scholarly journals Correlation of hs-CRP with environmental risk factors of nephropathy in type 2 diabetes

2015 ◽  
Vol 2 (2) ◽  
pp. 217
Author(s):  
Jay Sah ◽  
Chandra Yadav ◽  
Dipendra Yadav ◽  
Md salauddin
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Hs Crp

scholarly journals Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Meng Cui ◽  
Yumin Gao ◽  
Yanping Zhao ◽  
Hui Pang ◽  
Le Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Environmental Risk ◽  
Gene Polymorphisms ◽  
Central Obesity ◽  
Environmental Risk Factors ◽  
Adiponectin Gene

Objective. The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at providing approaches for the prevention and control of T2DM in combination with the characteristics of the local population. Methods. A case-control study was conducted including 406 Chinese participants, comprising 203 cases and 203 controls from various hospitals. Adiponectin (ADIPOQ) gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were detected using an improved multiple ligation detection reaction technique. Generalized multifactor dimensionality reduction (GMDR) and logistic regression were conducted to analyze the associations between adiponectin gene polymorphisms and T2DM, as well as the interactions between adiponectin gene polymorphisms and environmental factors. Results. ADIPOQ gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were associated with type 2 diabetes. Based on the haplotype of the five adiponectin gene single-nucleotide polymorphism (SNP) loci, we found that G-G-A-A-C was a susceptible haplotype of T2DM (P<0.05). Interaction analyses demonstrated associations between rs1501299 and central obesity (consistency=80%, P=0.011) and between rs266729 and rs182052 and central obesity (consistency=70%, P=0.011). Conclusions. Our findings indicate that there is an interaction between the ADIPOQ gene and central obesity, which provides new insights into the prevention and treatment of T2DM.

scholarly journals Predicting type 2 diabetes using genetic and environmental risk factors in a multi-ethnic Malaysian cohort

Public Health ◽  
2017 ◽  
Vol 149 ◽  
pp. 31-38 ◽  
Author(s):  
N. Abdullah ◽  
N.A. Abdul Murad ◽  
E.A. Mohd Haniff ◽  
S.E. Syafruddin ◽  
J. Attia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Environmental Risk ◽  
Environmental Risk Factors

scholarly journals Environmental risk factors of type 2 diabetes—an exposome approach

Diabetologia ◽  
2021 ◽  
Author(s):  
Joline W. J. Beulens ◽  
Maria G. M. Pinho ◽  
Taymara C. Abreu ◽  
Nicole R. den Braver ◽  
Thao M. Lam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Environmental Risk ◽  
Environmental Risk Factors

Genistein supplementation improves some cardiovascular risk factors in postmenopausal women with Type 2 diabetes mellitus

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Hassan Braxas ◽  
Maryam Rafraf ◽  
Saadat Karimi Hasanabad ◽  
Mohammad Asghari Jafarabadi
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Placebo Group ◽  
Postmenopausal Women ◽  
Serum Levels ◽  
Content Type ◽  
Hs Crp

Purpose Type 2 diabetes mellitus (T2DM) is a worldwide health problem. Blood pressure (BP) and inflammation are well-established risk factors for the cardiovascular complications of T2DM. Genistein is known to improve endothelial dysfunction. The purpose of this study is to investigate the effects of genistein supplementation on BP, high-sensitive C-reactive protein (hs-CRP) and homocysteine (Hcy) levels in postmenopausal women with T2DM. Design/methodology/approach This randomized, double-blind, placebo-controlled clinical trial is conducted on postmenopausal women with T2DM. A total of 54 subjects aged between 47 and 69 years are divided into two groups. Participants in the genistein group (n = 28) are given two genistein capsules (each capsule contained 54 mg genistein) and those in the placebo group (n = 26) received two placebo capsules (each capsule contained 54 mg maltodextrin) daily for 12 weeks. General characteristics, BP, hs-CRP and Hcy levels are measured at the baseline and at the end of the trial. Findings Genistein supplementation resulted in a significant reduction in systolic BP (SBP) (p < 0.001), diastolic BP (DBP) (p = 0.020), mean arterial pressure (MAP) (p < 0.001), serum levels of hs-CRP (p = 0.005) and Hcy (p = 0.001) in genistein group compared with placebo group at the end of the study. Significant decreases are also found in SBP by 5.4%, p < 0.001, DBP by 6.7%, p < 0.001, MAP by 6.2%, p < 0.001, serum levels of hs-CRP by 47.0%, p = 0.015 and Hcy by 18.4%, p < 0.001 in the genistein supplemented group. No significant changes are observed in terms of all post-intervention values in the placebo group. Originality/value Genistein administration improved BP, hs-CRP and Hcy levels in postmenopausal women with T2DM and may be useful in control of some CVD risk factors in these subjects.

