Trapeziometacarpal joint arthritis: A retrospective study of the natural history of symptomatic thumb arthritis

Objective: Trapeziometacarpal (TM) joint arthritis is a common source of hand pain in patients presenting to the hand surgeon’s clinic. Long-term data on the natural history of symptomatic TM arthritis is lacking.Methods: We identified 251 patients with symptomatic TM arthritis and performed a retrospective chart review which identified treatment modalities (including surgery) and long term outcomes which were assessed via a telephone survey.Results: We found that of the 251 patients who presented with symptomatic TM arthritis, the 114 patients who had surgery had less pain and disability in the long term than those patients who were treated conservatively with splinting or injection (average pain score 1.8 vs. 3.8). However, the majority of patients did not ultimately undergo surgery.Conclusions: Although patients fare better from a pain and function standpoint with surgery, surgery is not inevitable.

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Management of isolated calf vein thrombosis in cancer patients

Vascular ◽

10.1177/1708538115584726 ◽

2015 ◽

Vol 24 (1) ◽

pp. 64-69

Author(s):

Anand S Brahmandam ◽

Kirstyn Brownson ◽

Laura Skrip ◽

Terri Parker ◽

Jeffrey Indes ◽

...

Keyword(s):

Risk Factors ◽

Cancer Patients ◽

Chart Review ◽

Retrospective Chart Review ◽

Treatment Modalities ◽

Vein Thrombosis ◽

History Of ◽

Calf Vein ◽

History Of Cancer

The treatment of isolated calf vein thrombosis remains widely debated. This study highlights the characteristics of isolated calf vein thrombosis in cancer patients and compares to isolated calf vein thrombosis in patients without history of cancer. Between July 2013 and April 2014, a retrospective chart review of consecutive patients with isolated calf vein thrombosis was performed recording patient risk factors, ultrasound characteristics of the thrombus, treatment modalities, long-term recurrence of venous-thromboembolism, incidence of bleeding, and mortality. Of 131 patients with isolated calf vein thrombosis, 53 (40.1%) had history of cancer. Isolated calf vein thrombosis occurred at an older age in cancer patients (66.7 vs 58.5 years, p = 0.004). The anatomical characteristics of isolated calf vein thrombosis on ultrasound were comparable in both groups. Isolated calf vein thrombosis in cancer patients was less likely to be treated with anticoagulation (60.4% vs 80.8%, p = 0.018). However, a trend towards higher incidence of bleeding after initiation of anticoagulation for isolated calf vein thrombosis in cancer patients (11.3% vs 6.4%, p = 0.351) was noted. Mortality in cancer patients was higher (37.7% vs 9.00%, p < 0.001) but was unrelated to isolated calf vein thrombosis or its treatment. In conclusion, the risks of bleeding seem to exceed the benefits of anticoagulation in approximately 50% of cancer patients with isolated calf vein thrombosis. The management of isolated calf vein thrombosis does not seem to impact the survival of cancer patients.

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The natural history of pituitary apoplexy: long term follow-up study

Endocrine Abstracts ◽

10.1530/endoabs.65.p301 ◽

2019 ◽

Author(s):

Ayesha Shaikh ◽

Natasha Shrikrishnapalasuriyar ◽

Giselle Sharaf ◽

David Price ◽

Maneesh Udiawar ◽

...

Keyword(s):

Natural History ◽

Pituitary Apoplexy ◽

Follow Up Study ◽

Long Term Follow Up ◽

History Of

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Faculty Opinions recommendation of Natural history of imatinib-naive GISTs: a retrospective analysis of 929 cases with long-term follow-up and development of a survival nomogram based on mitotic index and size as continuous variables.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13356067.14726207 ◽

2011 ◽

Author(s):

Richard Riedel

Keyword(s):

Natural History ◽

Retrospective Analysis ◽

Mitotic Index ◽

Continuous Variables ◽

Long Term Follow Up ◽

History Of

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Long-term Natural History of Dry Eye Disease from the Patient's Perspective

Ophthalmology ◽

10.1016/j.ophtha.2015.10.011 ◽

2016 ◽

Vol 123 (2) ◽

pp. 425-433 ◽

Cited By ~ 23

Author(s):

Jeffrey P. Lienert ◽

Laura Tarko ◽

Miki Uchino ◽

William G. Christen ◽

Debra A. Schaumberg

Keyword(s):

Natural History ◽

Dry Eye ◽

Dry Eye Disease ◽

Eye Disease ◽

Patient’S Perspective ◽

History Of

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The Natural History of Long-Term Cardiac Pacing

The Annals of Thoracic Surgery ◽

10.1016/s0003-4975(10)63700-9 ◽

1977 ◽

Vol 23 (6) ◽

pp. 550-554 ◽

Cited By ~ 10

Author(s):

William S. Stoney ◽

Frederick E. Finger ◽

William C. Alford ◽

George R. Burrus ◽

Robert A. Frist ◽

...

Keyword(s):

Natural History ◽

Cardiac Pacing ◽

History Of

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Effects of long-term chloroquine administration on the natural history of aortic aneurysms in mice

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2015-0068 ◽

2015 ◽

Vol 93 (8) ◽

pp. 641-648 ◽

Cited By ~ 8

Author(s):

Azza Ramadan ◽

Mark D. Wheatcroft ◽

Adrian Quan ◽

Krishna K. Singh ◽

Fina Lovren ◽

...

Keyword(s):

Natural History ◽

Thrombus Formation ◽

Aortic Aneurysms ◽

Ang Ii ◽

Abdominal Aortic ◽

Suprarenal Aorta ◽

History Of ◽

Categorical Distribution

Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of murine abdominal aortic aneurysms (AAA). ApoE−/− mice were implanted with saline- or angiotensin II (Ang-II)-filled miniosmotic pumps then treated with either the autophagy inhibitor chloroquine (CQ; 50 mg·(kg body mass)–1·day–1, by intraperitoneal injection) or saline. Ang-II-elicited aneurysmal expansion of the suprarenal aorta coupled with thrombus formation were apparent 8 weeks later. CQ had no impact on the incidence (50% for Ang-II compared with 46.2% for Ang-II + CQ; P = NS) and categorical distribution of aneurysms. The markedly reduced survival rate observed with Ang-II (57.1% for Ang-II compared with 100% for saline; P < 0.05) was unaffected by CQ (61.5% for Ang-II + CQ; P = NS compared with Ang-II). CQ did not affect the mean maximum suprarenal aortic diameter (1.91 ± 0.19 mm for Ang-II compared with 1.97 ± 0.21 mm for Ang-II + CQ; P = NS). Elastin fragmentation, collagen accumulation, and smooth muscle attrition, which were higher in Ang-II-treated mice, were unaffected by CQ treatment. Long-term CQ administration does not affect the natural history and prognosis of experimental AAA, suggesting that global loss of autophagy is unlikely to be a causal factor in the development of aortic aneurysms. Manipulation of autophagy as a mechanism to reduce AAA may need re-evaluation.

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