scholarly journals Determination of the inorganic composition and short term effect of aqueous extracts of root, pod, and stem of Telfairia occidentalis on some hematological parameters in rats

2016 ◽  
Vol 7 (5) ◽  
pp. 75-80
Author(s):  
Enyinnaya A Ogbonnaya ◽  
Patrick O Uadia
Keyword(s):  
Blood Cell ◽  
Hematological Parameters ◽  
Atomic Absorption Spectrophotometry ◽  
Mineral Elements ◽  
Root Extract ◽  
Aqueous Extracts ◽  
Telfairia Occidentalis ◽  
Stem Extract ◽  
Inorganic Composition ◽  
Wbc Count

Aims and Objectives: This study is to investigate the inorganic composition and the effect of fourteen (14) -day oral administration of aqueous extracts of root, pod and stem of Telfairia occidentalis in rats.Materials and Methods: Plant samples were analyzed for K, P, Mg, Ca, S, Mn, Fe, Cu, Zn, Pb, and Cr using atomic absorption spectrophotometry (AAS). Wister rats of both sexes were assigned to sixteen (16) groups of 4 animals per group. Different animal groups received distilled water and   root, stem, and pod extracts at the doses of 250, 750, 1500, 2250, and 3000mg/kg of body weight. All animals were treated for 14 days and sacrificed on the 15th day.Results: The inorganic composition result showed that potassium (K) was the highest in abundance in all the samples (root, pod, and stem), compared to the other mineral elements. The root contained high levels of potassium and manganese; the stem had magnesium, manganese and iron while the pod contained high amount of potassium, manganese and iron. Hematological assay results showed reduction in the values of white blood cell (WBC) count for higher doses of root extract and all doses (except for 1500mg/kg bw) of pod extract. Platelet count (PLT) was significantly high for root extract at 750mg/kg bw. The stem extract showed a consistent decrease in the red blood cell (RBC) count for all dose administered.Conclusion: Telfairia occidentalis root, pod, and stem may be a good source of inorganic elements. The extracts have varying effects on hematological parameters which may be dosage- and duration- dependent.Asian Journal of Medical Sciences Vol.7(5) 2016 75-80

scholarly journals Effects of Telfairia occidentalis (Hook F.) Methanol Leaf Extract on the Haematological Indices and Histomorphology of the Endometrium and Liver of Female Albino Rats

2016 ◽  
Vol 8 (3) ◽  
pp. 272-276
Author(s):  
Chidozie Nwabuisi OKOYE ◽  
David OGWU ◽  
John I. IHEDIOHA ◽  
Izuchukwu S. OCHIOGU ◽  
Anietie F. UDOUMOH ◽  
...  
Keyword(s):  
Blood Cell ◽  
Histological Examination ◽  
Leaf Extract ◽  
Hematological Parameters ◽  
Female Rats ◽  
Albino Rats ◽  
Telfairia Occidentalis ◽  
Significant Difference ◽  
The Mean ◽  
Liver Tissues

The objective of this study was to evaluate the effects of administration of Telfairia occidentalis (Hook f.) methanol leaf extract on some hematological indices and histomorphology of the uterus and liver of female albino rats. Acute toxicity study of the extract was performed with female rats, following standard procedure. They were randomly assigned into 3 groups. The first group (A) served as the untreated control and received distilled water, while the second group (B) and third (C) received 200 and 800 mg/kg mg/kg body weight of the methanol leaf extract of T. occidentalis respectively. Administration of the extract was done daily via the oral route for 21 days. Blood was collected for hematological evaluation at weekly intervals. Hematological parameters assessed were the packed cell volume (PCV), red blood cell (RBC) count, hemoglobin concentration (HB) and total white blood cell (TWBC) count. At the end of the study period uterine and liver tissues were excised and prepared for histological examination. Results showed that there was a significant decrease (P < 0.05) in the mean PCV, RBC and HB values of the treatment groups, but only at the end of the second week of administration of the extract. There was no significant difference (P > 0.05) in the mean total WBC throughout the duration of the study. Histological examination of uterine and liver tissues of the different groups did not show any lesions. It was concluded that the T. occidentalis leaf methanolic extract does not adversely affect the reproductive functions of the uterus.

