Serum uric acid and its relation to adenosine deaminase, lipid profile and oxidative stress in Diabetes Mellitus type 2

Incidence of diabetes mellitus type 2 has been increasing worldwide, making the disease of extreme importance. Several reports have suggested a possible association between serum levels of uric acid (SUA) and higher incidence of diabetes mellitus type 2. On a biological basis, uric acid can negatively affect insulin resistance in animals. This occurs due to the inhibition of nitric oxide which is crucial to achieve glucose uptake. In this study, we aim to: report on previous literature on relation between serum uric acid and diabetes type II in Saudi and prevalence of association between them. PubMed database and EBSCO Information Services were used for articles selection. All relevant articles to our review with the topics regarding the relation between serum uric acid and diabetes type II, and other articles have been used. We excluded other articles, which are not related to this field. The data will be extracted according to specific form in which it is going to be reviewed by the group members. In this meta-analysis we found that SUA levels positively correlate with diabetes mellitus type 2. Future studies should try to determine the reliability of using SUA levels to predict diabetes mellitus type 2 and improve prevention.

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Relation of Serum Adenosine Deaminase to Some Risk Factors in Type 2 Diabetes Mellitus

Journal of Health Science Research ◽

10.18311/jhsr/2016/v1/i1/4726 ◽

2016 ◽

Vol 1 (1) ◽

pp. 13

Author(s):

Shashikala Magadi Dasegowda ◽

Ashok Kumar Jeppu ◽

Sushith ◽

Kavitha Ashok Kumar

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Uric Acid ◽

Lipid Profile ◽

Adenosine Deaminase ◽

Serum Uric Acid ◽

Glycated Haemoglobin ◽

Long Term Effects

Aim: Study was conducted to compare and correlate the levels of serum adenosine deaminase and serum uric acid with Fasting Plasmaglucose (FPG), Post Prandial Blood Sugar (PPBS) and glycated hemoglobin in type 2 diabetes mellitus. Materials and Method: Study group consisted of 60 diabetics and 50 age and sex matched healthy individuals. Blood sample was collected in fasting state and two hours after the food for estimation of serum Adenosine Deaminase (ADA), uric acid, parameters of lipid profile, fasting and postprandial glucose. Result: An increased level of serum ADA, FPG, PPBS, parameters of lipid profile and glycated haemoglobin in type 2 diabetes mellitus compared to controls. A statistically significant correlation was seen between serum ADA as well as serum uric acid with, Fasting Plasma Glucose (FPG), Post Prandial Blood Glucose (PPBS), glycated haemoglobin. Serum ADA had shown significant correlation with the Triglyceride (TG), Total Cholesterol (TC), Low Density Cholesterol (LDL cholesterol). A negative correlation was seen between serum ADA acid and High Density Lipoprotein cholesterol (HDL cholesterol). Conclusion: Adenosine deaminase and serum uric acid levels increased and positively correlated with parameters of lipid profile and glycemic control. This indicates that ADA and serum uric acid can serve as predictor of glycaemic index and help to monitor the long term effects of diabetes mellitus.

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The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes)

Diabetes & Metabolic Syndrome Clinical Research & Reviews ◽

10.1016/j.dsx.2019.01.040 ◽

2019 ◽

Vol 13 (2) ◽

pp. 1165-1172 ◽

Cited By ~ 22

Author(s):

Michael Halim ◽

Alice Halim

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Diabetes Mellitus Type 2 ◽

Diabetes Mellitus Type ◽

And Oxidative Stress

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The Effects of Coriander Seed Supplementation on Serum Glycemic Indices, Lipid Profile and Parameters of Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Clinical Trial

10.21203/rs.3.rs-262149/v1 ◽

2021 ◽

Author(s):

Sanaz Zamany ◽

Aida Malek Mahdavi ◽

Saeed Pirouzpanah ◽

Ali Barzegar

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Lipid Profile ◽

Serum Insulin ◽

Glycemic Indices ◽

And Oxidative Stress ◽

Coriander Seed

Abstract Background: This research aimed to study the effect of coriander seed supplementation on serum glycemic indices, lipid profile and oxidative stress parameters in patients with type 2 diabetes mellitus (T2DM).Methods: In this randomized double-blinded, placebo-controlled trial, eligible 40 T2DM patients aged 30-60 years were recruited from Sina Hospital (Tabriz, Iran) and randomly assigned into two groups to receive either coriander seed powder (1000 mg/day, n=20) or placebo (1000 mg/day, n=20) for 6 weeks. Anthropometric measurements, dietary intake, and biochemical parameters including fasting blood sugar (FBS), serum insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), total cholesterol (TC), triglyceride (TG), high- and low-density lipoprotein cholesterols (HDL-C and LDL-C), malondialdehyde (MDA), and total antioxidant capacity (TAC) were assessed before and after supplementation.Results: Anthropometric measurements were not significantly different between intervention and placebo groups. Coriander seed supplementation led to significant within-group reductions in FBS (156.15±23.19 to 130.30±21.15), serum insulin (17.72±0.47 to 17.12±0.76), HOMA-IR (6.82±0.95 to 5.52±0.99), TC (183.85±55.68 to 145.20±31.36), TG (152.50±37.59 to 130.40 ±27.96), LDL-C (127.35±23.45 to 111.40±25.71), and MDA (1.65±0.15 to 1.49±0.15), whereas there were significant increases observed in serum TAC (1.93±0.12 to 1.97±0.09) (P<0.05). Post-dose comparisons showed significant between-group differences for FBS, serum insulin, HOMA-IR, TC, TG, LDL-C, MDA, and TAC levels after adjusting for baseline values (P<0.05).Conclusions: Coriander seed supplementation was able to improve glycemic indices, lipid profile and oxidative stress status in T2DM and it may be useful complementary treatment in management of these patients.Trial registration: The study protocol was registered on the Iranian Registry of Clinical Trials website (IRCT20190224042821N2) on 2019/Oct/11.

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