scholarly journals Current Status of Clinical Diagnosis and Genetic Analysis of Hereditary Hemorrhagic Telangiectasia in South Korea: Multicenter Case Series and a Systematic Review

2019 ◽  
Vol 14 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Donghyun Kim ◽  
Eul-Ju Seo ◽  
Yun Sun Song ◽  
Chong Hyun Suh ◽  
Jong Won Kim ◽  
...  
Keyword(s):  
Systematic Review ◽  
Genetic Analysis ◽  
South Korea ◽  
Clinical Diagnosis ◽  
Hereditary Hemorrhagic Telangiectasia ◽  
Case Series ◽  
Current Status

scholarly journals Current status of case reports and case series reported by Korean Medicine doctors in primary clinics: a systematic review

2020 ◽  
Vol 9 (4) ◽  
pp. 100417 ◽  
Author(s):  
Jeong Hwan Park ◽  
Sanghun Lee ◽  
Tae-Hun Kim ◽  
Soyoung Kim ◽  
Jun-Hwan Lee
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Case Series ◽  
Current Status ◽  
Korean Medicine

scholarly journals Hypogonadotropic Hypogonadism Associated with Hereditary Hemorrhagic Telengiectasia

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Scarano Valentina ◽  
De Santis Daniele ◽  
Suppressa Patrizia ◽  
Lastella Patrizia ◽  
Lenato Gennaro Mariano ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Ischaemic Stroke ◽  
Clinical Diagnosis ◽  
Hereditary Hemorrhagic Telangiectasia ◽  
Hypogonadotropic Hypogonadism ◽  
Lower Limbs ◽  
Definite Diagnosis ◽  
Clinical Criteria ◽  
Postphlebitic Syndrome ◽  
Males And Females

A 65-year-old man was referred to our clinic for the rehabilitation of right hemiparesis caused by ischaemic stroke. Hypertension, postphlebitic syndrome of lower limbs, frequent nose bleeding, and anemia were present in his history; in his adolescence, he was treated for idiopathic hypogonadotropic hypogonadism. Further investigations have revealed also microsomia, suggesting a clinical diagnosis of Kallmann syndrome, that is, an association, possible in males and females, of hypogonadotropic hypogonadism with olfactory deficits. A definite diagnosis of hereditary hemorrhagic telangiectasia was made based on clinical criteria and confirmed by genetic analysis.

scholarly journals Poisoning due to ingestion of amatoxin-containing mushrooms in South Korea: a systematic review and meta-analysis

2021 ◽  
Keyword(s):  
Systematic Review ◽  
Central Nervous System ◽  
Nervous System ◽  
South Korea ◽  
Mental Status ◽  
Meta Analysis ◽  
Case Series ◽  
Altered Mental Status ◽  
Watery Diarrhea ◽  
Mushroom Poisoning

Objective: Poisoning caused by the ingestion of amatoxin-containing mushrooms is life-threatening and requires urgent attention. However, only few studies have evaluated the factors that predict mortality owing to mushroom poisoning. We conducted a systematic review of amatoxin poisoning in South Korea and meta-analysis of the association between severe early-stage central nervous system symptoms and mortality in cases of amatoxin poisoning. Methods: The Embase, MEDLINE, Web of Science, KMbase, and Korean Studies Information System databases were searched for articles up to July 2020. We included case reports, case series, and observational studies on Amanita poisoning in South Korea. Outbreak area, incubation time, clinical course, management, and outcomes were evaluated. We then conducted a meta-analysis of the association between severe central nervous system symptoms and mortality. Results: Sixteen articles were included in the review and five in the meta-analysis. Outbreaks occurred principally in Gyeongbuk and in the western part of Gangwon. All patients had gastrointestinal symptoms, such as watery diarrhea. Liver failure occurred 2-3 days after mushroom intake in most patients, and ingestion of amatoxins from mushroom consumption was associated with high mortality risk. The risk of mortality among patients with altered mental status or seizures was 10 times higher than that among patients without these symptoms (risk ratio = 10.56, 95% confidence interval = 2.73-40.83). Conclusions: Amanita mushrooms are often mistaken for edible mushrooms, and their ingestion is frequently fatal. Aggressive treatment must be pursued in patients with severe central nervous system symptoms, such as altered mental status or seizures.

Cannabis-associated arteritis

VASA ◽  
2010 ◽  
Vol 39 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Grotenhermen
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Case Series ◽  
Cardiovascular Effects ◽  
Causative Factor ◽  
Cannabis Use ◽  
Thromboangiitis Obliterans ◽  
Pathological Features ◽  
Scientific Support ◽  
Clinical And Pathological Features

Background: To investigate the hypothesis that cases of arteritis similar to thromboangiitis obliterans (TAO) and associated with the use of cannabis were caused by cannabis or THC (dronabinol), or that cannabis use is a co-factor of TAO. Patients and methods: A systematic review on case reports and the literature on so-called cannabis arteritis, TAO, and cardiovascular effects of cannabinoids was conducted. Results: Fifteen reports with 57 cases of an arteritis associated with the use of cannabis and two additional case series of TAO, in which some patients also used cannabis, were identified. Clinical and pathological features of cannabis-associated arteritis do not differ from TAO and the major risk factor of TAO, tobacco use, was present in most, if not in all of these cases. The proposed pathophysiological mechanisms for the development of an arteritis by cannabis use are not substantiated. Conclusions: The hypothesis of cannabis being a causative factor or co-factor of TAO or an arteritis similar to TAO is not supported by the available evidence. The use of the term “cannabis arteritis” should be avoided until or unless more convincing scientific support is forthcoming.

