The article considers theoretical and practical aspects of management of foreign economic activity of chemical industry enterprises of Ukraine through the prism of crisis management. Attention is focused on the fact that at the moment chemical production in Ukraine is in the shadow of import substitution, and exports in general are losing production and economic potential, perseverance. The chemical industry is closely linked to the agro-industrial complex, and this issue is especially relevant in light of the possible food crisis, the arrival of which is predicted at the UN after the pandemic. That is why the answers at the state level should be found in the appropriate chronology, which will help to find a moment of distortion of the balance between justified imports and lost export potential. The aim of the anti-crisis strategy is to create a huge potential for environmentally friendly products through the introduction of appropriate innovations (based on domestic resources, such as bioethanol from biomass and stubble, biomethanol from solid waste, algae-based projects (from the Black and Azov Seas). The benefits of the strategy will be as follows: 1) dual benefits by reducing dependence on imports and increasing capacity for chemical production projects; 2) stimulating the overall growth of the chemical industry through public-private partnerships; 3) elimination of the current stagnant conditions of the industry caused by the consequences of the pandemic. Proposals to pursue a policy of reasonable protectionism in relation to import substitution for all participants in the domestic market are formulated. At the state level, in order to support the whole sector, it is advisable to adopt a model that emphasizes the use of appropriate fuels / raw materials based on domestic resources to reduce dependence on imports; replace mass imports with exclusive imports of only environmentally friendly and updated foreign innovative chemical technologies; attracting investment from TNC through appropriate government policies. The task of the Government in this situation is to carefully study the situation in each case and make a balanced decision.