The effect of Cinacalcet on Serum Calcium, Phosphorus and Parathyroid Hormone in Hemodialysis Patients

2012 ◽  
Vol 1 (2) ◽  
pp. 55-60
Author(s):  
Erkan Sengul ◽  
Selma Satilmisoglu ◽  
Aysun Sengul ◽  
Sevim Dindar
Keyword(s):  
Parathyroid Hormone ◽  
Serum Calcium ◽  
Hemodialysis Patients ◽  
Calcium Phosphorus

scholarly journals Serum Sulphate Levels in Hemodialysis Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Ibrahim Yildirim ◽  
Ender Hur ◽  
Kemal Magden ◽  
Sevil İlikhan ◽  
Hüseyin Engin ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Free Form ◽  
Control Group ◽  
Dialysis Patients ◽  
Sulphur Compounds ◽  
Adequate Knowledge ◽  
Inorganic Sulphate ◽  
Calcium Phosphorus

Objective. Sulphur, similar to phosphorus, is easily attached to organic compounds. The inadequate elimination of sulphate may cause high sulphate concentrations in hemodialysis (HD) patients because sulphate is low in free form in plasma. Although we are well aware of the accumulation of phosphorus in chronic dialysis patients, we do not have an adequate knowledge database about the sulphur compounds. This study was designed to determine the level of sulphate in hemodialysis patients. Materials and Methods. Ninety-four prevalent HD patients and 33 patients without renal failure were included in the study. The serum inorganic sulphate levels were measured by turbidimetric technique. Moreover, the serum level of urea, creatinine, albumin, calcium, phosphorus, and parathyroid hormone concentrations was simultaneously recorded. Results. Mean levels of plasma sulphate were significantly higher (0.56 ± 0.17 mM vs 0.31 ± 0.13 mM, p<0.001) in HD patients. Serum sulphate level correlated with patient’s age, serum albumin, serum BUN and creatinine, and serum phosphorus level in HD patients. Serum sulphate levels were not associated with serum parathyroid hormone levels. Conclusion. Serum sulphate levels were approximately twofold higher in HD patients than in the normal control group. Inorganic sulphate does not seem to accumulate in long-term dialysis patients, and mild increased serum levels of sulphate has no poor clinical outcome in these patients.

scholarly journals Does Erythropoietin Have a Beneficial Effect on Calcium, Phosphorus and Parathyroid Hormone Levels in Pediatric Hemodialysis Patients?

Nephron ◽  
1994 ◽  
Vol 67 (3) ◽  
pp. 371-371
Author(s):  
Umit Saatci ◽  
Rezan Topaloglu ◽  
Seza Ozen ◽  
Aysin Bakkkaloglu ◽  
Nesrin Besbas
Keyword(s):  
Parathyroid Hormone ◽  
Beneficial Effect ◽  
Hemodialysis Patients ◽  
Hormone Levels ◽  
Pediatric Hemodialysis ◽  
Calcium Phosphorus

scholarly journals Differences in the dynamics of parathyroid hormone secretion in hemodialysis patients with marked secondary hyperparathyroidism.

1995 ◽  
Vol 6 (5) ◽  
pp. 1371-1378
Author(s):  
A J Felsenfeld ◽  
A Jara ◽  
M Pahl ◽  
J Bover ◽  
M Rodriguez
Keyword(s):  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Serum Calcium ◽  
Hormone Secretion ◽  
Hemodialysis Patients ◽  
Basal Serum ◽  
Group I ◽  
The Difference ◽  
Pth Level ◽  
Uniform Group

Hemodialysis patients with predialysis intact parathyroid hormone (PTH) levels of more than 500 pg/mL are generally considered to have marked secondary hyperparathyroidism. Because the serum calcium level in these patients varies from low to high, it is not clear whether every hemodialysis patient with a PTH level > 500 pg/mL is part of a uniform group. The dynamics of PTH secretion in 21 hemodialysis patients with predialysis (basal) intact PTH levels > 500 pg/mL (range, 506 to 1978 pg/mL) has been evaluated. The basal/maximal PTH ratio, an indicator of the degree of relative PTH stimulation in the baseline state, was inversely correlated with the maximal PTH (r = -0.71), the basal serum calcium (r = -0.70), and the difference between the serum calcium at basal and maximal PTH (r = 0.81); the latter is the decrement in serum calcium from baseline necessary to maximally stimulate PTH. Because the basal PTH level appeared to be disproportionately influenced by hypocalcemia, the 21 patients were separated into two groups on the basis of the basal serum calcium (Group I < 9 mg/dL and Group II > 9 mg/dL). Basal PTH was not different between the two groups, even though maximally stimulated PTH (1,219 +/- 204 versus 2,739 +/- 412 pg/mL; P < 0.01) as induced by hypocalcemia and maximally suppressed PTH (217 +/- 37 versus 528 +/- 104; P = 0.05) as induced by hypercalcemia were less in Group I with the low basal calcium; moreover, the ratio of basal/maximal PTH was higher (73 +/- 6 versus 47 +/- 5%; P < 0.01) in Group I with the low basal calcium. These results suggest that the reason for a basal PTH > 500 pg/mL may be different among hemodialysis patients. In hypocalcemic patients, the low serum calcium appeared to be a major impetus for the high basal PTH level. In conclusion, (1) the maximally stimulated PTH appears to provide a better means of separating patients with marked secondary hyperparathyroidism than the basal PTH and (2) hemodialysis patients with basal PTH levels > 500 pg/mL may not be a uniform group.

