A randomized, open-label, comparative study of efficacy of low-dose continuous versus low-dose intermittent oral isotretinoin therapy in moderate-to-severe acne vulgaris

2017 ◽  
pp. 1
Author(s):  
Santoshkumar Shetti ◽  
Nagesh HN ◽  
Nagabushan Hanumantharaya
Keyword(s):  
Comparative Study ◽  
Low Dose ◽  
Acne Vulgaris ◽  
Open Label ◽  
Severe Acne ◽  
Oral Isotretinoin ◽  
Isotretinoin Therapy

scholarly journals Standard daily dosage versus pulse dosage of Isotretinoin in acne vulgaris: A hospital based comparative study

2018 ◽  
Vol 7 (2) ◽  
pp. 68-74
Author(s):  
Eliz Aryal ◽  
SB Shrestha ◽  
G Pokhrel ◽  
S Bhattarrai
Keyword(s):  
Side Effects ◽  
Comparative Study ◽  
Acne Vulgaris ◽  
College Teaching ◽  
Poor Response ◽  
Lumbosacral Spine ◽  
Daily Regimen ◽  
Severe Acne ◽  
Pulse Dose ◽  
Oral Isotretinoin

Background: Acne is a multi factorial disease ranging from a couple of comedones and pustules to severe nodulocystic fulminantacne. Isotretinoin (13-cis-retinoic-acid) drug affect all the factors involved in pathogenesis of acne and approved by Food and Drug Administration in 1982. It causes several dose-dependent mucocutaneous and systemic side effects and cost effectObjective: To assess and compare the efficacy and tolerability of two regimens (daily conventional and pulse dose) in moderate to severe acne vulgaris.Methodology: This is a prospective randomized comparative study in moderate to severe acne vulgaris in Kathmandu Medical College Teaching Hospital. The patients were randomly divided into two groups (A and B). In group A conventional dose of 20 mg of oral isotretinoin was given daily and in group B 20 mg of oral isotretinoin was given thrice (Pulse Dosage in alternate day) in a week for six months. The baseline haematological, biochemical and radiological (lumbosacral spine) was compare on first, third and six month.Results: Seventy-four patients were enrolled with mean age of 21.73 years. Patients with daily regimen show good response throughout the therapy for six months (1st, 3rd 6th months), where as those in pulse therapy show moderate to poor response during early month and gradually improve by end of sixth month. At end of sixth month, both the regimen show good response and was statistically significant.Conclusion: However, the pulse dose regimen makes the treatment more acceptable, for patients with acne than the classical standard daily regimen, in term of side effects and cost effectiveness and patient compliance. Journal of Kathmandu Medical CollegeVol. 7, No. 2, Issue 24, Apr.-Jun., 2018, Page: 68-74

scholarly journals A randomized comparative trial of two low-dose oral isotretinoin regimens in moderate to severe acne vulgaris

2016 ◽  
Vol 7 (5) ◽  
pp. 378 ◽  
Author(s):  
DaulatRam Dhaked ◽  
RamSingh Meena ◽  
Anshul Maheshwari ◽  
UmaShankar Agarwal ◽  
Saroj Purohit
Keyword(s):  
Low Dose ◽  
Acne Vulgaris ◽  
Comparative Trial ◽  
Severe Acne ◽  
Dose Oral ◽  
Oral Isotretinoin

Low-dose oral isotretinoin therapy in lichen planus pigmentosus: an open-label non-randomized prospective pilot study

2016 ◽  
Vol 55 (9) ◽  
pp. 1048-1054 ◽  
Author(s):  
Sendhil Kumaran Muthu ◽  
Tarun Narang ◽  
Uma N. Saikia ◽  
Amrinder Jit Kanwar ◽  
Davinder Parsad ◽  
...  
Keyword(s):  
Pilot Study ◽  
Lichen Planus ◽  
Low Dose ◽  
Open Label ◽  
Prospective Pilot Study ◽  
Dose Oral ◽  
Oral Isotretinoin ◽  
Isotretinoin Therapy

