scholarly journals Effect of Metformin on Locomotor Function Recovery in Rat Spinal Cord Injury Model: A Meta-analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Qing Chen ◽  
Dong Xie ◽  
Qiuju Yao ◽  
Lili Yang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Experimental Studies ◽  
High Quality ◽  
Locomotor Function ◽  
Function Recovery ◽  
Cord Injury

Background. Disorder of locomotor function is universal in patients with spinal cord injury (SCI) and has a severe impairment on their quality of life. Metformin, the first-line antidiabetic drug, has been used to improve locomotor function in SCI rats through antioxidative mechanisms recently. Methods. A search strategy was conducted from databases, including PubMed, Web of Science, MEDLINE, and Scopus database until April 2021. The methodological quality of the animal experimental studies was assessed according to the Systematic Review Centre for Laboratory animal Experimentation’s Risk of Bias tool. The weighted mean difference was calculated with the random-effects model. Results. Seven eligible studies on SCI and metformin were reviewed. The meta-analysis indicated that SCI rats receiving metformin therapy showed a significant locomotor function recovery. Limitations and no obvious publication bias were presented in the studies. Conclusion. Metformin can promote the recovery of the locomotor function of SCI rats. However, the use of this meta-analysis was influenced due to the not high quality of studies. Consequently, more high-quality studies are necessary for preclinical studies of SCI in the future.

A combination of mesenchymal stem cells and scaffolds promotes motor functional recovery in spinal cord injury: a systematic review and meta-analysis

2020 ◽  
Vol 32 (2) ◽  
pp. 269-284 ◽  
Author(s):  
Mahmoud Yousefifard ◽  
Solmaz Nasseri Maleki ◽  
Shaghayegh Askarian-Amiri ◽  
Alexander R. Vaccaro ◽  
Jens R. Chapman ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Combination Therapy ◽  
Motor Function ◽  
Acute Phase ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Motor Dysfunction ◽  
Function Recovery ◽  
Cord Injury

OBJECTIVEThere is controversy about the role of scaffolds as an adjunctive therapy to mesenchymal stem cell (MSC) transplantation in spinal cord injury (SCI). Thus, the authors aimed to design a meta-analysis on preclinical evidence to evaluate the effectiveness of combination therapy of scaffold + MSC transplantation in comparison with scaffolds alone and MSCs alone in improving motor dysfunction in SCI.METHODSElectronic databases including Medline, Embase, Scopus, and Web of Science were searched from inception until the end of August 2018. Two independent reviewers screened related experimental studies. Animal studies that evaluated the effectiveness of scaffolds and/or MSCs on motor function recovery following experimental SCI were included. The findings were reported as standardized mean difference (SMD) and 95% confidence interval (CI).RESULTSA total of 34 articles were included in the meta-analysis. Analyses show that combination therapy in comparison with the scaffold group alone (SMD 2.00, 95% CI 1.53–2.46, p < 0.0001), the MSCs alone (SMD 1.58, 95% CI 0.84–2.31, p < 0.0001), and the nontreated group (SMD 3.52, 95% CI 2.84–4.20, p < 0.0001) significantly improved motor function recovery. Co-administration of MSCs + scaffolds only in the acute phase of injury (during the first 3 days after injury) leads to a significant recovery compared to scaffold alone (SMD 2.18, p < 0.0001). In addition, the cotransplantation of scaffolds with bone marrow–derived MSCs (SMD 1.99, p < 0.0001) and umbilical cord–derived MSCs (SMD 1.50, p = 0.001) also improved motor function following SCI.CONCLUSIONSThe findings showed that scaffolds + MSCs is more effective than scaffolds and MSCs alone in improving motor function following SCI in animal models, when used in the acute phase of injury.

scholarly journals The effectiveness and safety of LMWH for preventing thrombosis in patients with spinal cord injury: a meta-analysis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Ze Lin ◽  
Yun Sun ◽  
Hang Xue ◽  
Lang Chen ◽  
Chenchen Yan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Venous Thrombosis ◽  
Meta Analysis ◽  
Therapeutic Effects ◽  
Significant Difference ◽  
Cord Injury ◽  
Review Manager ◽  
Evident Difference

