STUDY OF BUCKWHEAT (FAGOPYRUM ESCULENTUM) SEED POWDER AS A TABLET BINDER

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (02) ◽  
pp. 73-76
Author(s):  
P. Singh ◽  
◽  
V. Kashikar ◽  
V. Shinde ◽  
J. Tayade
Keyword(s):  
Dosage Form ◽  
Binding Capacity ◽  
Tablet Formulation ◽  
Fagopyrum Esculentum ◽  
Processing Cost ◽  
Model Drug ◽  
Whole Seed ◽  
Single Dosage ◽  
Good Range

The aim the study was to expand the area of tablet binders from gums and extracted polysaccharides to whole seed powders so as to reduce processing cost involved with other synthetic binders and involvement of whole seed benefits to single dosage form. In the present study, buckwheat seed powder was used in the concentrations of 1%, 2%, 4%, 6% and it was compared with binding capacity of 2.5% acacia in tablet formulation as direct compressible agent. Valsartan was used as a model drug. It was found out that 2% w/w concentration of buckwheat seed powder performed well and all the parameters were in good range.

Exploration of Neem Gum, Acrylamide Grafted Neem Gum and Carboxymethylated Neem Gum as Retardant in Tablet Formulation

2020 ◽  
Vol 16 (9) ◽  
pp. 1404-1410
Author(s):  
Rishabha Malviya
Keyword(s):  
Diclofenac Sodium ◽  
Tablet Formulation ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Binding Agent ◽  
Grafted Polymer ◽  
Model Drug ◽  
Tablet Dosage ◽  
Tapped Density ◽  
Derivatives Of

Background: In the previous study, investigators have synthesized acrylamide grafted and carboxymethylated derivatives of neem gum and evaluated their potential in the formulation of nanoparticles. In continuation of previous work, authors have evaluated neem gum polysaccharide (NGP), acrylamide grafted neem gum polysaccharide (NGP-g-Am) and carboxymethylated neem gum polysaccharide (CMNGP) as binding agent in the tablet dosage form. Methods: Diclofenac sodium was used as a model drug while microcrystalline cellulose and talc were used as excipient in the preparation of granules employing wet granulation technique. NGP, NGP-g-Am and CMNGP were utilized as binding agent in the preparation of granules. Prepared granules were characterized for various pre-compression and post-compression parameters. Results and Discussion: Binding agents were used in the concentration of 4-24%w/w. NGP incorporated granules showed more bulk density and lower values of tapped density, Carr’s index, bulkiness, Hausner’s ratio and angle of repose as compared to NGP-g-Am consisting granules. NGP-g-Am consisting tablets showed more hardness and zero friability as compared to NGP based tablets. Drug content was found lower for the tablets having grafted polymer in place of NGP. CMNGP were also utilized to prepare granules but granules were not be able to compress keeping all the compacting parameters same as used in the case of NGP and NGP-g-Am consisting granules. NGP and NGP-g-Am were able to sustain drug release up to 6 and 8 h, respectively. Conclusion: It can be concluded that NGP-g-Am induces better properties when used as a binder in the tablet formulation than native polymer, while CMNGP cannot be utilized as a binding agent in the preparation of a tablet.

Development of Capsule containing Immediate Release Tablet and Extended Release Floating Tablet for Monitoring Release of Atenolol

2021 ◽  
pp. 2216-2220
Author(s):  
Mahesh Hari Kolhe ◽  
Ritu Mehra Gilhotra ◽  
Govind Sarangdhar Asane
Keyword(s):  
Dosage Form ◽  
Extended Release ◽  
Heart Diseases ◽  
Immediate Release ◽  
High Plasma ◽  
Release Behavior ◽  
Dose Frequency ◽  
Floating Tablet ◽  
Formulation Parameters ◽  
Single Dosage

Atenolol is beta blocker absorbed through GIT use for heart diseases. Single tablets, floating tablets and sustained released formulations studied are insufficient to produce effective dose to enhance bioavailability and effectiveness. Our study is focused on development of capsule dosage form containing immediate release (IR) and floating extended release (ER) tablets for monitoring release of atenolol in single dosage form. Two different tablets for IR and ER were prepared in three different combinations (Batch). Pre-formulation and post formulation parameters found to be within acceptable limits of formulation. Release behavior of individual tablets and capsule containing two tablets were studied. Among the batches, capsules containing smaller amount of atenolol in IR and large amount of Atenolol in ER (batch II) showed impressive drug release pattern. This formulation was stable even after a month and achieved optimum release behavior of immediate release and sustained release. This study could be used for effective treatment for different heart complications and reduce toxicity due to high plasma concentration in increased dose frequency.

