Screening for HIV Infection in Pregnancy

Combination testing with anti-HIV Elisa and Western blot is both sensitive and specific for diagnosis of established HIV-1 infection but could not detect acute HIV infection (AHI). AHI is a time of extremely high viral load, which may correlate to increased risk of horizontal or vertical transmission. Thus, early identification of AHI could allow for interventions to decrease transmission. However, recognition of AHI can be challenging as symptoms could be absent or nonspecific, therefore, AHI is often not detected, particularly in pregnancy. We present a case report of AHI in a pregnant woman who presented with headache and fever. She tested negative for HIV in the first trimester and at time of AHI at 26 3/7 weeks by anti-HIV Elisa, but was diagnosed with AHI based on an HIV RNA viral load of 434,000 copies/mL. This report presents a case for improved awareness of AHI in pregnancy, and the need for repeat HIV testing in late pregnancy, and highlighted that early detection of AHI might be possible with adding HIV RNA testing at time of standard anti-HIV Elisa screening test in pregnancy. Novel laboratory approaches including pooling of sera for HIV RNA could reduce the cost of HIV RNA testing.

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HIV Antibody Seroprevalence and Determinants Amongst Antenatal Clients in a Tertiary Hospital in the Niger Delta

European Scientific Journal ESJ ◽

10.19044/esj.2018.v14n9p300 ◽

2018 ◽

Vol 14 (9) ◽

pp. 300

Author(s):

Kotingo E.L. ◽

Allagoa D.O.B.

Keyword(s):

Hiv Infection ◽

Sex Education ◽

Significant Risk ◽

Data Entry ◽

Public Health Problem ◽

Sexual Partners ◽

P Value ◽

Cross Sectional ◽

Multiple Sexual Partners ◽

In Pregnancy

Background: The pandemicity of the human immunodeficiency virus (HIV) has continued to be a ‘medical quagmire,’ one of the most serious global catastrophe and public health problem that plagues the world today. Objectives: To determine the seroprevalence and clinico-epidemiological correlates of HIV infection in pregnancy. Methodology: This is a descriptive cross sectional study. Two hundred and twenty (220) consecutive healthy pregnant women attending the antenatal booking clinic of the hospital who met the inclusion criteria were recruited. Data was collected via a questionnaire. Data entry and analysis was done using SPSS (statistical package forsocial sciences) 22 statistical package (SPSS Inc., Illinois, U.S.A). P value less than 0.05 was taken as being significant. Results: Of the 220 women, 4.6% (n=10) were seropositive for HIV antibodies. Multiple sexual partners was the significant risk factors for HIV seropositivity (p<0.05). There was no significant association with respect to tattoo/scarification marks, female circumcision, previous blood transfusion, intravenous drug abuse or sharing of sharps, previous surgery, episiotomies or dilatation and curettage (p>0.05). Conclusion: The high endemicity of HIV infection in this study justifies the need for routine screening in pregnancy to identify and institute treatment of the infection promptly as this will reduce the mother to child transmission of the virus. Sex education on the dangers of multiple sexual partners or sexual promiscuity, availability of barrier methods of contraception and patronage, more efforts/interventions by relevant agencies, high sense of vigilance amongst others are very vital to curtailing this global pandemic in our society.

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