Role of Berberis lycium in Reducing Serum Cholesterol in Broilers

Abstract We measured serum cholesterol, triglyceride, and lipoprotein Lp(a) concentrations in serum of 37 patients with massive proteinuria of different origin, comparing values with those for age- and sex-matched controls and finding significantly increased Lp(a) concentration in the total group of patients compared with controls. Lp(a) concentration was not correlated with serum cholesterol, triglyceride, serum creatinine, daily urinary protein loss, or selectivity index. Selecting the patients according to their histological diagnosis obtained by renal needle biopsy, we found divergent results in seven patients with minimal change disease (MCD) compared with 11 patients with membranoproliferative glomerulonephritis. Lp(a) in MCD patients did not differ from that controls (101 +/- 102 and 90 +/- 115 mg/L) and correlated positively with total daily urinary protein loss (r = 0.7962, P less than 0.05). In contrast, the patients with membranoproliferative glomerulonephritis had significantly higher Lp(a) values than the controls (219 +/- 222 mg/L), and Lp(a) concentrations correlated negatively with the daily protein loss in urine (r = -0.6545, P less than 0.05). The most surprising results were the marked Lp(a) concentrations in serum of three patients with primary amyloidosis and nephrosis syndrome. Our results indicate a regulatory role of the kidney in the metabolism of Lp(a) and different effects on the serum Lp(a) concentration, depending on the type of damage to renal tissue.

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Serum Cholesterol Esterification in Human Liver Disease: Role of Lecithin-Cholesterol Acyltransferase and Cholesterol Ester Hydrolase

Gastroenterology ◽

10.1016/s0016-5085(74)80042-9 ◽

1974 ◽

Vol 66 (4) ◽

pp. 539-547 ◽

Cited By ~ 11

Author(s):

Jerome B. Simon ◽

David L. Kepkay ◽

Raymond Poon

Keyword(s):

Liver Disease ◽

Serum Cholesterol ◽

Cholesterol Ester ◽

Human Liver ◽

Cholesterol Acyltransferase ◽

Cholesterol Esterification ◽

Lecithin Cholesterol Acyltransferase ◽

Ester Hydrolase ◽

Human Liver Disease

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Prophylactic Potential of Conventional and Supercritical Garlic Extracts to Alleviate Diet Related Malfunctions

Recent Patents on Food Nutrition & Agriculturee ◽

10.2174/2212798410666180724103827 ◽

2019 ◽

Vol 10 (1) ◽

pp. 34-47 ◽

Cited By ~ 1

Author(s):

Kanza A. Awan ◽

Masood S. Butt ◽

Faiza Ashfaq ◽

Hussan Munir ◽

Hafiz A.R. Suleria

Keyword(s):

Weight Gain ◽

Glucose Level ◽

Serum Cholesterol ◽

Therapeutic Interventions ◽

Sprague Dawley ◽

Maximum Increase ◽

Antidiabetic Agents ◽

Sprague Dawley Rats ◽

Maximum Decrease

Objectives: The present research was tailored to explore the prophylactic role of garlic extracts to mitigate some diet related malfunctions. The recent patents regarding antidiabetic agents (US 20140147528 A1) and garlic compositions (US 20110129580 A1) also helped in the study design. Methods: Bioevaluation trials were conducted on Sprague Dawley rats by feeding garlic extracts for a period of sixty days. Accordingly, three studies were carried out comprising of normal, hyperglycemic and hypercholesterolemic rats. Drink & feed intakes and weight gain were measured throughout the trial. After sixty days, collected sera from rats were analyzed for serum cholesterol, LDL, HDL & triglyceride levels and glucose & insulin concentrations. Finally, the data obtained were subjected to statistical modeling. Results: Results concerning the bioevaluation trials revealed that maximum 12.39% reduction was observed in serum cholesterol in Study III (hypercholesterolemic rats) on the provision of garlic supercritical extract (nutraceutical diet) followed by 10.24% decline in rats fed on solvent extract supplemented diet (functional diet). Regarding LDL, maximum decrease (17.02%) was recorded on the administration of diet having garlic supercritical extract to the hypercholesterolemic rats. While in Study II (hyperglycemic rats) maximum decrease of 11.03% in glucose level was recorded in rats fed on supercritical extract containing diet. In the same group maximum increase in insulin (7.95%) was recorded. Conclusions: From the current investigations, it can be concluded that garlic based designer foods possess the prophylactic perspectives to alleviate the risk of metabolic ailments. Thus, it can be used in the diet based therapeutic interventions as an adjuvant to pharmaceuticals.

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The role of potassium in lowering serum cholesterol remains unresolved

Inpharma Weekly ◽

10.2165/00128413-199007650-00012 ◽

1990 ◽

Vol &NA; (765) ◽

pp. 6

Author(s):

&NA;

Keyword(s):

Serum Cholesterol

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Cholesterol and stroke

Reviews in Clinical Gerontology ◽

10.1017/s0959259899009119 ◽

1999 ◽

Vol 9 (1) ◽

pp. 1-12 ◽

Cited By ~ 2

Author(s):

SN Evans ◽

MD Fotherby

Keyword(s):

Risk Factors ◽

Coronary Heart Disease ◽

Clinical Trials ◽

Risk Factor ◽

Heart Disease ◽

Serum Cholesterol ◽

Intervention Studies ◽

The Elderly

Stroke and coronary heart disease (CHD) share many risk factors, suggesting at least some similarities in pathogenesis. It is therefore surprising that the role of one of the major risks for CHD, dyslipidaemia, remains so contentious as a risk factor for stroke. Because of a lack of good clinical trials, conflicting views have been expressed on the association of lipids, primarily serum cholesterol and its subfractions, with stroke disease and the merits of preventing stroke by lowering cholesterol. Many of the issues involved are intimately related to those of managing dyslipidaemia in the elderly. If stroke occurred as commonly below the age of 65 as above this age it is likely that the necessary epidemiological and intervention studies would already have been undertaken.

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