Effects of Changes in Neuropsychiatric Symptoms on Cognitive Function, Activities of Daily Living and Quality of Life Among Patients with Subacute Stroke after Rehabilitation Treatment

Introduction: Although the impacts of marital status on health have long been recognized, little is known about its role in stroke outcomes. The study examined the association of marital status with neuropsychiatric, cognitive, functional, and quality of life outcomes at 90 days post-stroke in a population-based sample. Methods: Data were obtained from the Brain Attack Surveillance in Corpus Christi (BASIC) project (2009-2016). Post-stroke outcomes included neurological status assessed by the National Institutes of Health Stroke Scale, cognitive function assessed by the Modified Mini-Mental State Examination, functioning assessed by an activities of daily living (ADL)/instrumental activities of daily living (IADL) score, depression assessed by the 8-item Patient Health Questionnaire, and quality of life assessed by the short-form Stroke Specific Quality of Life scale. Linear or Tobit regression models were used to examine the association between marital status and stroke outcomes, accounting for attrition. Results: Among 1,226 ischemic or hemorrhagic cases, mean age was 67.6 (SD=12.3), half were women, and three-fifths were Mexican American; 23.0% were widowed, 20.1% were divorced/separated, and 8.4% were never married. Widowed participants were more likely to be female, aged above 75, and less educated than other groups. After adjustment for age, sex, ethnicity, education and stroke severity, compared with those married, those widowed had significantly worse cognitive function and quality of life, those never married had worse neurological and cognitive outcomes, and those divorced/separated had more depressive symptoms and poorer quality of life (Table). Conclusions: Being unmarried at stroke onset is associated with worse outcomes after stroke, and the outcome profiles vary by marital status. Further research should investigate potential mechanisms and develop interventions to improve outcomes of unmarried stroke survivors.

Download Full-text

Gingko biloba extract EGb 761®: clinical data in dementia

International Psychogeriatrics ◽

10.1017/s1041610212000543 ◽

2012 ◽

Vol 24 (S1) ◽

pp. S35-S40 ◽

Cited By ~ 13

Author(s):

Ralf Ihl

Keyword(s):

Quality Of Life ◽

Cognitive Function ◽

Daily Living ◽

Neuropsychiatric Symptoms ◽

Safety Data ◽

Egb 761 ◽

Gingko Biloba ◽

Moderate Dementia ◽

Independent Trials

ABSTRACTResearch into Gingko biloba extract EGb 761® has been ongoing for many years. Early studies showed that the extract was superior to placebo in improving symptoms of dementia, and this has been confirmed by more recent research. The GINDEM-NP, GOTADAY and GOT-IT! studies showed that 240 mg/day EGb 761® improved cognitive function, neuropsychiatric symptoms, activities of daily living, and quality of life in patients with mild to moderate dementia compared with placebo, with results reproducible in independent trials. The strength of the effect in terms of improvements in neurosensory symptoms associated with old age and dementia was strong enough to be detected by caregivers and independent clinicians. A combination of 240 mg/day EGb 761® and 10 mg/day (initially 5 mg/day) donepezil was also more effective than either drug alone. Regarding the improvement of neuropsychiatric symptoms, a cross-comparison of studies with different antidementia agents suggests that EGb 761® is at least as effective as memantine, galantamine, and donepezil. Safety data revealed no important safety concerns with EGb 761®.

Download Full-text

The path linking disease severity and cognitive function with quality of life in Parkinson's disease:the mediating effect of activities of daily living and depression.

10.21203/rs.3.rs-46784/v2 ◽

2020 ◽

Author(s):

Yao He ◽

Yuling Tian ◽

Hongjuan Han ◽

Jing Cui ◽

Xiaoyan Ge ◽

...

Keyword(s):

