A Novel Method for Qualification of a Potency Assay through Partial Computer Simulation

2018 ◽  
Vol 72 (3) ◽  
pp. 249-263
Author(s):  
Steven Novick ◽  
Perceval Sondag ◽  
Tim Schofield ◽  
Kenneth Miller
Keyword(s):  
Computer Simulation ◽  
Potency Assay ◽  
Novel Method

Optimization of Bending Process of Large Marine Crankthrow by Computer Simulation

2007 ◽  
Vol 561-565 ◽  
pp. 1949-1952 ◽  
Author(s):  
Ming Yue Sun ◽  
Shan Ping Lu ◽  
Dian Zhong Li ◽  
Yi Yi Li
Keyword(s):  
Computer Simulation ◽  
Conventional Method ◽  
Transformation Method ◽  
Actual Process ◽  
The Novel ◽  
Fem Model ◽  
Maximum Resistance ◽  
Bending Process ◽  
Novel Method ◽  
Simulation Results

The conventional method of bending the large crankthrow was investigated by computer simulation combined with manufacturing trial, and the typical forging defects, such as constricted waist, folded cracks and horn mouth on forged blank were analyzed. On the basis of these results, a novel forging shape of preformed blank was proposed using anti-transformation method by computer simulation. The FEM simulated results show that all the above defects can be avoided by carrying out the novel method, furthermore, the maximum resistance of the novel bending deformation was reduced to 72% of conventional process, and the weight of forging blank can be decreased by 15%. Finally, the optimum forging shape was applied to the actual process, the simulation results were confirmed by manufacturing trial, and qualified forged piece was gained. The FEM model established can be used for further optimization of other types of crankthrow.

scholarly journals Multi-fidelity Gaussian Process Bandit Optimisation

2019 ◽  
Vol 66 ◽  
pp. 151-196 ◽  
Author(s):  
Kirthevasan Kandasamy ◽  
Gautam Dasarathy ◽  
Junier Oliva ◽  
Jeff Schneider ◽  
Barnabás Póczos
Keyword(s):  
Computer Simulation ◽  
Theoretical Analysis ◽  
Gaussian Process ◽  
Target Function ◽  
Black Box ◽  
Confidence Bound ◽  
Bandit Problem ◽  
Single Function ◽  
Novel Method ◽  
Upper Confidence Bound

In many scientific and engineering applications, we are tasked with the maximisation of an expensive to evaluate black box function f. Traditional settings for this problem assume just the availability of this single function. However, in many cases, cheap approximations to f may be obtainable. For example, the expensive real world behaviour of a robot can be approximated by a cheap computer simulation. We can use these approximations to eliminate low function value regions cheaply and use the expensive evaluations of f in a small but promising region and speedily identify the optimum. We formalise this task as a multi-fidelity bandit problem where the target function and its approximations are sampled from a Gaussian process. We develop MF-GP-UCB, a novel method based on upper confidence bound techniques. In our theoretical analysis we demonstrate that it exhibits precisely the above behaviour and achieves better bounds on the regret than strategies which ignore multi-fidelity information. Empirically, MF-GP-UCB outperforms such naive strategies and other multi-fidelity methods on several synthetic and real experiments.

A Novel Method of Spike Detection for Interferograms Based on Two-Step Filtering

2014 ◽  
Vol 599-601 ◽  
pp. 1364-1368
Author(s):  
Yao Pu Zou ◽  
Chang Pei Han ◽  
Lei Zhang ◽  
Wen Gui Pan ◽  
Chao Wang
Keyword(s):  
Computer Simulation ◽  
Theoretical Analysis ◽  
Detection Method ◽  
High Accuracy ◽  
Spike Detection ◽  
Novel Method

According to the characteristics of interferogram, we design a new spike detection method, which firstly filters an interferogram with two different ways and then detects spikes based on both results. Theoretical analysis and computer simulation shows that this algorithm performs well in detecting spikes in any position of an interferogram with high accuracy, and can be easily implemented in hardware.

scholarly journals He’s Max-Min Approach for Coupled Cubic Nonlinear Equations Arising in Packaging System

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Jun Wang
Keyword(s):  
Computer Simulation ◽  
Approximate Solution ◽  
Numerical Solution ◽  
Nonlinear Equations ◽  
High Accuracy ◽  
Packaging System ◽  
Novel Method ◽  
Runge Kutta

He’s inequalities and the Max-Min approach are briefly introduced, and their application to a coupled cubic nonlinear packaging system is elucidated. The approximate solution is obtained and compared with the numerical solution solved by the Runge-Kutta algorithm yielded by computer simulation. The result shows a great high accuracy of this method. The research extends the application of He’s Max-Min approach for coupled nonlinear equations and provides a novel method to solve some essential problems in packaging engineering.

