scholarly journals The efficacy of conversion from IUI to IVF-ET in infertility patients with hyper-response to ovulation induction: A retrospective study

2012 ◽  
Vol 156 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Yiping Zhong ◽  
Jin Li ◽  
Ying Ying ◽  
Haitao Wu ◽  
Canquan Zhou ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Ovulation Induction ◽  
Infertility Patients ◽  
Ivf Et

scholarly journals Efficacy of letrozole versus clomiphene citrate for infertile women with polycystic ovary syndrome

2021 ◽  
Vol 10 (8) ◽  
pp. 2944
Author(s):  
Sinan S. Ay ◽  
Özer Birge ◽  
Mehmet S. Bakır ◽  
Ayşe E. Yumru
Keyword(s):  
Aromatase Inhibitor ◽  
Ovulation Induction ◽  
Polycystic Ovary ◽  
Clomiphene Citrate ◽  
Ovary Syndrome ◽  
Infertile Women ◽  
Appropriate Treatment ◽  
The Mean ◽  
Infertility Patients ◽  
Infertile Patients

Background: The aim was to compare ovulation induction protocols in anovulatory patients, who make up a significant percentage of infertility patients, and to determine the most appropriate treatment for patients in the clinic based on the findings.Methods: The effectiveness of clomiphene citrate (CC) and letrozole (aromatase inhibitor) in ovulation induction treatments were retrospectively compared in patients who applied for infertility in the last 5 years and were found to be anovulatory. 20 of these patients were being treated with clomiphene citrate, while the 18 were being treated with letrozole.Results: The study included a total of 38 anovulatory infertile patients. The mean age of the patients was found to be 29.3. When the endometrial thicknesses (ET) after the treatment were compared, the first group's mean EC was 6.1, while that of the second group was 9.05. The endometrial thicknesses measured after the treatments were found to be significantly different, which were consistent with other studies in the literature. Post-treatment ovulation responses were similar with 55% in both groups. In the evaluation of pregnancy outcomes, 20% of pregnancy was achieved in the first group and 33% in the second group.Conclusions: The use of letrozole, an aromatase inhibitor, may be suggested as an alternative to CC in the ovulation induction protocol in our clinical practice, particularly in obese patients.

scholarly journals Association Between Serum Oestradiol Level on the Human Chorionic Gonadotrophin Administration Day and Neonatal Birthweight After in Vitro Fertilization-embryo Transfer: A Retrospective Study of 3659 Singleton Live Births

2020 ◽  
Author(s):  
Yu Liu ◽  
Jing Li ◽  
Yihong Guo
Keyword(s):  
Retrospective Study ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Vitro Fertilization ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Ivf Et ◽  
Group 1

Abstract BackgroundOestradiol, an important hormone in follicular development and endometrial receptivity, is closely related to clinical outcomes of fresh in vitro fertilization-embryo transfer (IVF-ET) cycles. A supraphysiologic E2 level is inevitable during controlled ovarian hyper-stimulation (COH), and its effect on the outcome of IVF-ET is controversial. The aim of this retrospective study is to evaluate the association between elevated serum oestradiol (E2) levels on the day of human chorionic gonadotrophin (hCG) administration and neonatal birthweight after IVF-ET cycles.MethodsThe data of 3659 infertile patients with fresh IVF-ET cycles were analysed retrospectively between August 2009 and February 2017 in First Hospital of Zhengzhou University. Patients were categorized by serum E2 levels on the day of hCG administration into six groups: group 1 (serum E2 levels≤1000 pg/mL, n=230), group 2 (serum E2 levels between 1001 and 2000 pg/mL, n=524), group 3 (serum E2 levels between 2001 and 3000 pg/mL, n=783), group 4 (serum E2 levels between 3001 and 4000 pg/mL, n = 721), group 5 (serum E2 levels between 4001 and 5000 pg/mL, n=548 ), and group 6 (serum E2 levels > 5000 pg/mL, n=852). Univariate linear regression was used to evaluate the independent correlation between each factor and outcome index. Multiple logistic regression was used to adjust for confounding factors.ResultsThe LBW rates were as follows: 3.0% (group 1), 2.9% (group 2), 1.9% (group 3), 2.9% (group 4), and 2.0% (group 6) (P =0.629), respectively. There were no statistically significant differences in the incidences of neonatal LBW among the six groups. We did not detect an association between peak serum E2 level during ovarian stimulation and neonatal birthweight after IVF-ET.ConclusionThe results of this retrospective cohort study showed that serum E2 peak levels during ovarian stimulation were not associated with birth weight during IVF cycles. In addition, no association was found between higher E2 levels and increased LBW risk. Our observations suggest that the hyper-oestrogenic milieu during COS does not seem to have adverse effects on the birthweight of offspring after IVF.