scholarly journals Embedded 3D Printing of Novel Bespoke Soft Dosage Form Concept for Pediatrics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 630 ◽  
Author(s):  
Katarzyna Rycerz ◽  
Krzysztof Adam Stepien ◽  
Marta Czapiewska ◽  
Basel T. Arafat ◽  
Rober Habashy ◽  
...  
Keyword(s):  
Dosage Form ◽  
Drug Loading ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Dose Titration ◽  
Step Method ◽  
Needle Size ◽  
Model Drug ◽  
Semi Solid ◽  
The Impact

Embedded three-dimensional printing (e-3DP) is an emerging method for additive manufacturing where semi-solid materials are extruded within a solidifying liquid matrix. Here, we present the first example of employing e-3DP in the pharmaceutical field and demonstrate the fabrication of bespoke chewable dosage forms with dual drug loading for potential use in pediatrics. LegoTM-like chewable bricks made of edible soft material (gelatin-based matrix) were produced by directly extruding novel printing patterns of model drug ink (embedded phase) into a liquid gelatin-based matrix (embedding phase) at an elevated temperature (70 °C) to then solidify at room temperature. Dose titration of the two model drugs (paracetamol and ibuprofen) was possible by using specially designed printing patterns of the embedded phase to produce varying doses. A linearity [R2 = 0.9804 (paracetamol) and 0.9976 (ibuprofen)] was achieved between percentage of completion of printing patterns and achieved doses using a multi-step method. The impact of embedded phase rheological behavior, the printing speed and the needle size of the embedded phase were examined. Owning to their appearance, modular nature, ease of personalizing dose and geometry, and tailoring and potential inclusion of various materials, this new dosage form concept holds a substantial promise for novel dosage forms in pediatrics.

scholarly journals Carboxymethylation of Karaya gum: application in gastroretentive drug delivery for sustained release of model drug

2020 ◽  
pp. 300-306
Author(s):  
Amit Verma ◽  
Neetu Sachan ◽  
Anurag Verma
Keyword(s):  
Drug Release ◽  
Dosage Form ◽  
Aqueous Solubility ◽  
Dosage Forms ◽  
Dissolution Medium ◽  
Propranolol Hcl ◽  
Model Drug ◽  
Karaya Gum ◽  
Ether Synthesis ◽  
Acidic Dissolution

Karaya gum (KG) is one of the least soluble of the gums. It does not dissolve in water to give a clear solution but instead absorbs water rapidly to form viscous colloidal sols. Carboxymethylation of Karaya gum is expected to improve its aqueous solubility and gelling behavior. Another objective of the research is to evaluate the potential of carboxymethylated Karaya gum (CMKG) as drug release modulator (in acidic dissolution medium) when combined with HPMC K15M based polymeric matrices bearing Propranolol HCl. In the present study, KG was carboxymethylated using Williamson Ether synthesis. FTIR spectroscopy confirmed the formation of CMKG. The prepared CMKG was used in conjunction with HPMC K15M as a polymer matrix in the formulation capsule dosage form, using Propranolol HCl as model drug. The filled capsules were then coated with Gelucire 43/01 to convert them into hydrodynamically balanced (HBS) capsule dosage form. Dextrose & fructose were also added to the drug-polymer mix as osmogen to facilitate the drug release. The degree of substitution of CMKG was found to be 0.87. HBS capsule dosage forms remained buoyant on 0.1 HCl for up to 6 hr, the buoyancy was attributed to the Gelucire 43/01 coating around the capsule shell. From the experimentation it was observed that CMKG, when mixed with HPMC K15M at 1:3 ratios, extended the release of model drug from HBS capsule dosage forms in 0.1 HCl. At CMKG: HPMC K15M ratio 2:1, release of Propranolol Hydrochloride from hydrodynamically balanced (HBS) capsules revealed fast drug release in 0.1 HCl. From the observations it is evident that KG is amenable to carboxymethylation to form CMKG. It is also evident that it is advantageous to combine CMKG with HPMC K15M as release modulator to retard the release of Propranolol HCl in acidic dissolution medium.

Formulation and Evaluation of Novel Enteric Coated Extended Release Multiparticulates of Model NSAID Ketoprofen

2010 ◽  
Vol 3 (2) ◽  
pp. 994-999
Author(s):  
Lotlikar V ◽  
S Shidhaye ◽  
U Kedar ◽  
V Kadam
Keyword(s):  
Rheumatoid Arthritis ◽  
Dosage Form ◽  
Extended Release ◽  
In Vitro Dissolution ◽  
Ph Responsive ◽  
Model Drug ◽  
Enteric Coated ◽  
Pan Coater ◽  
Barrier Coat