A NOVEL METHOD TO ANALYZE PHASE DIAGRAMS FOR TRAFFICS ON THE CROSSROAD

2012 ◽  
Vol 23 (10) ◽  
pp. 1250068 ◽  
Author(s):  
QI-LANG LI ◽  
RUI JIANG ◽  
BING-HONG WANG ◽  
MU-REN LIU
Keyword(s):  
Computer Simulation ◽  
Phase Diagrams ◽  
Traffic Flow ◽  
Occupation Probability ◽  
Traffic Model ◽  
Probability Method ◽  
The Novel ◽  
Novel Method ◽  
Simulation Results ◽  
Good Agreement

Traffic flow at a single crossroad consisting of two perpendicular one-lane roads, treated earlier by Ishibashi and Fukui [J. Phys. Soc. Jpn.70, 2793 (2001); 70, 3747 (2001)], has been studied on the basis of the local occupation probability method. However, in this work, based on the novel theoretical analysis and computer simulations, we have studied this crossroad traffic model again and presented the same phase diagrams of traffic flow in the case of various maximum vehicle velocities. We have also derived the flow formulas in all regions in the phase diagrams, which are in good agreement with computer simulation results. Compared with the previous local occupation probability method, our analytical way is simpler and may be widely used for other traffic bottlenecks research.

scholarly journals He Chengtian’s Inequalities for a Coupled Tangent Nonlinear System Arisen in Packaging System

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Jun Wang ◽  
Zhi-geng Fan ◽  
Li-xin Lu ◽  
An-jun Chen ◽  
Zhi-wei Wang
Keyword(s):  
Computer Simulation ◽  
Approximate Solution ◽  
Nonlinear System ◽  
High Accuracy ◽  
Packaging System ◽  
Suggested Approach ◽  
Novel Method

He Chengtian’s inequalities from ancient Chinese algorithm are applied to strong tangent nonlinear packaging system. The approximate solution is obtained and compared with the solution yielded by computer simulation, showing a great high accuracy of this method. The suggested approach provides a novel method to solve some essential problems in packaging engineering.

The removal and morphology of intact biofilms from implanted venous access devices

1995 ◽  
Vol 53 ◽  
pp. 1020-1021
Author(s):  
M.A. Gregory ◽  
G.P. Hadley
Keyword(s):  
Patient Selection ◽  
Surgical Oncology ◽  
Venous Access ◽  
Common Procedure ◽  
Indwelling Catheters ◽  
Careful Patient ◽  
Novel Method ◽  
The Subject ◽  
Vascular Catheters ◽  
Venous Access Devices

The insertion of implanted venous access systems for children undergoing prolonged courses of chemotherapy has become a common procedure in pediatric surgical oncology. While not permanently implanted, the devices are expected to remain functional until cure of the primary disease is assured. Despite careful patient selection and standardised insertion and access techniques, some devices fail. The most commonly encountered problems are colonisation of the device with bacteria and catheter occlusion. Both of these difficulties relate to the development of a biofilm within the port and catheter. The morphology and evolution of biofilms in indwelling vascular catheters is the subject of ongoing investigation. To date, however, such investigations have been confined to the examination of fragments of biofilm scraped or sonicated from sections of catheter. This report describes a novel method for the extraction of intact biofilms from indwelling catheters.15 children with Wilm’s tumour and who had received venous implants were studied. Catheters were removed because of infection (n=6) or electively at the end of chemotherapy.

Characterization of Modulated Structure Through Structure Images and their Computer Simulation

1990 ◽  
Vol 48 (1) ◽  
pp. 70-71
Author(s):  
Kiyomichi Nakai ◽  
Yusuke Isobe ◽  
Chiken Kinoshita ◽  
Kazutoshi Shinohara
Keyword(s):  
Computer Simulation ◽  
High Resolution ◽  
Spherical Aberration ◽  
High Resolution Electron Microscopy ◽  
Basic Mechanism ◽  
Objective Lens ◽  
Specimen Thickness ◽  
Transmitted Beam ◽  
Modulated Structure ◽  
Resolution Electron

Induced spinodal decomposition under electron irradiation in a Ni-Au alloy has been investigated with respect to its basic mechanism and confirmed to be caused by the relaxation of coherent strain associated with modulated structure. Modulation of white-dots on structure images of modulated structure due to high-resolution electron microscopy is reduced with irradiation. In this paper the atom arrangement of the modulated structure is confirmed with computer simulation on the structure images, and the relaxation of the coherent strain is concluded to be due to the reduction of phase-modulation.Structure images of three-dimensional modulated structure along <100> were taken with the JEM-4000EX high-resolution electron microscope at the HVEM Laboratory, Kyushu University. The transmitted beam and four 200 reflections with their satellites from the modulated structure in an fee Ni-30.0at%Au alloy under illumination of 400keV electrons were used for the structure images under a condition of the spherical aberration constant of the objective lens, Cs = 1mm, the divergence of the beam, α = 3 × 10-4 rad, underfocus, Δf ≃ -50nm and specimen thickness, t ≃ 15nm. The CIHRTEM code was used for the simulation of the structure image.

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