Efficacy and safety of intravenous ferric carboxymaltose in iron deficiency anemia; Real-life data from Turkey, a single center experience

Background: Anemia is one of the common manageable problem among the pregnant women worldwide, which contributes to maternal and perinatal mortality. This study aims to compare the efficacy and safety of intravenous ferric carboxymaltose with intravenous iron sucrose in treating anemia during pregnancy. Objective of this study was to compare safety and efficacy of intravenous ferric carboxymaltose with intravenous ferric sucrose in iron deficiency anemia during pregnancy.Methods: It’s an interventional prospective study conducted in Department of Obstetrics and Gynecology at NIMS, Jaipur, Rajasthan, India constituting of 100 pregnant women. Group 1- 50 pregnant women were treated with intravenous ferric carboxymaltose and Group 2: 50 pregnant women were treated with intravenous iron sucrose. Hemoglobin and serum ferritin levels were measured pre and post treatment with parenteral iron therapy. The efficacy of intravenous ferric carboxymaltose in comparison to intravenous iron sucrose was assessed. The evaluation of safety and tolerance with the parenteral therapy was also performed.Results: Anemia during pregnancy was more prevalent among the reproductive age group and in multiparous women. The mean rise in the hemoglobin level with ferric carboxymaltose was 2.92 gm/dl and with that of iron, sucrose was 1.08 gm/dl. The man rise in the serum ferritin levels with ferric carboxymaltose was 64.97ng/ml and with iron sucrose was 31.64 ng/ml. Ferric carboxymaltose was observed to be safer with no adverse events in comparison to the Iron sucrose which was related with adverse events among 03 pregnant women.Conclusions: Intravenous ferric carboxymaltose was more efficacious and safer in comparison to intravenous iron sucrose among pregnant women. Hence, ferric carboxymaltose is the drug of choice in treatment of iron deficiency anemia during pregnancy.

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Third-line treatment with second-generation tyrosine kinase inhibitors (dasatinib or nilotinib) in patients with chronic myeloid leukemia after two prior TKIs: real-life data on a single center experience along with the review of the literature

Hematology ◽

10.1080/10245332.2017.1385193 ◽

2017 ◽

Vol 23 (4) ◽

pp. 212-220 ◽

Cited By ~ 5

Author(s):

Seniz Ongoren ◽

Ahmet Emre Eskazan ◽

Veysel Suzan ◽

Sercan Savci ◽

Isil Erdogan Ozunal ◽

...

Keyword(s):

Myeloid Leukemia ◽

Kinase Inhibitors ◽

Real Life ◽

Review Of The Literature ◽

Single Center ◽

Life Data ◽

Single Center Experience ◽

Real Life Data ◽

Third Line ◽

Third Line Treatment

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Endoscopy as an Investigation for Non-iron Deficiency Anemia: Single Center Experience

The American Journal of Gastroenterology ◽

10.14309/00000434-201710001-02716 ◽

2017 ◽

Vol 112 ◽

pp. S1475-S1476

Author(s):

Sravani Kamatam ◽

Olakunle A Jayeola ◽

Parvez Khambatta ◽

Keyvan Ravakhah

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Deficiency Anemia ◽

Single Center ◽

Single Center Experience

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Su1087 Ferric Carboxymaltose: Efficacy and Safety in Patients With Gastrointestinal-Related Iron Deficiency Anemia: A Pooled Analysis

Gastroenterology ◽

10.1016/s0016-5085(14)61336-6 ◽

2014 ◽

Vol 146 (5) ◽

pp. S-369

Author(s):

Gary R. Lichtenstein ◽

Andy He ◽

Stephen B. Hanauer ◽

Satish Keshav ◽

Jane E. Onken

Keyword(s):

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Pooled Analysis ◽

Deficiency Anemia ◽

Ferric Carboxymaltose ◽

Efficacy And Safety

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Efficacy and safety of ferric carboxymaltose in Indian pregnant women with iron deficiency anemia

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20214471 ◽

2021 ◽

Author(s):

Vidya Bhat ◽

Brunda Kiran ◽

Girish Deshmukh ◽

Ketan Kulkarni ◽

Ajinkya Rodge

Keyword(s):

Iron Deficiency ◽

Pregnant Women ◽

Iron Deficiency Anemia ◽

Real Life ◽

Hemoglobin Concentration ◽

Deficiency Anemia ◽

Ferric Carboxymaltose ◽

Mean Corpuscular Hemoglobin ◽

Open Label ◽

Fatigue Score

Background: Iron deficiency anemia (IDA) is a significant problem worldwide particularly in women. The aim of the study was to evaluate the effectiveness of intravenous ferric carboxymaltose (FCM) in in Indian pregnant women with anemia.Method: This was a single centre, prospective, observational, open label, clinical study at real life scenario with 4 weeks follow up. Fifty pregnant women with IDA and visiting to the Radhakrishna multispecialty hospital, Bangalore, for antenatal care were enrolled for the study. IV FCM was given as per the standard protocol. Change in the laboratory parameters such as hemoglobin, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), packed cell volume (PCV) level at baseline and after 4 weeks of completion of parenteral iron therapy was recorded and fatigue score was assessed. The pregnant women were monitored for the adverse events. Results: All pregnant women received a single IV infusion of FCM 1000 mg. A significant increase in the hemoglobin of 2.37±0.51 g/dl (p<0.001) was noted at 4 weeks, MCV rise of 19.89±21.94 (p<0.001) was noted at 4 weeks, MCHC rise was of 2.56±5.65 and PCV rise was of 4.45±2.67 (p<0.011) at over 4 weeks. Significant improvement in fatigue score was observed at 4 weeks after single FCM infusion. No adverse effects were observed in any pregnant woman throughout the duration of the study.Conclusions: This real-life observational study highlights IV FCM is effective in management of IDA in pregnant women and well tolerated. Trial registration number: CTRI/2021/02/030874

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Advantages of Tailored Isotretinoin Treatment in Moderate to Severe Acne: Real-Life Data

Frontiers in Pharmacology ◽

10.3389/fphar.2021.733526 ◽

2021 ◽

Vol 12 ◽

Author(s):

Nevena Skroza ◽

Ersilia Tolino ◽

Veronica Balduzzi ◽

Nicoletta Bernardini ◽

Alessandra Mambrin ◽

...

Keyword(s):

Dose Adjustment ◽

Systemic Treatment ◽

Real Life ◽

Efficacy And Safety ◽

Single Center ◽

Severe Acne ◽

Life Data ◽

Real Life Data ◽

Single Center Study ◽

Center Study

This retrospective single-center study analyzes the efficacy and safety of isotretinoin for the treatment of moderate to severe acne in real-life clinical practice, particularly with regard to acne severity, isotretinoin cumulative dosage, and patients’ gender. The results suggest the opportunity of an early isotretinoin systemic treatment in patients affected by moderate acne and emphasize the importance of an appropriate dose adjustment in order to minimize adverse events.

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