scholarly journals External Powered Orthoses for Paraplegic Subjects: A Meta Analysis Review

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Mohammad Taghi Karimi ◽  
Amir Esrafilian
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Poor Quality ◽  
Energy Consumption Analysis ◽  
Cord Injury ◽  
Analysis Stability ◽  
Research Studies

Background. Various types of external powered orthoses have been designed to improve the function of paraplegic subjects; however it is not clear which one of them has better performance. Therefore, the aim of this paper is to evaluate the function of available external powered orthoses based on the research presented in the relevant literature. Method. An electronic search was done via the Pubmed, Embase, and ISI Web of Knowledge data from 1960 to 2010. The quality of the research studies was evaluated by use of Black and Down tool. The performances of the orthoses are evaluated based on the gait analysis, stability analysis, and energy consumption analysis. Results. Although various types of external powered orthoses have been designed to improve the performance of spinal cord injury individuals, there are a few research studies in this regard. Moreover, they have a poor quality. Conclusion. There is no research study regarding the performance of spinal cord injury subjects with the external powered orthoses. It is recommended to do clinical trial studies to evaluate the performance of these orthoses.

scholarly journals The effectiveness and safety of LMWH for preventing thrombosis in patients with spinal cord injury: a meta-analysis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Ze Lin ◽  
Yun Sun ◽  
Hang Xue ◽  
Lang Chen ◽  
Chenchen Yan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Venous Thrombosis ◽  
Meta Analysis ◽  
Therapeutic Effects ◽  
Significant Difference ◽  
Cord Injury ◽  
Review Manager ◽  
Evident Difference

Abstract Background Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) are commonly used for preventing venous thrombosis of the lower extremity in patients with traumatic spinal cord injury. Although, LMWH is the most commonly used drug, it has yet to be established whether it is more effective and safer than UFH. Further, a comparison of the effectiveness of LMWH in preventing thrombosis at different locations and different degrees of spinal cord injury has also not been clearly defined. Materials and methods Cohort studies comparing the use of LMWH and UFH in the prevention of lower limb venous thrombosis in patients with spinal cord injury were identified using PubMed. The risk of bias and clinical relevance of the included studies were assessed using forest plots. The Newcastle-Ottawa quality assessment scale was used to evaluate the quality of the included studies. The main results of the study were analyzed using Review Manager 5.3. Results A total of five studies were included in this meta-analysis. Four studies compared the effectiveness and safety of LMWH and UFH in preventing thrombosis in patients with spinal cord injury. No significant differences were found between the therapeutic effects of the two drugs, and the summary RR was 1.33 (95% CI 0.42–4.16; P = 0.63). There was also no significant difference in the risk of bleeding between the two medications, and the aggregate RR was 0.78 (95% CI 0.55–1.12; P = 0.18). When comparing the efficacy of LMWH in preventing thrombosis in different segments and different degrees of spinal cord injury, no significant differences were found. Conclusions The results of this analysis show that compared with UFH, LMWH has no obvious advantages in efficacy nor risk prevention, and there is no evident difference in the prevention of thrombosis for patients with injuries at different spinal cord segments.

scholarly journals The Effect of miRNA-Modified Exosomes in Animal Models of Spinal Cord Injury: A meta-Analysis

2022 ◽  
Vol 9 ◽  
Author(s):  
Mengdie Hu ◽  
Zhidong Cao ◽  
Dianming Jiang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Animal Models ◽  
Motor Function ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Preclinical Studies ◽  
Cord Injury ◽  
Administration Time ◽  
Trim And Fill

Background: Spinal cord injury (SCI) is currently not completely curable. Exosomes have been widely used in preclinical studies of spinal cord injury. Here, in this meta-analysis, we focused on evaluating the overall efficacy of therapies based on miRNA-modified exosomes on functional recovery in animal models of SCI.Methods: PubMed, embase and Web of Science library databases were searched. Relevant literature was included, and the random effects model was used to assess the overall effect of the intervention, with outcomes expressed as SMD. The primary outcome included motor function scores. Risk of bias (ROB) was assessed using the ROB tool of the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE). R version 4.1.1software and Review Manager software were used for meta-analysis.Results: A total of 11 preclinical studies were included. The meta-analysis revealed that miRNA-modified exosome therapy was effective in improving motor function scores compared with exosomes alone or control therapy (standardized mean difference: 4.21; 95% confidence interval: 3.39–5.04). There was significant asymmetry in the funnel plot, and trim-and-fill analysis revealed four unpublished studies of motor scores. The quality of all included studies was evaluated with SYRCLE’s ROB tool. The SCI model, administration time and dose had an impact on the effect of the treatment.Conclusion: MiRNA-modified exosomes have shown great potential in the treatment of SCI. Moreover, the efficacy of miRNA-modified exosomes was superior to that of exosomes alone.

