OK-432 treatment of pediatric patients with recurrent thyroglossal duct cyst after surgery

2021 ◽  
Vol 75 (4) ◽  
pp. 1-4
Author(s):  
Nobuo Ohta ◽  
Shigeru Fukase ◽  
Miho Nakazumi ◽  
Teruyuki Sato ◽  
Takahiro Suzuki
Keyword(s):  
Pediatric Patients ◽  
Case Series ◽  
Rare Condition ◽  
Thyroglossal Duct Cyst ◽  
Outpatient Basis ◽  
First Line ◽  
Duct Cyst ◽  
Thyroglossal Duct ◽  
Total Shrinkage ◽  
First Line Treatment

<b>Introduction:</b> Recurrent thyroglossal duct cyst after surgery is not a rare condition and first-line treatment has not been established yet.<br/><br/> <b>Aim:</b> Evaluation of outcomes and complications of OK-432 treatment in patients with recurrent thyroglossal duct cyst after surgery. <br/><br/> <b>Material and methods:</b> This study is designed as a case series with planned data collection at Tohoku Medical and Pharmaceutical University and Fukase Clinic. Five patients with recurrent thyroglossal duct cyst after surgery received this therapy between January 2014 and February 2020 on an outpatient basis, without hospitalization. OK-432 solution was injected into the lesion using an 18- or 27-gauge needle, depending on the location and size of the lesion, as well as on possible complications.<br/> <br/> <b>Results:</b> Lesions showed marked reduction or total shrinkage in all patients, with no local scarring or deformity at the injection site. Side effects manifested as local pain at the site of injection and fever (37.5–38.5°C) observed in three patients, but the symptoms resolved within a few days.<br/> <br/> <b>Conclusions:</b> Since OK-432 therapy is simple, easy, safe and effective, it can be used as an alternative to surgery in the treatment of recurrent thyroglossal duct cyst after surgery.

scholarly journals Thyroglossal Duct Cyst & Sistrunk: a Case Series

2015 ◽  
pp. 322-326
Author(s):  
Viresh Arora ◽  
Bhushan Kathuria ◽  
SPS Yadav ◽  
Sharad Hernot
Keyword(s):  
Case Series ◽  
Thyroglossal Duct Cyst ◽  
Duct Cyst ◽  
Thyroglossal Duct

scholarly journals Thyroglossal duct cyst carcinoma

2016 ◽  
Vol 6 (2) ◽  
pp. 172
Author(s):  
Ashim Kumar Biswas ◽  
Kazi Shameemus Salam ◽  
Md. Mosleb Uddin ◽  
Kanu Lal Saha ◽  
Belayat Hossain Siddiquee ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Papillary Carcinoma ◽  
Cystic Lesion ◽  
Histopathological Examination ◽  
Rare Condition ◽  
Thyroglossal Duct Cyst ◽  
Thyroglossal Cyst ◽  
Duct Cyst ◽  
Thyroglossal Duct

Thyroglossal duct cyst carcinoma in a rare condition. Only around 250 cases of malignant thyroglossal cyst have been reported as far. We report a 45 years old women presenting with a painless swelling in the midline in the upper part of front of neck for 1 yr. This swelling moves with deglutition, multilobulated moves up on protrusion of tongue. FNAC revealed cystic lesion compatible with thyroglossal duct cyst. Ultrasonogram revealed mass is separated from thyroid gland. Patient underwent sistnmk's operation and tissue was sent for histopathological examination and report reveled papillary carcinoma of thyroglossal duct cyst.

scholarly journals Squamous cell carcinoma arising from a thyroglossal duct cyst: A case report and review of the literature

2018 ◽  
Vol 6 ◽  
pp. 2050313X1876705
Author(s):  
Qi Huang ◽  
Yi Shen ◽  
Allen Y Wang ◽  
Shijie Qiu ◽  
Qun Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Series ◽  
Cervical Lymphadenopathy ◽  
Thyroglossal Duct Cyst ◽  
Duct Cyst ◽  
Thyroglossal Duct ◽  
Sistrunk Procedure