Summary

ESC CardioMed ◽  
2018 ◽  
pp. 3099-3099
Author(s):  
Thomas Münzel ◽  
Sanjay Rajagopalan ◽  
Mette Sørensen ◽  
Dave Newby ◽  
Robert D. Brook
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Air Pollution ◽  
Environmental Risk ◽  
Traffic Noise ◽  
Traditional Risk Factor ◽  
Environmental Risk Factors ◽  
Epidemiologic Evidence ◽  
Traditional Risk Factors

Environmental risk factors are increasingly being recognized as important determinants of cardiovascular disease. While the contribution of diet, exercise, and smoking are well understood, the contribution to cardiovascular disease by factors such as chemical pollutants, noise, and air pollution are not frequently acknowledged, despite the recognition that noise and air pollution together represent the two most important environmental risk factors in urbanized societies. This chapter discusses the epidemiologic evidence in support of an association between noise and air pollution with cardiovascular and metabolic disease. Recent studies also suggest that the two exposures may synergize with each other and with traditional risk factors such as hypertension and type 2 diabetes. From a societal and policy perspective, the health effects of both air pollution and traffic noise are observed for exposures well below the thresholds currently accepted as being safe. Current gaps in knowledge, effects of intervention, and their impact on cardiovascular disease, are discussed. Increased awareness of the societal burden posed by these novel risk factors and acknowledgement in traditional risk factor guidelines may intensify the efforts required for effective legislation to reduce air pollution and noise.

scholarly journals High Sensitivity C-Reactive Protein as Atherogenic Marker Among Type 2 Diabetes

2017 ◽  
Vol 13 (33) ◽  
pp. 403
Author(s):  
Abdelmarouf H. Mohieldein ◽  
Marghoob Hasan ◽  
Mahmoud I. El-Habiby
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Diabetic Patients ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Vascular Events ◽  
Apo B ◽  
Hs Crp

Background: People with type 2 diabetes are threefold affected by cardiovascular disease (CVD) compared with non-diabetics. Many studies reported the absence of traditional CVD risk factors in a substantial portion of individuals experiencing clinical vascular events. Novel risk markers for CVD are often said to add independent predictive value for risk prediction. Objective: In the present study we evaluated different CVD risk factors based on highsensitivity C-reactive (hs- CRP) protein quartiles among diabetics and nondiabetics population. Methods: In this population- based cross- sectional study, we recruited a total of onehundred and nine participants (64 type 2 diabetics and 45 healthy controls). Venous blood sample collected from each subject. Body weight and height were measured and body mass index (BMI) was calculated. Biochemical analytes were measured according to standard procedures. Data analyzed using SPSS software. Results: Mean serum hs-CRP levels were significantly higher among diabetics (2.3 mg/l) compared to controls (1.8 mg/l; P = 0.019). Moreover, the 3rd & 4th quartiles of hs-CRP were characterized by more frequency of diabetes as well as hypertension. The percent of participants with diabetes or hypertension seemed positively related to hs CRP concentrations. Lipid profile analysis revealed the highest levels of LDL-C and Apo B in 4th quartile hs-CRP. In addition, participants in the 4th quartile hs-CRP were characterized by the highest age, BMI, plasma glucose. However, there was European Scientific Journal November 2017 edition Vol.13, No.33 ISSN: 1857 – 7881 (Print) e - ISSN 1857- 7431 404 no clear association between levels of hs-CRP and the HbA1c, TC, TG, HDL-C, and Apo A1. Conclusion: Measurement of hs-CRP in diabetic patients might provide useful information for development of atherosclerosis and cardiovascular disease and help in early intervention.

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