Clinical and Radiological Features of Bone Disease in Long-Term (15 or more years) Hemodialysis Patients

1993 ◽  
Vol 16 (10) ◽  
pp. 704-710 ◽  
Author(s):  
P.L. Bedani ◽  
C. Orzincolo ◽  
A. Storari ◽  
L. Perini ◽  
S. Soffritti ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Hemodialysis Patients ◽  
X Rays ◽  
Hip Joints ◽  
Radiological Features ◽  
Calcium Phosphorus ◽  
Long Term Survivors ◽  
Dialytic Treatment

Fifteen patients on regular dialytic treatment for more than 15 years were given X-rays of the skull, spine, shoulders, wrists, pelvis and knees with the purpose of studying the principal skeletal and articular alterations due or not due to the uraemic status. Serum calcium, phosphorus, parathyroid hormone, alkaline phosphatase and basal aluminium were recorded. Osteopenia was evident in all the patients. Ten of whom (67%) showed alterations due to hyperparathyroidism. Nine patients presented the marks of dialysis spondyloarthropathy; in 14/15 cases geodes were present in the wrists, humeral heads or hip-joints; in ten patients there were multiple amyloid lesions. Two patients with serum basal aluminum above 100 μg/L showed the typical radiographic marks of osteomalacia. The majority of the long-term survivors showed multifactorial osteo-articular alterations resulting mainly from the combination of hyperparathyroidism and dialysis-related amyloidosis. The less frequent joint alterations were represented by arthrosis, enthesopathy and Chondrocalcinosis. Disability and decreased articular mobility resulted in being mainly due to amyloid osteo-arthropathy.

scholarly journals Nocturnal calcium, phosphorus and parathyroid hormone in the diagnosis of concealed and subclinical hypoparathyroidism

2007 ◽  
Vol 156 (1) ◽  
pp. 113-116 ◽  
Author(s):  
Leah Even ◽  
Tarif Bader ◽  
Ze’ev Hochberg
Keyword(s):  
Parathyroid Hormone ◽  
Serum Calcium ◽  
Healthy Subjects ◽  
Thalassemia Major ◽  
Model System ◽  
Diurnal Variations ◽  
Control Subjects ◽  
Serum Minerals ◽  
Calcium Phosphorus ◽  
Healthy Control

Context: Circadian rhythms of plasma parathyroid hormone (PTH) show peak values at night, whereas serum calcium levels peak in the evening and display a nadir at night. Hypotheses: Subclinical hypoparathyroidism (HPT) can be detected by utilizing the knowledge of diurnal variations. Thalassemia major (TM) may provide a model system of subclinical HPT. Design: Nocturnal plasma PTH and serum calcium values were determined in 13 TM patients with normal morning serum calcium levels as compared with the corresponding values in eight healthy control subjects. Results: Six patients with TM presented a nadir serum calcium level of 8.3 mg/dl or lower (hypoCa TM) at 0200 h, whereas the remaining seven showed nadir levels of 8.4 mg/dl or higher (normoCa TM). Patients with hypoCa TM displayed a drop between peak and nadir of 1.2 ± 0.5 mg/dl as compared with a considerably smaller fall of 0.3 ± 0.7 mg/dl in control subjects (P < 0.05). NormoCa TM patients experienced comparable nocturnal variation to that of control subjects. Patients from both the hypoCa and normoCa TM groups presented significantly lower nocturnal PTH levels than those of control subjects and lost the nocturnal PTH variation characteristic of healthy subjects. A plot of all serum calcium against plasma PTH levels provides a clear distinction of the three groups. Conclusions: All 13 daytime normocalcemic TM patients presented a certain degree of HPT. The hypoCa TM group displayed a concealed HPT detected in all, except the morning sampling, whereas normoCa TM patients experienced sub clinical HPT observed in the absence of nocturnal HPT variation. Nocturnal measurements of serum minerals thus enhance the sensitivity of HPT diagnosis.

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