scholarly journals Passive immunization in the combat against infectious diseases (COVID-19 included)

2021 ◽  
Vol 14 (2) ◽  
pp. 50-57
Author(s):  
Joanna Lasocka ◽  
Artur Bielawski ◽  
Elżbieta Lachert
Keyword(s):  
Infectious Diseases ◽  
Passive Immunization

Antisera, Toxoids, Vaccines and Tuberculins in Prophylaxis and Treatment

PEDIATRICS ◽  
1959 ◽  
Vol 23 (2) ◽  
pp. 430-430
Author(s):  
C. ARDEN MILLER
Keyword(s):  
Infectious Diseases ◽  
Passive Immunization ◽  
Active Immunization ◽  
Biological Products

This book begins: "Biological products used in infectious diseases may be divided into three groups, namely: 1) Sera of various types for prophylaxis and treatment by passive immunization; 2) Prophylactics, such as toxins, toxoids, and vaccines (both bacterial and viral), for active immunization; 3) Diagnostic products, such as diluted toxins and tuberculins, used by the clinician to detect the presence or absence of immunity and also of allergy. Most of these materials come within the scope of this book.

Red Book (2015)

2015 ◽  
Keyword(s):  
Infectious Diseases ◽  
Antimicrobial Prophylaxis ◽  
Medical Center ◽  
Passive Immunization ◽  
High Yield ◽  
Injection Pain ◽  
Parasitic Infections ◽  
Health Providers ◽  
Pneumococcal Infections ◽  
Pediculosis Capitis

4-Star Review "This is an unparalleled resource in both content and authority for pediatric infectious diseases knowledge, from diagnosis to management and prevention." Kari A. Simonsen, MD, University of Nebraska Medical Center Doody's Book Review The AAP's authoritative guide to the manifestations, etiology, epidemiology, diagnosis, and treatment of more than 200 childhood conditions. The Red Book provides evidence-based guidance to practicing clinicians on pediatric infections and vaccinations based on the recommendations of the committee as well as the combined expertise of the CDC, the FDA and hundreds of physician contributors. The Red Book is an essential reference for pediatric infectious diseases specialists and general pediatricians, and is useful for family medicine and emergency medicine physicians as well. Public health and school health providers, medical residents and students also will find it a high-yield source of pediatric infectious disease and vaccine information. The book is divided into sections that cover * Active and passive immunization * Disease summaries * Antimicrobial therapy for treatment and prophylaxis * Care of children in special situations Updated information and recommendations you cannot afford to be without... * Standardized approach to disease prevention through immunizations, antimicrobial prophylaxis, and infection control practices * New chapter on Hemorrhagic Fevers Caused by Filoviruses has been added * New chapter on human parechovirus infections has been added * Updated information on hypersensitivity reactions after immunizations * The latest on sexually transmitted infections (STIs) in adolescents and children * Updated coverage of actinomycosis, amebiases, arbovirus, bacterial vaginosis, blastocystis, candidiasis, Clostridium difficle, coronaviruses, dengue, enteroviruses, Escherichia coli, Giardia intestinalis, gonococcal infections, Helicobacter pylori infections, lyme disease, meningococcal infections, pediculosis capitis, pertussis, pneumococcal infections, rotavirus, and more * Managing Injection Pain has been significantly expanded * Updated information on hepatitis C * Updated information on group B streptococcal infections * Updated section on drugs for parasitic infections * Significantly revised chapter on Respiratory Syncytial Virus * Recommendations for using MMR or MMRV vaccines have been updated * The Antimicrobial Resistance and Antimicrobial Stewardship chapter has been significantly broaded and updated * Updated information on HIV * And much more!

scholarly journals Hyper-Enriched Anti-RSV Immunoglobulins Nasally Administered: A Promising Approach for Respiratory Syncytial Virus Prophylaxis

2021 ◽  
Vol 12 ◽  
Author(s):  
Emilie Jacque ◽  
Claire Chottin ◽  
Daphné Laubreton ◽  
Michel Nogre ◽  
Cécile Ferret ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Mouse Model ◽  
Infectious Diseases ◽  
Affinity Chromatography ◽  
Passive Immunization ◽  
Health Concern ◽  
Nasal Administration ◽  
New Class ◽  
Normal Plasma ◽  
Syncytial Virus