Quality Of Life ◽

Cognitive Function ◽

Activities Of Daily Living ◽

Direct Effect ◽

Daily Living ◽

Mediating Effect ◽

Equation Modeling ◽

Effect Of Pd ◽

Significant Direct Effect

Abstract Background: Research on quality of life (QOL) with Parkinson’s disease (PD) has examined direct influencing factors, not mediators. The study aim was to explore whether PD severity and poor cognitive function may decrease physical and mental QOL by reducing activities of daily living (ADL) and increasing depression in sequence. Methods: We conducted a cross-sectional questionnaire study of 150 PD hospital patients in China. PD severity, cognitive function, ADL, depression, and QOL were evaluated. We used structural equation modeling to analyze the mediating effects of ADL and depression on the association between PD severity/cognition and physical (PCS) and mental (MCS) QOL. Results:There was a significant mediating effect of PD severity on PCS via ADL and depression (95%CI: −0.669, −0.026), and a significant direct effect (p<0.001). The mediating effect of PD severity on MCS via ADL and depression was significant (95%CI: −2.135, −0.726), but there was no direct effect (p = 0.548). There was a significant mediating effect of cognitive function on PCS via ADL and depression (95%CI: 0.025, 0.219) and a significant direct effect (p<0.001). The mediating effect of cognitive function on MCS via ADL and depression was significant (95%CI: 0.256, 0.645), but there was no direct effect (p = 0.313). The PCS models showed a partial mediation, and the MCS models showed a complete mediation, of ADL and depression.Conclusions:PD severity and cognitive function increase depression by reducing ADL, leading to lower QOL, and directly or indirectly affect PCS and MCS through different pathways.

Download Full-text

Group-Based Exercise as a Therapeutic Strategy for the Improvement of Mental Outcomes in Mild to Moderate Alzheimer’s Patients in Low Resource Care Facilities

Asian Journal of Sports Medicine ◽

10.5812/asjsm.106593 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Ina Shaw ◽

Melany Cronje ◽

Brandon Stuwart Shaw

Keyword(s):

Quality Of Life ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Function ◽

Activities Of Daily Living ◽

Daily Living ◽

Brain Plasticity ◽

Low Cost ◽

Group Exercise

Background: Exercise is related to enhanced cognitive functioning and brain plasticity. Exercise might represent a potential adjunctive treatment for neuropsychiatric disorders, such as Alzheimer's disease (AD). Furthermore, group exercise may prove especially useful due to its additional benefits. Objectives: This study aimed to determine the effect of low-cost, group-based exercise on mental outcomes in patients with mild to moderate AD. Methods: Participants with mild to moderate AD were randomized to either a non-exercising control (CON) group or a group-exercise (GEX) group (n = 20 each). The GEX participated in eight weeks of three-times-weekly non-consecutive 45-minute sessions consisting of balance, resistance, aerobic, and flexibility exercises to determine their effect on mental outcomes, namely, cognitive function, activities of daily living (ADLs), and quality of life (QOL). Results: The intervention program showed a significant (P ≤ 0.05) increase in Mini-Mental State Examination (MMSE) scores (P = 0.023). While the GEX were found to have no change in their (Alzheimer’s disease cooperative study activities of daily living) ADCS-ADL scores (P = 0.574). The CON demonstrated a significant, but deleterious 13.77% decrease in their ADCS-ADL scores from pre- to mid-test (P = 0.023) and from pre- to post-test (P = 0.038). Quality of Life-Alzheimer’s Disease (QOL-AD) scores were unchanged in both the GEX and CON. Conclusions: Our results indicate that a low-cost, multidimensional group exercise intervention can positively influence cognitive function and improve patients with mild to moderate AD ability to perform ADLs.

Download Full-text

The Path Linking Disease Severity and Cognitive Function with Quality of Life in Parkinson's Disease: the Mediating Effect of Activities of Daily Living and Depression.

10.21203/rs.3.rs-46784/v1 ◽

2020 ◽

Author(s):

Yao He ◽

Yuling Tian ◽

Hongjuan Han ◽

Jing Cui ◽

Xiaoyan Ge ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Cognitive Function ◽

Activities Of Daily Living ◽

Direct Effect ◽

Daily Living ◽

Mediating Effect ◽

Effect Of Pd ◽

Significant Direct Effect

Abstract Background: Research on quality of life (QOL) with Parkinson’s disease (PD) has examined direct influencing factors, not mediators. The study aim was to explore whether PD severity and poor cognitive function may decrease physical and mental QOL by reducing activities of daily living (ADL) and increasing depression in sequence. Methods: We conducted a cross-sectional questionnaire study of 150 PD hospital patients in China. PD severity, cognitive function, ADL, depression, and QOL were evaluated. We used structural equation modeling to analyze the mediating effects of ADL and depression on the association between PD severity/cognition and physical (PCS) and mental (MCS) QOL. Results:There was a significant mediating effect of PD severity on PCS via ADL and depression (95%CI: −0.669, −0.026), and a significant direct effect (p<0.001). The mediating effect of PD severity on MCS via ADL and depression was significant (95%CI: −2.135, −0.726), but there was no direct effect (p = 0.548). There was a significant mediating effect of cognitive function on PCS via ADL and depression (95%CI: 0.025, 0.219) and a significant direct effect (p<0.001). The mediating effect of cognitive function on MCS via ADL and depression was significant (95%CI: 0.256, 0.645), but there was no direct effect (p = 0.313). The PCS models showed a partial mediation, and the MCS models showed a complete mediation, of ADL and depression.Conclusions:PD severity and cognitive function increase depression by reducing ADL, leading to lower QOL, and directly or indirectly affect PCS and MCS through different pathways.

