Evaluation of Toxoplasma gondii, Rubella virus and Cytomegalovirus Infections in Pregnant Women

Objective: Toxoplasma gondii, rubella virus and cytomegalovirus (CMV) are important infectious agents that can be transmitted vertically from mother to baby, and can cause clinical signs in the fetus and the newborn. In our study, it was aimed to determine the distribution of antibodies against T. gondii, Rubella and CMV in pregnant women applied to our hospital. Method: In our study, the serological test results of the blood samples of pregnant women used in the diagnosis of T. gondii, Rubella and CMV infections in Microbiology Laboratory of Sivas Cumhuriyet University Faculty of Medicine, were retrospectively analyzed in a two-year period between 2018 and 2019. Results: The positivity rates were determined to be 26.7% for T. gondii IgG, 87.9% for Rubella virus IgG and 99% for CMV IgG. While IgM test positivities for the same pathogens were 1.3%, 0.3%, and 0.7%, respectively. Low avidity results were encountered in 4 patients (22.2%) for T. gondii, whereas the results of all examined tests for Rubella and CMV were found to have high avidity. Conclusion: Regional epidemiological data are important to determine routine screening approach or infectious agents that will be more important for the newborn. We think that we will contribute to the literature with our study based on regional data.

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Serological detection of Toxoplasma gondii and associated risk factors among pregnant women in Lahore Pakistan

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2020.09.1099 ◽

2020 ◽

Vol 101 ◽

pp. 419

Author(s):

T. Ijaz ◽

S. Ijaz ◽

M. Afzal ◽

N. Ijaz

Keyword(s):

Risk Factors ◽

Toxoplasma Gondii ◽

Pregnant Women ◽

Serological Detection ◽

Associated Risk Factors

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Do the placental barrier, parasite genotype and Toll-like receptor polymorphisms contribute to the course of primary infection with various Toxoplasma gondii genotypes in pregnant women?

European Journal of Clinical Microbiology & Infectious Diseases ◽

10.1007/s10096-013-2017-3 ◽

2013 ◽

Vol 33 (5) ◽

pp. 703-709 ◽

Cited By ~ 21

Author(s):

W. Wujcicka ◽

J. Wilczyński ◽

D. Nowakowska

Keyword(s):

Toxoplasma Gondii ◽

Pregnant Women ◽

Primary Infection ◽

Placental Barrier ◽

Toll Like Receptor ◽

Parasite Genotype

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Prevalence of toxoplasmosis in pregnant women and vertical transmission of Toxoplasma gondii in patients from basic units of health from Gurupi, Tocantins, Brazil, from 2012 to 2014

PLoS ONE ◽

10.1371/journal.pone.0141700 ◽

2015 ◽

Vol 10 (11) ◽

pp. e0141700 ◽

Cited By ~ 27

Author(s):

Marcos Gontijo da Silva ◽

Marina Clare Vinaud ◽

Ana Maria de Castro

Keyword(s):

Toxoplasma Gondii ◽

Pregnant Women ◽

Vertical Transmission

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Seroprevalence of toxoplasmosis in Vojvodina

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1006333b ◽

2010 ◽

Vol 138 (5-6) ◽

pp. 333-336 ◽

Cited By ~ 1

Author(s):

Snezana Brkic ◽

Gorana Gajski ◽

Mirjana Bogavac ◽

Daniela Maric ◽

Vesna Turkulov ◽

...

Keyword(s):

Toxoplasma Gondii ◽

General Population ◽

Pregnant Women ◽

Acute Infection ◽

Clinical Manifestations ◽

Congenital Toxoplasmosis ◽

Reproductive Age ◽

Female Population ◽

Effective Measure ◽

Female Patients

Introduction Toxoplasmosis is an acute infectious anthropozoonotic disease with mild asymptomatic clinical manifestations in immunocompetent persons and more severe in immunocompromised patients. Acute infection in pregnancy can result in severe congenital toxoplasmosis with severe sequels. Objective Aims of study were to detect Toxoplasma gondii seroprevalence in general population of Vojvodina, Serbia, differences between genders and determination of seroprevalence in women of reproductive age and pregnant women. Methods Our retrospective study was conducted from 2006 to 2008 including 625 immunocompetent patients, hospitalized or observed as outpatients at the Clinical Centre of Vojvodina, Novi Sad. We performed commercial ELISA kits SERION - ELISA classic test by VIRION for the presence of specific IgG and IgM antibodies. According to seroepidemiological aim of the study, our results were presented only in qualitative values. Results We observed 173 male and 452 female patients. Seroprevalence in general population of Vojvodina was 38.1%. In male population seroprevalence was 45.7%, and in female population it was 35.2%, the difference which was statistically significant (p<0.05). Seroprevalence increased with age and seroconversion was detected to occur in persons aged about 20 years. In all female patients, 353 (78.1%) were in reproductive age with seroprevalence of 30%. In 161 pregnant women seroprevalence was 31.7%. Conclusion In this study we screened actual seroepidemiological situation to Toxoplasma gondii in Vojvodina, thus giving a contribution to the continuous epidemiological screening done in this region and in the country. According to our results, almost 70% of women in reproductive age were sensitive to primary acute infection during further pregnancies, which is highly important for the prevention of congenital toxoplasmosis. Although not routinely conducted in many countries, routine serological testing to Toxoplasma gondii in pregnant women and their education about preventive measures against this infection could be an effective measure in the future.

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