scholarly journals Relation between insulin resistance and hematological parameters in a Brazilian sample

2006 ◽  
Vol 50 (1) ◽  
pp. 114-117 ◽  
Author(s):  
Vivian C.M. Ellinger ◽  
Ludmila T. Carlini ◽  
Rodrigo O. Moreira ◽  
Ricardo M.R. Meirelles
Keyword(s):  
Insulin Resistance ◽  
Blood Cell ◽  
Hematological Parameters ◽  
Model Assessment ◽  
Erythroid Progenitors ◽  
Brazilian Sample ◽  
Plasma Hemoglobin ◽  
And Gender ◽  
Wbc Count ◽  
Hematological Alterations

It has already been demonstrated that insulin resistance (IR) is associated with the stimulation of erythroid progenitors and with increased levels of inflammation markers. Therefore, IR should also be associated with increased red blood cell (RBC) and white blood cell (WBC) count. The aim of this study is to demonstrate that IR is independently associated with altered hematological parameters in a Brazilian sample. We analyzed laboratorial exams from 925 subjects. All data on hematological parameters, insulin resistance (Homeostasis Model Assessment [HOMA]) and lipid levels were included in the analysis. Demographic information included age and gender. HOMA correlated positively with RBC (r= 0.17, p< 0.001), plasma hemoglobin concentrations (r= 0.14, p< 0.001), hematocrit value (r= 0.15, p< 0.001) and WBC (r= 0.17, p< 0.01). Subjects in the upper quartile of IR had higher levels of plasma glucose, fasting insulin, triglycerides, hematocrit, hemoglobin, RBC and WBC count than those in the lower quartile. In conclusion, IR seems to be associated with alterations in several hematological parameters. These hematological alterations may be considered an indirect feature of the IR syndrome.

scholarly journals A comparative study of hematological parameters between hypertensive and normotensive individuals in Harar, eastern Ethiopia

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260751
Author(s):  
Beza Sileshi ◽  
Fekadu Urgessa ◽  
Moges Wordofa
Keyword(s):  
Blood Cell ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
University Hospital ◽  
Health Concern ◽  
Control Group ◽  
Eastern Ethiopia ◽  
Distribution Width ◽  
Wbc Count ◽  
Apparently Healthy

Background Hypertension is the major public health concern; leading to cardiovascular disease. It is associated with alteration in hematological parameters which may lead to end-organ damage. Thus, this study aimed to compare hematological parameters between hypertensive and normotensive adult groups in Harar, eastern Ethiopia. Methods A comparative cross-sectional study was conducted from January to March, 2020 at Jugel and Hiwotfana Specialized University hospital, Harar, eastern Ethiopia. Convenient sampling technique was used to recruit 102 hypertensive patients from the two hospitals and 102 apparently healthy blood donors. Participant’s socio-demographic and clinical information were collected using pre-tested structured questionnaire. Blood sample were collected and analyzed by Beckman Coulter DxH 500 analyzer for complete blood count. The data were entered and analyzed using SPSS version 23. Independent t-test and Mann Whitney u-test was used for comparison between groups. Spearman’s correlation was used for correlation test. P values less than 0.05 was considered as statistically significant. Result 102 hypertensive and 102 healthy controls were enrolled in this study. The median ± IQR value of white blood cell (WBC) count, hemoglobin (Hgb), hematocrit (HCT), red cell distribution width (RDW) and mean platelet volume (MPV) were significantly higher in hypertensive group compared to apparently healthy control group. Additionally, RBC (red blood cell) count, HCT and RDW showed statistically significant positive correlations with systolic and diastolic blood pressure. WBC count and RDW were significantly and positively correlated with body mass index (BMI). Platelet (PLT) count had a significant but negative correlation (r = -0.219, P = 0.027) with duration of hypertension illness while MPV showed positive and significant correlation (r = 0.255, P = 0.010). Conclusion The median values of WBC, Hgb, HCT, RDW and MPV were significantly higher in hypertensive patient compared to apparently healthy individuals. Hence, it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated with hematological aberrations. However, further studies are required to understand hypertensive associated changes in hematological parameters.

