EVALUATION OF COMPLEMENTARY EFFECTS OF TURMERIC, GINGER AND CINNAMON WITH ASPIRIN

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (07) ◽  
pp. 28-35
Author(s):  
T. K. Mohapatra ◽  
P Sarkar ◽  
R. N Dash ◽  
A. K Moharana ◽  
B. B. Subudhi
Keyword(s):  
Analgesic Effect ◽  
Term Treatment ◽  
Positive Interaction ◽  
Inflammatory Disorders ◽  
Stomach Mucosa ◽  
Long Term Treatment ◽  
Growing Body ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Aspirin (ASA) has been utilized against many inflammatory disorders. In recent years a growing body of research also suggests its efficacy against cancer. The use of ASA in these conditions requires long-term treatment. However, gastro-toxicity associated with ASA is a major challenge. Household species including turmeric, ginger, and cinnamon have enjoyed medicinal values including gastroprotective properties. Accordingly, their co-use with ASA may be beneficial in ensuring a safe long-term treatment. With this objective, the study was undertaken which revealed encouraging effects. A positive interaction was found with analgesic effect and anti-inflammatory effect of ASA. Further, these spices were shown to prevent gastro toxicity of ASA. In conclusion, ginger and turmeric can be used to complement the use of ASA against inflammatory disorders without the deleterious effects on stomach mucosa.

Which preparation of aspirin?

1978 ◽  
Vol 16 (13) ◽  
pp. 51-52
Keyword(s):  
Rheumatoid Arthritis ◽  
Influenza A ◽  
Term Treatment ◽  
Duration Of Treatment ◽  
First Choice ◽  
Long Term Treatment ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Aspirin is often used to treat complaints expected to be transient, such as toothache, headache and influenza. A rapid analgesic and sometimes anti-pyretic effect is required, and duration of treatment is likely to be short. Aspirin is often considered the first-choice drug for rheumatic disorders, particularly rheumatoid arthritis;1 here the circumstances are quite different because long-term treatment is required at the relatively high dosage necessary to obtain an anti-inflammatory effect.2

scholarly journals Autologous Red Blood Cell Delivery of Betamethasone Phosphate Sodium for Long Anti-Inflammation

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 286 ◽  
Author(s):  
Xiumei Zhang ◽  
Mingfeng Qiu ◽  
Pengcheng Guo ◽  
Yumei Lian ◽  
Enge Xu ◽  
...  
Keyword(s):  
Side Effects ◽  
Osmotic Fragility ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Anti Inflammatory ◽  
Loading Amount ◽  
Long Acting ◽  
Inflammatory Effect

Although glucocorticoids are highly effective in treating various types of inflammation such as skin disease, rheumatic disease, and allergic disease, their application have been seriously limited for their high incidence of side effects, particularly in long term treatment. To improve efficacy and reduce side effects, we encapsulated betamethasone phosphate (BSP) into biocompatible red blood cells (RBCs) and explored its long acting-effect. BSP was loaded into rat autologous erythrocytes by hypotonic preswelling method, and the loading amount was about 2.5 mg/mL cells. In vitro, BSP loaded RBCs (BSP-RBCs) presented similar morphology, osmotic fragility to native RBCs (NRBCs). After the loading process, the loaded cells can maintain around 70% of Na+/K+-ATPase activity of natural cells. In vivo, a series of tests including survival, pharmacokinetics, and anti-inflammatory effect were carried out to examine the long-acting effect of BSP-RBCs. The results shown that the loaded cells could circulate in plasma for over nine days, the release of BSP can last for over seven days and the anti-inflammatory effect can still be observed on day 5 after injection. Totally, BSP-loaded autologous erythrocytes seem to be a promising sustained releasing delivery system with long anti-inflammatory effect.

