INSULIN SECRETAGOGUE POTENTIAL OF FERONIA ELEPHANTUM FRUIT EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (08) ◽  
pp. 45-50
Author(s):  
N. A Khatib ◽  
◽  
P. A Patil ◽  
P. Ismail
Keyword(s):  
Blood Glucose ◽  
Muscle Glycogen ◽  
Glycogen Content ◽  
Methanol Extract ◽  
Diabetic Rats ◽  
Fruit Extract ◽  
Insulin Secretagogue ◽  
Muscle Glycogen Content ◽  
Feronia Elephantum

Methanol extract of Feronia elephantum fruit at a dose of 400 mg/kg twice a day, was evaluated for its insulin secretagogue potential in streptozotocin (STZ) 50 mg/kg induced diabetic rats. Treatment showed significant (P<0.001) decrease in blood glucose and significant (P<0.001) increase in seruminsulin, hepatic, muscle glycogen content and restoration of disturbed dyslipidemia. Result obtained from the present study indicates that methanol extract of Feronia elephantum fruit has insulin secretagogue potential in STZ induced diabetic rats.

scholarly journals Apigenin: A methanol fraction component of Newbouldia laevis leaf, as a potential antidiabetic agent

2017 ◽  
Vol 6 (1) ◽  
pp. 38-44
Author(s):  
Chinyelu C. Osigwe ◽  
◽  
Peter A. Akah ◽  
Chukwuemeka S. Nworu ◽  
Festus B. C. Okoye ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Muscle Glycogen ◽  
Glycogen Content ◽  
Diabetic Rats ◽  
Antidiabetic Agent ◽  
Methanol Fraction ◽  
Antihyperglycemic Activity ◽  
Muscle Glycogen Content ◽  
Isolated Compound

The leaves of Newbouldia laevis is traditionally used to treat diabetes mellitus in southeast Nigeria. The apigenin isolated from the methanol fraction of dichloromethane/methanol (1:1) extract of the leaves was evaluated for antidiabetic and antihyperglycemic activity in alloxan-induced diabetic rats and on normal rats. Treatment of alloxan-diabetic rats with the compound (apigenin) significantly (p < 0.05) reduced blood glucose, and increased the liver and muscle glycogen content. The adrenaline-induced elevation of blood glucose of normal rats was significantly (p < 0.05) reduced by the isolated compound. These results suggest that apigenin may be the anti-diabetic principle in the leaves of Newbouldia laevis..

Influence of carbohydrate loading on fuel substrate turnover and oxidation during prolonged exercise

1993 ◽  
Vol 74 (4) ◽  
pp. 1921-1927 ◽  
Author(s):  
A. N. Bosch ◽  
S. C. Dennis ◽  
T. D. Noakes
Keyword(s):  
Blood Glucose ◽  
Muscle Glycogen ◽  
Glucose Oxidation ◽  
Prolonged Exercise ◽  
Glycogen Content ◽  
Glucose Turnover ◽  
Muscle Glycogen Content ◽  
Glycogen Utilization ◽  
Total Muscle ◽  
Glycogen Breakdown

This study compared liver glucose turnover, blood glucose oxidation, and muscle glycogen utilization in 15 male endurance-trained cyclists who rode for 180 min at 70% of maximal O2 consumption in either a carbohydrate-(CHO) loaded (CL) or a non-CHO-loaded (NL) state. Total CHO oxidation during exercise was similar in the CL and NL subjects (492 +/- 77 vs. 448 +/- 43 g, respectively), as were blood glucose oxidation (103 +/- 19 vs. 99 +/- 7 g, respectively) and liver glucose appearance (110 +/- 15 vs. 127 +/- 16 g, respectively). However, total muscle glycogen utilization was greater in CL than NL subjects (134 +/- 11 vs. 95 +/- 12 mmol/kg wet wt; P < 0.05), the former of which had higher muscle glycogen content at the start (194 +/- 4 vs. 124 +/- 7 mmol/kg wet wt; P < 0.05) and throughout the trial. Whereas high rates of muscle glycogen breakdown were maintained throughout the trial in CL subjects, rates of muscle glycogenolysis in NL subjects decreased to 26 mmol.kg wet wt-1.h-1 after 60 min of exercise (P < 0.05) when their muscle glycogen content had declined to 70 mmol/kg wet wt. Comparable rates of blood glucose and overall CHO oxidation in CL and NL subjects, despite a slowing of muscle glycogenolysis in the NL group, could be explained by an accelerated breakdown of glycogen in the nonworking muscles to redistribute CHO (lactate) to the working muscles for oxidation.(ABSTRACT TRUNCATED AT 250 WORDS)

A major locus (RN) affecting muscle glycogen content is located on pig Chromosome 15

