scholarly journals A case of pancreatic metastasis arising from occult lung cancer

2018 ◽  
Vol 5 (3) ◽  
pp. 21
Author(s):  
Ryo Kodama ◽  
Hisanobu Saegusa ◽  
Hiroyasu Ushimaru ◽  
Mutsuki Makino ◽  
Kenji Kawaguchi
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Primary Lung Cancer ◽  
Pancreatic Mass ◽  
Pancreatic Metastasis ◽  
Unknown Primary ◽  
Cancer Tissue ◽  
Poorly Differentiated Adenocarcinoma ◽  
Small Nodule ◽  
Poorly Differentiated

A 57-year-old man was admitted with complaints of stiffness on the right clavicle. Imaging study revealed swelling of multiple lymph nodes and pancreatic mass, but there were no such findings in the lung. Endoscopic ultrasound-guided fine needle aspiration for mediastinum lymph node and pancreatic mass revealed a poorly differentiated adenocarcinoma. He was diagnosed of pancreatic cancer with multiple lymph node metastases. Chemoradiotherapy was conducted. Six months later, he suffered from cardiac tamponade and died. The autopsy revealed a small nodule of poorly differentiated adenocarcinoma in the lung that could not be pointed out by computed tomography. Immunohistochemistry showed that both tumors of the lung and pancreas were positive for thyroid transcription factor-1 and napsin A, which are specific markers of lung cancer. Final diagnosis was primary lung cancer with metastases to the pancreas and heart. Pancreatic metastasis from occult lung cancer is rare. Lung cancer must be suspected when carcinoma of unknown primary is detected, even in the absence of the image findings of the lung. Immunostaining is useful in determining the primary site; hence, obtaining the cancer tissue is important.

scholarly journals From Raw Pixels to Recurrence Image for Deep Learning of Benign and Malignant Mediastinal Lymph Nodes on Computed Tomography

2020 ◽  
Author(s):  
Tuan Pham
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Deep Learning ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Mediastinal Lymph Node ◽  
Survival Rates ◽  
Primary Lung Cancer ◽  
Lymph Node Status ◽  
Mediastinal Lymph Nodes

<div>Lung cancer causes the most cancer deaths worldwide and has one of the lowest five-year survival rates of all cancer types. It is reported that more than half of patients with lung cancer die within one year of being diagnosed. Because mediastinal lymph node status is the most important factor for the treatment and prognosis of lung cancer, the aim of this study is to improve the predictive value in assessing the computed tomography (CT) of mediastinal lymph-node malignancy in patients with primary lung cancer. This paper introduces a new method for creating pseudo-labeled images of CT regions of mediastinal lymph nodes by using the concept of recurrence analysis in nonlinear dynamics for the transfer learning. Pseudo-labeled images of original CT images are used as input into deep-learning models. Three popular pretrained convolutional neural networks (AlexNet, SqueezeNet, and DenseNet-201) were used for the implementation of the proposed concept for the classification of benign and malignant mediastinal lymph nodes using a public CT database. In comparison with the use of the original CT data, the results show the high performance of the transformed images for the task of classification. The proposed method has the potential for differentiating benign from malignant mediastinal lymph nodes on CT, and may provide a new way for studying lung cancer using radiology imaging. </div><div><br></div>

Complete Mediastinal and Hilar Lymph Node Staging of Primary Lung Cancer by Endobronchial Ultrasound

CHEST Journal ◽  
2008 ◽  
Vol 134 (6) ◽  
pp. 1350-1351 ◽  
Author(s):  
Marcus P. Kennedy ◽  
Yousef Shweihat ◽  
Mona Sarkiss ◽  
Georgie A. Eapen
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Primary Lung Cancer ◽  
Endobronchial Ultrasound ◽  
Lymph Node Staging ◽  
Hilar Lymph Node

scholarly journals Lymph node metastasis outside of a tumor-bearing lobe in primary lung cancer and the status of interlobar fissures

Medicine ◽  
2019 ◽  
Vol 98 (12) ◽  
pp. e14800 ◽  
Author(s):  
Hui Li ◽  
Ruimin Wang ◽  
Dexian Zhang ◽  
Yongming Zhang ◽  
Wanhu Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Primary Lung Cancer ◽  
Node Metastasis ◽  
Tumor Bearing ◽  
The Status

Poorly differentiated carcinoma and poorly differentiated adenocarcinoma of unknown origin: favorable subsets of patients with unknown-primary carcinoma?