scholarly journals Some Immunological and Hematological Parameters among Refugees in Kawergosk Camp – Erbil Governorate

2019 ◽  
Vol 3 (1) ◽  
pp. 80-84
Author(s):  
Tanya S. Salih ◽  
Safa Safin Haydar ◽  
Muhsin H. Ubeid ◽  
Ameena S. M. Juma
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
White Blood Cell ◽  
Immunoglobulin E ◽  
Hematological Parameters ◽  
Serum Levels ◽  
Control Group ◽  
Syrian Refugees ◽  
Male And Female ◽  
Wbc Count

The study included 258 Syrian refugees of different ages and sex and another 60 volunteers as control group (C.G). These refugees were in Kawergosk camp in Erbil Governorate. Blood was collected from each individual for the estimation of white blood cell (WBC), eosinophil, iron, hemoglobin (Hb), and immunoglobulin E (IgE) levels. Mean serum levels of IgE among male and female refugees showed highly significant increasing when compared to C.G. Most of the refugees had normal iron levels, where iron concentrations were more than 65 mg/dl among 67 males and more than 50 mg/dl among 104 females and 48 children, while some had iron deficiency in which the majority were female (9 males, 24 females, and 6 children had iron deficiency). In addition, Hb concentrations were normal among 65 males (more than 13.0 g/dl), 89 females (more than 11.0 g/dl), and 48 children (more than 12.0 g/dl). However, anemia was found among 8 men, 42 women, and 6 children. It was revealed that there was a highly significant rising in eosinophils in male and female refugees in comparison to C.G. WBC count is non-significantly slightly increased in both male’s and female’s refugees when compared to C.G.

scholarly journals Stability of hematological parameters of canine blood samples stored with citrate phosphate dextrose adenine-1 anticoagulated plastic vacutainers

2019 ◽  
Vol 12 (3) ◽  
pp. 449-453 ◽  
Author(s):  
Okereke Henry Nnamdi ◽  
Udegbunam Rita Ijeoma ◽  
Nnaji Theophilus Okaforx
Keyword(s):  
Blood Cell ◽  
Hematological Parameters ◽  
Blood Banking ◽  
Citrate Phosphate Dextrose ◽  
Healthy Dogs ◽  
The Stability ◽  
Wbc Count ◽  
Differential White Blood Cell ◽  
Citrate Phosphate ◽  
Rbc Count

Aim: The effect of citrate phosphate dextrose adenine-1 on the hematological parameters of stored Nigerian indigenous dog's blood with plastic vacutainer was investigated. This was done in view of determining the viability and stability of the studied parameters for blood banking purpose. Till date, there is no literature on the stability of whole blood of Nigerian indigenous dogs for blood banking purposes. Materials and Methods: A total of six apparently adult healthy dogs were sampled, and their blood was stored at 4°C and analyzed for their packed cell volume (PCV), hemoglobin (Hgb) concentration, red blood cell (RBC) count, total and differential white blood cell (WBC) count, platelet count (PC), mean corpuscular values (mean corpuscular Hgb [MCH], MCH concentration, and mean corpuscular volume [MCV]), blood potency of hydrogen (pH), and erythrocyte sedimentation rate (ESR) over a period of 14 days. Results: Significant changes were observed in some of the studied parameters. Of the 14 days' study period, PCV, Hgb concentration, total WBC count, PC, and neutrophil count showed no significant (p≥0.05) difference until day 2 post-storage (PS), while RBC count, ESR, MCV, and lymphocyte count showed no significant (p≥0.05) variation up until day 3 PS. Blood pH showed no significant (p≥0.05) variation within 24-h PS but was significantly (p≤0.05) higher than obtained values on days 1, 3, 7, 10, and 14 PS. Conclusion: Based on our finding, we could suggest that hematological laboratories and hemotherapists could use canine blood stored in a plastic vacutainer for 2-3 days.

scholarly journals Prognostic value of pre-treatment routine hematological parameters in breast carcinoma: Advantageous or deleterious?

