groups. Clinical examination findings & specifically designed data collection sheet with a set questionnaire were used as research instruments. Formulated data was analyzed by SPSS version 17, taking p value <0.05 as significant.Results: It is noted that, after 24 hours of operation most of the patients 56.7% of group A had mild pain whereas 90% patients of group B had moderate pain (p<0.001)& during that time there was no patient with severe pain in group A whereas in group B 10% patients were with severe pain. At 48 hours, pain was absent in 13.3% children of group A and 6.7% in group B. In group A most of the children 76.7%had mild pain compared to moderate pain 18 (60%) in group B children at that hours (P<0.001). Again, regarding required amount of analgesics, patients received I/V lidocaine required less amount of analgesics than its counterpart. In present study, complications was noted only 3.3% patien in group A, where as in the opposite group it was found in 23.3% & p was <0.05. In group A, in 50% patients post operative bowel sound was returned within 72 hours, compared to 73.3% patients in group B. The p value was 0.001. About post-operative hospital stay, 83.3% children of the group A were released from hospital after 5th P.O.D whereas, in group B, only 50% children were released after 7th P.O.D of operation. The P value was 0.03 that is also significant.Conclusion: Intravenous lidocaine could improve immediate and late post-operative pain with early recovery after major abdominal surgery in children & it can contribute to rapid postoperative rehabilitation programs.J Shaheed Suhrawardy Med Coll, June 2018, Vol.10(1); 23-27

scholarly journals Palonosetron for the prevention of chemotherapy induced nausea and vomiting: a comparative study in a tertiary care hospital from India

2019 ◽  
Vol 8 (10) ◽  
pp. 2197
Author(s):  
Shubhatara Swamy ◽  
Vijaya Rajendran ◽  
Durga Prasan ◽  
Pratibha Nadig
Keyword(s):  
Tertiary Care ◽  
Nausea And Vomiting ◽  
Research Centre ◽  
Care Hospital ◽  
Serious Adverse Events ◽  
Female Ratio ◽  
First Line Therapy ◽  
Significant Difference ◽  
Group A ◽  
Group B

Background: Despite advances in symptom management, chemotherapy-induced nausea and vomiting (CINV) remains one of the most dreadful consequences of cancer therapy.Methods: The study was carried out at Medical Oncology Department, Vydehi Institute of Medical Sciences and Research Centre, Bangalore. Hundred and forty-four cancer patients of either sex, aged 18-65 years with adequate blood counts requiring moderately emetogenic chemotherapy (MEC) as per Hesketh classification were included. The patients were prospectively divided into two groups before the initial cycle of chemotherapy. Patients in Group A (n=71) received ondansetron, and dexamethasone along with aprepitant capsules, Whereas, Group B (n=73) received palonosetron, and dexamethasone along with placebo capsules, 30 minutes before chemotherapy. Thereafter the patients were administered with the drugs and observed for nausea and vomiting. The efficiency of both regimens was assessed by adopting validated functional living index emesis (FLIE) questionnaire. Analysis of the data was done using the SPSS 21.0 software.Results: The mean age of the patients was 40.5 years and the male to female ratio was 1:2.4. In all the patients, no changes were detected in the ECG readings after MEC. The nausea and vomiting score were comparable in both groups. No significant difference (p>0.05) was noticed between group A and group B in both mm and in FLIE points. No serious adverse events were found relating to antiemetic treatment.Conclusions: Palonosetron in combination with corticosteroids was non inferior to ondansetron in combination with aprepitant and corticosteroids in controlling acute and delayed stages of CINV in patients requiring MEC. Thus, it can be recommended as first-line therapy for patients treated with MEC.

scholarly journals A prospective study of lornoxicam as pre-emptive analgesic in abdominal surgeries in tertiary care hospital in Salem, India

