scholarly journals Maternal Hypercholesterolemia in Gestational Diabetes and the Association with Placental Endothelial Dysfunction

10.5772/55297 ◽  
2013 ◽  
Author(s):  
A. Leiva ◽  
C Diez de Medina ◽  
E. Guzmn-Gutierrez ◽  
F. Pardo ◽  
L. Sobrevi
Keyword(s):  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Maternal Hypercholesterolemia

Gestational diabetes and feto-placental endothelial dysfunction: Role of exosomes from human umbilical vein endothelial cells on L-arginine/NO signalling pathway

Placenta ◽  
2016 ◽  
Vol 45 ◽  
pp. 111
Author(s):  
Tamara Sáez ◽  
Rocío Salsoso ◽  
Carlos Sanhueza ◽  
Fabian Pardo ◽  
Andrea Leiva ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Umbilical Vein ◽  
Signalling Pathway ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

scholarly journals Maternal Hypercholesterolemia in Pregnancy Associates With Umbilical Vein Endothelial Dysfunction

2013 ◽  
Vol 33 (10) ◽  
pp. 2444-2453 ◽  
Author(s):  
Andrea Leiva ◽  
Camila Diez de Medina ◽  
Rocío Salsoso ◽  
Tamara Sáez ◽  
Sebastián San Martín ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Umbilical Vein ◽  
Maternal Hypercholesterolemia ◽  
In Pregnancy

Previous gestational diabetes impairs long-term endothelial function in a mouse model of complicated pregnancy

2010 ◽  
Vol 299 (3) ◽  
pp. R862-R870 ◽  
Author(s):  
Joanna L. Stanley ◽  
Sowndramalingam Sankaralingam ◽  
Philip N. Baker ◽  
Sandra T. Davidge
Keyword(s):  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Mouse Model ◽  
Endothelial Function ◽  
Fluorescence Intensity ◽  
Mean Fluorescence Intensity ◽  
Mesenteric Arteries ◽  
Superoxide Production ◽  
Increased Risk

Women who develop gestational diabetes mellitis (GDM) display endothelial dysfunction up to 1 yr after pregnancy, despite a return to normoglycemia. It is unknown whether this dysfunction was preexisting or whether GDM pregnancy leads to long-term endothelial dysfunction. A mouse model that spontaneously develops GDM ( Lepr db/+) was used to determine whether the endothelial dysfunction that develops during GDM is evident in later life. Heterozygous and wild-type (WT) controls were allowed to litter once, then age to 9–10 mo, and were compared with virgin controls. Vascular function of small mesenteric arteries was assessed using wire myography. Concentration response curves to the thromboxane A2mimetic U46619 and the endothelium-dependent vasodilator methacholine were constructed. Superoxide production and peroxynitrite formation was also measured. Mice with previous GDM displayed blood glucose concentrations similar to previously pregnant WT mice (8.0 ± 0.1 vs. 7.1 ± 0.3 mmol/l, P > 0.05). Arteries from mice with previous GDM displayed increased sensitivity to U46619 (EC50 5.2 ± 0.7 vs. 45.2 ± 1.0 nmol/l, P < 0.01) and impaired endothelium-dependent relaxation compared with WT controls (29 ± 8 vs. 58 ± 16 percent relaxation, P < 0.05). This was associated with increased superoxide production (93.3 ± 2.3 vs. 64.6 ± 1.6 mean fluorescence intensity, P < 0.001) and increased peroxynitrite formation (173.5 ± 11.0 vs. 57.4 ± 16.2 mean fluorescence intensity, P < 0.01) compared with virgin controls. In summary, endothelial dysfunction was evident in mice with previous GDM compared with previously healthy pregnant mice or virgin controls. These data suggest that GDM affects endothelial function and may contribute to an increased risk of cardiovascular disease.

Association of advanced glycation end products (AGEs) with endothelial dysfunction, oxidative stress in gestational diabetes mellitus (GDM)

2019 ◽  
Vol 40 (2) ◽  
pp. 276-282 ◽  
Author(s):  
Sundar Krishnasamy ◽  
Barathi Rajaraman ◽  
Vidya Ravi ◽  
Rashmi Rajagopal ◽  
Arunkumar Ganeshprasad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Exogenous insulin requires MAPK activation to reverse the umbilical vein endothelial dysfunction observed in pregnant women with gestational diabetes mellitus treated with insulin

Placenta ◽  
2019 ◽  
Vol 83 ◽  
pp. e95
Author(s):  
Mario Subiabre ◽  
Roberto Villalobos-Labra ◽  
Luis Silva ◽  
Gonzalo Fuentes ◽  
Fernando Toledo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Umbilical Vein ◽  
Exogenous Insulin ◽  
Mapk Activation

Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation

2018 ◽  
Vol 17 (1) ◽  
pp. 52-71 ◽  
Author(s):  
Susana Contreras-Duarte ◽  
Lorena Carvajal ◽  
Bárbara Fuenzalida ◽  
Claudette Cantin ◽  
Luis Sobrevia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vascular Function ◽  
Physiological Adaptation ◽  
Aortic Atherosclerosis ◽  
Plasma Total Cholesterol ◽  
Foetal Development ◽  
In Pregnancy

Dyslipidaemia occurs in pregnancy to secure foetal development. The mother shows a physiological increase in plasma total cholesterol and Triglycerides (TG) as pregnancy progresses (i.e. maternal physiological dyslipidaemia in pregnancy). However, in some women pregnancy-associated dyslipidaemia exceeds this physiological adaptation. The consequences of this condition on the developing fetus include endothelial dysfunction of the foetoplacental vasculature and development of foetal aortic atherosclerosis. Gestational Diabetes Mellitus (GDM) associates with abnormal function of the foetoplacental vasculature due to foetal hyperglycaemia and hyperinsulinaemia, and associates with development of cardiovascular disease in adulthood. Supraphysiological dyslipidaemia is also detected in GDM pregnancies. Although there are several studies showing the alteration in the maternal and neonatal lipid profile in GDM pregnancies, there are no studies addressing the effect of dyslipidaemia in the maternal and foetal vasculature. The literature reviewed suggests that dyslipidaemia in GDM pregnancy should be an additional factor contributing to worsen GDM-associated endothelial dysfunction by altering signalling pathways involving nitric oxide bioavailability and neonatal lipoproteins.

Functional Link Between Adenosine and Insulin: A Hypothesis for Fetoplacental Vascular Endothelial Dysfunction in Gestational Diabetes

2011 ◽  
Vol 9 (6) ◽  
pp. 750-762 ◽  
Author(s):  
Enrique Guzman-Gutierrez ◽  
Fernando Abarzua ◽  
Cristian Belmar ◽  
Jyh K. Nien ◽  
Marco A. Ramirez ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Functional Link

Fetal sex in the development of gestational diabetes mellitus and endothelial dysfunction

2020 ◽  
Vol 9_2020 ◽  
pp. 56-64
Author(s):  
Botasheva T.L. Botasheva ◽  
Palieva N.V. Palieva ◽  
Khloponina A.V. Khloponina ◽  
Vasiljeva V.V. Vasiljeva ◽  
Zheleznyakova E.V. Zheleznyakova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Fetal Sex
Sign in / Sign up

Export Citation Format

Share Document