Clinicopathological correlation of serum prostate specific antigen levels in patients of prostatomegaly in a tertiary care hospital

Prostate Specific Antigen (PSA) has become the most commonly used tumour marker for prostate cancer. Studies have suggested that age specific cutoff values for PSA screening are better than the currently used standard cutoff of 4.0ng/ml and different races have their own reference ranges. The objective of this study was to measure the PSA values of elderly individuals attending a tertiary care centre in southern India and postulate the possible normal values of PSA in different age groups of elderly. A total of 1038 males over the age of 60 years presenting to the Elderly Comprehensive Health clinic at the Department of Geriatrics of a tertiary hospital in Southern India between March 2009 and February 2011were studied. 4ml blood was collected and PSA was estimated by Chemiluminiscent Micro-particle Immunoassay. PSA values were analyzed in terms of mean, standard deviation and 5th and 95th percentiles. Results showed that 5th and 95th percentile values were 0.27 and 3.82 among those who were 60-69 years, 0.28 and 3.43 among those who were 70-79 years and 0.26 and 3.95 among those who were more than 80 years. 10 % of the elderly population in all age subsets had PSA values over the normal. This study showed that the PSA values from South India are similar to the expected. The age specific Indians being ethnically distinct, need to have separate PSA reference ranges which need to be established with large community-based multicentre Indian studies.

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Clinicopathological correlation of ovarian tumors in a tertiary care hospital

Indian Journal of Pathology and Oncology ◽

10.18231/2394-6792.2018.0062 ◽

2018 ◽

Vol 5 (2) ◽

pp. 332-337

Keyword(s):

Tertiary Care Hospital ◽

Tertiary Care ◽

Ovarian Tumors ◽

Care Hospital ◽

Clinicopathological Correlation

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Serum ferritin and iron profile in helicobacter pylori infected young adult male reporting at a tertiary care hospital

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.06.3591 ◽

2019 ◽

Vol 26 (06) ◽

Author(s):

Arshad ◽

Suresh Kumar ◽

Bilawal Hingorjo ◽

Nathumal Maheshwari ◽

Rewachand ◽

...

Keyword(s):

Helicobacter Pylori ◽

Young Adult ◽

Adult Male ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Specific Antigen ◽

Care Hospital ◽

Young Adult Male ◽

H Pylori ◽

Iron Profile

Objectives: Determination of serum ferritin and iron profile in Helicobacter pylori infected young adult male reporting at a tertiary care hospital of Sindh. Study Design: Case control study. Study Setting & Duration: Department of Medicine, Layari General Hospital Shaheed Muhtrama Benazir Bhutto Medical College from January 2015 to February 2016. Study Subjects and Methods: 100 cases (H. pylori stool specific antigen positive) and 100 controls (H pylori negative) were selected and studied. 5 ml blood was collected in a disposable syringe by venesection. 2 ml was put in EDTA tubes and 3 ml was centrifuged (3000 x rpm for 10 minutes). Sera were used for the estimation of iron profile. Elisa assay method (Fortress diagnostics) detected the H. pylori stool specific antigen (HpSA). Data was analyzed on SPSS 22.0 (USA) at 95% CI (P≤ 0.05). Results: Age of control and cases was noted 35.48±4.79 and 33.60±3.96 years (P=0.053). Hb, Hct and RBC counts were low in cases (P=0.0001) significantly. Serum iron (Fe++), ferritin and TIBC in controls and cases were noted 152.72±6.08 and 118.79±43.30 μg/dl, 394.34±136.50 and 529.87±101.0 ng/dl, & 140.80±19.99 and 130.88±28.46 μg/dl respectively (P=0.0001) (Table-I). Conclusion: Helicobacter pylori infection causes iron malabsorption as detected by serum iron and ferritin and total iron binding capacity in young adult male.

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