2017 ◽  
Vol 6 (7) ◽  
pp. 1778
Author(s):  
Mohammed Ziauddin Sarkhil ◽  
Hemant Kumar Dutt ◽  
Rajaram S.
Keyword(s):  
Rating Scale ◽  
Tertiary Care ◽  
Open Appendectomy ◽  
Care Hospital ◽  
Pain Rating ◽  
Pain Scores ◽  
Analgesic Regimen ◽  
Group A ◽  
Group B ◽  
Pain Rating Scale

Background: Preemptive analgesia, involves the introduction of an analgesic regimen before the onset of noxious stimuli, with the goal of preventing sensitization of the nervous system to subsequent stimuli that could amplify pain.Methods: To determine the efficacy and safety of Lornoxicam when administered preemptively by using Wong-Baker FACES Pain Rating scale. The patients undergoing abdominal surgery were randomly categorized into group A and B of 25 each. Group A- Received Lornoxicam 8mg (1ml) one hour before surgery. Group B- Not received any analgesic before surgery. Primary measurement of the efficacy was done by using Wong-Baker Faces Pain Rating Scale at 2, 4, 8, 12 and 24 hour. All parameters were analyzed by using student t test.Results: Surgeries which were included in the study are hernia repair, open appendectomy, laparoscopic (appendectomy, cholecystectomy). Reduction in pain scores at 12th hourly and 24th hourly pain scores (<0.05) was significant. Tramadol usage decreased significantly with laparoscopic surgeries.Conclusions: In this study we could demonstrate that lornoxicam when used preemptively reduces the pain score slightly and reduces the requirement of post-operative analgesics significantly.

A COMPARATIVE STUDY OF INTRALESIONAL TRIAMCINOLONE ACETONIDE ALONE VERSUS COMBINATION OF 5-FLUOROURACIL AND TRIAMCINOLONE ACETONIDE IN THE TREATMENT OF KELOID

2021 ◽  
pp. 71-74
Author(s):  
Neha Gupta ◽  
Vijay Paliwal ◽  
Kanchan Kumawat ◽  
Narendra Kumar ◽  
Imran Khan ◽  
...  
Keyword(s):  
Triamcinolone Acetonide ◽  
Tertiary Care ◽  
Inhibitory Effect ◽  
Combination Group ◽  
Intralesional Injection ◽  
Care Hospital ◽  
Intralesional Corticosteroid ◽  
Pyrimidine Analogue ◽  
The Difference ◽  
Group B

Background: Keloids are benign proliferative condition of dermal broblast. Intralesional corticosteroid improves keloid but associated with signicant adverse effects like dyspigmentation, tissue atrophy and telengectasia and contraindicated in certain conditions like hypertension and diabetes. 5-Fluorouracil (5-FU), a pyrimidine analogue with an inhibitory effect on TGF-β induced broblast proliferation is useful in treatment of keloids but is associated with ulceration and pain. A low dose of Triamcinolone if added to 5-FU injection overcomes these issues. Approach: This study was conducted in a tertiary care hospital. Sixty patients; thirty in each group were included. In group A, once weekly intralesional Triamcinolone and in group B, intralesional injection of Triamcinolone mixed with 5-Flurouracil in 1: 9 dilution were injected for 8 sessions. Parameters of Vancouver scale were noted at the baseline and at the end of treatment. Results: Out of 60 patients enrolled in this study. The combination group was better in improving height (62.11% vs 78%), pliability (44.14% vs 8.81%), and vascularity (55.78% vs 61.30%) and results were statistically signicant (P valve <0.05) however it was not better in improving pigmentation (43.47% vs 20%) and volume (69.79% vs 80.76%) (P valve > 0.05). Pain and pruritus improved completely (100%) in both the groups at the end of the treatment. Excellent improvement in patient and observer assessment score was seen in 96.67% vs 3.33% in combination group and TAC group respectively. The difference was statistically signicant (P valve<0.05). Combination was better irrespective of age of the patient, duration, site, and origin of keloid. All patients treated with 5 FU develop ulceration and pain. Conclusion: Both the therapies are effective but combination is superior to TAC alone. We advocate that 5-FU should be used alone, addition of TCA does not have any added advantage in therapeutic outcome rather it increases the cost of treatment.

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