ANTIARTHRITIC ACTIVITY OF NARDOSTACHYS JATAMANSI ROOT EXTRACT ON FREUND’S ADJUVANT INDUCED ARTHRITIS IN RATS

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (10) ◽  
pp. 58-64
Author(s):  
S. Shah ◽  
◽  
K. Shah ◽  
B. Patel
Keyword(s):  
Blood Cell ◽  
Research Work ◽  
Treated Group ◽  
Root Extract ◽  
Adjuvant Induced Arthritis ◽  
Nardostachys Jatamansi ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant ◽  
Wbc Count ◽  
Histopathological Studies

The present research work was aimed to evaluate anti-arthritic activity of methanolic extract of Nardostachys jatamansi root on Freund’s adjuvant induced arthritis model in rats. Dried root powder was extracted and coded as NJRE (Nardostachys jatamansi root extract). Antiarthritic activity of NJRE was screened at the doses of 100 mg/kg and 400 mg/kg p.o. Treatment with NJRE markedly reduced paw volume, arthritic index, Erythrocyte Sedimentation Rate (ESR) and Total White Blood Cell (WBC) count, while markedly increasing Red Blood Cell (RBC) count and Hb as compared to arthritic animals. Rheumatoid Factor was significantly reduced in NJRE treated group when compared to arthritic animals. The abnormalities found in histopathological studies of joints of arthritic animals were prevented by the administration of NJRE 400 mg/kg. It can be concluded that NJRE possesses a significant antiarthritic activity that may be due to the presence of flavonoids, glycosides, phenols and tannins.

scholarly journals Evaluation of in vitro and in vivo anti-arthritic potential of Berberis calliobotrys

2015 ◽  
Vol 10 (4) ◽  
pp. 807 ◽  
Author(s):  
. Alamgeer ◽  
Umme Habiba Hasan ◽  
Ambreen Malik Uttra ◽  
Shahid Rasool
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Complete Freund’S Adjuvant ◽  
Membrane Stabilization ◽  
Adjuvant Induced Arthritis ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

<p class="Abstract">The present study was commenced to evaluate the anti-arthritic effect of 70% methanol extract and <em>n</em>-butanol and aqueous fractions of <em>Berberis calliobotrys</em> using both <em>in vitro</em> and <em>in vivo</em> arthritis models. Extract and fractions were investigated<em> in vitro</em> for inhibition of protein (bovine serum and egg albumin) denaturation and human red blood cell membrane stabilization. <em>In vivo</em> anti-arthritic activity of extract and fractions at 50, 100 and 200 mg/kg was assessed using turpentine oil and formaldehyde-induced arthritis, while, 200 mg/kg dose was evaluated against complete Freund’s adjuvant-induced arthritis. <em>B. calliobotrys</em> produced significant (p&lt;0.001) dose dependent inhibition of protein denaturation and human red blood cell membrane stabilization. In turpentine oil, formaldehyde and complete Freund’s adjuvant-induced arthritis models,<em> B. calliobotrys</em> significantly (p&lt;0.001) reduced joint and paw swelling. <em>B. calliobotrys</em> markedly improved body weight, hematology profile, radiological and histopathological parameters in complete Freund’s adjuvant model. It could be concluded that <em>B. calliobotrys</em> holds anti-arthritic potential, supporting its traditional use in treatment of rheumatoid arthritis.</p><br /><p> </p>

scholarly journals Determination of the inorganic composition and short term effect of aqueous extracts of root, pod, and stem of Telfairia occidentalis on some hematological parameters in rats

2016 ◽  
Vol 7 (5) ◽  
pp. 75-80
Author(s):  
Enyinnaya A Ogbonnaya ◽  
Patrick O Uadia
Keyword(s):  
Blood Cell ◽  
Hematological Parameters ◽  
Atomic Absorption Spectrophotometry ◽  
Mineral Elements ◽  
Root Extract ◽  
Aqueous Extracts ◽  
Telfairia Occidentalis ◽  
Stem Extract ◽  
Inorganic Composition ◽  
Wbc Count

Aims and Objectives: This study is to investigate the inorganic composition and the effect of fourteen (14) -day oral administration of aqueous extracts of root, pod and stem of Telfairia occidentalis in rats.Materials and Methods: Plant samples were analyzed for K, P, Mg, Ca, S, Mn, Fe, Cu, Zn, Pb, and Cr using atomic absorption spectrophotometry (AAS). Wister rats of both sexes were assigned to sixteen (16) groups of 4 animals per group. Different animal groups received distilled water and   root, stem, and pod extracts at the doses of 250, 750, 1500, 2250, and 3000mg/kg of body weight. All animals were treated for 14 days and sacrificed on the 15th day.Results: The inorganic composition result showed that potassium (K) was the highest in abundance in all the samples (root, pod, and stem), compared to the other mineral elements. The root contained high levels of potassium and manganese; the stem had magnesium, manganese and iron while the pod contained high amount of potassium, manganese and iron. Hematological assay results showed reduction in the values of white blood cell (WBC) count for higher doses of root extract and all doses (except for 1500mg/kg bw) of pod extract. Platelet count (PLT) was significantly high for root extract at 750mg/kg bw. The stem extract showed a consistent decrease in the red blood cell (RBC) count for all dose administered.Conclusion: Telfairia occidentalis root, pod, and stem may be a good source of inorganic elements. The extracts have varying effects on hematological parameters which may be dosage- and duration- dependent.Asian Journal of Medical Sciences Vol.7(5) 2016 75-80

scholarly journals Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Srinivasa Reddy Jitta ◽  
Prasanthi Daram ◽  
Karthik Gourishetti ◽  
C. S. Misra ◽  
Picheswara Rao Polu ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Complete Freund’S Adjuvant ◽  
Inflammatory Activity ◽  
Aqueous Extracts ◽  
Adjuvant Induced Arthritis ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant ◽  
Anti Inflammatory

Terminalia tomentosa bark belongs to the family Combretaceae. The plant bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis, and diarrhea. Phytochemical investigation of T. tomentosa bark confirms the presence of flavonoids, polyphenols, and tannins. The plant has not been investigated for its anti-inflammatory and antiarthritic activity. The present study was undertaken to explore its possible anti-inflammatory and antiarthritic activity. Anti-inflammatory activity of alcoholic and aqueous extracts of the bark was assessed by in vivo methods. In vivo antiarthritic potential of the extracts was evaluated by Complete Freund’s Adjuvant (CFA) induced arthritis in Wistar rats. Our findings showed that the alcoholic and aqueous extracts exhibited anti-inflammatory activity at 500 mg/kg oral dose in carrageenan-induced hind paw edema and carrageenan-induced air pouch inflammation models. We also found alcoholic as well as aqueous extracts of the bark restored the altered blood and serum parameters caused by the Complete Freund’s Adjuvant-induced arthritis in Wistar rats. This study shows that the T. tomentosa bark extracts possess anti-inflammatory activity and have pronounced effects on adjuvant arthritis also. Future studies are necessary to provide deeper insight into the exact mechanism of the action of anti-inflammatory and antiarthritic activity of T. tomentosa.

Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis

Life Sciences ◽  
2019 ◽  
Vol 226 ◽  
pp. 68-76 ◽  
Author(s):  
Kamel M. Kamel ◽  
Amany M. Gad ◽  
Suzan M. Mansour ◽  
Marwa M. Safar ◽  
Hala M. Fawzy
Keyword(s):  
Complete Freund’S Adjuvant ◽  
Adjuvant Induced Arthritis ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant
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