scholarly journals Mammalian Sugar Transporters

10.5772/58325 ◽  
2014 ◽  
Author(s):  
Robert Augustin ◽  
Eric Mayoux
Keyword(s):  
Sugar Transporters

scholarly journals Identification of novel potential interaction partners of UDP-galactose (SLC35A2), UDP-N-acetylglucosamine (SLC35A3) and an orphan (SLC35A4) nucleotide sugar transporters

2021 ◽  
pp. 104321
Author(s):  
Maciej Wiktor ◽  
Wojciech Wiertelak ◽  
Dorota Maszczak-Seneczko ◽  
Piotr Jan Balwierz ◽  
Bożena Szulc ◽  
...  
Keyword(s):  
Potential Interaction ◽  
Nucleotide Sugar ◽  
Sugar Transporters ◽  
Interaction Partners ◽  
Nucleotide Sugar Transporters

scholarly journals Degradation of biological macromolecules supports uncultured microbial populations in Guaymas Basin hydrothermal sediments

2021 ◽  
Author(s):  
Sherlynette Pérez Castro ◽  
Mikayla A. Borton ◽  
Kathleen Regan ◽  
Isabella Hrabe de Angelis ◽  
Kelly C. Wrighton ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Extracellular Enzyme ◽  
Trophic Levels ◽  
Glycoside Hydrolases ◽  
Biological Macromolecules ◽  
Guaymas Basin ◽  
Bacterial Phyla ◽  
Sugar Transporters ◽  
Hydrothermal Sediments ◽  
Thermophilic Conditions

AbstractHydrothermal sediments contain large numbers of uncultured heterotrophic microbial lineages. Here, we amended Guaymas Basin sediments with proteins, polysaccharides, nucleic acids or lipids under different redox conditions and cultivated heterotrophic thermophiles with the genomic potential for macromolecule degradation. We reconstructed 20 metagenome-assembled genomes (MAGs) of uncultured lineages affiliating with known archaeal and bacterial phyla, including endospore-forming Bacilli and candidate phylum Marinisomatota. One Marinisomatota MAG had 35 different glycoside hydrolases often in multiple copies, seven extracellular CAZymes, six polysaccharide lyases, and multiple sugar transporters. This population has the potential to degrade a broad spectrum of polysaccharides including chitin, cellulose, pectin, alginate, chondroitin, and carrageenan. We also describe thermophiles affiliating with the genera Thermosyntropha, Thermovirga, and Kosmotoga with the capability to make a living on nucleic acids, lipids, or multiple macromolecule classes, respectively. Several populations seemed to lack extracellular enzyme machinery and thus likely scavenged oligo- or monomers (e.g., MAGs affiliating with Archaeoglobus) or metabolic products like hydrogen (e.g., MAGs affiliating with Thermodesulfobacterium or Desulforudaceae). The growth of methanogens or the production of methane was not observed in any condition, indicating that the tested macromolecules are not degraded into substrates for methanogenesis in hydrothermal sediments. We provide new insights into the niches, and genomes of microorganisms that actively degrade abundant necromass macromolecules under oxic, sulfate-reducing, and fermentative thermophilic conditions. These findings improve our understanding of the carbon flow across trophic levels and indicate how primary produced biomass sustains complex and productive ecosystems.

scholarly journals Electrophysiological characterization of a diverse group of sugar transporters from Trichoderma reesei

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sami Havukainen ◽  
Jonai Pujol-Giménez ◽  
Mari Valkonen ◽  
Ann Westerholm-Parvinen ◽  
Matthias A. Hediger ◽  
...  
Keyword(s):  
Trichoderma Reesei ◽  
Scientific Literature ◽  
Large Body ◽  
Comprehensive Analysis ◽  
Transport Function ◽  
Sugar Transporters ◽  
New Knowledge ◽  
Electrophysiological Characterization ◽  
Shed Light

AbstractTrichoderma reesei is an ascomycete fungus known for its capability to secrete high amounts of extracellular cellulose- and hemicellulose-degrading enzymes. These enzymes are utilized in the production of second-generation biofuels and T. reesei is a well-established host for their production. Although this species has gained considerable interest in the scientific literature, the sugar transportome of T. reesei remains poorly characterized. Better understanding of the proteins involved in the transport of different sugars could be utilized for engineering better enzyme production strains. In this study we aimed to shed light on this matter by characterizing multiple T. reesei transporters capable of transporting various types of sugars. We used phylogenetics to select transporters for expression in Xenopus laevis oocytes to screen for transport activities. Of the 18 tested transporters, 8 were found to be functional in oocytes. 10 transporters in total were investigated in oocytes and in yeast, and for 3 of them no transport function had been described in literature. This comprehensive analysis provides a large body of new knowledge about T. reesei sugar transporters, and further establishes X. laevis oocytes as a valuable tool for studying fungal sugar transporters.

scholarly journals Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa

2011 ◽  
Vol 10 (1) ◽  
Author(s):  
Ksenija Slavic ◽  
Sanjeev Krishna ◽  
Elvira T Derbyshire ◽  
Henry M Staines
Keyword(s):  
Drug Targets ◽  
Sugar Transporters

Molecular Biology of Sugar Transporters in Plants

Botanica Acta ◽  
1993 ◽  
Vol 106 (4) ◽  
pp. 277-286 ◽  
Author(s):  
N. Sauer ◽  
W. Tanner
Keyword(s):  
Molecular Biology ◽  
Sugar Transporters

scholarly journals Transcripts repressed at the stop of phloem unloading highlight the energy efficiency of sugar import in the ripening V. vinifera fruit.

2021 ◽  
Author(s):  
Stefania Savoi ◽  
Laurent Torregrosa ◽  
Charles Romieu
Keyword(s):  
Cell Wall ◽  
Regulatory Elements ◽  
Solute Concentration ◽  
Growth Patterns ◽  
Individual Growth ◽  
Sugar Accumulation ◽  
Minor Role ◽  
Phloem Unloading ◽  
Sugar Transporters ◽  
A Minor

AbstractTranscriptomic changes at the cessation of sugar accumulation in the pericarp of Vitis vinifera were addressed on single berries re-synchronized according to their individual growth patterns. The net rates of water, sugars and K+ accumulation inferred from individual growth and solute concentration confirmed that these inflows stopped simultaneously in the ripe berry, while the small amount of malic acid remaining at this stage was still being oxidized at a low rate. Resynchronized individual berries displayed negligible variations in gene expression among triplicates. RNA-Seq studies revealed sharp reprogramming of cell wall enzymes and structural proteins, associated with an 80% repression of specific sugar transporters and aquaporins on the plasma or tonoplast membranes, at the stop of phloem unloading in the three genotypes and two environments investigated. The prevalence of SWEET transporters suggests that electrogenic transporters would just play a minor role on the plasma membrane of SE/CC complex, and the one of the flesh, while sucrose/H+ exchangers dominate on its tonoplast. Cis-regulatory elements present in their promoters allowed to sort these transporters in different groups, also including specific TIPs and PIPs paralogs, and cohorts of cell wall related genes. These results lead us to propose which structural, developmental and energy adaptations would give this fruit such a power of attraction for water and photoassimilates.

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