Prevalence and antibacterial drug sensitivity pattern of Pseudomonas aeruginosa in tertiary care hospital in Jamnagar region, Gujarat, India

Pseudomonas aeruginosa is one of the most widespread gram-negative microorganisms identified in the clinical samples and most common causes of hospital acquired infection. P. aeruginosa is affecting both indoor and outdoor patients throughout the world. Due to frequent mutation in P. aeruginosa highly resistant strain developed rapidly. The aim of the study to determine the prevalence of P. aeruginosa species in different samples isolated from a Tertiary care Hospital as well as determination their diverse antibiotic resistance pattern. This cross-sectional study was carried out to determine in-vitro resistance pattern of P. aeruginosa isolates to common antimicrobial agents by disc diffusion method. Various clinical samples were collected from Bangladesh Health Sciences Hospital (BIHS) General Hospital, Dhaka. This research was carried out in the Department of Microbiology of Bangladesh University of Health Sciences (BUHS). Isolation, identification and antibiogram were performed for P. aeruginosa following standard microbiological laboratory procedure. A total of 218 P. aeruginosa were isolated from 3062 different clinical specimens which are statistically significant (p<0.0001). Among the highest number of P. aeruginosa were isolated from outdoor patients 140 compare to Indoor patients which are significantly higher (p <0.013). In this study Male (68.3%) are more vulnerable to P. aeruginosa infection compare to females (31.7%) which is also statistically significant. Young people (less than 35 years) were more susceptible to P. aeruginosa infection which is also statistically significant (p< 0.01). The highest number of P. aeruginosa was isolated from wound (43.12%), followed by pus (40.33%), sputum (8.71%) urine (7.80%). The maximum number of P. aeruginosa in various samples was resistant to aztreonam and co-tromoxazole followed by cephalosporins, aminoglycosides, carbapenems. The most sensitive antibiotic was colistin of followed by gentamycin and tetracycline. To control the spread of resistant bacteria, it is disparagingly vital to have stringent antibiotic guidelines. The antibiotic susceptibility pattern of P. aeruginosa requires to be continuously monitored in specialized clinical units and the results readily made available to the clinicians to minimize the resistance.

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Bacteriological Profile & Drug Sensitivity Pattern of Burn Wound Infections in a Tertiary Care Hospital of Rajkot, Gujarat

Indian Journal of Medical Microbiology ◽

10.1016/j.ijmmb.2021.08.184 ◽

2021 ◽

Vol 39 ◽

pp. S53-S54

Author(s):

Shaili Mukesh Jethva ◽

Sejul Antala

Keyword(s):

Drug Sensitivity ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Wound Infections ◽

Burn Wound ◽

Bacteriological Profile ◽

Sensitivity Pattern

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A descriptive study to assess the drug sensitivity pattern to antitubercular drugs in patients visiting department of respiratory medicine at a tertiary care hospital at Western Maharashtra

The Journal of Community Health Management ◽

10.18231/2394-2738.2018.0024 ◽

2018 ◽

Vol 5 (2) ◽

pp. 106-109

Keyword(s):

Drug Sensitivity ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Descriptive Study ◽

Respiratory Medicine ◽

Care Hospital ◽

Antitubercular Drugs ◽

Sensitivity Pattern

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Therapeutic guidelines for antimicrobial use in chronic suppurative otitis media for a tertiary care hospital in Sub Himalayan region

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20180652 ◽

2018 ◽

Vol 7 (3) ◽

pp. 416

Author(s):

Sushma Sawaraj ◽

Sunder Singh Dogra ◽

Dinesh Kansal ◽

Kamlesh Thakur ◽

Parveen Kumar Sharma

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Otitis Media ◽

Antimicrobial Therapy ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Chronic Suppurative Otitis Media ◽

Care Hospital ◽

Suppurative Otitis Media ◽

Sensitivity Pattern

Background: The battle against micro-organisms, in their role as primary cause of the disease and infective complications of medical and surgical techniques, has not decreased in spite of modern antimicrobial therapy. Chronic suppurative otitis media (CSOM) is a disease with worldwide prevalence having potentially serious long term effects. The disease remains an important global public health problem leading to hearing impairment, and due to wide spread irrational use microbial resistance is very common to these antibiotics, thereby leading to treatment failure. Hence it is important to know the type of bacteria and their sensitivity pattern so that appropriate antibiotics may be given for treatment and prevention of complications.Methods: 428 patients of otitis media were enrolled from ENT OPD of Tertiary Care Hospital. Ear swab was taken from diagnosed cases of CSOM and culture and sensitivity were done.Results: The microbiology of the swab showed no growth in (25.4%) of samples. Staphylococcus aureus (26%) and Pseudomonas (25%) were the main organisms isolated. Staphylococcus aureus isolated was sensitive to vancomycin, clindamycin, cefixime, gentamicin and cefipime in descending order. Pseudomonas aeruginosa was sensitive to ceftazidime, imipenem, piperacillin, gentamicin, cefipime. In the present study Staph. aureus and Pseudomonas were the predominant bacteria, it is suggested to undertake a gram staining in all patients. If gram positive organisms are isolated it is suggested that presumptive treatment should be directed against Staphylococcus aureus and if gram negative then against Pseudomonas aeruginosa. Such a treatment is not only likely to be effective but will also go a long way in preventing emergence of drug resistance.Conclusions: The antimicrobial therapy should be based on locally determined microbiological isolates and local sensitivity patterns to a particular antimicrobial agent. The presumptive antimicrobial therapy should therefore be directed against these organisms.

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