Association of Vitamin D Level with Severity of Angiographically Documented Coronary Artery Disease: Observations from Bangladeshi Patients

Background: Vitamin D, a fat-soluble vitamin has its receptor present in myriad of tissues and it modulates multiple cellular processes. Vitamin D deficiency is reported to be associated with coronary artery disease. Cardiovascular disease is the leading cause of mortality worldwide. Aims and Objective: The primary outcome was to investigate if there is a correlation of 25-OH levels with the percentage of luminal stenosis, as measured with coronary angiogram. The secondary outcome was to determine the differences in angiographically proven luminal stenosis across categories of 25-OH vitamin D levels. Materials and Methods: Thirty patients with acute coronary syndrome with diabetes mellitus were included in this cross-sectional descriptive study. All patients were tested for fasting vitamin D levels, fasting blood sugar, HbA1C and serum creatinine. Detailed history of the patients was recorded. Data was analyzed by the statistical software SPSS version 19 and p value <0.05 was considered significant. Statistical tests like Chi- square, independent t test and log regression was used. Results: In this study 30 patients undergoing coronary angiography for acute coronary syndrome, Vitamin D levels showed severe deficiency in 6.7% (2) cases while mild deficiency was seen in 50% of the cases. Patients with single vessel disease on the coronary angiogram had lower mean HbA1C (9.18) levels in our study. Patients with triple vessel disease had poorly controlled mean HbA1C levels (10.42). Conclusion: In this study we did not find any significant difference between the serum Vitamin D deficiency levels with patients with angiographic severity of the coronary artery disease. Patients with poorly controlled diabetes mellitus had more severe angiographic proven coronary artery disease.

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Role of exercise testing and stress thallium scintigraphy in the management of old men with suspected or documented coronary artery disease

European Heart Journal ◽

10.1093/eurheartj/5.suppl_e.75 ◽

1984 ◽

Vol 5 (suppl E) ◽

pp. 75-78

Author(s):

J. M. R. Detry ◽

J. A. Melin ◽

C. Derwael-Barchy ◽

A.-M. D'Hondt ◽

A. Robert ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Exercise Testing ◽

Thallium Scintigraphy ◽

Artery Disease ◽

Old Men ◽

Documented Coronary Artery Disease

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Vitamin D Deficiency is Associated With the Development of Subclinical Coronary Artery Disease in African Americans With HIV Infection

Journal of Investigative Medicine ◽

10.2310/jim.0b013e318250bf99 ◽

2012 ◽

Vol 60 (5) ◽

pp. 801-807 ◽

Cited By ~ 7

Author(s):

Hong Lai ◽

Barbara Detrick ◽

Elliot K. Fishman ◽

Gary Gerstenblith ◽

Jeffrey A. Brinker ◽

...

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Coronary Artery ◽

African Americans ◽

Hiv Infection ◽

Vitamin D Deficiency ◽

Artery Disease

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Controlling lipids in a high-risk population with documented coronary artery disease for secondary prevention: are we doing enough?

European Journal of Cardiovascular Prevention & Rehabilitation ◽

10.1097/hjr.0b013e328338978e ◽

2010 ◽

Vol 17 (5) ◽

pp. 556-561 ◽

Cited By ~ 1

Author(s):

Mukesh Singh ◽

Shui Hao Chin ◽

Paul D. Giles ◽

David Crothers ◽

Karim Al-Allaf ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

High Risk ◽

Secondary Prevention ◽

High Risk Population ◽

Risk Population ◽

Artery Disease ◽

Documented Coronary Artery Disease

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Serum Level of Vitamin D Is Associated with Severity of Coronary Atherosclerosis in Postmenopausal Women

Biology ◽

10.3390/biology10111139 ◽

2021 ◽

Vol 10 (11) ◽

pp. 1139

Author(s):

Ewelina Anna Dziedzic ◽

Wiktor Smyk ◽

Izabela Sowińska ◽

Marek Dąbrowski ◽

Piotr Jankowski

Keyword(s):

Coronary Artery Disease ◽

Vitamin D ◽

Risk Factor ◽

Coronary Artery ◽

Serum Level ◽

Postmenopausal Women ◽

Coronary Atherosclerosis ◽

History Of ◽

Artery Disease ◽

The Impact

Background: Postmenopausal women experience rapid progression of coronary artery disease. Vitamin D deficiency appears to be a modifiable risk factor for cardiovascular diseases. This study aimed to analyze the impact of 25-hydroxyvitamin D3 (25(OH)D) level on the severity of coronary atherosclerosis and its potential cardioprotective effect in postmenopausal women. Material and Methods: The study prospectively recruited 351 women in postmenopausal age undergoing coronary angiography. The severity of coronary atherosclerosis was assessed using the Coronary Artery Surgery Study Score (CASSS). A level of 25(OH)D was measured with electrochemiluminescence. Results: Women with more severe coronary atherosclerosis have significantly lower 25(OH)D serum level (p = 0.0001). Vitamin D (β = −0.02; p = 0.016), hypertension (β = 0.44; p = 0.025), age (β = 0.02; p = 0.003), and history of MI (β = 0.63; p < 0.0001), were shown as CASSS determinants. Age, hyperlipidemia, and history of MI were found to determine the level of vitamin D (all p < 0.05). Women with a three-vessel disease hospitalized due to ACS, with a history of MI, hyperlipidemia and hypertension presented the lowest vitamin D level. Conclusions: Our study showed that lower serum 25(OH)D in postmenopausal women is associated with more significant stenosis in the coronary arteries. Therefore, we suggest considering low vitamin D level as a potential risk factor for coronary artery disease.

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