1996 ◽  
Vol 7 (1) ◽  
pp. 52-54 ◽  
Author(s):  
P. Mariani ◽  
K. Lundström ◽  
U. Gustafsson ◽  
A. -C. Enfält ◽  
R. K. Juneja ◽  
...  
Keyword(s):  
Muscle Glycogen ◽  
Glycogen Content ◽  
Chromosome 15 ◽  
Major Locus ◽  
Muscle Glycogen Content

scholarly journals Pharmacological potential of methanol extract of Anacardium occidentale stem bark on alloxan-induced diabetic rats

2018 ◽  
Vol 5 (7) ◽  
pp. 2440-2454
Author(s):  
D. A. Omoboyowa ◽  
F. O. Afolabi ◽  
T. C. Aribigbola
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Methanol Extract ◽  
Stem Bark ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Β Cells

Background: The anti-hyperglycemic potential of methanol stem bark extract of Anacardium occidentale (MSBEAO) was investigated using an alloxan-induced diabetic rat model. Alloxan administration induces the generation of free radicals which can affect antioxidant status resulting in the disruption of the β-cells of the pancreas. Therefore, this study examines the antioxidant potential of the plant extract and the ameliorating effect on the pancreas of alloxan-induced diabetic rats. Methods: Diabetes was induced by intraperitoneal injection of 150 mg/kg body weight of alloxan monohydrate. MSBEAO, at a concentration of 100 or 200 mg/kg b.w. was orally administered to alloxan-induced diabetic rats and normal rats. The hypoglycemic effect, oral glucose tolerance test, and biochemical assay of alloxan-induced diabetic rats were assayed using standard procedures. Results: Preliminary phytochemical screening of the extract revealed the presence of alkaloids, tannins, saponins, terpenoids, carbohydrates, and phenols at moderate concentrations. The lethality dose (LD50) of the plant extract was found to be equal to or less than 5000 mg/kg b.w. The hypoglycemic effect of the extract on the non-diabetic rats revealed a significant (p<0.05) decrease in the blood glucose concentration of animals administered with 1 g/kg b.w. of the extract, compared to normal control rats administered with normal saline. In the oral glucose tolerance test, the methanol extract exerted the highest response, similar to glibenclamide after 15 and 30 minutes of administration, compared to the control rats. The methanol extract yielded the highest blood glucose lowering effects after 9 days of treatment (p<0.05), compared to diabetic rats administered with normal saline and 0.3 mg/kg b.w. of glibenclamide. Administration of the extract at 200 mg/kg b.w. showed improved pancreas architecture and regeneration of the β-cells, compared with the pancreas of animals in the other groups. Conclusion: The results of this study suggest that MSBEAO is a potentially effective agent for the management of diabetes which might result from the antioxidant-generating capacity of the stem bark.

1047 Effects of Training and Testosterone on Muscle Glycogen Content In Streptozotocin-Induced Diabelic Female Rats

1993 ◽  
Vol 25 (Supplement) ◽  
pp. S186
Author(s):  
H. A. Kolzer ◽  
E. van Breda ◽  
P. Geurlen ◽  
H. Kuipers ◽  
J. F.C. Glatz
Keyword(s):  
Muscle Glycogen ◽  
Glycogen Content ◽  
Female Rats ◽  
Muscle Glycogen Content

scholarly journals Relationship between changes in core body temperature in lambs and post-slaughter muscle glycogen content and dark-cutting

2014 ◽  
Vol 54 (4) ◽  
pp. 459 ◽  
Author(s):  
D. G. Pighin ◽  
W. Brown ◽  
D. M. Ferguson ◽  
A. D. Fisher ◽  
R. D. Warner
Keyword(s):  
Lactic Acid ◽  
Body Temperature ◽  
Meat Quality ◽  
Muscle Glycogen ◽  
Glycogen Content ◽  
Core Body Temperature ◽  
Correlation Coefficients ◽  
Significant Negative Correlation ◽  
Muscle Glycogen Content ◽  
Core Body

Pre-slaughter stress may decrease muscle glycogen content, a key element for a suitable low ultimate pH and prevention of dark-cutting meat. Body temperature monitoring is a tool used in research on animal stress, as an indicator of stress events. Possible relationships between body temperature of sheep and post-mortem muscle glycogen were investigated in this study. Body temperature was measured with intravaginal loggers inserted into each animal at 3 days pre-slaughter, to record body temperature every 3 min over a period of 3 days. Blood samples were collected from each animal at exsanguination for measurement of glucose and lactic acid concentrations. The muscle content of glycogen and lactic acid were determined in samples of M. longissimus collected at the level of the 13th rib, at 1 h post-slaughter. A plot of body temperature versus time showed a rise in body temperature from all animals during events such as mustering, loading onto the truck, unloading at the abattoir, during pre-slaughter handling and at slaughter. Pearson’s correlation coefficients were determined between (1) the main temperature increments occurring between farm and slaughter; and (2) post-slaughter muscle glycogen and lactate levels. A significant negative correlation was detected between elevation in core body temperature due to physical stress of sheep and muscle glycogen levels at slaughter. A low correlation was detected between body temperature and blood glucose or lactate concentrations. Further research should examine the relationship between core body temperature and meat quality in order to better understand the complex relationship between animal stress and meat quality.

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