scholarly journals Tumor Markers of Neo-Adjuvant Chemo-Radiation Response in Rectal Cancer

10.5772/28095 ◽  
2011 ◽  
Author(s):  
Jacintha N. ◽  
Mary Clare ◽  
John V.
Keyword(s):  
Rectal Cancer ◽  
Tumor Markers ◽  
Radiation Response

scholarly journals Evaluation of potential tumor markers that may predict neoadjuvant treatment efficiency in rectal cancer

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Fatma Demet Arslan ◽  
Ayse Kocak ◽  
Cengiz Aydın ◽  
Emel Ebru Pala ◽  
Dilek Oncel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rectal Cancer ◽  
Tumor Markers ◽  
Locally Advanced ◽  
Neoadjuvant Treatment ◽  
Beclin 1 ◽  
Tumor Regression Grade ◽  
Protein Levels ◽  
Study Gene Expression ◽  
Regression Grade

AbstractObjectivesThe recurrence of rectal cancer or its resistance to neoadjuvant treatment develops due to the adaptation to hypoxia, apoptosis or autophagy. Survivin, one of the inhibitors of apoptosis; Beclin 1, which is a positive regulator in the autophagy pathway; and hypoxia-inducible factor-1α (HIF-1α) and carbonic anhydrase-9 (CA9), which are associated with tumor tissue hypoxia, may be related to resistance to treatment. Our aim was to evaluate the potential tumor markers that may help to monitor the response to neoadjuvant treatment in locally advanced rectal cancer (RC).MethodsTwenty-five patients with locally advanced RC were included in the study. Gene expression and protein levels of Beclin 1, Survivin, HIF-1α, and CA9 were analyzed in fresh tissue specimens and blood samples. The relationships of these markers to tumor staging and regression grade were evaluated.ResultsHigher blood CA9 gene expression levels and lower blood HIF-1α protein levels were found in the response group according to tumor regression grade. After neoadjuvant treatment, tissue Beclin 1 and blood Survivin gene expressions and tissue CA9, blood Beclin 1 and blood HIF-1α protein levels decreased significantly.ConclusionBeclin 1, Survivin, HIF-1α ve CA9 may help to predict the effects of the applied treatment approach.

scholarly journals Association of microRNA-652 Expression with Radiation Response of Colorectal Cancer: A Study from Rectal Cancer Patients in a Swedish Trial of Preoperative Radiotherapy to Public Data Analysis and in Vitro Investigation

2021 ◽  
Author(s):  
Surajit Pathak ◽  
Wen-Jian Meng ◽  
Sushmitha Sriram ◽  
Jaganmohan Reddy Jangamreddy ◽  
Antara Banerjee ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Patients ◽  
Disease Free Survival ◽  
Human Colon ◽  
Radiation Response ◽  
Human Colon Cancer ◽  
In Vitro Investigation ◽  
Public Data ◽  
Relationship Of

Abstract Purpose: Radiotherapy (RT) is a standard adjuvant therapy in progressive rectal cancer patients, but many patients are resistant to RT, leading to poor prognosis. Our study identified microRNA-652 (miR-652) value on RT response and outcome in rectal cancer patients.Methods: miR-652 expression was determined by RT-PCR in primary rectal cancer from 48 patients with and 53 patients without RT. The relationship of miR-652 with biological factors and prognosis were examined. The biological function of miR-652 was identified through TCGA and GEPIA database search. Two human colon cancer cell lines (HCT116 p53+/+ and p53-/-) were used for in vitro study. Results: miR-652 expression was augmented significantly in cancer than normal mucosa in non-RT patients (P=0.044). High miR-652 expression in non-RT patients was related to more apoptosis (P=0.036), ATM (P=0.010) and DNp73 expression (P=0.009). High miR-652 expression was related to worse disease-free survival of non-RT patients, independent of gender, age, tumor stage and differentiation (P=0.028; HR=7.398, 95% CI 0.217-3.786). The biological functional analysis further identified the prognostic value and potential relationship of miR-652 with the apoptosis in rectal cancer. In RT patients, miR-652 expression was notably decreased in cancers when compared to non-RT cases (P=0.047), and miR-652 expression in cancers was negatively related to WRAP53 expression (P=0.022). After miR-652 inhibition, the estimation of reactive oxygen species, caspase activity and apoptosis in HCT116 p53+/+ cells were significantly increased compared with HCT116 p53-/- cells after radiation.Conclusions Our findings suggest the potential value of miR-652 expression as a marker for the prediction of radiation response and clinical outcome in rectal cancer patients.

Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response

2018 ◽  
Vol 179 ◽  
pp. 53-60 ◽  
Author(s):  
D.L. Bowden ◽  
P.A. Sutton ◽  
M.A. Wall ◽  
P.V. Jithesh ◽  
R.E. Jenkins ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Response ◽  
Proteomic Profiling ◽  
Acid Ceramidase

Clinical Significance and Radiation Response of miR-302a, miR-105 and miR-888 Expression in Rectal Cancer

2018 ◽  
Author(s):  
Xiao-feng Sun ◽  
Wen-Jian Meng ◽  
Surajit Pathak ◽  
Hong Zhang ◽  
Gunnar Adell ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Clinical Significance ◽  
Radiation Response

Intravoxel Incoherent Motion MRI of Rectal Cancer: Correlation of Diffusion and Perfusion Characteristics With Prognostic Tumor Markers

2018 ◽  
Vol 210 (4) ◽  
pp. W139-W147 ◽  
Author(s):  
Hongliang Sun ◽  
Yanyan Xu ◽  
Aiping Song ◽  
Kaining Shi ◽  
Wu Wang
Keyword(s):  
Rectal Cancer ◽  
Tumor Markers ◽  
Intravoxel Incoherent Motion ◽  
Motion Mri

scholarly journals PINCH expression in relation to radiation response in co-cultured colon cancer cells and in rectal cancer patients

2013 ◽  
Vol 30 (5) ◽  
pp. 2097-2104 ◽  
Author(s):  
ANNICA HOLMQVIST ◽  
BIRGITTA HOLMLUND ◽  
MALIN ARDSBY ◽  
SURAJIT PATHAK ◽  
XIAO-FENG SUN
Keyword(s):  
Rectal Cancer ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Radiation Response ◽  
Colon Cancer Cells

scholarly journals Tumor markers and rectal cancer: Support for an inflammation-related pathway

2009 ◽  
Vol 125 (7) ◽  
pp. 1698-1704 ◽  
Author(s):  
Martha L. Slattery ◽  
Roger K. Wolff ◽  
Jennifer Herrick ◽  
Bette J. Caan ◽  
Wade Samowitz
Keyword(s):  
Rectal Cancer ◽  
Tumor Markers ◽  
Cancer Support ◽  
Related Pathway

scholarly journals Network Mapping of Molecular Biomarkers Influencing Radiation Response in Rectal Cancer

2019 ◽  
Vol 18 (2) ◽  
pp. e210-e222 ◽  
Author(s):  
Liam Poynter ◽  
Dieter Galea ◽  
Kirill Veselkov ◽  
Alexander Mirnezami ◽  
James Kinross ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Molecular Biomarkers ◽  
Radiation Response ◽  
Network Mapping

Differences in serum tumor markers between colon and rectal cancer

1996 ◽  
Vol 39 (7) ◽  
pp. 799-805 ◽  
Author(s):  
Monika A. Carpelan-Holmström ◽  
Caj H. Haglund ◽  
Peter J. Roberts
Keyword(s):  
Rectal Cancer ◽  
Tumor Markers ◽  
Serum Tumor Markers ◽  
Colon And Rectal Cancer
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