Objectives: Squamous cell carcinoma in a thyroglossal duct cyst is exceedingly rare with only 26 reported cases in the literature so far, which only account for 6% of the patients. Methods: We report a unique case of squamous cell carcinoma arising from a thyroglossal duct cyst in a 49-year-old male who was primarily diagnosed as a thyroglossal duct cyst with inflammation. The patient underwent Sistrunk procedure with wide local excision and radiation therapy as well as chemotherapy post-operatively and had no evidence of recurrence or metastasis for 24 months. In addition, we reviewed the relevant literatures. Results: Whether squamous cell carcinoma actually arises from thyroglossal duct cyst is still controversial; however, carcinoma originating from metaplasia of columnar and squamous epithelium in thyroglossal duct cyst has been well accepted. The gold-standard diagnostic method is fine needle aspiration biopsy with ultrasound guidance. Sistrunk procedure alone or with wide excision is likely to be beneficial. Neck dissection is necessary in patients with positive cervical lymphadenopathy. Radiation therapy and chemotherapy have not yet been clearly defined. Conclusion: Squamous cell carcinoma arising from thyroglossal duct cyst is really a rare disease, whose origin, treatments and prognosis still remain uncertain. These are solely based on case reports, case series and expert opinions. Hence, more investigations about squamous cell carcinoma will be conducted in the near future.

scholarly journals Papillary Thyroid Carcinoma within Thyroglossal Duct Cyst: Case Series and Literature Review

2017 ◽  
Vol 22 (03) ◽  
pp. 253-255 ◽  
Author(s):  
Haissan Iftikhar ◽  
Mubasher Ikram ◽  
Karim Rizwan Nathani ◽  
Adnan Yar Muhammad
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Adult Population ◽  
Thyroid Tissue ◽  
Case Series ◽  
Thyroglossal Duct Cyst ◽  
Selective Neck Dissection ◽  
Papillary Thyroid ◽  
Duct Cyst ◽  
Thyroglossal Duct

Introduction Thyroglossal duct cyst (TGDC) is the most common congenital anomaly of the neck, and approximately 7% of all the adult population presents it. Ectopic thyroid tissue is found in the thyroglossal duct cyst wall in up to 65% of cases. This thyroid tissue has the potential to develop some type of malignancy, the most common of which is the papillary carcinoma of the thyroid. There are just over 270 cases of thyroglossal duct cyst malignancy reported in the literature. Objectives We aimed to study our population of patients in order to identify cases with thyroglossal duct cyst malignancy. Methods A retrospective chart review was conducted in the section of otolaryngology/head and neck surgery at a hospital in Karachi, Pakistan, from January of 2004 to December of 2014 on patients with the diagnosis of thyroglossal duct cyst. Results Fifty-eight patients were diagnosed with TGDC, two of whom also presented with thyroglossal duct cyst carcinoma. Both patients revealed papillary thyroid carcinoma on histopathology. Case 1 had an open biopsy before undergoing definitive surgery. Both patients underwent subsequent total thyroidectomy after Sistrunk procedure, and case 2 had selective neck dissection revealing lymph node metastasis. Conclusion Thyroglossal duct cyst carcinoma is a rare finding that comes as a surprise to both the patient and the surgeon. We report 2 out of 58 cases diagnosed with thyroglossal duct cyst carcinoma.

scholarly journals Insidensi Kista Duktus Tiroglosus di Bagian Bedah RSUP Prof. Dr. R. D. Kandou Manado Periode Januari 2014 - Desember 2016

e-CliniC ◽  
2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Meidina Kinontoa ◽  
Nico Lumintang ◽  
Andreissanto C. Lengkong
Keyword(s):  
Medical Records ◽  
Pediatric Patients ◽  
Neck Region ◽  
Thyroglossal Duct Cyst ◽  
Age Group ◽  
Duct Cyst ◽  
Thyroglossal Duct ◽  
Thyroglossal Duct Cysts ◽  
Male Patients ◽  
Surgery Department

