scholarly journals Recent progress in induced pluripotent stem cell-derived cardiac cell sheets for tissue engineering

2019 ◽  
Vol 13 (4) ◽  
pp. 292-298 ◽  
Author(s):  
Botao Gao ◽  
Katsuhisa Matsuura ◽  
Tatsuya Shimizu
PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0198026 ◽  
Author(s):  
Daisuke Sasaki ◽  
Katsuhisa Matsuura ◽  
Hiroyoshi Seta ◽  
Yuji Haraguchi ◽  
Teruo Okano ◽  
...  

2018 ◽  
Vol 12 (5) ◽  
pp. 1273-1284 ◽  
Author(s):  
Viktoriia Starokozhko ◽  
Mette Hemmingsen ◽  
Layla Larsen ◽  
Soumyaranjan Mohanty ◽  
Marjolijn Merema ◽  
...  

2020 ◽  
Vol 7 (3) ◽  
pp. 105
Author(s):  
Taylor Cook Suh ◽  
Alaowei Y. Amanah ◽  
Jessica M. Gluck

Tissue engineering (TE) combines cells, scaffolds, and growth factors to assemble functional tissues for repair or replacement of tissues and organs. Cardiac TE is focused on developing cardiac cells, tissues, and structures—most notably the heart. This review presents the requirements, challenges, and research surrounding electrospun scaffolds and induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) towards applications to TE hearts. Electrospinning is an attractive fabrication method for cardiac TE scaffolds because it produces fibers that demonstrate the optimal potential for mimicking the complex structure of the cardiac extracellular matrix (ECM). iPSCs theoretically offer the capacity to generate limitless numbers of CMs for use in TE hearts, however these iPSC-CMs are electrophysiologically, morphologically, mechanically, and metabolically immature compared to adult CMs. This presents a functional limitation to their use in cardiac TE, and research aiming to address this limitation is presented in this review.


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