Management of Endometriosis—A Two Years Study at a Tertiary Care Center

2010 ◽  
Vol 2 (1) ◽  
pp. 41-43
Author(s):  
K Kapur ◽  
M Biswas ◽  
GS Joneja ◽  
R Sharma ◽  
P Talwar
Keyword(s):  
Pelvic Pain ◽  
Ovulation Induction ◽  
Care Center ◽  
Tertiary Care ◽  
Expectant Management ◽  
Male Factor ◽  
Number Of Patients ◽  
Tertiary Center ◽  
Operative Endoscopy ◽  
Ivf Et

ABSTRACT Objective The purpose of this study was to analyze the line of treatment and its outcome in cases of endometriosis presenting with infertility and pelvic pain at a tertiary center having facilities of operative endoscopy and assisted reproductive technology. Methods All cases of Infertility and pelvic pain over a period of two years were subjected to laparoscopy. Patients who were diagnosed with endometriosis were classified into categories. Different system of classification was used for patients of Infertility and pelvic pain. A large number of patients were subjected to expectant management. Selected cases underwent IUI, IVF-ET and ICSI. The numbers of pregnancies were recorded in these cases. Patients with pelvic pain were treated with hormonal therapy. Results 1038 patients were studied over a period of 2 years out of which 983 presented with Infertility and 55 with pelvic pain. 294 cases of infertility were detected and biopsy proven to be having endometriosis and 20 of the 55 cases of pelvic pain were also detected to have endometriosis. In the infertility group 76 patients were found to have bilateral tubal block. 215 patients were detected to have various grades of lesions but with patent bilateral/unilateral tubes. 6 patients with blocked tubes and 11 patients with patent tube/tubes also were associated with male factor infertility. 88 patients with blocked tubes and/or male factor received treatment with IVF-ET/ICSI. 178 patients underwent ovulation induction and 28 were simply observed. There were 42.8% pregnancies in the observation group, 49.4% in the ovulation induction-IUI group and 45.4% in IVF-ET/ICSI group. Conclusion 30% of the cases of Infertility had endometriosis. Following operative endoscopy treatment for all cases, the occurrence of pregnancy was similar in patients who were simply observed and those who received treatment with ovulation induction-IUI. Those with mechanical problems of sperm-egg union are best treated with IVF-ET where facilities exist.

scholarly journals Inositol supplement improves clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET

Medicine ◽  
2017 ◽  
Vol 96 (49) ◽  
pp. e8842 ◽  
Author(s):  
Xiangqin Zheng ◽  
Danmei Lin ◽  
Yulong Zhang ◽  
Yuan Lin ◽  
Jianrong Song ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Ovulation Induction ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Infertile Women ◽  
Ivf Et

scholarly journals Effects of Half-Dose and Full-Dose GnRH Antagonists on IVF-ET Outcomes: A Retrospective Study

2021 ◽  
Author(s):  
Yingge Zhao ◽  
Fang Lian ◽  
Shan Xiang ◽  
Yi Yu ◽  
Conghui Pang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Pregnancy Rate ◽  
Production Rate ◽  
Endometrial Receptivity ◽  
Small Sample ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Full Dose ◽  
Half Dose ◽  
Ivf Et

Abstract BackgroundGonadotropin-releasing hormone antagonist(GnRH-ant) has been shown to have a negative effect on endometrial receptivity. Therefore, the use of GnRH-ant dose as small as possible during controlled ovarian stimulation(COS) may has an impact on improving endometrial receptivity and pregnancy rate. However, the GnRH-ant dose is relatively flexible and there is no fixed requirement for guidance. In this retrospective study, we tried to study the effects of half-dose or full-dose GnRH-ant on IVF-ET outcomes.MethodsOf the 316 cycles for 314 patients analyzed in this study, 149 received half-dose GnRH-ant(Group1) and 167 received full-dose GnRH-ant(Group2). According to age and BMI, the two groups were divided into four subgroups. Age subgroups, they were divided into age≤35(subgroupA)and age>35(subgroupB): 180 cycles in subgroup A(107 cycles in subgroupA1,73 cycles in subgroupA2), 136 cycles in subgroup B(42 cycles in subgroup B1,94 cycles in subgroupB2). BMI subgroups, they were divided into BMI<25 (subgroupC)and BMI≥25 (subgroupD):208 cycles in subgroupC(94 cycles in subgroup C1,114 cycles in subgroupC2), 108 cycles in subgroupD (55 cycles in subgroupD1,53 cycles in subgroupD2).ResultsNeither fertilized oocytes and the number of superior-quality embryos nor clinical pregnancy rate and live production rate significantly differed between the two groups. However, the number of retrieved oocytes and available embryos were significantly larger in Group 1 than in Group 2 (8.17±4.10vs.7.07±4.05,2.96±2.03vs.2.52±1.62, respectively,p＜0.05). Indicators in each age subgroups showed no statistical significance.However, in BMI subgroups, neither fertilized oocytes, available embryos and the number of superior-quality embryos nor live production rate significantly differed between the four subgroups. The number of retrieved oocytes was higher in subgroupC1 than in subgroupC2 (8.24±4.04vs.6.83±3.92,p < 0.05), In addition the clinical pregnancy rate was slightly higher in subgroupD1 than in subgroupD2(45.45vs.24.53%,P< 0.05). ConclusionsThe results showed that half-dose GnRH-ant was as effective as full-dose GnRH-ant for most patients. And patients with BMI≥25 may be more suitable for half-dose GnRH-ant. This retrospective analysis and the small sample size are the main limitations of this study, and a large sample RCT will be carried out in the future.Trial registrationRetrospectively registered

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