The aim of this study was to develop a pH responsive enteric coated extended release multiparticulate dosage form containing a model drug ketoprofen, a nonsteroidal anti-inflammatory drug used for rheumatoid arthritis. The drug loaded pellets in matrix form were prepared by using extrusion/spheronization method. The optimized pelletization method revealed that extrusion using 1 mm sieve plate and spheronization friction disc of 2mm carried out at 700 rpm for 5-10 minutes resulted in good spherical pellets and uniformity in size. Evaluated core pellets were coated with polymer Eudragit® RS 30D on Fluid bed coater to achieve a sustainable release for 12 hours. Ketoprofen as like other NSAID have been reported for gastric mucosal irritation so a pH responsive barrier coat of Eudragit L®100-55 was employed on a pan coater for abstaining release in acidic media. The formulated pellets were characterized for shape and size uniformity, friability, surface morphology studies. The particle size of core and polymer coated pellets were found to be in the range of 0.95-1.2 mm and 1.32-1.51 mm respectively. The pellets were spherical in shape with smooth texture and uniformity in size. In-vitro dissolution tests were carried out for pellets in a USP type II dissolution apparatus in media-simulating pH conditions of the gastrointestinal tract. The release of the ketoprofen from formulated pellets was established in pH 1.2 for a period of 2 h, followed by pH 7.5 for rest of the study. The study concluded that the formulated multiparticulate dosage form of ketoprofen was able to relieve symptoms of rheumatoid arthritis.

Influence of acetylation and heat-moisture treatment on physio-chemical, pasting and morphological properties of buckwheat(Fagopyrum esculentum) starch

2016 ◽  
Vol 35 (4) ◽  
Author(s):  
Shatabhisha Sarkar
Keyword(s):  
Amylose Content ◽  
Binding Capacity ◽  
Fagopyrum Esculentum ◽  
Morphological Properties ◽  
Water Binding ◽  
Native Starch ◽  
Swelling Power ◽  
Heat Moisture Treatment ◽  
Moisture Treatment ◽  
Oil Binding

Effect of acetylation and heat moisture treatment (HMT) on physicochemical, morphological and rheological properties of buckwheat starch (Fagopyrum esculentum) was investigated. Acetylation, decreased amylose content of starch with increase in water binding capacity, oil binding capacity, swelling power, solubility and sediment volume. Acetylated starch showed improved paste clarity (five days storage) and increased peak viscosity as compared to native starch. Amylose content, water binding capacity, and oil binding capacity was also improved in HMT starch. The increase in onset temperature of viscosity development and the decrease in peak viscosity was observed in HMT starch. HMT decreased swelling power and solubility of native starch.

scholarly journals Development of the Composition and Technology of a Granular Dosage form Based on a Thick Milk Thistle Extract and Ademetionine

2020 ◽  
Vol 9 (2) ◽  
pp. 106-112
Author(s):  
D. I. Pisarev ◽  
O. O. Novikov ◽  
E. T. Zhilyakova ◽  
N. N. Boyko ◽  
R. A. Abramovich ◽  
...  
Keyword(s):  
Dosage Form ◽  
Hepatoprotective Activity ◽  
Hplc Method ◽  
Milk Thistle ◽  
Percolation Method ◽  
Pharmacological Tests ◽  
Validation Parameters ◽  
Wide Range ◽  
Model Drug ◽  
Method Accuracy

Introduction. The creation of rational combined medicines with hepatoprotective activity is an urgent task of medicinal science. Ademetionin shows pharmacological ef-fectiveness in cytolysis, cholestasis, synthetic insufficiency. Silybin, in turn, is effective in cytolysis, synthetic insufficiency, mesenchymal inflammation, fibrosis and pathological regeneration. Thus, the combination of these substances covers almost the entire set of clinical and morphological syndromes of liver damage and has a wide range of effects in various liver pathologies.Aim. The purpose of this study was to develop a combined granular dosage form containing a thick extract of milk thistle, ademetionin and analytical support for this process.Materials and methods. To obtain a thick extract from the fruits of Silybum marianum L. a traditional percolation method was used in a battery of 3 diffusers. Extractant removal was performed using a rotary evaporator IR-1M3 under vacuum. For the analysis of silybin in the obtained thick extract from the fruit of S. marianum L. the method of HPLC was used. Validation evaluation of the method was performed according to generally accepted parameters.Results and discussion. A modular combined dosage form based on a thick extract of S. marianum L. and ademethionine was developed. Lactose was introduced as an auxiliary agent. The quality of pellets was evaluated according to generally accepted criteria. The validation parameters of the manufactured dosage form were determined using the HPLC method. Accuracy and precision were determined by the method of additives in a series of 9 experimental samples of granules. The results of determining the linearity, precision and correctness of the method for determining silybin and ademetionin in a combined model drug form showed correct results.Conclusion.Thus, a combined granular dosage form containing a thick extract of milk thistle, ademetionin, has been developed. Analytical support of this process using the HPLC method was performed. Validation studies of the developed methodology were carried out. The field of application of the obtained results is practical pharmacy. Further research should concern the conduct of a set of pharmacological tests.

Sign in / Sign up

Export Citation Format

Share Document