Frequency of patient-reported UTIs is associated with poor quality of life after spinal cord injury: a prospective observational study

Spinal Cord ◽  
2020 ◽  
Vol 58 (12) ◽  
pp. 1274-1281 ◽  
Author(s):  
Katherine M. Theisen ◽  
Rachel Mann ◽  
Joshua D. Roth ◽  
Joseph J. Pariser ◽  
John T. Stoffel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Poor Quality ◽  
Cord Injury ◽  
Patient Reported

scholarly journals MP48-07 FREQUENCY OF PATIENT-REPORTED UTIs PREDICTS POOR QUALITY OF LIFE AFTER SPINAL CORD INJURY

2020 ◽  
Vol 203 ◽  
pp. e696-e697
Author(s):  
Katherine Theisen* ◽  
Rachel Mann ◽  
Joshua Roth ◽  
Joseph Pariser ◽  
John Stoffel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Poor Quality ◽  
Cord Injury ◽  
Patient Reported

Chinese Herbal Medicine in Treatment of Spinal Cord Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 48 (07) ◽  
pp. 1593-1616
Author(s):  
Yang Zheng ◽  
Shangfeng Qi ◽  
Fengqing Wu ◽  
Jintao Hu ◽  
Ronglin Zhong ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Methodological Quality ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Chinese Herbal ◽  
Sensory Score ◽  
Cord Injury

Spinal cord injury (SCI) is a catastrophic disease associated with damaged neurological structures and has become a significant social and economic burden for the health care system and patients’ families. The use of Chinese Herbal Medicine (CHM) to treat SCI has been increasing in recent years. This meta-analysis aimed to investigate the effectiveness of CHM for patients with SCI. Therefore, we included randomized controlled trials (RCTs) of CHM for SCI in seven databases. A total of 26 studies involving 1961 participants were included in this study. No serious heterogeneity or publication bias was observed across each study. The results showed that significant improvements of the American Spinal Injury Association (ASIA)-grading improvement rate ([Formula: see text], [Formula: see text]), clinical effective rate ([Formula: see text], [Formula: see text]), ASIA motor score ([Formula: see text], [Formula: see text]), ASIA sensory score (total) ([Formula: see text], [Formula: see text]), ASIA sensory score (light touch) ([Formula: see text], [Formula: see text]), ASIA sensory score (pinprick) ([Formula: see text], [Formula: see text]), and activities of daily living (ADL) score ([Formula: see text], [Formula: see text]) in CHM group compared with the control group. Among the CHM groups, Buyang Huanwu decoction was the most frequently prescribed herbal formula, while Astragalus membranaceus was the most commonly used single herb. In addition, there were no serious and permanent adverse effects in the two groups. The methodological quality of the most included RCTs was poor and the quality of evidence for the main outcomes was from very low to moderate according to the GRADE system. Current evidence suggests that CHM is an effective and safe treatment for SCI and could be treated as a complementary and alternative option with few side effects. However, considering the low quality, small size, and high risk of the studies identified in this meta-analysis, higher methodological quality, rigorously designed RCTs with large sample sizes are needed to confirm the results.

scholarly journals Effect of Metformin on Locomotor Function Recovery in Rat Spinal Cord Injury Model: A Meta-analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Qing Chen ◽  
Dong Xie ◽  
Qiuju Yao ◽  
Lili Yang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Experimental Studies ◽  
High Quality ◽  
Locomotor Function ◽  
Function Recovery ◽  
Cord Injury

Background. Disorder of locomotor function is universal in patients with spinal cord injury (SCI) and has a severe impairment on their quality of life. Metformin, the first-line antidiabetic drug, has been used to improve locomotor function in SCI rats through antioxidative mechanisms recently. Methods. A search strategy was conducted from databases, including PubMed, Web of Science, MEDLINE, and Scopus database until April 2021. The methodological quality of the animal experimental studies was assessed according to the Systematic Review Centre for Laboratory animal Experimentation’s Risk of Bias tool. The weighted mean difference was calculated with the random-effects model. Results. Seven eligible studies on SCI and metformin were reviewed. The meta-analysis indicated that SCI rats receiving metformin therapy showed a significant locomotor function recovery. Limitations and no obvious publication bias were presented in the studies. Conclusion. Metformin can promote the recovery of the locomotor function of SCI rats. However, the use of this meta-analysis was influenced due to the not high quality of studies. Consequently, more high-quality studies are necessary for preclinical studies of SCI in the future.

Quality of Life After Spinal Cord Injury: A Literature Critique and Meta-analysis (1983–1992)

1994 ◽  
Vol 17 (2) ◽  
pp. 60-66 ◽  
Author(s):  
Ron L. Evans ◽  
Robert D. Hendricks ◽  
Richard T. Connis ◽  
Jodie K. Haselkorn ◽  
Karen R. Ries ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Meta Analysis ◽  
Cord Injury
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