2020 ◽  
Vol 7 (8) ◽  
pp. 3916-3920
Author(s):  
Manigatta Doddagowda Shilpa ◽  
Raju Kalyani ◽  
P N Sreeramulu
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Blood Cell ◽  
Cancer Patients ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Study Group ◽  
Breast Cancer Patients ◽  
Wbc Count ◽  
Rbc Count

Introduction: The most common malignancy which endangers the quality of life in females is breast cancer. It is also the major public problem in society and despite advances in treatment strategies, it still leads to high mortality. In all breast cancer patients, the first assessment done before surgery is the complete blood count (CBC). There exists a strong relationship between immune response of the body and clinical staging of breast cancer. This study aimed to determine the most reliable hematological markers for the prognosis of breast cancer, and to evaluate the correlation between hematological parameters and disease staging. Methods: This study was a case control study conducted for a period of 3 years from Jan 2016 to December 2018 in the Department of Pathology (R.L. hospital and Research Center attached to Sri Devaraj Urs medical college, Tamaka, Kolar, Karnataka). The comparison of the hematological parameters was done between the study group (70 cases) and the control group (20 cases). The relation between the hematological parameters and the various stages of breast cancer was analyzed before initiating the treatment. Results: The majority of the breast cancer patients were of stage 2. The hemoglobin concentration, red blood cell (RBC) count, lymphocyte count, and were reduced in the study group, with a significant difference (p < 0.05) when compared to the controls. Hemoglobin concentration, RBC count, hematocrit, white blood cell (WBC) count, and absolute lymphocyte count were inversely proportional to the stage of breast cancer. The absolute count, ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were directly proportional to the progression of disease. Conclusion: Hemoglobin, RBC count, WBC count (including differential count), NLR, and PLR are the key hematological indicators which predict the severity and mortality risk of breast carcinoma.  

Time course of hemorheological alterations after heavy anaerobic exercise in untrained human subjects

2003 ◽  
Vol 94 (3) ◽  
pp. 997-1002 ◽  
Author(s):  
Ozlem Yalcin ◽  
Alpaslan Erman ◽  
Sedat Muratli ◽  
Melek Bor-Kucukatay ◽  
Oguz K. Baskurt
Keyword(s):  
Blood Cell ◽  
Blood Lactate ◽  
Time Course ◽  
Human Subjects ◽  
Hematological Parameters ◽  
Anaerobic Exercise ◽  
Single Bout ◽  
Rbc Aggregation ◽  
Wbc Count ◽  
Rbc Deformability

The time course of hemorheological alterations was investigated after heavy anaerobic exercise in untrained male human subjects. The Wingate protocol was performed by each subject, and blood lactate, red blood cell (RBC) deformability and aggregation, white blood cell (WBC) activation, and several hematological parameters were investigated during 24 h after the exercise and compared with preexercise values. Compared with the preexercise value, blood lactate level was found to be ∼10-fold higher immediately after the exercise. There was a transient, significant increment of RBC and WBC counts immediately after exercise that was followed by a decrement of RBC count. There was a second increase of WBC count, accompanied with increased percentages of granulocytes and granulocyte activation, starting 45 min after exercise. RBC deformability was found to be impaired immediately after exercise and remained reduced for at least 12 h; RBC aggregation was also found to be decreased after exercise, with the onset of this decrease delayed by 30 min. The results of this study indicate that a single bout of heavy anaerobic exercise may induce significant hemorheological deterioration lasting for up to 12 h and thus suggest the need to consider such effects in individuals with impaired cardiovascular function.

