Treatment Outcome of Sudden Sensorineural Hearing Loss: A Retrospective Analysis of 118 Cases

This study investigated the etiology and treatment outcome in sudden sensorineural hearing loss (SSHL) patients following dental procedure. During the past 2 decades, only 6 patients with SSHL following dental procedure were experienced including tooth extraction in 5 and endodontic treatment in 1. Three were males and 3 were females, with ages ranging from 10 to 75 years (median, 47 years). All patients underwent an inner ear test battery. Types of audiogram consisted of total deafness in 3 ears, flat-type loss in 2 ears, and high-tone loss in 1 ear. The pretreatment mean hearing level from 4 frequencies was 76 ± 37 dB for the lesion ears, significantly higher than 23 ± 15 dB for the opposite healthy ears. The treatment outcome is unsatisfactory. Five patients remained hearing unchanged 3 months after treatment. Only 1 (17%) patient had hearing improvement who was proved as having reactivation of the varicella-zoster virus. In conclusion, reactivation of the varicella-zoster virus may be one of the etiologies for SSHL patients following dental procedure. Serological assay coupled with MR imaging may help identify the etiology, determine the medication, and predict the outcome.

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Treatment Outcome of Intratympanic Infusions in Sudden Sensorineural Hearing Loss

Skull Base ◽

10.1055/s-2009-1224374 ◽

2009 ◽

Vol 19 (S 02) ◽

Author(s):

E. Passou

Keyword(s):

Hearing Loss ◽

Treatment Outcome ◽

Sensorineural Hearing Loss ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing

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Exploratory tympanotomy in sudden sensorineural hearing loss for the identification of a perilymphatic fistula – retrospective analysis and review of the literature

The Journal of Laryngology & Otology ◽

10.1017/s0022215120000948 ◽

2020 ◽

Vol 134 (6) ◽

pp. 501-508

Author(s):

S Heilen ◽

C P Lang ◽

A Warnecke ◽

T Lenarz ◽

M Durisin

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Retrospective Analysis ◽

Diagnostic Value ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Review Of The Literature ◽

Perilymphatic Fistula

AbstractObjectiveThe diagnostic value of exploratory tympanotomy in sudden sensorineural hearing loss remains controversial. This study and review were performed to identify the incidence of perilymphatic fistula in patients with sudden sensorineural hearing loss. The effectiveness of tympanotomy for sealing of the cochlear windows in cases with perilymphatic fistula was evaluated.MethodsA search in common databases was performed. Overall, 5034 studies were retrieved. Further, a retrospective analysis on 90 patients was performed.ResultsEight publications dealing with tympanotomy in patients with sudden sensorineural hearing loss were identified. In 90 patients diagnosed with sudden sensorineural hearing loss and undergoing exploratory tympanotomy, 10 patients (11 per cent) were identified with a perilymphatic fistula, and this corresponds to the results obtained from our review (13.6 per cent).ConclusionThere was no significant improvement after exploratory tympanotomy and sealing of the membranes for patients with a definite perilymphatic fistula.

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The Expression of TNFα, IL-6, IL-2 and IL-8 in the Serum of Patients with Idiopathic Sudden Sensorineural Hearing Loss: Possible Prognostic Factors of Response to Corticosteroid Treatment

Audiology and Neurotology Extra ◽

10.1159/000442016 ◽

2016 ◽

Vol 6 (1) ◽

pp. 9-19 ◽

Cited By ~ 4

Author(s):

Zinovia Tsinaslanidou ◽

Miltiadis Tsaligopoulos ◽

Nikolaos Angouridakis ◽

Victor Vital ◽

Georgios Kekes ◽

...

Keyword(s):

Hearing Loss ◽

Treatment Outcome ◽

Prognostic Factors ◽

Sensorineural Hearing Loss ◽

Proinflammatory Cytokines ◽

Corticosteroid Treatment ◽

Sudden Sensorineural Hearing Loss ◽

Therapeutic Outcome ◽

Sensorineural Hearing ◽

Enzyme Linked Immunosorbent Assay

Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) remains one of the major unsolved otologic emergencies. A viral infection, a systemic inflammatory disorder, as well as physical, mental and metabolic stress can trigger an innate immune response in the inner ear resulting in ISSNHL. Proinflammatory cytokines play a central role in this cochlear immunological cascade. Objective: To examine the expression of proinflammatory cytokines in the serum of patients with ISSNHL in correlation with the therapeutic outcome of intravenous administration of corticosteroids. Method: Forty-three patients primarily diagnosed with ISSNHL underwent intravenous corticosteroid treatment for 8 days. The expression of tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), interleukin-2 (IL-2) and interleukin-8 (IL-8) was detected with the use of enzyme-linked immunosorbent assay in serum specimens on the 1st and 8th day of treatment and it was correlated with the treatment outcome. Results: TNFα reduction and IL-6 increase strongly correlate with a good therapeutic result [χ2(2) = 13.12, p = 0.001 and χ2(2) = 16.78, p = 0.0001]. IL-8 increase reflects negatively on the outcome, however, not in a statistically significant way. No association was established between IL-2 variations and the therapeutic outcome. Conclusions: TNFα and IL-6 can be used as prognostic factors for the treatment outcome, whereas the prognostic value of IL-8 requires further statistical confirmation.

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