Respiratory syncytial virus (RSV) is a public health concern that causes acute lower respiratory tract infection. So far, no vaccine candidate under development has reached the market and the only licensed product to prevent RSV infection in at-risk infants and young children is a monoclonal antibody (Synagis®). Polyclonal human anti-RSV hyper-immune immunoglobulins (Igs) have also been used but were superseded by Synagis® owing to their low titer and large infused volume. Here we report a new drug class of immunoglobulins, derived from human non hyper-immune plasma that was generated by an innovative bioprocess, called Ig cracking, combining expertises in plasma-derived products and affinity chromatography. By using the RSV fusion protein (F protein) as ligand, the Ig cracking process provided a purified and concentrated product, designated hyper-enriched anti-RSV IgG, composed of at least 15-20% target-specific-antibodies from normal plasma. These anti-RSV Ig displayed a strong in vitro neutralization effect on RSV replication. Moreover, we described a novel prophylactic strategy based on local nasal administration of this unique hyper-enriched anti-RSV IgG solution using a mouse model of infection with bioluminescent RSV. Our results demonstrated that very low doses of hyper-enriched anti-RSV IgG can be administered locally to ensure rapid and efficient inhibition of virus infection. Thus, the general hyper-enriched Ig concept appeared a promising approach and might provide solutions to prevent and treat other infectious diseases.ImportanceRespiratory Syncytial Virus (RSV) is the major cause of acute lower respiratory infections in children, and is also recognized as a cause of morbidity in the elderly. There are still no vaccines and no efficient antiviral therapy against this virus. Here, we described an approach of passive immunization with a new class of hyper-enriched anti-RSV immunoglobulins (Ig) manufactured from human normal plasma. This new class of immunoglobulin plasma derived product is generated by an innovative bioprocess, called Ig cracking, which requires a combination of expertise in both plasma derived products and affinity chromatography. The strong efficacy in a small volume of these hyper-enriched anti-RSV IgG to inhibit the viral infection was demonstrated using a mouse model. This new class of immunoglobulin plasma-derived products could be applied to other pathogens to address specific therapeutic needs in the field of infectious diseases or even pandemics, such as COVID-19.

scholarly journals Current aspects on vaccines and immunization in the dog and cat. Part I. General aspects-Vaccines and vaccinations in the dog

2018 ◽  
Vol 50 (1) ◽  
pp. 15 ◽  
Author(s):  
M. M. MYLONAKIS (Μ.Μ. ΜΥΛΩΝΑΚΗΣ) ◽  
A. F. KOUTINAS (Α.Φ. ΚΟΥΤΙΝΑΣ) ◽  
K. G. PLEVRAKI (Κ.Γ. ΠΛΕΥΡΑΚΗ)
Keyword(s):  
Infectious Diseases ◽  
Passive Immunization ◽  
Small Animal ◽  
Risk Groups ◽  
Vaccination Schedule ◽  
Infectious Hepatitis ◽  
Active Immunization ◽  
Hyperimmune Serum ◽  
Life Itself ◽  
General Aspects

Immunoprophylaxis plays a pivotal role within the frame of contemporary preventive medicine, enabling the practicing veterinarian to control the most common infectious diseases that may pose a threat on the health status or life itself in the dog and cat. Passive immunization is the administration of preformed antibodies in animals of the same or different species. An alternative to maternal immunity, the natural way of passive immunity, is the use of hyperimmune serum or plasma in colostrum-deprived neonates, in unvaccinated puppies and kittens that belong to high risk groups and in immunocompromised animals. In small animal practice the main vaccine types currently in use for vaccination, an active immunization procedure, include the modified live vaccines, the inactivated and the subunit vaccines. The sound knowledge of these vaccines special features and the potential causes of vaccination failures are essential if a successful vaccination schedule is to be implemented. Vaccinations can start at the 6th week of life in colostrum-afforded neonates while in colostrum-deprived puppies at the 4th week with the use of inactivated vaccines. In the dog, infectious diseases such as distemper, infectious hepatitis, leptospirosis (L. canicola, L. icterohaemorrhagiae), rabies, infectious tracheobronchitis, parvovirus infection, Coronavirus enteritis and babesiosis can be prevented by the use of vaccines which are currently available.

Red Book (2012)

2012 ◽  
Author(s):  
AAP Committee on Infectious Diseases
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Medical Center ◽  
Passive Immunization ◽  
Pediatric Infectious Disease ◽  
High Yield ◽  
Evidence Based ◽  
Health Providers ◽  
Digital Version ◽  
Pediatric Infections

Full text of Doody’s Red Book 5 Star review: Description The Red Book, updated every three years by the Committee on Infectious Diseases (COID) of the American Academy of Pediatrics (AAP), is a concise summary of over 200 pediatric infectious diseases and current AAP recommendations regarding prevention, diagnosis, and management. It provides evidence-based guidance to practicing clinicians on pediatric infections and vaccinations based on the recommendations of the committee as well as the combined expertise of hundreds of physician contributors. Purpose The Red Book is larger and more comprehensive than a handbook, but is indispensible for the rapid location of information about pediatric infectious diseases and vaccines. As a single reference, it is unmatched in the field in terms of practical applicability and usefulness. This edition offers substantial revisions and additions. Audience This publication is essential for pediatric infectious diseases specialists and general pediatricians, and is useful for family medicine and emergency medicine physicians as well. Public health and school health providers, medical residents and students also will find it a high-yield source of pediatric infectious disease and vaccine information. Features Available in print and a digital version that can be downloaded onto mobile devices, this dual platform offers flexibility. The digital version contains many useful direct links to supplemental materials including recommendations and guidelines from other agencies, and an extensive collection of images depicting disease features. The book is divided into sections that cover active and passive immunization, disease summaries, antimicrobial therapy for treatment and prophylaxis, and care of children in special situations. Assessment This is an essential reference for practicing pediatricians and pediatric infectious disease specialists. The AAP COID has done an exceptional job of keeping it timely and updated, evidence-based, and comprehensive, while also rendering it accessible and engaging in format and style. The Red Book is unparalleled in content and authority on pediatric infections and their prevention and management. Reviewer: Kari A. Simonsen, MD (University of Nebraska Medical Center) Doody’s Book Review

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