Dental Implant Placement in Patients with a History of Medications Related to Osteonecrosis of the Jaws: A Systematic Review

2020 ◽  
Author(s):  
Judd Sher ◽  
Kate Kirkham-Ali ◽  
Denny Luo ◽  
Catherine Miller ◽  
Dileep Sharma
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Drug Therapy ◽  
Dental Implant ◽  
Case Series ◽  
Cochrane Central Register ◽  
Bisphosphonate Treatment ◽  
Implant Placement ◽  
Increased Risk ◽  
History Of

The present systematic review evaluates the safety of placing dental implants in patients with a history of antiresorptive or antiangiogenic drug therapy. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. PubMed, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and OpenGrey databases were used to search for clinical studies (English only) to July 16, 2019. Study quality was assessed regarding randomization, allocation sequence concealment, blinding, incomplete outcome data, selective outcome reporting, and other biases using a modified Newcastle-Ottawa scale and the Joanna Briggs Institute critical appraisal checklist for case series. A broad search strategy resulted in the identification of 7542 studies. There were 28 studies reporting on bisphosphonates (5 cohort, 6 case control, and 17 case series) and one study reporting on denosumab (case series) that met the inclusion criteria and were included in the qualitative synthesis. The quality assessment revealed an overall moderate quality of evidence among the studies. Results demonstrated that patients with a history of bisphosphonate treatment for osteoporosis are not at increased risk of implant failure in terms of osseointegration. However, all patients with a history of bisphosphonate treatment, whether taken orally for osteoporosis or intravenously for malignancy, appear to be at risk of ‘implant surgery-triggered’ MRONJ. In contrast, the risk of MRONJ in patients treated with denosumab for osteoporosis was found to be negligible. In conclusion, general and specialist dentists should exercise caution when planning dental implant therapy in patients with a history of bisphosphonate and denosumab drug therapy. Importantly, all patients with a history of bisphosphonates are at risk of MRONJ, necessitating this to be included in the informed consent obtained prior to implant placement. The James Cook University College of Medicine and Dentistry Honours program and the Australian Dental Research Foundation Colin Cormie Grant were the primary sources of funding for this systematic review.

Mechanical thrombectomy in pediatric stroke: systematic review, individual patient data meta-analysis, and case series

2019 ◽  
Vol 24 (5) ◽  
pp. 558-571 ◽  
Author(s):  
Kartik Bhatia ◽  
Hans Kortman ◽  
Christopher Blair ◽  
Geoffrey Parker ◽  
David Brunacci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mechanical Thrombectomy ◽  
Case Reports ◽  
Meta Analysis ◽  
Case Series ◽  
Neurological Outcomes

OBJECTIVEThe role of mechanical thrombectomy in pediatric acute ischemic stroke is uncertain, despite extensive evidence of benefit in adults. The existing literature consists of several recent small single-arm cohort studies, as well as multiple prior small case series and case reports. Published reports of pediatric cases have increased markedly since 2015, after the publication of the positive trials in adults. The recent AHA/ASA Scientific Statement on this issue was informed predominantly by pre-2015 case reports and identified several knowledge gaps, including how young a child may undergo thrombectomy. A repeat systematic review and meta-analysis is warranted to help guide therapeutic decisions and address gaps in knowledge.METHODSUsing PRISMA-IPD guidelines, the authors performed a systematic review of the literature from 1999 to April 2019 and individual patient data meta-analysis, with 2 independent reviewers. An additional series of 3 cases in adolescent males from one of the authors’ centers was also included. The primary outcomes were the rate of good long-term (mRS score 0–2 at final follow-up) and short-term (reduction in NIHSS score by ≥ 8 points or NIHSS score 0–1 at up to 24 hours post-thrombectomy) neurological outcomes following mechanical thrombectomy for acute ischemic stroke in patients < 18 years of age. The secondary outcome was the rate of successful angiographic recanalization (mTICI score 2b/3).RESULTSThe authors’ review yielded 113 cases of mechanical thrombectomy in 110 pediatric patients. Although complete follow-up data are not available for all patients, 87 of 96 (90.6%) had good long-term neurological outcomes (mRS score 0–2), 55 of 79 (69.6%) had good short-term neurological outcomes, and 86 of 98 (87.8%) had successful angiographic recanalization (mTICI score 2b/3). Death occurred in 2 patients and symptomatic intracranial hemorrhage in 1 patient. Sixteen published thrombectomy cases were identified in children < 5 years of age.CONCLUSIONSMechanical thrombectomy may be considered for acute ischemic stroke due to large vessel occlusion (ICA terminus, M1, basilar artery) in patients aged 1–18 years (Level C evidence; Class IIb recommendation). The existing evidence base is likely affected by selection and publication bias. A prospective multinational registry is recommended as the next investigative step.

Sign in / Sign up

Export Citation Format

Share Document