The effect of continuous high versus low dose oral isotretinoin regimens on dermcidin expression in patients with moderate to severe acne vulgaris

2018 ◽  
Vol 31 (6) ◽  
pp. e12715 ◽  
Author(s):  
Magdy Abd El Aziz Ragab ◽  
Salma Samir Omar ◽  
Andrew Collier ◽  
Reham Abdel Haleem Abo El-Wafa ◽  
Neveen Gomaa
Keyword(s):  
Low Dose ◽  
Acne Vulgaris ◽  
Severe Acne ◽  
Dose Oral ◽  
Oral Isotretinoin

scholarly journals Open label multi-centre trial on efficacy and tolerability of microionized isotretinion therapy in treatment of moderate to severe acne vulgaris

2020 ◽  
Vol 7 (1) ◽  
pp. 7
Author(s):  
Bela Shah ◽  
Neha Jangid ◽  
Aswini A. Naidu
Keyword(s):  
Acne Vulgaris ◽  
Open Label ◽  
Total N ◽  
Severe Acne ◽  
Drug Tolerability ◽  
Satisfactory Outcome ◽  
United States Food ◽  
States Food ◽  
Us Fda ◽  
Isotretinoin Therapy

<p class="abstract"><strong>Background:</strong> Isotretinion was approved by United States Food and Drug Administration (US FDA) in 1982 for the treatment of severe recalcitrant nodulocystic acne. Its conventional recommended dose has been 0.5-1.0 mg/kg body weight per day for 16-32 weeks, with a maximum cumulative dose of 120 mg/kg. Objective of the study was to assess the efficacy and tolerability of 24 week of once daily micronized isotretinoin therapy in the treatment of moderate to severe acne vulgaris was conducted.</p><p class="abstract"><strong>Methods:</strong> Total n=580 of patients were included with 249 (43%) male and 331 (57%) females. Patients were assessed at baseline 6, 12 and 24 weeks and 12 weeks post treatment follow-up based on the assessment of severity of acne vulgaris using global acne grading system (GAGS), assessment of improvement in lesion counts, global assessment of overall efficacy by doctor (based on overall assessment) and by patients (based on overall relief in symptoms) and overall assessment of drug tolerability.<strong></strong></p><p class="abstract"><strong>Results:</strong> In terms of improvement in lesions, excellent results from 4% (22) in week 6th has move to 34% (193) in week 24th. In terms of global efficacy examined by doctors, very effective results i.e. 40% (234) in 12th week has moved to 70% (403) in 24th week. In terms of drug tolerability, excellent results have moved from 119 patients to 190 patients by end of the study.</p><p class="abstract"><strong>Conclusions:</strong> Hence the micronized isotretinoin therapy had overall satisfactory outcome in the treatment of patients with moderate to severe acne vulgaris (grade 2, 3 and 4).</p>

scholarly journals Comparative Efficacy and Safety of Low Dose versus High Dose Isotretinoin in Severe Acne Vulgaris Patients

2019 ◽  
Vol 8 (1) ◽  
pp. 18-22
Author(s):  
Maria Syed ◽  
Syed Afaq Ahmed
Keyword(s):  
Side Effects ◽  
Low Dose ◽  
Acne Vulgaris ◽  
High Dose ◽  
High Dose Regimen ◽  
Severe Acne ◽  
Dose Oral ◽  
Group A ◽  
Oral Isotretinoin ◽  
Group B