Abstract: Thyroglossal duct cyst is the most common asymptomatic congenital mass found in the neck region. It is more commonly occurs in pediatric patients but not uncommon in adult patients. According to epidemiologic data, there is no difference in predilection among sexes. Diagnosis of thyroglossal duct cyst is ascertained by anamnesis, physical examination, and ancillary examination. Treatment of thyroglossal duct cyst is surgery. This study was aimed to establish the incidence of thyroglossal duct cysts at the Surgery Department of Prof. Dr. R. D. Kandou Hospital Manado in the period of January 2014 - December 2016 based on age, gender, surgical treatment, as well as the location of thyroglossal duct cysts. This was a descriptive retrospective study using all thyroglossal duct cyst medical records at the Surgery Department of Prof. Dr. R. D. Kandou Hospital Manado in the period of January 2014-December 2016. The results showed that the highest incidence of thyroglossal duct cyst was in 2014 (37%), and in the age group of 6-11 years old. Male patients were more common than females. Meanwhile, the most common locations of this cyst were suprahyoid and subhyoid (25%) and the most common surgical procedure used was modified Sistrunk (88%). Conclusion: Thyroglossal duct cyst was more common in age group of 6-11 years, males, suprahyoid and subhyoid locations, and treated with modified Sistrunk surgeryKeywords: thyroglossal duct cyst Abstrak: Kista duktus tiroglosus merupakan massa kongenital asimtomatik yang paling sering ditemukan di daerah leher. Kasus ini lebih sering terjadi pada anak tetapi juga tidak jarang ditemukan pada orang dewasa. Secara epidemiologi tidak ada perbedaan predileksi jenis kelamin antara laki-laki dan perempuan. Diagnosis kista duktus tiroglosus ditegakkan berdasarkan anamnesis, pemeriksaan fisik dan pemeriksaan penunjang. Penatalaksanaan dari kista duktus tiroglosus adalah tindakan pembedahan. Penelitian ini bertujuan unuk mengetahui insidensi kista duktus tiroglosus di Bagian Bedah RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2014-Desember 2016, berdasarkan tahun, usia, jenis kelamin, tindakan pembedahan, serta letak kista duktus tiroglosus. Jenis penelitian ialah deskriptif retrospektif dengan menggunakan semua data rekam medik pasien kista duktus tiroglosus di Bagian Bedah RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2014-Desember 2016. Hasil penelitian menunjukkan bahwa insidensi kista duktus tiroglosus selama periode Januari 2014-Desember 2016 tertinggi pada tahun 2014 (37%) dan pada kelompok usia 6-11 tahun (37%). Jumlah pasien laki-laki ditemukan lebih banyak daripada perempuan. Letak kista tersering ditemukan di suprahioid dan subhioid (25%) dan tindakan pembedahan yang tersering dilakukan ialah modifikasi Sistrunk (88%). Simpulan: Kista tiroglosus paling sering ditemukan pada kelompok usia 6-11 tahun, jenis kelamin laki-laki, dengan letak kista suprahiod dan subhiod, serta tindakan pembedahan modifikasi Sistrunk.Kata kunci: kista duktus tiroglosus

scholarly journals Micro-CT Imaging of Pediatric Thyroglossal Duct Cysts: A Prospective Case Series

2021 ◽  
Vol 9 ◽  
Author(s):  
Claire Frauenfelder ◽  
Susan C. Shelmerdine ◽  
Ian C. Simcock ◽  
Andrew Hall ◽  
John Ciaran Hutchinson ◽  
...  
Keyword(s):  
3D Imaging ◽  
Histopathological Examination ◽  
Case Series ◽  
Ct Imaging ◽  
Thyroglossal Duct Cyst ◽  
Micro Ct ◽  
Duct Cyst ◽  
Thyroglossal Duct ◽  
Thyroglossal Duct Cysts ◽  
Prospective Case Series

Objectives: To determine the feasibility of micro-CT as a high-resolution 3D imaging tool for thyroglossal duct cysts and to evaluate its role augmenting traditional histopathological examination of resected specimens.Methods: A single centre, prospective case series of consecutive children undergoing excision of a thyroglossal duct cyst was performed at a quaternary paediatric referral hospital in the United Kingdom. Consecutive children listed for excision of a thyroglossal duct cyst whose parents agreed to participate were included and there were no exclusion criteria.Results: Surgically excised thyroglossal duct cyst or remnant specimens from five patients (two males, three females) were examined using micro-CT alongside traditional histopathological examination. In all cases, micro-CT imaging was able to demonstrate 3D imaging datasets of the specimens successfully and direct radio-pathological comparisons were made (Figures 1–5, Supplementary Video 1).Conclusions: The study has shown the feasibility and utility of post-operative micro-CT imaging of thyroglossal duct cysts specimens as a visual aid to traditional histopathological examination. It better informs the pathological specimen sectioning using multi-planar reconstruction and volume rendering tools without tissue destruction. In the complex, often arborised relationship between a thyroglossal duct cyst and the hyoid, micro-CT provides valuable image plane orientation and indicates proximity of the duct to the surgical margins. This is the first case series to explore the use of micro-CT imaging for pediatric thyroglossal duct specimens and it informs future work investigating the generalizability of micro-CT imaging methods for other lesions, particularly those from the head and neck region where precisely defining margins of excision may be challenging.

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