A Controlled Clinical Trial of a New Anti-Inflammatory Drug, Diftalone, in Rheumatoid Arthritis

1974 ◽  
Vol 2 (5) ◽  
pp. 338-346 ◽  
Author(s):  
Valentin Stroescu ◽  
Carmen Georgescu ◽  
Radu Voiosu
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trial ◽  
Randomized Trial ◽  
Term Treatment ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Inflammatory Drug ◽  
Long Term Treatment ◽  
Anti Inflammatory

In a double-blind, randomized trial on thirty-two patients affected by classical or definite rheumatoid arthritis, we have tried the effectiveness and safety of 500 mg/day oral diftalone versus 75 mg/day oral indomethacin for a period of six to twelve months treatment. Diftalone proved to be an effective and well tolerated anti-inflammatory drug in long-term treatment of rheumatoid arthritis. Its activity and safety is at least comparable to that achieved by the use of indomethacin.

scholarly journals HYALURONIC ACID PREPARATIONS IN BIG JOINT OSTEOARTHRITIS MANAGEMENT

2021 ◽  
pp. 80-96
Author(s):  
O. V. Kalashnikov ◽  
O. M. Sulyma ◽  
T. I. Osadchuk ◽  
А. V. Kalashnikov ◽  
V. B. Zayets ◽  
...  
Keyword(s):  
Side Effects ◽  
Term Treatment ◽  
Safety Level ◽  
Orthopedic Surgeons ◽  
Effi Ciency ◽  
Long Term Treatment ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
And Function

Abstract. The authors of the paper analyzed the experience of domestic and foreign experts on the effi-ciency of HA preparation in big joint osteoarthritis management. Task of the study is to analyze literature sources to identify the efficiency of HA preparations in big joints osteoarthritis management. Materials and methods: articles published by specialized scientific journals, paper collections, internet sources. Results: The analysis of literature sources determined the essential role of HA in joint cartilage nutrition and function. The researches tend to believe that an ideal HA preparation must be as close as possible to the physiological HA of joint’s synovial fluid. The HA preparation elaborated in our state, Artropatch meets these demands completely. Conclusions. Modern HA injectable preparations are expedient on the 1-3 stage of OA. Anti-inflammatory effect of HA preparations predetermines the possibility to decrease the intake dose and period of non-steroid anti-inflammatory drugs, consequently decreasing the risk of many unfavorable side effects of NSAIPs. The high safety level of HA preparations and no significant side effects after long-term treatment make them widely used in clinical practice of modern orthopedic surgeons.

Long-Term Tolerability Study of Voltaren

1975 ◽  
Vol 3 (3) ◽  
pp. 145-152 ◽  
Author(s):  
T Miura
Keyword(s):  
Serum Proteins ◽  
Term Treatment ◽  
Total Serum ◽  
Term Therapy ◽  
Analgesic Agent ◽  
Long Term Treatment ◽  
Term Tolerability ◽  
Anti Inflammatory ◽  
Pre Treatment

Clinical and laboratory examinations were conducted in order to assess the long-term tolerability of Voltaren, a new anti-inflammatory and analgesic agent. Pre-treatment, repeated on-treatment and after-treatment investigations of haemoglobin, erythrocyte count, total and differential leucocyte count, platelet count, SGOT, SGPT, alkaline phosphatase, total serum proteins and urinary protein and sugar were conducted in 13 patients. The period of treatment with Voltaren was 110 to 559 days. In all these tests, there were no unwanted effects attributable to long-term treatment with Voltaren. Our study would indicate that Voltaren is a safe drug which has no effect on the organs of haemopoiesis, nor on hepatic or renal function, even in long-term therapy. Therefore, Voltaren can be used as an anti-inflammatory and analgesic agent not only in short-term therapy but also in the long-term treatment of chronic diseases.

scholarly journals The glucocorticoid receptor in inflammatory processes: transrepression is not enough

2015 ◽  
Vol 396 (11) ◽  
pp. 1223-1231 ◽  
Author(s):  
Sabine Hübner ◽  
Lien Dejager ◽  
Claude Libert ◽  
Jan P. Tuckermann
Keyword(s):  
Side Effects ◽  
Glucocorticoid Receptor ◽  
Term Treatment ◽  
Disease Models ◽  
Side Effect Profile ◽  
Inflammatory Mechanism ◽  
Long Term Treatment ◽  
Inflammatory Processes ◽  
Anti Inflammatory

Abstract Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by tethering of the glucocorticoid receptor (GR) to DNA-bound pro-inflammatory transcription factors, is the main anti-inflammatory mechanism, is now challenged. Recent discoveries using conditional GR mutant mice and genomic approaches reveal that transactivation of anti-inflammatory acting genes is essential to suppress many inflammatory disease models. This novel view radically changes the concept to design selective acting GR ligands with a reduced side-effect profile.

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