Background: Oral isotretinoin is the recommended treatment for acne vulgaris, a skin disease especially common in teenagers and adolescents. This study was designed to compare the efficacy and safety of low dose with high dose isotretinoin in severe acne vulgaris patients.Material and Methods: This randomized controlled trial included 110 patients with a clinical diagnosis of acne vulgaris. They were divided into two groups. Both groups were matched for age (mean 18.2±3.7 vs 17.6±3.2 years), weight (mean 58±10.2 vs 60.7±9.3 Kg), gender and disease duration (3±1.1 vs 3±1.0 years). Group A received low dose oral isotretinoin (20 mg/day) while group B received standard high dose regimen (1mg/kg/day). All patients were followed up for 16 weeks to assess efficacy (assessment of complete remission) and safety (mucocutaneous side effects). All calculations were performed using SPSS v. 16 with p value <0.05 considered as statistically significant.Results: There was no statistically significant difference in efficacy. However, significantly fewer mucocutaneous side effects were reported in group A (80%) as compared to group B (100%). This safety profile spectrum was observed across all pre-defined subsets i.e chielitis (78.1% vs 98.2%), dry skin (69.1% vs 92.7%), dry mouth (47.2% vs 72.7%) and facial rash (12.7% vs 30.9%).Conclusion: In patients with severe acne vulgaris, efficacy (complete remission) of low dose oral isotretinoin is almost equal to conventional high dose regimen but it is statistically superior in terms of safety (mucocutaneous side effects).

scholarly journals A randomized open label comparative study to determine the various side effects and patient satisfaction of low dose continuous versus low dose intermittent oral isotretinoin therapy in moderate to severe acne vulgaris

2018 ◽  
Vol 7 (6) ◽  
pp. 1169
Author(s):  
Santhosh A. Shetti ◽  
Nagesh H. N. ◽  
Nagabushan Hanumanthaiah
Keyword(s):  
Patient Satisfaction ◽  
Side Effects ◽  
Low Dose ◽  
Acne Vulgaris ◽  
Once Daily ◽  
Severe Acne ◽  
Treatment Regimens ◽  
Group A ◽  
Oral Isotretinoin ◽  
Group B

Background: Acne Vulgaris is chronic inflammatory disease of pilosebaceous units. Oral isotretinoin is recommended for moderate to severe acne vulgaris who are not responding satisfactorily to conventional therapies. Recent reports indicate that acne patients have been benefiting from the low dose treatment protocols. However, long term daily use of this drug results in frequent side effects such mucocutaneous and systemic side effects. Our aim was to assess and compare the various side effects and patient satisfaction of oral isotretinoin in low dose continuous and intermittent treatment of moderate to severe acne vulgaris.Methods: This was a prospective randomized open labeled comparative study carried out at outpatient department in the Department of Dermatology in Mandya Institute of Medical sciences, Mandya. Patients with moderate to severe acne were assigned equally (50 subjects each) to one of the two treatment regimens by using block randomization technique, Group A was given low dose continuous regimen-20 mg oral isotretinoin once daily for 4 months and Group B was given low dose intermittent regimen-20 mg oral isotretinoin once daily for 1 week out of every 4 weeks. The patients were followed up every 4th week during the treatment period. The patients were examined and side effects were noted in each visit. A six month follow-up evaluation was done to analyze patient satisfaction.Results: Muco-cutaneous dryness was most common adverse effect noted in both the groups A and B. Itching (42%), Alopecia (44%), Myalgia (36%) were seen most commonly in group A and Acne flaring (47%) was most common with group B. With regard to patient satisfaction, in group A 42% were satisfied and 20% were very satisfied, in group B 36% were satisfied and 14% were very satisfied.Conclusions: Study suggests that, Muco-cutaneous dryness was most common side effect in both treatment regimens. Side effects were more frequent with low dose continuous than low dose intermittent isotretinoin regimen. Patient satisfaction was better in continuous regimen.

scholarly journals Comparing the efficacy of low dose and conventional dose of oral isotretinoin in treatment of moderate and severe acne vulgaris

2017 ◽  
Vol 6 (4) ◽  
pp. 233 ◽  
Author(s):  
NasrinMotamedi Fard ◽  
Gita Faghihi ◽  
Fatemeh Mokhtari ◽  
Narges Motamedi ◽  
SayedMohsen Hosseini
Keyword(s):  
Low Dose ◽  
Acne Vulgaris ◽  
Severe Acne ◽  
Conventional Dose ◽  
Oral Isotretinoin
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