Abstract Background Unfractionated heparin (UFH) and low molecular weight heparin (LMWH) are commonly used for preventing venous thrombosis of the lower extremity in patients with traumatic spinal cord injury. Although, LMWH is the most commonly used drug, it has yet to be established whether it is more effective and safer than UFH. Further, a comparison of the effectiveness of LMWH in preventing thrombosis at different locations and different degrees of spinal cord injury has also not been clearly defined. Materials and methods Cohort studies comparing the use of LMWH and UFH in the prevention of lower limb venous thrombosis in patients with spinal cord injury were identified using PubMed. The risk of bias and clinical relevance of the included studies were assessed using forest plots. The Newcastle-Ottawa quality assessment scale was used to evaluate the quality of the included studies. The main results of the study were analyzed using Review Manager 5.3. Results A total of five studies were included in this meta-analysis. Four studies compared the effectiveness and safety of LMWH and UFH in preventing thrombosis in patients with spinal cord injury. No significant differences were found between the therapeutic effects of the two drugs, and the summary RR was 1.33 (95% CI 0.42–4.16; P = 0.63). There was also no significant difference in the risk of bleeding between the two medications, and the aggregate RR was 0.78 (95% CI 0.55–1.12; P = 0.18). When comparing the efficacy of LMWH in preventing thrombosis in different segments and different degrees of spinal cord injury, no significant differences were found. Conclusions The results of this analysis show that compared with UFH, LMWH has no obvious advantages in efficacy nor risk prevention, and there is no evident difference in the prevention of thrombosis for patients with injuries at different spinal cord segments.

scholarly journals The impact of myelination on axon sparing and locomotor function recovery in spinal cord injury assessed using diffusion tensor imaging

2013 ◽  
Vol 26 (11) ◽  
pp. 1484-1495 ◽  
Author(s):  
Tsang-Wei Tu ◽  
Joong H. Kim ◽  
Feng Qin Yin ◽  
Lyn B. Jakeman ◽  
Sheng-Kwei Song
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Locomotor Function ◽  
Function Recovery ◽  
Cord Injury ◽  
The Impact

scholarly journals Retraction Note to: Triptolide (TPL) improves locomotor function recovery in rats and reduces inflammation after spinal cord injury

2017 ◽  
Vol 38 (4) ◽  
pp. 707-707
Author(s):  
Bing Wang ◽  
Chen Chen ◽  
Jing-Tao Zhang ◽  
Ruo-Xian Song ◽  
Xiu-Chun Yu
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Locomotor Function ◽  
Function Recovery ◽  
Cord Injury

scholarly journals A meta-analysis of exosome in the treatment of spinal cord injury

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 1043-1060
Author(s):  
Hanxiao Yi ◽  
Yang Wang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Sequential Analysis ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Trial Sequential Analysis ◽  
Therapeutic Effects ◽  
Locomotor Function ◽  
Cord Injury

Abstract Context There are no recommended therapeutic agents for acute spinal cord injury (SCI) due to the pathophysiological complexity of the injury. Objective The objective of this study is to investigate the efficacy of various exosomes and potential factors impacting the efficacy of exosomes. Methods We searched the PubMed, EMBASE, Web of Science, Medline, Scopus, and Cochrane Library databases to systematically collect articles comparing the locomotor function of SCI rodents undergoing exosome treatment and untreated SCI rodents. No language was preferred. Results Pooled analysis revealed that the locomotor function recovery of SCI rodents receiving exosomes was greatly improved (583 rats, 3.12, 95% CI: 2.56–3.67, p < 0.01; 116 mice, 2.46, 95% CI: 1.20–3.72, p < 0.01) compared to those of control rodents. The trial sequential analysis demonstrated the findings of the meta-analysis with the cumulative Z-curve crossing the upper monitoring boundary for the benefit and reaching the adjusted required information size. However, the origin of the exosome, SCI model, and administration method determined the therapeutic effect to some extent. Conclusions Despite the proven therapeutic effects of exosomes on SCI rodents, the results should be interpreted cautiously considering the diversity in vivo and in vitro in relation to future trials.

scholarly journals External Powered Orthoses for Paraplegic Subjects: A Meta Analysis Review

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Mohammad Taghi Karimi ◽  
Amir Esrafilian
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Poor Quality ◽  
Energy Consumption Analysis ◽  
Cord Injury ◽  
Analysis Stability ◽  
Research Studies

Background. Various types of external powered orthoses have been designed to improve the function of paraplegic subjects; however it is not clear which one of them has better performance. Therefore, the aim of this paper is to evaluate the function of available external powered orthoses based on the research presented in the relevant literature. Method. An electronic search was done via the Pubmed, Embase, and ISI Web of Knowledge data from 1960 to 2010. The quality of the research studies was evaluated by use of Black and Down tool. The performances of the orthoses are evaluated based on the gait analysis, stability analysis, and energy consumption analysis. Results. Although various types of external powered orthoses have been designed to improve the performance of spinal cord injury individuals, there are a few research studies in this regard. Moreover, they have a poor quality. Conclusion. There is no research study regarding the performance of spinal cord injury subjects with the external powered orthoses. It is recommended to do clinical trial studies to evaluate the performance of these orthoses.

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