1997 ◽  
Vol 15 (5) ◽  
pp. 2056-2066 ◽  
Author(s):  
R Lenzi ◽  
K R Hess ◽  
M C Abbruzzese ◽  
M N Raber ◽  
N G Ordoñez ◽  
...  
Keyword(s):  
Median Survival ◽  
Proportional Hazards ◽  
Primary Carcinoma ◽  
Unknown Primary ◽  
Entire Group ◽  
Poorly Differentiated Adenocarcinoma ◽  
Prognostic Features ◽  
Poorly Differentiated Carcinoma ◽  
Poorly Differentiated ◽  
Unknown Primary Carcinoma

PURPOSE The objectives of this study were to assess clinical outcomes and prognostic factors in unselected, consecutive patients with poorly differentiated carcinoma (PDC) or poorly differentiated adenocarcinoma (PDA). PATIENTS AND METHODS The 1,400 patients analyzed were referred to our unknown-primary tumor (UPT) clinic from January 1, 1987 through July 31, 1994. Clinical data from these patients were entered into a computerized data base for storage, retrieval, and analysis. Survival was measured from the time of diagnosis; survival distribution was estimated using the product-limit method. Multivariate survival analyses were performed using proportional hazards regression and by recursive partitioning. RESULTS Nine hundred seventy-seven patients were diagnosed with unknown-primary carcinoma (UPC) and 337 of these patients had PDC or PDA. No clinical differences were identified among patients with PDC, PDA, or UPC patients with other carcinoma or adenocarcinoma subtypes. PDC patients enjoyed better survival than PDA patients. Poor cellular differentiation was not an important prognostic variable. Variables predictive of survival included lymph node metastases, sex, number of metastatic sites, histology (PDC v PDA), and age. Although chemotherapy did not appear to influence survival for the entire group of PDC or PDA patients, a subset of patients with good prognostic features experienced median survival durations of up to 40 months. CONCLUSION The long median survival and chemotherapy responsiveness of UPC patients with PDC and PDA could not be confirmed. However, subpopulations with prolonged median survival durations could be defined, and the value of chemotherapy in this group remains to be determined. Identification and exclusion of treatable or slow-growing malignancies may account for the poor survival of the PDC and PDA patients reported in this study.

scholarly journals Lung Cancer with Skin and Breast Metastasis: A Case Report and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Bikash Bhattarai ◽  
Marie Frances Schmidt ◽  
Meenakshi Ghosh ◽  
Abhisekh Sinha Ray ◽  
Saveena Manhas ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Primary Lung Cancer ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Patients At Risk ◽  
Poorly Differentiated ◽  
Unclear Etiology

Lung cancer is one of the most common cancers in America. Frequent sites of metastasis include the Hilar lymph nodes, adrenal glands, liver, brain, and bone. The following case report is of a primary lung cancer with metastases to the breast and skin.Case. A 48-year-old African American male with a past medical history of poorly differentiated left breast cancer status after modified radical mastectomy (MRM), chronic obstructive pulmonary disease, and smoking (20 pack-years) presents to the ER with progressive shortness of breath on exertion, upper back pain, and weight loss for 2 months in duration. On physical examination he is found to have a MRM scar on his left breast and a left periumbilical cutaneous mass. Chest X-ray and chest CT reveal a right upper lobe mass and biopsies from the breast, lung, and the periumbilical mass indicate a poorly differentiated carcinoma of unclear etiology; all tumor markers are negative. The patient is male and a chronic smoker; therefore the diagnosis is made as lung carcinoma with metastases to the breast and skin.Conclusion. A high index of suspicion for cutaneous metastases should be cast when investigating cutaneous pathologies in patients at risk for primary lung malignancy.

scholarly journals P3.04-046 Cases of Surgical Resection of Post-Operative Lymph Node Recurrences from Primary Lung Cancer

2017 ◽  
Vol 12 (1) ◽  
pp. S1411-S1412
Author(s):  
Ema Mitsui ◽  
Masafumi Kataoka ◽  
Daisuke Okutani ◽  
Haruyuki Kawai ◽  
Kazuhiko Watanabe ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Surgical Resection ◽  
Primary Lung Cancer
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