Download Full-text

Analysis of Medication Adherence and Its Influencing Factors in Patients with Schizophrenia in the Chinese Institutional Environment

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094746 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4746

Author(s):

Wei Yu ◽

Jie Tong ◽

Xirong Sun ◽

Fazhan Chen ◽

Jie Zhang ◽

...

Keyword(s):

Quality Of Life ◽

Medication Adherence ◽

Activities Of Daily Living ◽

Influencing Factors ◽

Self Efficacy ◽

Daily Living ◽

Institutional Environment ◽

Factors Influencing ◽

Quality Of Life Scale

Background: Factors related to medication adherence in patients with schizophrenia have always been key to the treatment and rehabilitation of these patients. However, the treatment modes in different countries are not the same, and there is no research on the factors influencing medication adherence under different mental health service modes. Objectives: The purpose of this study was to explore medication adherence and its influencing factors in patients with schizophrenia in the Chinese institutional environment. Methods: We conducted a cross-sectional study of hospitalized persons living with schizophrenia from November 2018 to January 2019. A systematic sampling method was used to select 217 hospitalized persons living with schizophrenia. The Medication Adherence Rating Scale (MARS), Positive and Negative Syndrome Scale (PANSS), General Self-Efficacy Scale (GSES), Schizophrenia Quality of Life Scale (SQLS), and Scale of Social Skills for Psychiatric Inpatients (SSPI) were used to explore medication compliance and its influencing factors in the Chinese institutional environment. Results: The descriptive analysis and ANOVA showed that there were no significant differences in medication adherence when assessed by demographic characteristics such as sex, marital status, and education level (p > 0.05). A correlation analysis showed that there was no significant correlation between medication adherence and mental symptoms (p > 0.05) but that there was a positive correlation with self-efficacy, quality of life, and activities of daily living (p < 0.01). The linear regression analysis showed that self-efficacy, psychosocial factors, symptoms/side effects, and activities of daily living had significant effects on medication adherence (F = 30.210, p < 0.001). Conclusions: Our findings show that the self-efficacy, quality of life, and social function of patients with schizophrenia are important self-factors influencing medication adherence in the Chinese institutional environment.

Download Full-text

Rehabilitation training based on virtual reality for patients with Parkinson’s disease in improving balance, quality of life, activities of daily living, and depressive symptoms: A systematic review and meta-regression analysis

Clinical Rehabilitation ◽

10.1177/0269215521995179 ◽

2021 ◽

pp. 026921552199517

Author(s):

Runze Li ◽

Yanran Zhang ◽

Yunxia Jiang ◽

Mengyao Wang ◽

Wei How Darryl Ang ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Virtual Reality ◽

Depressive Symptoms ◽

Activities Of Daily Living ◽

Daily Living ◽

Meta Analysis ◽

Rehabilitation Training

Objective: To examine the effectiveness of rehabilitation training based on virtual reality in improving balance, quality of life, activities of daily living, and depressive symptoms of patients with Parkinson’s disease. Data sources: PubMed, EMBASE, CINAHL, Scopus, Cochrane Library, PsycINFO, ProQuest, Physiotherapy Evidence Database, IEEE Xplore, China National Knowledge Infrastructure, Wanfang, and VIP Information databases were searched from their inception to October 15, 2020. Trial registries, gray literature, and target journals were also searched. Methods: Eligible randomized controlled trials included studies with patients with Parkinson’s disease in rehabilitation training based on virtual reality. Comprehensive Meta-Analysis 3.0 software was used. Physiotherapy Evidence Database Scale and the Grading of Recommendation, Assessment, Development, and Evaluation system were used to assess the methodological quality of individual trials and the overall quality of the evidence, respectively. Results: A total of 22 randomized controlled trials with 836 patients were included. Meta-analysis revealed that training significantly improved balance ( g = 0.66, P < 0.001), quality of life ( g = 0.28, P = 0.015), activities of daily living ( g = 0.62, P < 0.001), and depressive symptoms ( g = 0.67, P = 0.021) compared to the control group. Subgroup analysis indicated that training should utilize video game consoles. Meta-regression analyses showed that age, sessions, and frequency of training had statistically significant impacts on balance scores. Quality of individual trials was high and overall evidence ranged from very low to low. Conclusion: Virtual rehabilitation training could be adopted in healthcare institutions as supplementary training for patients with Parkinson’s disease.

Download Full-text