ANTIARTHRITIC ACTIVITY OF NARDOSTACHYS JATAMANSI ROOT EXTRACT ON FREUND’S ADJUVANT INDUCED ARTHRITIS IN RATS

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (10) ◽  
pp. 58-64
Author(s):  
S. Shah ◽  
◽  
K. Shah ◽  
B. Patel
Keyword(s):  
Blood Cell ◽  
Research Work ◽  
Treated Group ◽  
Root Extract ◽  
Adjuvant Induced Arthritis ◽  
Nardostachys Jatamansi ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant ◽  
Wbc Count ◽  
Histopathological Studies

The present research work was aimed to evaluate anti-arthritic activity of methanolic extract of Nardostachys jatamansi root on Freund’s adjuvant induced arthritis model in rats. Dried root powder was extracted and coded as NJRE (Nardostachys jatamansi root extract). Antiarthritic activity of NJRE was screened at the doses of 100 mg/kg and 400 mg/kg p.o. Treatment with NJRE markedly reduced paw volume, arthritic index, Erythrocyte Sedimentation Rate (ESR) and Total White Blood Cell (WBC) count, while markedly increasing Red Blood Cell (RBC) count and Hb as compared to arthritic animals. Rheumatoid Factor was significantly reduced in NJRE treated group when compared to arthritic animals. The abnormalities found in histopathological studies of joints of arthritic animals were prevented by the administration of NJRE 400 mg/kg. It can be concluded that NJRE possesses a significant antiarthritic activity that may be due to the presence of flavonoids, glycosides, phenols and tannins.

The Predictive Role of Biochemical Plasma Factors in Patients with Severe Traumatic Brain Injuries

2019 ◽  
Vol 70 (5) ◽  
pp. 1754-1757
Author(s):  
Marius Toma Papacocea ◽  
Ioana Anca Badarau ◽  
Mugurel Radoi ◽  
Ioana Raluca Papacocea
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Cell ◽  
Brain Injuries ◽  
Hematological Parameters ◽  
Group Versus ◽  
Public Health Problem ◽  
Traumatic Brain Injuries ◽  
High Rate ◽  
Control Group

Traumatic brain injuries (TBI) represent a high impact public health problem due to a high rate of death , long term disability and occurrence especially in young adults. Despite several promising animal studies, several parameters were proposed as biological markers and were assessed for this aim. Our study proposes the study of the early biochemical changes in association to hematological parameters for severe TBI patients prognosis. 43 patients with acute TBI were included in study based on clinical, laboratory and imagistic findings. The severity of the TBI was established by Glasgow Coma Scale GCS 3-8. In all patients were evaluated hematologic parameters (Red blood cell count - RBC, Hematocrit, blood Hemoglobin, White blood cell - WBC, Platelet count and biochemical parameters (glucose, urea, creatinine, electrolytes). Outcome was expressed as Glasgow Outcome Scale (GOS), between 1-5. Values were compared to control group -15 cases. Significant early differences in body temperature, heart rate, and systolic blood pressure were observed in TBI group versus control (p[0.05). After correlation, laboratory findings significantly associated to severe outcome - GOS = 1, 2 - (p[0.05) were plasma Na decrease and significant glucose increase. An early increase of temperature and decrease of Na may predict a severe outcome in patients with acute TBI; association with shifts in heart rate and blood pressure, imposes aggressive treatment measures.

Association Between White Blood Cell Counts and Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults: A Cross-Sectional Study

Angiology ◽  
2021 ◽  
pp. 000331972110211
Author(s):  
Buyun Jia ◽  
Chongfei Jiang ◽  
Yun Song ◽  
Chenfangyuan Duan ◽  
Lishun Liu ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Blood Cell ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
White Blood Cell ◽  
Pulse Wave ◽  
Final Analysis ◽  
Cross Sectional ◽  
Cell Counts ◽  
Wbc Count

Increased arterial stiffness is highly prevalent in patients with hypertension and is associated with cardiovascular (CV) risk. Increased white blood cell (WBC) counts may also be an independent risk factor for arterial stiffness and CV events. The aim of the study was to investigate the relationship between differential WBC counts and brachial-ankle pulse wave velocity (baPWV) in hypertensive adults. A total of 14 390 participants were included in the final analysis. A multivariate linear regression model was applied for the correlation analysis of WBC count and baPWV. Higher WBC counts were associated with a greater baPWV: adjusted β = 10 (95% CI, 8-13, P < .001). The same significant association was also found when WBC count was assessed as categories or quartiles. In addition, the effect of differential WBC subtypes, including neutrophil count and lymphocyte count on baPWV, showed the similar results. These findings showed that baPWV has positive associations with differential WBC counts in hypertensive adults.

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